cefotaxime / Generic mfg. - LARVOL DELTA

Metagenomic analysis reveals the influence of wastewater discharge on the microbial community structures and spread of antibiotic-resistant bacteria at Mohar river, Gujarat. (PubMed, Environ Monit Assess) - "The resistance profiling of ARBs showed the higher resistance towards cefotaxime at MP1 (77.4%), followed by SO1 (70.5%), SI1 (64.14%), and the least at C1 (57.13%)...The abundance of intI1 was found to correlate positively with mercury, chromium, and chlorine, and a negative correlation was observed with arsenic. The results obtained in this research suggest that AMR spreads and evolves in the water environment via discharge of wastewaters from STPs into the river ecosystems."

Journal • Gene Therapies

Understanding the Microbiology of Chronic Otitis Media (AAO-HNSF 2025) - "Regarding the bacterial spectrum, Corynebacterium amycolatum showed 100% susceptibility to cefotaxime, tetracycline, and linezolid, with 83% resistance to levofloxacin. Pseudomonas were susceptible to gentamicin, amikacin, cefepime, ceftazidime, and meropenem, but resistant to cephalothin, ceftriaxone, and fosfomycin...aureus was highly susceptible to vancomycin, nitrofurantoin, trimethoprim/sulfamethoxazole, linezolid and 33% resistance to ciprofloxacin and erythromycin. Corynebacterium amycolatum was the most common isolated microorganism.we found an increase antibiotic resistance to commonly used drugs such as fluoroquinolones, macrolides and penicillins. Corynebacterium amycolatum was the most common isolated microorganism.we found an increase antibiotic resistance to commonly used drugs such as fluoroquinolones, macrolides and penicillins. This study highlights the need for targeted therapy based on local resistance patterns. Further research on biofilms and fungal..."

Otorhinolaryngology

Cephalothin, a First-Generation Cephem Antibiotic, Works as a Potent Inducer of Parthanatos. (PubMed, Biol Pharm Bull) - "We have previously identified the human fibrosarcoma HT1080 cells as highly sensitive cells to parthanatos, and cefotaxime, a 3rd-generation cephem antibiotic, as the parthanatos inducer. In this study, we comprehensively characterized the ability of various cephem antibiotics, including cephalothin (also called cefalotin) (CET), cefoxitin, ceftriaxone, cefoperazone, ceftezole, and cefalexin, to induce parthanatos. Among them, CET exhibited the lowest LD50. Therefore, our results show that CET works as the more potent and useful parthanatos inducer."

Journal • Fibrosarcoma • Oncology • Sarcoma • Solid Tumor

Contamination of hospital surfaces by third-generation cephalosporin-resistant gram-negative bacteria in district hospitals in Mwanza, Tanzania: Urgent need for enhanced infection prevention and control. (PubMed, Infect Prev Pract) - "Isolation of 3GC-R-GNB was done on MacConkey agar supplemented with cefotaxime (2 μg/ml)...Multiplex PCR of selected isolates (n=243) revealed that 99.6% (242/243), 93.4% (227/243), and 2.9% (7/243) 3GC-R-GNB harbored bla TEM, bla CTX-M, and bla SHV genes encoding ESBLs, respectively. This study reveals substantial dispersion of highly resistant Gram-negative bacteria to hospital surfaces, showing the need to prevent dispersion of such contamination and targeted hospital hygiene measures to protect patients."

Journal • Infectious Disease • Pneumonia

The First Reported Case of Infant Soft Tissues Infection Caused by Legionella Maceachernii: A Case Report and Literature Review. (PubMed, Infect Drug Resist) - "Initial empiric therapy with vancomycin and cefotaxime yielded no clinical improvement...maceachernii infection, prompting targeted antimicrobial therapy with levofloxacin and rifampicin that resulted in clinical resolution...This case highlights three paradigm-shifting concepts in pediatric infectious disease management, including 1) L. maceachernii should be included in the differential diagnosis of pediatric soft tissue infections refractory to standard therapy, 2) underlying immunodeficiency must be systematically evaluated in pediatric patients with atypical Legionella infections, and 3) the diagnostic utility of mNGS in identifying fastidious pathogens and underscore the importance of genomic investigations in elucidating immunological comorbidities."

Journal • Genetic Disorders • Immunology • Infectious Disease • Pediatrics • Primary Immunodeficiency • IL2RG

Iron and Manganese Azooxime Complexes as Anti-Microbial Agents Against Antibiotics Resistant Wild Bacteria From Hospital Drainage. (PubMed, J Cell Mol Med) - "The strains were treated with various broad-spectrum antibiotics, namely, Penicillin G, Oxacillin, Cephalothin, Clindamycin, Erythromycin, Amoxyclav, Cefotaxime, Levofloxacin, Aztreonam, Imipenem, Amikacin, Ceftazidime, and found to be resistant against many of them, viz., Clindamycin, Ceftazidime, Erythromycin, Amoxyclav, and some others, thereby signifying that the molecular mechanism of action of the aforesaid complexes is multidimensional. These complexes were producing ROS in sufficient amounts that can cause lipid peroxidation, and subsequent damage to the bacterial cell membrane and translation machinery was found to be inhibited by RNA. Bacterial genomic DNA was also affected by the chelates, and this has been authenticated by the decreased genomic DNA concentration and presence of DNA debris on agarose gel electrophoresis of the DNA of bacterial cultures treated with the complexes."

Journal • CAT

The investigation of bacteria in the oral of Trichomonas gallinae infected pigeons and the antibiotic resistance analysis of Klebsiella pneumoniae clinical isolates from farm pigeons in Shandong Province of China. (PubMed, Poult Sci) - "Furthermore, we assessed the resistance profiles of K. pneumoniae isolates against quinolones, tetracyclines, and aminoglycosides, and identified the carriers of related resistance genes, including bla genes encoding SHV, TEM, and CTX-M-9 ESBLs.Our results revealed that approximately 30% of pigeons from Laiwu City and Tai'an City in Shandong Province were infected with T. gallinae...The majority of these isolates exhibited multidrug resistance to ampicillin, ceftazidime, cefotaxime, and aminoglycosides...These findings provide a overview of antibiotic susceptibility patterns and the emergence of resistance genes in K. pneumoniae isolates from farm pigeons in Shandong, China. They underscore the widespread multidrug resistance in these isolates and highlight the potential risk of antibiotic resistance transmission between animals and humans."

Journal • Infectious Disease • Pneumonia

Pediatric Preseptal Cellulitis: A 5-year Retrospective Study in an Iranian Referral Hospital. (PubMed, Infect Disord Drug Targets) - "According to this study, children with preseptal cellulitis might exhibit a variety of symptoms. The most common risk factors for preseptal cellulitis infection are sinusitis, odontogenic infections, animal or insect bites, and periocular trauma. Patients usually received clindamycin, ceftri-axone, and combination antibiotics."

Journal • Retrospective data • Dermatology • Infectious Disease • Mood Disorders • Ocular Infections • Otorhinolaryngology • Pediatrics • Respiratory Diseases • Sinusitis

Antimicrobial use in pediatric patients: a subgroup analysis of the 2020 point prevalence survey in Aichi, Japan. (PubMed, J Infect Chemother) - "This subgroup analysis provides the first demographic data on AMU among pediatric inpatients at Japanese hospitals. The distinct distribution of AMU suggests that different approaches are necessary to promote antimicrobial stewardship in hospital settings."

Journal • Infectious Disease • Pediatrics

One health approach unravels worrying antimicrobial resistance patterns: A cross-sectional study in Kisii, Kenya. (PubMed, PLoS One) - "Shared resistance patterns across human, animal, and environmental samples highlight interconnected AMR pathways. These findings reinforce the need for a One Health approach through integrated AMR surveillance and interventions."

Journal • Observational data

Epidemiology and Antimicrobial Resistance Trends of Bloodstream Infections During and After the Implementation of the National Action Plan on Antimicrobial Resistance in Mwanza, Tanzania: A Comparative Cross-Sectional Study. (PubMed, Infect Drug Resist) - "Klebsiella pneumoniae resistance to cefotaxime (65.3% vs 93.2%, p=0.001), gentamicin (63.3% vs 94.9%, p=0.001), and ciprofloxacin (28.6% vs 76.3%, p=0.001) increased significantly. We observed a high prevalence of BSIs with a rising proportion of BSIs caused by WHO-BPPs, particularly in higher-tier hospitals and after the implementation of NAP-AMR. Our findings highlight the need of hospital-specific antibiograms and reinforced infection prevention measures."

Journal • Observational data • Infectious Disease • Pneumonia • Septic Shock

Antimicrobial susceptibility patterns of Escherichia coli from various clinical sources. (PubMed, Antimicrob Steward Healthc Epidemiol) - "There were high sensitivity rates to Amikacin, Tigecycline, and Imipenem by (97.49%), (90.87%), and (90.35%), respectively, while there were high resistance rates to Norfloxacin, Ampicillin, and Cefotaxime by (93.67%), (79.60%), and (71.65%), respectively. Antibiotics, including imipenem, amikacin, and nitrofurantoin, demonstrated the highest efficacy against E. coli isolates. Nalidixic acid, cefexime, and ceftriaxone showed efficacy against E. coli; nevertheless, several clinical isolates exhibited resistance."

Journal • Gastrointestinal Disorder

In-Silico discovery of novel cephalosporin antibiotic conformers via ligand-based pharmacophore modelling and de novo molecular design. (PubMed, J Genet Eng Biotechnol) - "A shared features pharmacophore (SFP) model was constructed using cephalosporins from PubChem, including cephalothin, ceftriaxone, and cefotaxime. To ensure feasible synthesis, molecular architecture comparison and computational retrosynthesis were performed, confirming the likelihood of successful laboratory synthesis. These findings advance the fight against antimicrobial resistance by establishing a method for designing new, highly effective antibiotic drugs."

Journal • Infectious Disease

Hospital acquired drug resistant pathogens infections in patients with viral respiratory tract infections: a retrospective study. (PubMed, BMC Infect Dis) - "The drug resistance rate of P. aeruginosa to third-generation cephalosporins (such as ceftriaxone and cefotaxime) exceeds 89%, but it has relatively higher sensitivity to ceftazidime (71.7%) and cefepime (69.6%)...pneumoniae shows resistance rates of 53.3% to imipenem and 46.7% to meropenem, with over 50% resistance to levofloxacin and ciprofloxacin. Effective agents include sulfamethoxazole (68.9% susceptible), tigecycline (64.4%), chloramphenicol (62.2%), and amikacin (62.2%)...baumannii was highly resistant to nearly all tested antibiotics, showing only partial susceptibility to minocycline (59.5%) and trimethoprim-sulfamethoxazole (38.1%). Among the seven ML models, the neural network (NN) achieved the best predictive performance. The SHAP method revealed the top 15 predictive variables by importance ranking, including length of stay (LOS), cholinesterase (CHE), age, albumin (ALB), etc."

Journal • Retrospective data • Infectious Disease • Influenza • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

Bacteriological profile and antibiotic susceptibility of early-onset neonatal bacterial infection in a neonatal unit in Cameroon. (PubMed, BMC Pediatr) - "This study shown a high prevalence of early neonatal infection with a variability of the local ecology. Also there was a high resistance of bacterial pathogens to the common antibiotics. All these findings were associated with a high mortality which is suggesting that a timely identification and initiation of effective antibiotherapy is necessary to reduce morbidity and mortality associated with neonatal infection."

Journal • Infectious Disease • Obstetrics • Pediatrics • Pneumonia

Invasive whistling frogs (Eleutherodactylus johnstonei) act as a reservoir for antimicrobial-resistant Enterobacteriaceae in Latin America's most populous city. (PubMed, Vet Res Commun) - "Resistance to amoxicillin + clavulanate and cefoxitin were the most frequent (16.67%; 4/24), followed by cefotaxime (5.71%; 2/35), ceftriaxone (2.86%; 1/35), and tetracycline (2.86%; 1/35). The whole genome of the blaCTX-M group 8-positive E. coli strain was assessed and confirmed blaCTX-M-8 presence and phylogenetic analysis. Given the synanthropic behavior of whistling frogs, these amphibians may act as carriers of antimicrobial-resistant bacteria."

Journal

From Triad of Trouble to Recovery: Plasmapheresis as Lifeline in G6PD-Mediated Crisis and AKI Triggered by Viral Hepatitis (ACG 2025) - "The case describes a male with this complex interplay managed ultimately with therapeutic plasmapheresis.Case Description/ This is case of 23‑year male, referred from a peripheral center for persistent jaundice after empiric treatment with broad‑spectrum antibiotics (Ceftriaxone, metronidazole, ciprofloxacin) and supportive care for acalculous cholecystitis(based on USG)...On admission, he was shifted to only Cefotaxime, ursodeoxycholic acid, rifaximin and supportive treatment...Delta bilirubin was brought back to normal in days as compared to months naturally. The heroic return of patient to baseline emphasizes on the role of plasmapheresis as a bridge to recovery when conventional therapies fail."

Acute Kidney Injury • Anemia • CNS Disorders • Gastroenterology • Hematological Disorders • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Metabolic Disorders • Nephrology • Renal Disease

Prevalence and Characterization of the Antimicrobial Resistance and Virulence Profiles of Staphylococcus aureus in Ready-to-Eat (Meat, Chicken, and Tuna) Pizzas in Mansoura City, Egypt. (PubMed, Antibiotics (Basel)) - "All recovered isolates (n = 560) were classified as multidrug-resistant and were resistant to penicillin, oxacillin, and ampicillin. Moreover, 77% (431/560), 24% (134/560), 8% (45/560), and 8.6% (48/560) of isolates were resistant to cefotaxime, ciprofloxacin, azithromycin, and vancomycin, respectively. The current study emphasizes that ready-to-eat pizza is highly contaminated with multidrug-resistant S. aureus, highlighting the urgent need for rationalizing antibiotic use in both veterinary and human medicine to prevent the transmission of resistant bacteria through the food chain. Additionally, strict adherence to good hygienic practices throughout all stages of the food chain is essential to minimize overall contamination and enhance food safety."

Journal • Cardiovascular • Infectious Disease • Pneumonia • Respiratory Diseases • CAT

Unique Regulation of Sed-1 β-Lactamase in Citrobacter sedlakii: Insights on Resistance to Third-Generation Cephalosporin. (PubMed, Antibiotics (Basel)) - " The AmpD mutant (pCR2807/ML4953) showed an 8-fold increase in cefotaxime MIC and an 8.46-fold increase in Sed-1 activity compared to the wild-type (pCR2807/ML4947). Finally, mutagenesis revealed that amino acid substitution in Sed-1 conferred resistance to ceftazidime and extended-spectrum β-lactamase characteristics. Sed-1 producers, though usually susceptible to third-generation cephalosporins, may develop extended-spectrum β-lactamase traits due to AmpD or Sed-1 mutations, thereby requiring careful monitoring."

Journal

Prevalence of Antibiotic Resistance Bacteria in Manure, Soil, and Vegetables in Urban Blantyre, Malawi, from a Farm-to-Fork Perspective. (PubMed, Int J Environ Res Public Health) - "All manure isolates exhibited sulfamethoxazole-trimethoprim resistance, with 50% of pig manure E. coli showing cefotaxime resistance. Soil isolates mirrored these patterns (100% ampicillin resistance in K. pneumoniae and 77% cefotaxime resistance in farm soil E. coli). Vegetables displayed severe multidrug resistance (100% E. coli and 80% K. pneumoniae resistant to ≥3 classes), including critical gentamicin resistance (100% E. coli)...and 6.1% in Brassica rapa, suggesting a potential zoonotic transmission route from livestock farms that requires molecular confirmation. These findings demonstrate manure-amended farms as AMR reservoirs, necessitating extended composting and antibiotic stewardship to mitigate One Health risks."

Journal • Infectious Disease • Pneumonia

Outbreak Caused by VIM-1- and VIM-4-Positive Proteus mirabilis in a Hospital in Zagreb. (PubMed, Pathogens) - "This study revealed an epidemic spread of carbapenemase-producing P. mirabilis in two wards in a psychiatric hospital. Due to the extensively resistant phenotype (XDR), therapeutic options were limited. This is the first report of carbapenemase-producing P. mirabilis in Croatia."

Journal • Infectious Disease • Psychiatry

Carbapenem Resistance and ESBL-Producing Enterobacteriaceae in Patients with Urological Infections from 2012 to 2021 in Three Korean Hospitals. (PubMed, Diagnostics (Basel)) - "Resistance rates for E. coli increased from 44.5% to 60.0% (ciprofloxacin) and from 26.3% to 40.2% (cefotaxime), while carbapenem resistance (ertapenem) remained low, at 0.3% to 1.2%. Although carbapenem resistance in E. coli remains low, K. pneumoniae has experienced a significant rise, primarily attributable to its ESBL-producing strains. These findings underscore the importance of vigilant antimicrobial stewardship and continuous surveillance to guide empirical UTI therapies in Korean clinical practice."

Journal • Infectious Disease • Nephrology • Pneumonia

Functional metagenomics reveals novel antibiotic resistomes in polar soils. (PubMed, Imeta) - "Consequently, we identified 671 novel polar ARGs with experimentally verified resistance against multiple clinical antibiotics (cefotaxime, folate synthesis inhibitors, and clindamycin). Bioinformatics analysis revealed that novel polar ARGs had limited mobility and dissemination potential and were seldom carried by human bacterial pathogens. Overall, this study offers a comprehensive perspective on previously overlooked novel ARGs in polar regions, advancing our understanding of environmental resistomes."

Journal

Beta-lactam underdosing is not more frequent in COVID-19 than in non-COVID-19 critically-ill patients. (PubMed, Infect Dis Now) - "Although underdosing of most commonly prescribed beta-lactams occurred in more than a third of cases in critically-ill COVID-19 patients, this rate was not different from non-COVID-19 patients."

Journal • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

Exploring the genetic diversity and the association of drug resistance and biofilm production in Acinetobacter baumannii strains isolated from burn wound infections. (PubMed, Iran J Microbiol) - "A vast majority of isolates (99%) exhibited resistance to meropenem, ciprofloxacin, ceftriaxone, cefotaxime, piperacillin-tazobactam, and imipenem, qualifying them as extensively drug-resistant (XDR). ERIC-PCR typing showed the presence of 3 clonal types and 7 single types, with biofilm producers predominantly clustering to clonal type 2. This work highlights a notable prevalence of biofilm-producing XDR A. baumannii in burn patients, underscoring the need for continuous surveillance and enhanced infection control strategies."

Journal • Infectious Disease • Thermal Injury