cefotaxime / Generic mfg. - LARVOL DELTA

Phage ZH4 rescues murine mastitis infected with hypervirulent multidrug-resistant Klebsiella pneumoniae through pathogen elimination and mammary barrier restoration. (PubMed, J Dairy Sci) - "In a murine mastitis model challenged with a hypervirulent MDR isolate (ZH-KP-4), a single intramammary ZH4 dose of 5 × 106 pfu/gland achieved complete bacterial clearance in mammary tissue within 72 h, significantly outperforming cefotaxime sodium, which failed to reduce bacterial burdens...No adverse effects were observed. These findings establish phage ZH4 as a safe and highly effective therapeutic against intractable MDR K. pneumoniae mastitis, uniquely combining rapid pathogen eradication with structural barrier preservation and offering a transformative alternative to failing antibiotics for sustainable dairy production."

IO biomarker • Journal • Preclinical • Infectious Disease • Pneumonia • IL1B • IL6 • TLR2 • TLR4 • TNFA

Isolation, molecular profiling, and antimicrobial sensitivity patterns of ESBL producing Acinetobacter baumannii in wastewater discharges from Goranchatbari sub-catchment area in Dhaka. (PubMed, PLoS One) - "The antibiotic susceptibility testing revealed a diverse range of resistance patterns with high levels of intermediate resistance being observed for cefotaxime and ceftriaxone. The phylogenetic clustering of the A. baumannii isolates resulted in the formation of 10 clusters at 60% similarity index, and the correlation matrix helped reveal important associations between genotypic and phenotypic traits. These results demonstrate the continued prevalence of A. baumannii within these environmental reservoirs and its ability to persist despite seasonal variations, prioritizing changes in environmental health policies that aim to reduce the widespread prevalence of these pathogens."

Journal

Genomic profiling of extended-spectrum beta-lactamase-producing Escherichia coli isolated from poultry and poultry farm workers in Accra, Ghana. (PubMed, Sci Rep) - "All isolates were resistant to cefotaxime, with significant resistance to tetracycline and sulfamethoxazole-trimethoprim also recorded. This study highlights the prevalence and genomic characteristics of ESBL-producing E. coli at the human-poultry interface in Ghana, emphasizing poultry as a potential reservoir for multidrug-resistant bacteria. The findings provide actionable insights for small- to medium-scale poultry farmers, including the importance of prudent antibiotic use, enhanced hygiene, and biosecurity practices, and underscore the need for ongoing genomic surveillance to guide interventions aimed at reducing the spread of antimicrobial resistance in Ghana."

Journal

A Case of Fatal Cupriavidus gilardii Sepsis Following Cord Blood Transplantation: Pitfalls of Novel Antimicrobial Agents. (PubMed, Int J Infect Dis) - "Cefiderocol (CFDC) is a novel antimicrobial agent that exhibits activity against carbapenem-resistant non-fermenting gram-negative bacilli, such as resistant Pseudomonas aeruginosa and Stenotrophomonas maltophilia, and has thus attracted considerable attention. Herein, we report a case in which a patient who was undergoing cord blood transplantation developed gram-negative rod sepsis after meropenem administration...The causative organism was later identified as Cupriavidus gilardii, which was resistant to novel antimicrobial agents, including CFDC, ceftazidime/avibactam, and ceftolozane/tazobactam. However, it was susceptible to cefepime and cefotaxime, suggesting a potential pitfall in the sole reliance on novel antibacterial drugs...This is the first reported case in the context of hematopoietic cell transplantation and the second diagnosed case using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Moreover, this report presents a..."

Journal • Hematological Disorders • Infectious Disease • Neutropenia • Septic Shock • Transplantation

Nasal Rhinomyiasis Caused by Cochliomyia hominivorax Complicated by a Parapharyngeal Abscess: A Case Report. (PubMed, Cureus) - "Treatment included ivermectin for myiasis, clindamycin and cefotaxime for the abscess, and functional endoscopic sinus surgery (FESS) for cleaning and debridement. The patient's clinical course was favourable after multidisciplinary treatment, and she was discharged after improvement."

Journal • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Pharmacokinetics of cefotaxime and its metabolite desacetyl-cefotaxime to optimize dosing in critically ill children and children with sickle cell disease. (PubMed, J Antimicrob Chemother) - "We identified bodyweight, SCD status and eGFR as significant covariate that influence cefotaxime PK. Continuous infusion was the most performant way to achieve the pharmacological target in critically ill children and neonates, making a first necessary step towards individualized prescription in this fragile population."

Journal • PK/PD data • Genetic Disorders • Hematological Disorders • Sickle Cell Disease

Nationwide emergence of cefotaxime-resistant Neisseria meningitidis via interspecies gene transfer from penA795-bearing Neisseria commensals in China. (PubMed, Clin Microbiol Infect) - No abstract available

Journal • Gene Therapies

Yinhuapinggan Granules Enhance Cefotaxime Efficacy and Alleviate Inflammation in Extended-Spectrum Beta-Lactamase-Producing Escherichia fergusonii Infections. (PubMed, Microb Pathog) - "YHPG enhances the antibacterial activity of CTX against ESBL-EF by increasing membrane permeability, disrupting biofilms, and modulating the inflammatory response. This study suggests that YHPG could serve as an adjunctive treatment for antibiotic-resistant infections, offering a promising approach to combat bacterial resistance and inflammation associated with ESBL-EF infections."

Journal • Acute Lung Injury • Infectious Disease • Inflammation • Pneumonia • Respiratory Diseases • IL1B • IL6 • NLRP3 • TNFA

Resistome, virulome and mobilome of clinical carbapenemase-producing Acinetobacter baumannii strains isolated in Togo. (PubMed, Int J Med Microbiol) - "All isolates exhibited resistance to imipenem, ticarcillin, clavulanic acid, cefotaxime, and ciprofloxacin, but remained susceptible to colistin, tigecycline, and rifampicin. Furthermore, several multidrug resistance plasmids and one virulence and AMR hybrid plasmid (accession number JBFMWK020002174.1) were identified. This study provides valuable insights into clinical A. baumannii in Togo, underscoring the need for more frequent genomic studies in sub-Saharan countries to effectively monitor and combat AMR in Africa."

Journal

Early-life antibiotics and childhood allergy: a multi-center cohort. (PubMed, Allergy Asthma Clin Immunol) - "Allergic conditions affect about one third of children treated with antibiotics in early life. While allergic conditions tended to decrease with age, no association was observed between antibiotic number/class and later allergy, except for a hypothesis-generating signal toward lower odds with TMP-SMX."

Journal • Allergy • Immunology • Pediatrics

Comparison of in vitro antimicrobial activity of tebipenem, sulopenem, meropenem, and ertapenem against cefotaxime-resistant Enterobacterales (ESCMID Global 2026) - No abstract available

Preclinical

Population Pharmacokinetics of Cefotaxime for Optimising Dosing in Paediatric Meningitis and Bacteraemia (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data • CNS Disorders • Infectious Disease • Pediatrics

Clinical characteristics of pediatric Moraxella bacteremia in a children's hospital. (PubMed, Pediatr Int) - "The patients with bacteremia due to M. osloensis or M. catarrhalis had favorable clinical outcomes."

Journal • Observational data • Retrospective data • Critical care • Glomerulonephritis • Infectious Disease • Nephrology • Pediatrics • Pneumonia • Renal Disease • Respiratory Diseases

Prevalence and antimicrobial susceptibility of Escherichia coli and Klebsiella spp. Isolated from retail seafood in Hanoi, Vietnam. (PubMed, Open Vet J) - "Among the 35 E. coli isolates, the highest resistance was observed against ceftazidime (71.4%), followed by cefotaxime (57.2%), sulfamethoxazole/trimethoprim (45.7%), ampicillin (37.2%), and tetracycline (37.2%). The high prevalence and antimicrobial resistance rates of E. coli and Klebsiella spp. isolated from seafood sold in the study area highlight the need for improved surveillance, stricter control of antimicrobial use in aquaculture, and enhanced food safety measures."

Journal

Sensitivity and resistance pattern of uropathogens causing urinary tract infections among adults at a teaching hospital in South India - A retrospective analysis. (PubMed, J Family Med Prim Care) - "Uropathogens exhibited >80% resistance to antibiotics such as ampicillin, cefazolin, ciprofloxacin, penicillin, ceftazidime/clavulanic acid, and cefotaxime in at least one of the study years. Our study shows a concerning trend of increasing resistance among uropathogens to commonly used antibiotics, warranting an urgent need for urine culture-based antibiotic prescribing practices."

Journal • Retrospective data • Infectious Disease • Nephrology

Assessment of Escherichia coli as an indicator of antimicrobial resistance and monitoring of ESBL/AmpC-Producing Enterobacteriaceae in retail seafood commonly consumed in Italy. (PubMed, Int J Food Microbiol) - "Cefotaxime-resistant E. coli isolates were identified at low but relevant frequencies, especially in bivalves, and were characterised phenotypically and by whole-genome sequencing...Overall, our findings support the suitability of E. coli as an AMR indicator organism for retail bivalves and crustaceans. The detection of ESBL-producing strains, carrying important plasmid-borne resistance determinants, highlights the need to strengthen AMR surveillance in these seafood commodities."

Journal

An Efficient and Streamlined System for In Vitro Regeneration and Genetic Transformation of Paper Mulberry (Broussonetia papyrifera). (PubMed, Life (Basel)) - "After co-cultivation, explants were transferred sequentially to callus induction, shoot induction, shoot multiplication, and rooting media supplemented with 250 mg·L-1 cefotaxime and 200 mg·L-1 Timentin, as well as 5.0 mg·L-1 hygromycin at a concentration that completely suppressed regeneration of non-transformed explants...The integration and expression of the transgene were further confirmed by PCR and quantitative reverse transcription PCR (qRT-PCR) after the resistant calli developed into plantlets. Collectively, this streamlined protocol provides a practical platform for functional genomics and genetic improvement of B. papyrifera."

Journal • Preclinical • Gene Therapies

Occurrence and Antimicrobial Susceptibility of Major Bacterial Pathogens Associated with Subclinical Mastitis in Dairy Cows in Western Romania. (PubMed, Microorganisms) - "Among S. aureus, the highest resistance rates were to fosfomycin (58.3%), penicillin (44.4%), clindamycin (44.4%), and tetracycline (41.7%), with 47.2% MDR isolates...coli showed resistance to amoxicillin/clavulanic acid (88.9%), ampicillin (55.6%), and cefotaxime (55.6%), with 66.6% MDR...aureus remains the leading cause of subclinical mastitis in Western Romania. The high MDR rates highlight the need for targeted antimicrobial stewardship, culture-based therapy, and continuous AMR monitoring under the "One Health" framework."

Journal • Infectious Disease • Pneumonia

Dual Core-Shell Loaded Lipid-Polymer Hybrid Nanoparticles as Combination Anti-Infective Delivery Platforms. (PubMed, Pharmaceutics) - " LPHNPs containing the antibiotic cefotaxime within a chitosan polymer core and the novel antimicrobial peptide RN7IN6 within a bacteria-mimicking lipid shell were produced by microfluidic mixing, and optimized with respect to parameters including total flow rate, flow rate ratio, and lipid concentration... The current findings clearly demonstrate the feasibility of formulating LPHNPs for core-shell co-encapsulation and delivery of anti-infectives. The promising antibacterial efficacy of co-loaded LPHNPs warrants further in-depth investigation to determine the extent of co-loaded LPHNP applications as combination anti-infective delivery platforms."

Journal • Infectious Disease

Clonal and Plasmid-Mediated Dissemination of Multidrug-Resistant Salmonella Enteritidis in Chicken Production, Northeastern Thailand. (PubMed, Pathogens) - "These findings indicate that MDR Salmonella dissemination is driven by two synergistic mechanisms: the clonal expansion of fit lineages and the horizontal transfer of conjugative plasmids harboring β-lactamase genes. We identified IncI-gamma-K1 and Col-related plasmids as key vectors in this process. This study advocates for targeted interventions, guided by a One Health approach, that specifically aim to disrupt plasmid transmission at critical control points, such as slaughterhouses, to curb the spread of antimicrobial resistance."

Journal

Design, Synthesis, Antimicrobial Activity and Molecular Docking of New 1,2,4-Triazepine, 1,3,4,6-Oxatriazepine and Pyridazino[1,2-a] Pyrimidine Derivatives. (PubMed, Pharmaceuticals (Basel)) - "These compounds demonstrated consistently superior binding affinities compared to control drugs cefotaxime and nystatin across a range of enzymes essential for pathogen viability and virulence. Molecular docking analysis indicated that the in silico results strongly suggest that compounds (6, 8, 9, and 10) are promising multi-target agents capable of disrupting essential bacterial processes and critical fungal pathways, making them excellent candidates for the development of novel antimicrobial therapeutics. These consistent findings support the conclusion that both practical and theoretical studies of the new compounds align with their antimicrobial effectiveness."

Journal

High Prevalence of Multidrug-Resistant Haemolytic Escherichia coli in Colombian Pig Farms. (PubMed, Antibiotics (Basel)) - "All isolates exhibited resistance to at least three antimicrobial classes (MDR), with high levels of resistance to tetracycline (98.0%), neomycin (97.3%), chloramphenicol (95.9%), sulfamethoxazole (93.9%), trimethoprim (91.9%), ampicillin (91.9%), nalidixic acid (82.4%), and ciprofloxacin (79.7%). Colistin resistance was observed in 5.4% of isolates, mediated by mcr1 or mcr3, while cefotaxime resistance (8.8%) was extensively associated with blaCTX-M. These findings reveal a concerning burden of MDR E. coli in Colombia's pig-producing regions and indicate that haemolysis alone is a poor indicator of ETEC. Integrating farm-level antimicrobial use data with genomic analyses will be essential to identify drivers of AMR and guide effective stewardship in the Colombian pig industry."

Journal • Hematological Disorders

International maritime organization, we may have a problem - ballast water treatment triggers global concerns with antimicrobial resistant bacteria. (PubMed, Mar Pollut Bull) - "The results of the disk diffusion method indicated an increase in resistance to ampicillin, ceftazidime, and the highest increase occurred in resistance to cefotaxime. The number of multi-drug resistant isolates decreased substantially in the discharged water. BWMS effectively eliminate plankton, while UV water treatment causes different negative changes in bacteria, introducing new threats to human health (microbiome to accumulate resistance genes) and aquaculture (increase diversity and volume of antibiotics used, lower seafood production), hence opening a new issue in global discharges of ballast water."

Journal

Efficacy of InP/ZnSe/ZnS Quantum Dots with Antibiotics in the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Keratitis: Preclinical Studies. (PubMed, Exp Eye Res) - "aeruginosa bacteria are resistant to cefotaxime in vitro but are susceptible to the QD solutions used in conjugates with an antibiotic. QD conjugates with tobramycin increase the effectiveness of keratitis treatment from 32±2% to 88±3% and accelerate the symptom reversal rate compared to standard antibacterial therapy with tobramycin."

Journal • Preclinical • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Orbital cellulitis with emm1-type M1UK sublineage group A Streptococcus detected in a blood culture: a case report. (PubMed, J Infect Chemother) - "The patient was initially treated with a combination of cefotaxime (CTX) and clindamycin (CLDM). We changed antibiotics from CTX to ampicillin after susceptibility results were known. After discharge, oral clavulanic acid/amoxicillin was continued as an oral medication, and antibiotics were administered for a total of 21 days...This case is unusual in that it involved bloodstream infection in a pediatric orbital cellulitis, and M1UK's highly toxin-producing and highly transmissible may have been implicated. In rapidly exacerbating orbital cellulitis, iGAS infection should be considered."

Journal • Dermatology • Infectious Disease • Ocular Infections • Ocular Inflammation • Pediatrics