cefotaxime / Generic mfg. - LARVOL DELTA

Antibacterial and Antibiofilm Activity of Aspergillus-Derived Gliotoxin Against Streptococcus pneumoniae and Staphylococcus aureus: Interaction with Conventional Antibiotics. (PubMed, J Fungi (Basel)) - "Moreover, its combination with conventional antibiotics (cefotaxime or vancomycin) showed strong synergy, drastically decreasing bacterial survival. These findings highlight the potent antibacterial and anti-biofilm activity of GT and its ability to enhance antibiotic efficacy, providing insight into fungal-bacterial interactions and suggesting potential therapeutic applications."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia

Ignatzschineria indica bacteremia in a fatal case of accidental wound myiasis. (PubMed, Folia Microbiol (Praha)) - "Antimicrobial susceptibility tests using gradient diffusion demonstrated susceptibility to all tested antibiotics (cefotaxime, cefepime, meropenem, piperacillin/tazobactam, ciprofloxacin, trimethoprim-sulfamethoxazole and gentamicin). This is unique in Central Europe, where no report on lethal infection with I. indica has been reported so far. Hence, this paper can serve as a valuable piece of knowledge on the treatment of maggot-infested wounds, particularly where I. indica infections are concerned."

Journal • Cardiovascular • Critical care • Fibrosis • Gastroenterology • Hepatology • Hypertension • Immunology • Infectious Disease • Liver Cirrhosis • Musculoskeletal Diseases • Orthopedics • Pulmonary Arterial Hypertension • Septic Shock

Detection of cefotaxime- and enrofloxacin-resistant and mcr-1-positive Escherichia coli at farm level in younger and older calf groups across different production systems in Germany. (PubMed, BMC Microbiol) - "Differences in the qualitative farm-level detection and genetic diversity of CTX- and ENR-resistant and mcr-1-positive E. coli subpopulations were observed between production systems and between younger and older calf groups within farms. These findings suggest that production system and sampled calf group should be considered in the surveillance of antibiotic-resistant E. coli in calves."

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Performance of a rapid direct-from-blood antibiotic susceptibility test based on MIC test strips on Enterobacterales blood cultures. (PubMed, J Antimicrob Chemother) - "MTS-AST provided rapid results (in 5 h) that correlated well with the comparator method on blood culture broth containing Enterobacterales. Given the shorter time to results, the reduced time cost, the limited handwork and the reduced cost per test, the MTS-AST constitutes a fast and reliable method."

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Coupling continuous directed evolution with base editors identifies combinatorial antibiotic resistance. (PubMed, Biotechnol Lett) - "The Escherichia coli strain harboring the vector cloned with 10 TEM-1 mutations showed a minimum inhibitory concentration of 1280 μg/mL to antibiotic cefotaxime, which is the highest data reported thus far. The research highlights the application of gene editing methods to provide insight into the molecular basis of antibiotic resistance."

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Molecular epidemiology of antimicrobial-resistant Klebsiella pneumoniae in intensive care unit patients, southwestern Saudi Arabia. (PubMed, Cell Mol Biol (Noisy-le-grand)) - "The highest resistance rates were observed against piperacillin‑tazobactam (55.1%), cefotaxime (55.1%), imipenem (53.0%), and meropenem (53.0%), while tigecycline (100% susceptibility) and amikacin (93.9% susceptibility) remained the most effective agents. Notably, susceptibility to trimethoprim‑sulfamethoxazole was 83.7% (corrected figure)...The alarmingly high prevalence of ESBL and carbapenemase phenotypes, coupled with significant multidrug resistance, underscores the urgent need for routine molecular surveillance and targeted antibiotic stewardship in this region. Rapid phenotypic screening combined with genotypic confirmation is essential to guide empirical therapy and curb the spread of these high‑risk clones in critically ill populations."

Journal • Retrospective data • Critical care • Infectious Disease • Pneumonia

Emerging food- and waterborne pathogen Arcobacter in wastewater: diversity and antibiotic resistance. (PubMed, Microbiol Spectr) - "Phenotypic testing revealed high proportions of non-wild-type isolates for clinically relevant antibiotics, including ampicillin, cefotaxime, tetracycline, and erythromycin. By characterizing the species-level diversity, genomic traits, and antibiotic resistance profiles of Arcobacter spp. in wastewater, this study provides critical insights into the ecology and epidemiology of this ubiquitous genus."

Journal • Infectious Disease

Establishment of epidemiological cut-off values of cefotaxime-sulbactam against Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, Serratia marcescens, Acinetobacter baumannii and Staphylococcus aureus. (PubMed, Front Microbiol) - "ECOFFs of cefotaxime-sulbactam were established for seven clinically important bacterial species. These results provide essential reference values for distinguishing wild-type from non-wild-type isolates and support future breakpoint-setting and antimicrobial resistance surveillance."

Journal • Infectious Disease • Pneumonia

A multinational genomic framework for predicting β-lactam resistance in Haemophilus influenzae. (PubMed, J Antimicrob Chemother) - "A recurrence-filtered k-mer-based vocabulary provides a promising standardized genomic framework that complements phenotypic AST, particularly when phenotypic testing is unavailable, incomplete or heterogeneous."

Journal • Infectious Disease • Influenza • Respiratory Diseases

Evaluating the probiotic potential of Bacillus pumilus HFS2 isolated from the gut microbiota of Heteropneustes fossilis for aquaculture applications. (PubMed, J Genet Eng Biotechnol) - "These results suggest that B. pumilus HFS2 is a resilient and promising potential probiotic candidate for aquaculture applications."

Journal • Infectious Disease • CAT

First Report and Integrated Characterization of Aeromonas veronii Associated with the Protected Fish Diptychus maculatus in Xinjiang, China. (PubMed, Animals (Basel)) - "The isolates were susceptible to enrofloxacin, cefotaxime, ceftriaxone, and florfenicol. Intermediate responses were observed for ciprofloxacin, ofloxacin, doxycycline, oxytetracycline, and trimethoprim-sulfamethoxazole, whereas resistance was detected against norfloxacin, neomycin, penicillin, amoxicillin, tetracycline, and erythromycin. In vitro biofilm assays demonstrated weak to moderate biofilm-forming capacity among isolates. These findings provide baseline data for wildlife microbial surveillance and conservation-oriented monitoring of protected fish populations, supporting future investigations into environmental monitoring, genomic characterization, and host-microbe interactions."

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Genomic diversity, antimicrobial resistance, and virulence-associated characteristics of Escherichia coli recovered from poultry hatchery-box material. (PubMed, Poult Sci) - "Following within-sample reduction based on antimicrobial susceptibility profiles and PCR screening for selected APEC-associated virulence genes, 91 isolates enriched for cefotaxime-medium recovery or APEC-associated gene profiles were selected for Illumina whole-genome sequencing...Seventeen isolates were resistant to ceftazidime; eight carried ESBL or plasmid-mediated AmpC determinants, while eight additional isolates had the chromosomal ampC promoter substitution C-42T as the only identified determinant associated with this phenotype...These findings document genomically diverse, resistance- and virulence-associated E. coli in hatchery-box material and identify genetically related isolates that warrant investigation through structured longitudinal sampling. Because sampling was unequal and isolates were purposively selected, the findings do not provide prevalence estimates or demonstrate source, transmission, persistence, or pathogenicity."

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Cefoxitin versus cefotaxime as empirical treatment of spontaneous bacterial peritonitis in liver cirrhotic patients: randomized controlled clinical trial. (PubMed, J Antimicrob Chemother) - "Cefoxitin showed comparable effectiveness to cefotaxime but may be utilized in selected clinically stable SBP patients."

Clinical • Journal • Fibrosis • Immunology • Liver Cirrhosis • Nephrology • Renal Disease

Antibacterial consumption in four paediatric inpatient facilities in Sri Lanka in 2023: a cross-sectional descriptive study. (PubMed, BMJ Open) - "High use of broad-spectrum and Watch-group antibacterials was observed across the four paediatric inpatient facilities. The findings highlight targets for antibacterial stewardship programmes and demonstrate the feasibility of ABC surveillance in Sri Lanka."

Journal • Pediatrics

Analysis of the Etiology and Antibiotic Resistance of Bacterial Infections in Newborns in a Chinese Tertiary Hospital: From 2019 to 2024. (PubMed, Infect Drug Resist) - "It demonstrated the highest resistance to penicillin (86.1%) and a relatively high resistance to erythromycin (52.6%), while remaining 100% sensitive to vancomycin, linezolid, and tigecycline. Staphylococcus epidermidis exhibited significant resistance to benzathine penicillin (75.3%) and erythromycin (62.3%), with a positive rate of 77.9% in the cefotaxime screening test...Among the Gram-negative pathogens, Escherichia coli showed high resistance (80.0-86.1%) to cefoperazone-sulbactam and other β-lactams but only 0.9% resistance to carbapenems and full sensitivity to amikacin...Additionally, multidrug-resistant strains have been identified. Temporal trend analysis revealed significant increasing trends for S. aureus (P=0.027) and S. epidermidis (P=0.038), and significant decreasing trends for E. coli (P=0.016)."

Journal • Critical care • Infectious Disease • Pneumonia

Genomic surveillance reveals escalating antimicrobial resistance and plasmid diversity in clinical Salmonella 1,4,[5],12:i:- ST34 isolates from Guizhou Province, China. (PubMed, Front Microbiol) - "The isolates exhibited resistance to first-line antibiotics, with 22.4% for ciprofloxacin, 11.4% for azithromycin, 18.5% for ceftazidime, and 39.1% for cefotaxime. ARGs showed substantial agreement with phenotypes for tetracycline, macrolides, third-generation cephalosporins (3GCs), carbapenems, and colistin (80.8-100.0% consistency; Kappa: 0.50-1.00)...Gene-content analysis revealed that isolates in Clades 4 and 5 harbored the largest mean gene complements, and cgST52428 isolates also harbored the largest among dominant cgSTs. This study presents a comprehensive genomic profile of Salmonella 1,4,[5],12:i:- ST34 in Guizhou, providing essential data for exploring the resistance characteristics and investigating the molecular epidemiology of Salmonella 1,4,[5],12:i:-."

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Shigella infections in the era of antimicrobial resistance: Insights into cephalosporin use. (PubMed, New Microbes New Infect) - "Third-generation cephalosporins (ceftriaxone, cefotaxime) remain highly effective for severe Shigella infections in hospitalized and pediatric patients when isolates are susceptible. Structured surveillance, susceptibility-guided therapy, and stewardship are essential. Complementary strategies (vaccines, probiotics, phage therapy, novel antibiotics) are urgently needed."

Journal • Review • Infectious Disease • Pediatrics

Detection and antimicrobial susceptibility patterns of Salmonella enterica subsp. arizonae and Proteus spp. associated with gastrointestinal disease in rescued hedgehogs (Erinaceus europaeus). (PubMed, Comp Immunol Microbiol Infect Dis) - "isolates were susceptible to cefotaxime, nalidixic acid, ciprofloxacin, levofloxacin, norfloxacin, amikacin, gentamicin, tobramycin, aztreonam, cefoxitin, ceftazidime and fosfomycin. However, resistance was observed to amoxicillin-clavulanic acid, ampicillin, ertapenem, meropenem, trimethoprim-sulfamethoxazole, cefuroxime, piperacillin-tazobactam, colistin and nitrofurantoin, with the latter two showing resistance in all Proteus spp...from hedgehog samples may display relevant antimicrobial resistance (AMR) patterns. Therefore, continuous bacteriological monitoring and antimicrobial susceptibility testing are important in wildlife rehabilitation settings to guide treatment decisions and support One Health surveillance."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease

Simulating an intravenous-to-oral cefotaxime-to-cefditoren/cefuroxime switch: an in vitro pharmacodynamic approach against selected Streptococcus pneumoniae strains with defined susceptibility profiles. (PubMed, Front Pharmacol) - "Overall, despite the limitations of the proposed model in reproducing the antimicrobial activity of agents with high plasma protein binding, such as CDN, greater in vitro pharmacodynamic activity was observed with CDN than with CXM in the simulated sequential regimens against the four strains tested, particularly against CTX-susceptible strains. These findings warrant confirmation in clinical studies before any therapeutic recommendation could be made."

Journal • PK/PD data • Preclinical • Infectious Disease • Pneumococcal Infections • Pneumonia

Prevalence and patterns of antimicrobial resistance in Escherichia coli from Indonesian broiler chickens: Comparison of CLSI and EUCAST 2025 standards. (PubMed, J Adv Vet Anim Res) - " The highest resistance rates under both standards were observed for ampicillin (78.33% according to CLSI and 78.63% according to EUCAST), while all isolates remained susceptible to meropenem (100%) based on both references. Significant differences between CLSI and EUCAST interpretations were observed for colistin and ciprofloxacin (p 0.91)...Strengthening and harmonizing AMR surveillance reporting based on both standards is essential to support evidence-based and effective AMR mitigation policies. This approach, within a One Health framework, is to safeguard animal health, public health, and food safety in Indonesia."

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Applications of AI-assisted interpreter Raman spectroscopy platform for rapid and accurate cefotaxime-resistant Escherichia coli classification. (PubMed, Anal Chim Acta) - "Especially, an exploratory 1D Transformer model achieved 94.38% accuracy with 8% gain and an AUC of 0.991 with 0.07 gain for Raman spectral classification, through introducing global feature modeling. In conclusion, this work offers a promising tool for rapid resistance screening (<0.5 h), while leveraging interpretable AI to reveal candidate spectral biomarkers, thereby aiding in elucidating resistance mechanisms and guiding targeted therapy."

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Photodynamic antimicrobial efficacy and mode of action of polypyridyl-based Ru(II) complexes against multidrug-resistant Klebsiella pneumoniae. (PubMed, Br J Pharmacol) - "Ruthenium-based photosensitisers appear to act predominantly through singlet oxygen-mediated oxidative stress, enhancing cefotaxime efficacy while exhibiting low cytotoxicity, and therefore represent promising adjunct therapies against MDR K. pneumoniae."

Journal • Infectious Disease • Pneumonia

Moraxella species isolated from blood cultures in Europe (MORAXEu): a multicentre study of epidemiology and antimicrobial susceptibility with complementary phylogenomic analysis of publicly available genomes. (PubMed, Eur J Clin Microbiol Infect Dis) - "The epidemiology of Moraxella species from BCs in Europe showed age-group-specific differences in species distribution and generally favourable antimicrobial susceptibility patterns. Phylogenomic data corroborated recent taxonomic revisions, highlighting the need for improved diagnostics, harmonized nomenclature and sustained surveillance to inform management and stewardship of Moraxella bacteraemia."

Journal • Infectious Disease • Pediatrics • Septic Shock

Genomic epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli across humans, poultry and wastewater sectors in Douala, Cameroon. (PubMed, JAC Antimicrob Resist) - "Samples were screened for ESBL-Ec using CHROMAgar™ ESBL and cefotaxime-supplemented Tryptone Bile X-glucuronide agar...High co-resistance (>70%) was observed for tetracycline, ciprofloxacin and trimethoprim/sulfamethoxazole...Cross-sectoral ESBL-Ec in Douala exhibits high genomic diversity and alarming resistance. The occurrence of last-resort genes requires immediate One Health surveillance and coordinated interventions."

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Antimicrobial-associated adverse events in neonates: an integrated literature review and FAERS pharmacovigilance analysis. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "In parallel, FAERS reports from Q1 2004 to Q2 2024 were retrieved through OpenVigil 2.1 for 12 commonly used antimicrobial agents: gentamicin, vancomycin, fluconazole, ampicillin, amphotericin B, metronidazole, piperacillin, meropenem, amikacin, amoxicillin, voriconazole, and cefotaxime. Clinically, our results support conservative antimicrobial stewardship, individualized dosing, and organ-specific monitoring in routine neonatal intensive care unit (NICU) care. Future research should prioritize gestational age-stratified analyses and prospective registries linking antimicrobial exposure to long-term outcomes to define drug-specific safety profiles."

Adverse events • Journal • Review • Candidiasis • Critical care • Gastroenterology • Gastrointestinal Disorder • Hepatology • Infectious Disease • Nephrology • Respiratory Diseases • Septic Shock