tramadol hydrochloride / Generic mfg. - LARVOL DELTA

Ameliorative Effect of Vitamin C Against Tramadol-Induced Learning and Memory Impairment in Juvenile Rat Via Attenuation of Oxidative Stress and Dysfunctional Synaptic Plasticity. (PubMed, J Neuroimmune Pharmacol) - "These findings suggest that Vit C can attenuate cognitive impairments associated with chronic TM consumption, likely through modulation of hippocampal oxidative stress and enhancement of LTP induction. Therefore, Vit C could be a promising candidate for further investigation as a potential therapeutic agent to mitigate cognitive dysfunction associated with TM use."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • CAT

Interdisciplinary pharmaceutical care model engaging patient participation alleviate the anticholinergic burden in community-dwelling older adults: subgroup analysis of a randomized controlled trial. (PubMed, Ther Adv Drug Saf) - "Famotidine, tramadol, alprazolam, and celecoxib were the most commonly prescribed and discontinued S-type AC drugs. This community-based interdisciplinary pharmaceutical care model, which included patient participation, was effective in reducing the burden of S-type AC drugs among older adults in rural communities."

Journal • Alzheimer's Disease • Cognitive Disorders • Xerostomia

Evaluation of Medetomidine Dose Variations on Tiletamine-Zolazepam and Tramadol Anesthetic Combination in Dogs. (PubMed, Animals (Basel)) - "While TZT provided adequate anesthesia for minor non-invasive procedures, the inclusion of medetomidine in TZTM resulted in enhanced anesthetic stability for simple surgical procedures such as gonadectomy. These findings suggest that TZTM20 is a viable anesthetic protocol, though careful patient monitoring remains essential due to its cardiovascular effects."

Journal • Anesthesia • Cardiovascular • Pain

Tramadol for treatment of neurogenic cough: a retrospective case series. (PubMed, J Laryngol Otol) - No abstract available

Journal • Retrospective data • Cough • Respiratory Diseases

Bioaccumulation of Psychoactive Contaminants and Their Effects on Brain-Gonad-Sperm Neurotransmitter Networks in Fish. (PubMed, Environ Sci Technol) - "Here, we investigated the effects of environmentally relevant concentrations of a mixture of seven PSYCs (citalopram, donepezil, gabapentin, methamphetamine, sertraline, tramadol, and venlafaxine) on European perch (Perca fluviatilis) during a 23 day exposure. No significant changes were observed in gonadal histopathology or sperm-quality parameters; however, the observed molecular alterations suggest potential consequences under longer or chronic exposures. These findings identify sperm as a previously overlooked target for psychoactive pollutants and reveal neurochemical disruption along the brain-gonad-sperm axis as a previously unrecognized mechanism through which PSYCs may affect fish physiology."

Journal

Opportunities and challenges for the implementation of pharmacogenomics in supportive care for gastrointestinal cancer patients in Zimbabwe. (PubMed, Pharmacogenomics) - "PGX guidelines were fully implemented for tramadol, codeine, omeprazole, and ondansetron; partially for ibuprofen and celecoxib; and unimplementable for amitriptyline. There is an opportunity to improve supportive care in gastrointestinal cancer patients through pharmacogenomics though some specific medicines challenges to full implementations are due to limited registered medicines."

Biomarker • Journal • Gastrointestinal Cancer • Oncology • Solid Tumor

Intercostal Cryoanalgesia in Pediatric Nuss Repair for Pectus Excavatum: A Three-Case Series From Ecuador. (PubMed, Cureus) - "A standardized multimodal protocol included bilateral pectoralis nerve II blocks, a type of ultrasound-guided regional anesthetic technique used to manage chest wall pain, plus a dexmedetomidine infusion and scheduled non-opioid analgesics; tramadol was reserved for rescue via the intravenous route. No neurologic deficits or wound complications were observed. These observations support the feasibility and safety of intercostal cryoanalgesia in a middle-income setting and suggest that immediate preoperative application (-24 hours) may provide earlier analgesic onset than intraoperative timing, warranting larger comparative evaluations."

Journal • Anesthesia • Critical care • Pain • Pediatrics

Catechin hydrate alleviates tramadol-induced ovarian and uterine injury through regulation of oxidative and ER stress, apoptosis, steroidogenesis, and hormonal imbalance. (PubMed, Reprod Toxicol) - "The findings of this study suggest that CTH may offer protective effects against TRD-induced ovarian and uterine toxicity by mitigating oxidative stress, inflammation, apoptosis, and ER stress, thereby supporting hormonal balance and tissue integrity."

IO biomarker • Journal • Inflammation • ATF6 • BCL2 • CASP3 • CYP17A1 • CYP19A1 • IL1B • TNFA

Comparison of Oblique Subcostal Transversus Abdominis Plane Block and External Oblique Intercostal Plane Block for Postoperative Pain Management in Laparoscopic Cholecystectomy. (PubMed, J Coll Physicians Surg Pak) - "Effective postoperative analgesia was achieved in both groups with similar opioid consumption and pain scores. However, the EOIP block may be considered as a technically easier and safer alternative for regional analgesia in LC. Further research is needed to determine the long-term benefits and optimum clinical applications of these blocks in laparoscopic surgery."

Clinical • Journal • Anesthesia • Pain

Patients on Regular Preoperative Weak Opioid Intake Can Achieve Successful Surgical Outcomes After Posterior Decompression Surgery for Cervical Spondylotic Myelopathy. (PubMed, Clin Spine Surg) - "Patients receiving regular weak opioids preoperatively can achieve successful surgical outcomes after posterior decompression surgery for cervical spondylotic myelopathy."

Journal • CNS Disorders • Musculoskeletal Pain • Orthopedics • Pain

Preoperative Suprazygomatic Maxillary Nerve Block to Reduce Perioperative Opioid Use in Pediatric Primary Cleft Palate Repair: Preliminary Clinical Experience. (PubMed, J Craniofac Surg) - "Preoperative ultrasound-guided SMNB may be associated with reduced perioperative opioid consumption in pediatric primary cleft palate surgery. Larger, preferably randomized trials are needed to confirm its role in multimodal analgesia protocols."

Journal • Anesthesia • Pain • Pediatrics

Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain (clinicaltrials.gov) - P=N/A | N=400 | Completed | Sponsor: Assiut University | Recruiting ➔ Completed

Trial completion • Oncology • Pain

Therapeutic challenges in a rare trigeminal autonomic cephalalgia (EHF-EHC 2025) - "A discrete improvement was noted with intravenous eptinezumab 300 mg every 12 weeks, in combination with duloxetine, gabapentin, topiramate and tapentadol. He makes excessive use of fast-acting tramadol and ibuprofen to alleviate acute pain...SUNCT remains a therapeutic challenge due to its rarity, limited evidence base, and frequent refractoriness. This reinforces the need for further research and therapeutic innovation."

Rheumatology

SUNCT-like headache secondary to herpes zoster in the ipsilateral ophthalmic nerve distribution: A case report (EHF-EHC 2025) - "A 52-year-old Sri Lankan male developed painful vesicular eruptions over the right ophthalmic dermatome and was treated with oral acyclovir (800 mg, five times daily)...Treatment included oral prednisolone (15 mg/day, tapered by 5 mg/week), carbamazepine (100 mg t.d.s., increased to 200 mg t.d.s. from week two), pregabalin (75 mg nocte), and tramadol (50 mg nocte)...This case underscores a SUNCT-like syndrome following ophthalmic zoster, which appears more pharmacoresponsive than primary SUNCT. Immunosuppressive states like diabetes, should be considered underlying zoster reactivation."

Case report • Clinical • Diabetes • Herpes Zoster • Metabolic Disorders • Ophthalmology • Pain • Varicella Zoster

The use of tramadol for cancer-associated pain-a systematic review. (PubMed, Support Care Cancer) - "Relative to other analgesics, tramadol is neither superior nor inferior. There may exist a different safety profile and therefore an opportunity to provide individualized patient-centered treatment strategies focused on safety and quality of life."

Journal • Review • Oncology • Pain

Modulation of PM20D1 expression by rosiglitazone confers neuroprotection in tramadol-induced Parkinsonian rats. (PubMed, Toxicol Rep) - "Parkinson's disease (PD) is a progressive neurodegenerative disorder with no available disease‑modifying therapy, and tramadol misuse has been increasingly associated with PD‑like neurotoxicity through oxidative stress, mitochondrial dysfunction, and apoptosis. The low-dose RSG plus levodopa-carbidopa combination achieved maximal behavioral recovery and dopamine restoration (1023.0 ± 248.0 pg/mL) compared to the tramadol-only group. These findings provide the first evidence that RSG confers neuroprotection against tramadol-induced Parkinsonism through PPARγ-mediated modulation of PM20D1 gene expression, highlighting a novel translational therapeutic axis with potential disease-modifying implications for PD."

IO biomarker • Journal • Preclinical • CNS Disorders • Metabolic Disorders • Movement Disorders • Parkinson's Disease • BCL2 • CASP3 • CASP9

Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Comparison of the Analgesic Efficacy and Safety of Intravenous Ketoprofen, Tramadol, and Morphine After Bony Impacted Mandibular Third Molar Surgery. (PubMed, Cureus) - "The lack of efficacy observed with IV morphine 4 mg raises concerns about potential analgesic assay insensitivity in postsurgical dental pain. The occurrence of seizures in subjects without known seizure risk factors highlights a potentially insufficient safety margin for tramadol in unselected patient populations."

Clinical • Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Epilepsy • Pain • Psychiatry

Is the serratus posterior superior intercostal plane block a viable alternative to the erector spinae plane block for postoperative analgesia in breast surgery? A prospective, randomized trial. (PubMed, BMC Anesthesiol) - "The SPSIPB may provide postoperative analgesia that is comparable in efficacy to the ESPB technique in breast surgery. Based on the findings of this study, SPSIPB provided postoperative analgesia comparable to ESPB and was associated with lower opioid consumption within the first 24 h after surgery. Furthermore, the ESPB group experienced pain relief earlier after surgery compared to the SPSIPB group, while pain relief in the SPSIPB group occurred later and lasted longer."

Journal • Anesthesia • Breast Cancer • Oncology • Pain • Solid Tumor

Hypophysitis Induced by Tislelizumab: A Case Report of Somnolence and Delirium with Elevated Eosinophils. (PubMed, Am J Case Rep) - "The patient developed worsening daytime somnolence and nocturnal delirium following tramadol administration for pain associated with a metastatic tumor in the left axilla...After receiving hydrocortisone treatment, the patient's symptoms of somnolence and delirium vanished...CONCLUSIONS This case underlines the necessity for timely assessment of the hypothalamic-pituitary-adrenal axis function in patients presenting with neurological symptoms, such as somnolence and delirium, particularly in the presence of elevated peripheral blood eosinophil counts. Simultaneously, it is essential for us to understand that patients with hypophysitis induced by ICIs require long-term hormone replacement therapy due to adrenocortical insufficiency."

Journal • Cardiovascular • CNS Disorders • Endometrial Cancer • Eosinophilia • Heart Failure • Oncology • Pain • Solid Tumor

Intraoperative and Postoperative Effects of Tramadol and Dexamethasone Added to Washing Solution in Knee Arthroscopies (clinicaltrials.gov) - P=N/A | N=80 | Active, not recruiting | Sponsor: Yuzuncu Yil University | Not yet recruiting ➔ Active, not recruiting

Enrollment closed • Orthopedics • Pain • Pruritus

Comparison of the Effects of Hyoscine-N-Butylbromide and Ondansetron on Postoperative Nausea-Vomiting after Laparoscopic Cholecystectomy: A Prospective Randomized Study. (PubMed, Niger J Clin Pract) - "The effects of hyoscine-n-butylbromide and ondansetron on PONV and pain are similar in laparoscopic cholecystectomy. In laparoscopic cholecystectomies, hyoscine-n-butylbromide is a good alternative for PONV prophylaxis in eligible patients."

Clinical • Journal • Pain

Effect of Bariatric Surgery on the Pharmacokinetics of Codeine, Oxycodone and Tramadol-A Case Series. (PubMed, Basic Clin Pharmacol Toxicol) - "From a pharmacokinetic point of view, we found no evidence that particular follow-up procedures should be needed for codeine, oxycodone and tramadol in patients undergoing bariatric surgery and continuing drug treatment. However, as always, doses should be adjusted based on clinical effect and the occurrence of adverse drug reactions."

Journal • PK/PD data

Analysis of the Prevalence of Alcohol and Psychoactive Substances Among Drivers in the Material from the Department of Forensic Medicine at the Medical University of Bialystok in Poland. (PubMed, Toxics) - "Among the total positive cases, psychoactive substances used alone or in combination included THC-46.3% (range 0.2-20 ng/mL), alcohol-26.8% (range 0.1-4.1‱), amphetamines-20.7% (range 15-2997 ng/mL), opiates-4.3% (morphine 66.0 ng/mL; methadone 174.0 ng/mL; ranges: tramadol 15.0-600.0 ng/mL; fentanyl 45.0-100.0 ng/mL), benzodiazepines-9.8% (ranges: diazepam 55.0-480.0 ng/mL; midazolam 17.0-1200.0 ng/mL; clonazepam 21.0-36.0 ng/mL), stimulants-6.10% (ranges: amphetamine 15.0-2997.0 ng/mL; cocaine 4.0-30.0 ng/mL; benzoylecgonine 38.0-602.0 ng/mL; PMMA 45.0-360.0 ng/mL; MDMA 20.0-75.0 ng/mL; mephedrone 37.5 ng/mL; alfa-PVP 120 ng/mL), psychotropic drugs-3.1% (carbamazepine 8.0-2100.0 ng/mL; zolpidem 233.0 ng/mL; citalopram 320.0 ng/mL; opipramol 220 ng/mL). Among the psychoactive substances most frequently used alone or in combination with others, THC was predominant. Roadside testing, based on effects similar to alcohol intoxication, was mainly conducted on male drivers."

Journal

Does Tramadol Match Lignocaine for Maxillary Tooth Extraction Under Supra-Periosteal Injection?-A Prospective Clinical Study. (PubMed, J Maxillofac Oral Surg) - "Consumption of analgesic tablets was more in lignocaine group, p = 0.022. Tramadol can be safely employed as an alternative to conventional local anaesthetic agents through supra-periosteal injection due to its dual local anaesthetic and analgesic action."

Journal • Anesthesia • Pain

Use of Dexamethasone via Two Methods in PENG Block for Patients Undergoing Femoral Fracture Surgery: A Prospective Observational Study. (PubMed, J Clin Med) - "The consumption of tramadol and the pain scores measured were noted to be decreased. By minimizing the use of systemic opioids, it may also help mitigate potential side effects. These findings indicate that perineural dexamethasone could serve as a beneficial adjuvant agent for patients undergoing femoral neck fracture surgeries."

Journal • Observational data • Anesthesia • Musculoskeletal Diseases • Orthopedics • Pain