cefotaxime / Generic mfg. - LARVOL DELTA

Polymer matrix of biofilm in Klebsiella pneumoniae reduced by sub-MIC hydrogen peroxide enhances cefotaxime efficacy. (PubMed, Polim Med) - "Sub-minimum inhibitory concentrations of H2O2 exhibited synergistic to strongly additive effects in enhancing the antibacterial activity of cefotaxime against CRKP and in reducing biofilm formation by the K. pneumoniae Kp10 isolate. This effect appears to be mediated by disruption of the biofilm polymer matrix, which may contribute to improved infection control."

Journal • Infectious Disease • Pneumonia

Longitudinal trends in antibiotic resistance of Escherichia coli: A 10-years retrospective analysis in a tertiary care hospital in Lahore, Pakistan. (PubMed, Pak J Med Sci) - "The results indicate a resistance rate of 98% to ampicillin, 93% to amoxicillin/clavulanic acid, and 87% and 82% to second and third-generation cephalosporins: cefuroxime, cefotaxime and ceftriaxone, respectively...However, over 10 years, an increasing resistance trend was observed against cefuroxime and imipenem and a significant decreasing trend was observed against gentamicin and nitrofurantoin. Likewise, resistance against beta-lactam like cefotaxime, ceftriaxone, and cefuroxime significantly increased compared to imipenem and meropenem compared to mean antibiotic resistance across all age groups. It highlights the emerging resistance trend against commonly prescribed antimicrobial drugs, leading to understanding the longitudinal resistance trends of E. coli in the region."

Journal • Retrospective data • Infectious Disease • Nephrology

Solid Medium Droplet Microarray for Miniaturized Antimicrobial Susceptibility Test. (PubMed, Small Sci) - "Using E. coli (DSM498) as a model organism, accurate determination of minimum inhibitory concentrations for clinically relevant antibiotics (cefotaxime, ciprofloxacin, and ampicillin), producing results consistent with EUCAST clinical breakpoints, is demonstrated. The platform is more time efficient (≈16-18 h total) compared to the conventional agar plate-based methods. Owing to the robustness, ease of use, and independence from specialized equipment, the SM-DMA can be adapted for POC applications by nontrained personnel or even by patients themselves."

Journal

Comparing the rates of incidence of Necrotizing Enterocolitis and associated morbidity and mortality in Neonatal Patients Receiving Cefotaxime vs Ceftazidime: A retrospective analysis (ASHP 2025) - No abstract available

Retrospective data • Gastrointestinal Disorder

Antimicrobial resistance profiling of Salmonella and Escherichia coli isolates from conventional poultry farms in Hossana Town, Central Ethiopia. (PubMed, BMC Vet Res) - "Similarly, E. coli O157:H7 isolates demonstrated complete resistance to ampicillin and high (90%) resistance to cefotaxime and tetracycline. Both pathogens showed significant sensitivity to gentamicin and azithromycin...This investigation underscore the importance of further investigations into the factors contributing to resistance, as well as the development of integrated AMR surveillance systems. Molecular investigations are recommended to confirm the mechanisms of resistance and to inform policy decisions and implement evidence based interventions."

Journal

Enhanced detection of bacterial etiologies, antibiotic resistance profile, and treatment outcomes of meningitis patients in Ethiopia: a prospective cross-sectional study. (PubMed, BMC Microbiol) - "PCR significantly outperformed culture in detecting bacterial pathogens. E. coli was the most common causative agent of bacterial meningitis, and we observed high rates of antibiotic resistance among Gram-negative bacteria. While most patients had favorable outcomes, low Glasgow Coma Scale scores, comorbidities, and delayed presentation to healthcare facilities were independently associated with unfavorable outcomes."

Journal • Observational data • CNS Disorders • Infectious Disease • Influenza • Pneumonia • Respiratory Diseases

The promising activity of apple cider vinegar on MDR Klebsiella spp. (K. variicola and K. pneumoniae) emerging pathogens in chicken. (PubMed, Vet Res Commun) - "The Klebsiella isolates exhibited remarkable resistance against ampicillin (94.7%), cefotaxime (89.5%), and ceftazidime (86.9%). Our data indicated multiple health risks linked to phenotypic and genotypic resistance, as well as zoonotic importance. The Apple Cider Vinegar (ACV) possesses significant antibacterial properties."

Journal • Infectious Disease • Pneumonia

β-Lactam dosing in critically ill children: predictors for target non-attainment. (PubMed, J Antimicrob Chemother) - "This study found an eGFR ≥90 mL/min/1.73 m2 to be associated with target non-attainment, indicating that kidney function should be taken into account when identifying individuals who may require higher dosages. These results may help identify subpopulations of paediatric patients requiring higher dosages or continuous infusion in order to achieve adequate β-lactam exposure."

Journal • Pediatrics

Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae in paediatric patients in Japan (2020-2023). (PubMed, J Med Microbiol) - "Overall resistance rates to penicillin (PEN), cefotaxime, meropenem (MEM) and erythromycin (ERY) were 31.8, 15.9, 18.5 and 88.7%, respectively...Genomic analysis revealed that the predominant genotypes were 15B/C-CC199, 15A-CC63, 24B-CC2754 and 10A-CC5236.Conclusion. Non-vaccine and PEN-, MEM- and ERY-resistant clones, particularly 15A-CC63 and 35B-CC558, were prevalent among paediatric pneumococci in Japan. Even with PCV20, less than half of the IPD isolates were covered; this underscores the need for ongoing genomic surveillance, antimicrobial stewardship and consideration of expanded-valency vaccines targeting additional serotypes, such as 15A and 35B."

Journal • Infectious Disease • Novel Coronavirus Disease • Pediatrics • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Dynamics of the gut microbiome and resistome in response to prophylactic antibiotic treatment in post-surgical giant pandas. (PubMed, Sci Rep) - "Here, we assessed the impact of intravenous cefotaxime administration by analyzing longitudinal fecal samples from five giant pandas via 16 S rRNA sequencing (n = 304 samples) and shotgun metagenomics (n = 22 samples)...Their abundance, however, remained unchanged throughout treatment. These findings provide new insights into the effects of short-term antibiotic exposure in giant pandas, highlighting its transient effect on microbial community structure and a limited effect on resistome diversity."

Journal

Effects of antibiotic treatments on symbiotic bacteria and life history traits of Bemisia tabaci and Trialeurodes vaporariorum (Hemiptera: Aleyrodidae): implications for pest control strategies. (PubMed, J Econ Entomol) - "The antibiotic treatments-tetracycline, rifampicin, and a cocktail of ampicillin, cefotaxime, and gentamicin-significantly altered the abundance of specific symbionts, with notable reductions of Rickettsia in B. tabaci and Arsenophonus in T. vaporariorum. A negative r value was also recorded in B. tabaci following tetracycline treatment. These results highlight the critical role of symbiotic bacteria in whitefly biology and provide insight into the potential consequences of disrupting these associations."

Journal

Penicillin remains an effective agent against Group A Streptococcus in low- and middle-income countries: A systematic review and meta-analysis of antibiotic resistance and associated genes. (PubMed, S Afr Med J) - "This review comprehensively characterises the latest evidence on the prevalence of antibiotic resistance in Strep A in LMICs. Strep A in LMICs continues to be highly susceptible to antibiotics in vitro, primarily to penicillins. Strep A macrolide resistance patterns in LMICs are similar to those observed in high-income countries. The findings of this review may serve to inform effective treatment decisions and public health interventions."

Clinical • Journal • Retrospective data • Review

Genomic insights and molecular epidemiology through whole genome sequencing in clinical Serratia marcescens ST-367 isolated from the Kingdom of Bahrain. (PubMed, J Infect Public Health) - "To our knowledge, this is the first report of S. marcescens ST-367 in the Gulf Cooperation Council. The genetic diversity and mechanisms of virulence and antibiotic resistance in this isolate shed light on the evolution of high-risk isolates. Additionally, this will serve as a foundation for future extensively drug-resistant isolates."

Journal • Gene Therapies • Infectious Disease

Risk Factors for Drug-Induced Severe Cutaneous Adverse Reactions: A Real-World Pharmacovigilance Analysis. (PubMed, J Dermatol) - "Logistic regression identified older age, male sex, and 114 drugs as independent risk factors for drug-induced SCARs, including amlodipine (adjusted ROR = 2.89), bisoprolol (adjusted ROR = 3.52), and losartan (adjusted ROR = 2.77). In the non-Asian population, the strongest signals were observed for allopurinol (adjusted ROR = 98.52), cefotaxime (adjusted ROR = 68.52), and lamotrigine (adjusted ROR = 38.59), whereas apalutamide (adjusted ROR = 14.57), ipilimumab (adjusted ROR = 3.24), and acetylsalicylic acid (adjusted ROR = 2.85) were detected only in Asians...The Asian population had a significantly shorter TTO compared to the non-Asian population (p < 0.001). This study uses FAERS data to analyze risk factors for drug-induced SCARs, emphasizing early identification and discontinuation of suspected drugs to enhance patient safety."

Adverse events • Journal • Real-world evidence • Immunology

Genomic dissection of the antimicrobial resistance epidemiology of Salmonella Typhimurium. (PubMed, Front Microbiol) - "The identification of recently emerged cefotaxime resistant and ciprofloxacin intermediate STs underscores the continued threat of resistance to antibiotics critical for treatment of severe salmonellosis. Integration of MGT strain typing with AMR prediction provides scalable, sharable, standardised and precise tracking of resistant isolates/STs, offering a powerful framework for global AMR surveillance."

Journal

Evaluating adverse events of antibacterials in infants: insights from FDA adverse event reporting system (FAERS) data. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "We use data spanning the period from 2005Q1 to 2025Q1, which we obtain from the FDA Adverse Event Reporting System (FAERS) to retrospectively assess adverse events (AEs) associated with three commonly used antibacterials-vancomycin, cefotaxime, and gentamicin-in this vulnerable population. These findings underscore the increased vulnerability of infants to drug toxicity. These results emphasize the critical need for cautious, individualized risk-benefit assessments in the context of prescribing antibacterials to infant patients."

Adverse events • Journal • Acute Kidney Injury • Hepatology • Liver Failure • Nephrology • Otorhinolaryngology • Renal Disease

Community-acquired pneumonia-causing bacteria and antibiotic resistance rate among Syrian patients. (PubMed, J Infect Dev Ctries) - "These findings underscore the importance of being able to adapt the general World Health Organization recommendations according to local evidence. It is crucial to emphasize the need for continuous local monitoring, functioning and well-equipped laboratories, and well-trained specialists in infectious diseases in hospitals to be able to make these decisions."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Commensal Clostridia in the preterm gut as reservoirs of antimicrobial resistance: susceptibility profiles, and resistance genes. (PubMed, FEMS Microbiol Ecol) - "While most isolates were susceptible to amoxicillin-clavulanic acid, imipenem, and metronidazole, resistance to tetracycline (12%), clindamycin (35%), and cefotaxime (35%) was observed. Distinct species-specific resistance included linezolid (Clostridium argentinense), chloramphenicol (Clostridium innocuum), and tigecycline (Paeniclostridium sordellii), and a one Robinsonella peoriensis isolate displayed vancomycin resistance. The detection of tet and erm genes corresponded with phenotypic resistance, while β-lactamase activity was uncommon. Although colonizing at low levels, these findings highlight the ecological significance of rarely studied commensal Clostridia and their contribution to the neonatal resistome, acting as underappreciated reservoirs of AMR genes during a critical window of microbiome assembly."

Journal

Genomic epidemiology and plasmid characterization of antimicrobial resistance and virulence in cattle Escherichia coli from China. (PubMed, Microbiol Spectr) - "Resistance to ampicillin (49.5%), cefotaxime (37.4%), and tetracycline (36.3%) was common, with NX showing the highest resistance rate. The strong association between plasmid types and resistance gene burden highlights key targets for surveillance. These findings offer valuable insights into the molecular epidemiology of bovine E. coli and support more effective, region-specific strategies to monitor and control the spread of AMR in livestock."

Journal • Gene Therapies

Meningitis neumocócica en un hospital de alta complejidad: características clínicas, distribución de serotipos y estado vacunal (PubMed, Rev Esp Quimioter) - "Pneumococcal meningitis remains a serious condition. Serotypes such as 8 and 3 are associated with high mortality rates. Low vaccination coverage in at-risk groups represents a critical gap in prevention. Knowing the serotypes involved and their resistance profiles is key to adapting vaccination strategies and reducing the burden of this disease."

Journal • CNS Disorders • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia

Repurposing of Cefotaxime for Its Therapeutic Potential in Alzheimer's Disease: An Explanation of the Possible Mechanism of Action. (PubMed, ACS Chem Neurosci) - "Adult male Sprague-Dawley rats were administered CTX (100-300 mg/kg, intraperitoneal, 28 days) and compared with donepezil (5 mg/kg). While CTX reduced mRNA expression of β-amyloid and tau, it did not lower their protein levels as determined by ELISA, suggesting selective modulation at transcriptional rather than post-translational levels. Together, these findings suggest a potential role for CTX as a promising repurposed candidate for alleviating AD-related neurobehavioral deficits through the modulation of oxidative stress and inflammatory pathways."

Journal • Alzheimer's Disease • CNS Disorders • Dementia • Inflammation • Mood Disorders • Psychiatry

An evaluation of screening methods for the detection of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in environmental samples from healthcare settings. (PubMed, J Appl Microbiol) - "Pre-enrichment for 18 hours in Buffered Peptone Water, followed by plating onto cefotaxime-supplemented Membrane Lactose Glucuronide Agar, was the most effective screening method in our context, having a high detection efficacy, whilst maintaining a scalable and accessible cost."

Journal • Infectious Disease • Pneumonia

Discordance between antibiotic therapy and recurrent urinary tract infections in young children with thirdgeneration cephalosporin-resistant infections. (PubMed, Clin Exp Pediatr) - "Among 989 children (mean age, 4.4 months), 424 (42.9%) had cefotaxime-resistant isolates; of them, 76 (17.9%) received concordant therapy and 348 (82.1%) received discordant therapy...Completing a third-generation cephalosporin course when isolates are not susceptible to thirdgeneration cephalosporins can increase early UTI recurrence rates in Korean children. Reviewing susceptibility on day 5 and switching to an active oral agent may reduce recurrence and limit unnecessary broad-spectrum antibiotic exposure."

Journal • Infectious Disease • Nephrology • Pediatrics

Prevalence, Risk Factors, and Antimicrobial Susceptibility Patterns of Salmonella From Bulk Milk at the Dairy Farm Level in Mekelle and Southeast Zones of Tigrai, Ethiopia. (PubMed, Microbiologyopen) - "Five (83.3%) isolates of Salmonella showed resistance to ampicillin and tetracycline, and four (66.7%) to streptomycin. All Salmonella isolates were susceptible to ceftazidime and cefotaxime...Three Salmonella isolates showed resistance to four and six antimicrobial classes. The finding highlights the need for appropriate hygiene practices and the correct use of antibiotics in the farms."

Journal • Infectious Disease

Inhibition of GABA metabolism by β-lactam antibiotics affects encystation in Acanthamoeba. (PubMed, Biomed Pharmacother) - "Cefotaxime, carbenicillin, and penicillin G significantly inhibited cyst formation without inducing cytotoxicity, whereas non-β-lactam antibiotics showed no such effect. These findings suggest that the inhibitory effect is associated with the β-lactam ring structure and may involve interference with GABA-mediated signaling pathways. Collectively, our study reveals a critical role of GABA metabolism in Acanthamoeba encystation and highlights β-lactam antibiotics as potential adjunctive agents for overcoming cyst-associated drug resistance in AK treatment."

Journal • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Pain