cefotaxime / Generic mfg. - LARVOL DELTA

Piperacillin-tazobactam resistance in Klebsiella pneumoniae is often associated with IS26-mediated blaSHV-1 amplification in a widespread Klebsiella-adapted plasmid. (PubMed, Antimicrob Agents Chemother) - "To elucidate these mechanisms, we analyzed K. pneumoniae clinical isolates resistant to TZP but susceptible to cefotaxime and cefepime. Among 53 isolates, 14 were further studied by MIC testing for TZP, amoxicillin-clavulanic acid (AMC), and ceftazidime (CAZ)...Analysis of a K. pneumoniae genome data set confirmed the frequent co-occurrence of this plasmid and the PTnSHV-L marker in strains with multiple blaSHV copies. These findings suggest the emergence of an epidemic plasmid adapted to K. pneumoniae and driving TZP resistance through blaSHV-1 amplification, underscoring the need for genomic surveillance to detect amplification-based resistance overlooked by standard phenotypic or PCR assays."

Journal • Infectious Disease • Pneumonia

DEPLETION OF GUT MICROBIOTA ALLEVIATES PROTEINURIA IN PUROMYCIN AMINONUCLEOSIDE-INDUCED NEPHROSIS IN RATS (ISN-WCN 2026) - "Rats were divided into three groups (n=6 each): a control group (oral PBS for 10 days followed by a single subcutaneous injection of PAN (50 mg/kg) on day 0, an antibiotic-treated group (oral amoxicillin, cefotaxime, vancomycin, and metronidazole) for 10 days, followed by PAN injection on day 0, and an indoxyl sulfate (IS)-treated group (antibiotics for 10 days followed by intraperitoneal IS and PAN injection on day 0). The protective effects of antibiotics were associated with the loss of indole-producing bacteria and reduced urinary IS, suggesting that pathogenic gut-derived metabolites drive podocyte injury. Targeting indole-producing bacteria or their metabolites may represent a novel therapeutic approach for MCNS, potentially reducing reliance on corticosteroids."

Gut Microbiota • Preclinical • Chronic Kidney Disease • Glomerulonephritis • Nephrology • Renal Disease

Pediatric cervicofacial actinomycosis presenting with mandibular osteomyelitis: a diagnostic and therapeutic challenge and literature review. (PubMed, Turk J Pediatr) - "The patient initially received empirical intravenous vancomycin, cefotaxime, and metronidazole. Due to persistent fever and elevated inflammatory markers, the regimen was switched to teicoplanin plus piperacillin/tazobactam. Therapy was subsequently escalated to meropenem due to recurrent fever and based on magnetic resonance imaging findings suggestive of osteomyelitis, then vancomycin was replaced with teicoplanin because of vancomycin-associated nephrotoxicity. Following clinical improvement, the patient was discharged on oral amoxicillin/clavulanate to complete a total of six weeks of therapy...Early recognition and combined medical-surgical management are crucial to avoid complications. This case highlights the importance of considering infectious causes in mandibular masses and underscores the diagnostic challenges associated with them."

Journal • Review • Infectious Disease • Inflammation • Musculoskeletal Pain • Oncology • Pain • Pediatrics

Co-selection of heavy metal and antibiotic resistance in Enterobacteriaceae members from Mula-Mutha River (Pune, India). (PubMed, Environ Monit Assess) - "Pearson correlation analysis revealed strong associations between HMR and ABR, including arsenic-lomefloxacin (r = 0.43), copper-cefotaxime (r = 0.46), and lead-piperacillin tazobactam (r = 0.365), suggesting co-selection via shared resistance mechanisms. These findings hold significance and highlight the convergence of chemical and biological pollution in shaping resistant microbial communities and emphasize the urgent need for integrated river basin monitoring and pollution control strategies."

Journal

Drug Resistance Patterns and Pathogen Distribution in Patients with Urinary Tract Infection in Suzhou, China: A Five-Year Retrospective Study (2020-2024). (PubMed, Infect Drug Resist) - "Its resistance to third/fourth-generation cephalosporins (eg, cefotaxime from 50.4% to 38.8%) decreased significantly (P 60%)...Enterococcus faecium displayed extreme resistance to ampicillin and fluoroquinolones (>94%), whereas Enterococcus faecalis was more susceptible...The dynamically high carbapenem resistance in Klebsiella pneumoniae and the severe, species-specific resistance profile of Enterococcus faecium critically limited treatment options. Significant temporal changes in pathogen distribution and resistance patterns underscored the necessity for ongoing local surveillance, tailored empirical therapy, and reinforced antimicrobial stewardship programs to guide effective UTI management in the region."

Journal • Retrospective data • Infectious Disease • Nephrology • Pneumonia • Urology

Single point mutations in global regulatory genes restore cephalosporin resistance in a low-MIC Enterococcus faecium natural isolate. (PubMed, Antimicrob Agents Chemother) - "At Parc Taulí University Hospital, we identified a clinical isolate of ampicillin-susceptible E. faecium (Efm5) that exhibited unusually low MICs to cefotaxime (1 mg/L), ceftriaxone (3 mg/L), and ceftaroline (0.19 mg/L). Transcriptional profiling showed upregulation of the pbp5 operon, which includes ftsW, psr, and pbp5, in the croS variants. This study provides evidence that E. faecium isolates with low MICs to CPH can arise in clinical settings without laboratory manipulation, enabling further investigation of resistance pathways."

Journal

Comparison of in vitro antimicrobial activity of tebipenem, sulopenem, meropenem, and ertapenem against cefotaxime-resistant Enterobacterales (ESCMID Global 2026) - No abstract available

Preclinical

Population Pharmacokinetics of Cefotaxime for Optimising Dosing in Paediatric Meningitis and Bacteraemia (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data • CNS Disorders • Infectious Disease • Pediatrics

AGES: Aminoglycosides in Early Sepsis (clinicaltrials.gov) - P4 | N=1900 | Recruiting | Sponsor: University Hospital, Akershus | Not yet recruiting ➔ Recruiting

Enrollment open • Infectious Disease • Septic Shock

Predicting oral cephalosporin susceptibility in Escherichia coli blood isolates using parenteral cephalosporin susceptibility testing. (PubMed, J Antimicrob Chemother) - "Prediction of oral second-generation cephalosporins may warrant cefazolin MIC ≤2 mg/L, despite limitations regarding false resistance and susceptibility discordant. Ceftriaxone/cefotaxime demonstrates a more reliable surrogate for predicting oral third-generation cephalosporins susceptibility. Future investigations are necessary to clinically corroborate these findings."

Journal • Infectious Disease

Identification of a high-regeneration Malus robusta Rehd. genotype and establishment of an efficient transformation system. (PubMed, Plant Sci) - "Leaf explants infected with Agrobacterium were cultured on bud induction medium supplemented with 6mg/L kanamycin and 250mg/L cefotaxime...In summary, we identified a M. robusta germplasm with high regeneration ability, and established an efficient leaf regeneration and transformation system. This platform provides a valuable tool for advancing molecular breeding and functional genomics research in apple."

Journal • Gene Therapies

Integrated Phenotypic and Genomic Characterization of Cefotaxime/Clavulanic Acid Inhibitor-Positive Multidrug-Resistant Escherichia coli from Large-Scale Pig Farms in Hungary. (PubMed, Animals (Basel)) - "In the sequenced subset (n = 116), 5427 ARG hits were identified (82 unique ARGs in the export), including frequent acquired determinants affecting tetracyclines, sulfonamides/trimethoprim, aminoglycosides, and phenicols; plasmid-mediated quinolone resistance (qnrB5) and mobilizable colistin resistance (mcr-1) were detected at low frequency. CTX-M and/or TEM were detected in 47/116 genomes (40.5%), dominated by CTX-M-32 (11.2%) and TEM-1 (23.3%); detected ESBL determinants were predominantly predicted to be located on contigs predicted to be of plasmid origin, with a subset showing signatures consistent with transposition-associated mobilization. The high burden of inhibitor-positive phenotype, together with an inferred plasmid-/MGE-associated context for a subset of ESBL genes, and substantial phenotype-genotype heterogeneity, supports integrated phenotypic-genomic surveillance to refine AMR risk assessment and guide targeted stewardship and biosecurity interventions..."

Journal

Effect of COVID-19 Pandemic on Epidemiology and Antimicrobial Susceptibility of Campylobacter Species, Salmonella enterica and Yersinia enterocolitica in Southwest Finland 2018-2022. (PubMed, APMIS) - "Among C. jejuni, ciprofloxacin resistance averaged 58% in domestic (n = 155) and 88% travel-associated (n = 10) strains, while tetracycline resistance averaged 36% and 63%, respectively; erythromycin resistance was not detected. In S. enterica, resistance averaged 42% and 33% to ampicillin, 33% and 45% to fluoroquinolones, 4% and 6% to cefotaxime, and 0% and 2% to co-trimoxazole, in domestic (n = 24) and travel-associated (n = 32) strains, respectively...This study shows that lockdowns due to the COVID-19 pandemic decreased the number of diagnosed enteropathogens and limited the emergence of resistant strains. Thus, our results reaffirm that travel remains the primary source of S. enterica infections in Finland."

Journal • Gastrointestinal Disorder • Infectious Disease • Novel Coronavirus Disease

Salmonella surveillance in raw pet food and dogs in Great Britain, 2013-2022. (PubMed, Front Vet Sci) - "Resistances to cefotaxime, ceftazidime or ciprofloxacin were rare, although exceptionally 9.9% of S. Infantis isolates from raw meat pet food showed ciprofloxacin resistance. Despite limitations for establishing direct transmission pathways, the findings highlight raw meat pet food as a potential vector for Salmonella transmission, emphasizing the risks to both animal and public health and underlining the need for vigilant monitoring and hygiene practices. For antimicrobial resistance risk, generally high susceptibility to the extended spectrum cephalosporin and fluoroquinolone classes is reassuring, although the detection of multi-drug-resistant strains highlights ongoing concerns."

Journal

Fecal carriage, transferable β-lactam resistance, and efflux pump contribution in third-generation cephalosporin-resistant Escherichia coli from small-scale farm animals and workers in northern Thailand. (PubMed, Vet World) - "Isolation of 3GC-R E. coli was performed using cefotaxime-supplemented selective media...Efflux pump involvement in ceftazidime resistance was evaluated using phenylalanine-arginine β-naphthylamide...Small-scale farms in Thailand harbor 3GC-R E. coli with transferable resistance determinants and multiple resistance mechanisms, underscoring their role in antimicrobial resistance dissemination. These findings highlight the need for strengthened biosecurity, antimicrobial stewardship, and integrated One Health surveillance in rural farming systems."

Journal • Gene Therapies

Epidemiological Analysis and Susceptibility Profile of Pathogens Isolated in Blood Cultures From Hospital Angeles Lindavista in Mexico City. (PubMed, Cureus) - "These isolates showed high susceptibility to amikacin, cefotaxime, and tigecycline but exhibited marked resistance to all other antibiotics, including carbapenems. Conclusions The findings show that the epidemiology of bloodstream infections in our hospital remains steady, with consistent demographic patterns, a high rate of gram-negative organisms, and no clear clinical predictors of positive cultures. These results highlight the importance of microbiological surveillance, appropriate empiric antibiotic selection, and the careful interpretation of results, especially when potentially contaminating organisms are involved."

Journal • Diabetes • Infectious Disease • Metabolic Disorders • Musculoskeletal Diseases • Nephrology • Septic Shock • Type 2 Diabetes Mellitus

Characterization of the novel class A β-Lactamase gene blaKOB-1 in an Enterobacter isolate. (PubMed, BMC Microbiol) - "The identification of additional resistance genes aids in the elucidation of bacterial resistance mechanisms and application of effective clinical treatments for infections caused by pathogens carrying similar resistance genes."

Journal • Infectious Disease

Pediatric Pneumococcal Eye Infection and Changes in Antibiotic Susceptibility: A Retrospective Study. (PubMed, Infect Chemother) - "Between the periods, antibiotic susceptibility showed no significant difference for cefotaxime (83.3% vs. 63.8%) and levofloxacin (100% vs. 95.5%), but there was a significant difference for penicillin susceptibility (48.5% vs. 16.7%, P=0.035). The results suggest an increase in non-susceptibility to penicillin in the later period."

Journal • Retrospective data • Infectious Disease • Ocular Infections • Ophthalmology • Pediatrics • Pneumococcal Infections

Antimicrobial resistance dynamics in Mycobacterium tuberculosis coinfection systems: A spatiotemporal strain analysis. (PubMed, Biochem Biophys Rep) - "The drug sensitivity tests results over different years showed that K. pneumoniae exhibited significant resistance rates against doxycycline, ceftazidime, cefepime, cefuroxime, cefazolin, cefotaxime, levofloxacin, ticarcillin/clavulanate, amikacin, and norfloxacin (P < 0.05). The resistance rates of P. aeruginosa to cefazolin and ciprofloxacin were also statistically significant (P < 0.05). The drug sensitivity test results across different regions showed that the resistance rate of K. pneumoniae to minocycline in urban patients was statistically significant (P = 0.012), while the resistance rates of P. aeruginosa to tobramycin and ciprofloxacin in rural patients were statistically significant (P < 0.05)...The rise of new carbapenem-resistant K. pneumoniae strains in 2023 should be monitored. This study provides strong data support to formulate antibiotic treatment plans for patients with tuberculosis and respiratory infections, reduce the risk of resistant..."

Journal • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Analysis of Antimicrobial Use and Bacterial Susceptibility in Patients with Urinary Tract Infections at a Certain Hospital From 2021 to 2023: A Retrospective Cohort Study. (PubMed, Int J Gen Med) - "Susceptibility testing indicated marked interspecies differences: E. coli showed 81.56% resistance to ampicillin; Proteus mirabilis exhibited 72.73% resistance to levofloxacin; E. faecalis demonstrated 94.74% resistance to tetracycline. Conversely, cefotaxime/clavulanic acid and vancomycin retained good activity against most isolates...There were significant differences in the susceptibility of various pathogens to antimicrobial agents. It is necessary to regularly monitor the distribution of pathogens causing UTIs and their sensitivity to antimicrobial agents to provide a scientific reference for the rational use of antimicrobial agents during treatment."

Journal • Retrospective data • Infectious Disease • Nephrology • Urology

Molecular epidemiological and genetic variability of Salmonella isolates from the tropical mountainous region of southern China (2017-2024). (PubMed, Microbiol Spectr) - "Antimicrobial susceptibility testing revealed high resistance rates to ampicillin (63.8%), tetracycline (62.7%), ciprofloxacin (17.7%), cefotaxime (16.4%), and ceftazidime (15.6%), with 115 isolates (29.9%) identified as multidrug-resistant. Notably, six isolates were tigecycline-resistant, including two harboring tet(X4) genes on an IncFIA(HI1)-IncHI1A- IncHI1B(R27) hybrid plasmid...Moreover, we observed high resistance to clinically important treatment drugs, including fluoroquinolones and third-generation cephalosporins, in these regions. These results provide critical evidence to inform more effective surveillance, treatment, and control strategies in tropical settings and underscore the need for continuous, real-time monitoring of pathogen dynamics."

Journal • Infectious Disease

Antimicrobial susceptibility of Escherichia coli isolated from wild deer (Cervus nippon yesoensis) and fox (Vulpes vulpes schrencki) in Hokkaido: a pilot study on sustainable antimicrobial resistance monitoring. (PubMed, J Vet Med Sci) - "Escherichia coli, a common AMR indicator bacterium, was isolated from rectal swabs of deer and foxes using Chromagar ECC, with and without antimicrobials (cefotaxime (CTX) or nalidixic acid (NA). Three strains from foxes had β-lactamase genes in plasmid. Finally, this study demonstrates the feasibility of sustainable AMR monitoring using wild deer transported to a slaughterhouse and wild foxes surveyed for E. multilocularis."

Journal

PIVOT: Pivmecillinam as oral step-down treatment for Escherichia coli febrile urinary tract infection versus standard of care; a randomized controlled non-inferiority multicenter trial (clinicaltrialsregister.eu) - P1/2 | N=560 | Recruiting | Sponsor: Uppsala Universitet

Head-to-Head • New P1/2 trial • Infectious Disease • Nephrology

Epidemiological investigation and antimicrobial resistance profiling of Salmonella in broiler chickens with assessment of Lactococcus lactis probiotic therapy. (PubMed, Poult Sci) - "Antimicrobial susceptibility testing revealed 100% resistance to spectinomycin, tigecycline, amoxicillin-clavulanic acid, cefoxitin, cefalexin, and cefazolin; 92% to ampicillin and cefotaxime; 80% to sulphatrimethoprim; 72% to chloramphenicol; 60% to nalidixic acid; 36% to colistin; and 40% to enrofloxacin. The most effective agents were ofloxacin (68% sensitive) and ciprofloxacin (60% sensitive)...In contrast, the Salmonella Give challenged group without probiotic treatment exhibited higher mortality (7/50; 14%) and complete liver colonization (7/7; 100%). These results highlight the high prevalence of multidrug-resistant Salmonella in broilers and support the potential of probiotics as alternative preventive strategies in poultry production."

Journal • Infectious Disease • TNFA

Assessment of Surgical Antimicrobial Prophylaxis Practices in a Tertiary Hospital in Iraq. (PubMed, Wiad Lek) - " The study highlights substantial gaps in adherence to SAP guidelines, emphasizing inappropriate antibiotic selection, timing, and excessive duration. These findings underscore the urgent need for implementing antimicrobial stewardship interventions to optimize SAP practices and reduce potential antibiotic resistance and SSIs."

Journal • Gynecology • Infectious Disease