cefotaxime / Generic mfg. - LARVOL DELTA

Susceptibility profile of Aeromonas spp. from clinical strains isolated in French Guiana. (PubMed, Microbiol Spectr) - "A secondary objective was to assess the resistance profile of these strains to cefepime (FEP), aztreonam (AZT), ciprofloxacin (CIP), levofloxacin (LEV), and trimethoprim-sulfamethoxazole (SXT)...The median ceftazidime (CAZ) MIC was 0.125 mg/L...This study provides essential MIC distribution data for piperacillin-tazobactam and cefotaxime, offering valuable insights for guiding empirical treatment choices...By analyzing a large collection of clinical isolates, our findings contribute to evidence-based decision-making for Aeromonas infections and emphasize the importance of continued surveillance of antimicrobial susceptibility. These findings suggest that PTZ and CTX may be therapeutic options for Aeromonas infections, supporting their potential use in clinical practice."

Journal • Infectious Disease

ESBL-Producing Enterobacter cloacae Complex and Klebsiella pneumoniae Harbouring blaCTX-M-15 and blaCTX-M-55 Potentially Risk the Worldwide Spread of ESBL-Producing Bacteria Through Contaminated Dried Fishery Products. (PubMed, Curr Microbiol) - "Enterobacterales were isolated using a CHROMagar Escherichia coli coliform agar containing cefotaxime or meropenem. cloacae AD2-1 isolated from the Vietnamese dried fish was resistant to 14 antibiotics, and approximately 300 kbp of the IncHI2 plasmid harboured multiple antibiotic resistance genes and formed an antibiotic resistance gene region. This E. cloacae is considered a risk for the spread of antibiotic resistance across countries."

Journal • Infectious Disease • Pneumonia

Epidemiological Study of Lactose- and Non-lactose-Fermenting Gram-Negative Bacterial Isolates From Clinical Specimens in the Middle Al-Furat Region of Iraq. (PubMed, Cureus) - "Antibiotic susceptibility testing showed the highest efficacy for ampicillin (84.2%) and amoxicillin/clavulanic acid (75.5%), followed by cefotaxime (75.5%), ceftazidime (71%), imipenem (58.4%), and meropenem (63.8%), with all isolates exhibiting significant resistance (p < 0.0001) This work emphasizes the place of the Gram-negative bacteria as nosocomial and community-acquired pathogens. The rates of resistance are in accordance with a public health problem in the Middle Euphrates region."

Journal • Infectious Disease • Pneumonia

Controlling drug-resistant bacteria in Arabian horses: bacteriophage cocktails for treating wound infections. (PubMed, Front Vet Sci) - "exhibited extensive drug resistance (XDR) with complete resistance to amoxicillin-clavulanic acid, amikacin, kanamycin, streptomycin, and cefotaxime...Staphylococci isolates were highly resistant to fusidic acid, β-lactams, and tetracyclines. Amoxicillin-clavulanic acid, fosfomycin, and cephalosporines were ineffective against Enterobacteriaceae isolates. Ticarcillin, clavulanic acid, and colistin were ineffective against P. aeruginosa and Acinetobacter baumannii...There were significant differences (p < 0.05) in the wound closure % among the gentamicin group and phage cocktaoil+gentamicin groups on days 3, 5, 7, 10, and 14. This study highlights the widespread antibiotic resistance in bacteria infecting Arabian horses and posing significant challenges to equine infection management. Bacteriophage therapy shows promise as a potential treatment for wound infections."

Journal • Infectious Disease • Ocular Infections • Ophthalmology • Pneumonia • Respiratory Diseases

Antibacterial profiling of selenium nanoparticles synthesized from Crinum species. (PubMed, Microb Pathog) - "The synergistic antibacterial activity of SeNPs and Cefotaxime was observed against Bacillus cereus (MIC = 128 μg/ml)...The study revealed cell elongation, increased cell size, cell wall swelling and changes in colony characteristics. Thus, SeNPs can be used for treating wounds and burns, promoting poultry growth, formulating antimicrobial products and soil supplementation in agriculture etc."

Journal • Thermal Injury

The Impact of an Ex Vivo Pediatric Extracorporeal Membrane Oxygenation Circuit on Sequestration of Antimicrobials. (PubMed, Crit Care Explor) - "The lipophilicity of an antimicrobial is a predictor of antimicrobial recovery in ECMO. Concentrations were significantly reduced at 7 hours for greater than 60% of the study antimicrobials in the ECMO models. Clinical studies are required for children receiving ECMO to determine if the current dosing regimens for antimicrobials provide therapeutic concentrations."

Journal • Preclinical • Pediatrics

Evaluation of the effect of the enzyme preparation Phlogenzym on the ability of clinical strains isolated from surgical wounds to form biofilms (PubMed, Khirurgiia (Mosk)) - "The enzyme preparation, Phlogenzym, significantly reduces the ability of bacterial cells to form films in surgical wounds, reducing the risk of chronic infection and recurrence. Additionally, it enhances the effectiveness of antibiotics in eradicating pathogens and has an anti-inflammatory effect. Phlogenzym also increases the efficacy of beta-lactam and aminoglycoside antibiotics."

Journal • Infectious Disease

Prevention of infection in peripheral arterial reconstruction of the lower limb. (PubMed, Cochrane Database Syst Rev) - "Prophylactic antibiotics may reduce SSIs in peripheral arterial reconstruction of the lower limb with low-certainty evidence. We found no superiority among specific antibiotics or differences in extended use (over 24 hours) compared with shorter use (up to 24 hours), with low-certainty evidence. Closed incision negative pressure therapy may lower the SSI risk, but this is based on very low-certainty evidence. For other interventions, very low- to moderate-certainty evidence showed little or no significant differences across various outcomes. We advise caution when interpreting these conclusions due to the limited number of events in all groups and comparisons."

Clinical • Journal • Review • Cardiovascular • Infectious Disease • Pain • Peripheral Arterial Disease

Genomic Surveillance of Streptococcus pneumoniae in India: Vaccine-Driven Serotype Shifts, Antimicrobial Resistance, and Emerging Clonal Lineages. (PubMed, J Appl Microbiol) - "India's pneumococcal population is undergoing vaccine-driven serotype replacement with concurrent expansion of multidrug-resistant NVTs. Moreover, 31.4% discordance between phenotypic and WGS serotyping indicates that older phenotypic methods likely overestimated PCV coverage by about 10-12%, underscoring the need for genomics-first surveillance, incorporation of WGS into national monitoring, and evaluation of higher-valency or protein-based vaccines to ensure long-term disease control."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia

Characterization of Multidrug-Resistant Trueperella (Arcanobacterium) pyogenes Isolates from Vertebral Osteomyelitis in Slaughtered Pigs. (PubMed, Animals (Basel)) - "Complete resistance (11/11, 100%) was observed against amikacin (AMI), nalidixic acid (NAL), chloramphenicol (CHL), florfenicol (FFN), and trimethoprim/sulfamethoxazole (SXT). High resistance rates were also detected for erythromycin (ERY) and clindamycin (CLI) (10/11, 90.9%), ceftazidime (TAZ), ceftriaxone (AXO), ciprofloxacin (CIP) (7/11, 63.6%), and tetracycline (TET) and streptomycin (STR) (5/11, 45.5%), while gentamicin (GEN) resistance was found in three isolates (27.3%). In contrast, none of the isolates showed resistance to ampicillin, cefoxitin, or cefotaxime. These findings underscore the epidemiological value of abattoir-based monitoring in detecting emerging pathogens and tracking antimicrobial resistance. The results provide important baseline data to inform disease control strategies, guide antimicrobial stewardship, and support One Health approaches, including the development of preventive measures such as vaccines."

Journal • Infectious Disease • Inflammation

Mutations in Penicillin G Acylase: A 4D QSAR-based Approach for Enhancing Efficacy of β-lactam Antibiotics. (PubMed, Curr Comput Aided Drug Des) - "The study highlights the critical role of residue Phe148 in mediating stable interactions with Cefotaxime and other β-lactam substrates. The integrated computational strategy establishes a robust framework for engineering catalytically superior PGA variants, offering a valuable basis for further experimental validation and application in antibiotic biosynthesis."

Journal

Target based biofilm inhibition and antibiotic enhancement strategy by miR.101.3p using DNA tetrahedrons. (PubMed, J Innate Immun) - "The mechanisms involve DNAtd-miR.101.3p targeting of ampC, fleN and pslK. MiR.101.3p, which is expressed in CF bronchial epithelial cells, displays unique inhibition properties against P. aeruginosa and S. aureus in vitro and increases the rate of the bactericidal activity of cefotaxime against P. aeruginosa."

Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Antimicrobial resistance among agents of community-associated lower respiratory tract infection in the UK and Ireland: trends from 1999/2000 to 2018/2019. (PubMed, J Antimicrob Chemother) - "CA-LRTI remains eminently treatable, yet shifts are occurring in the serotypes of S. pneumoniae most associated with resistance and in the nature of amoxicillin resistance in H. influenzae. β-Lactamase-related cephalosporin MIC differentials for M. catarrhalis are striking but their clinical significance remains uncertain."

Journal • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Effectiveness of cefotaxime sodium in combination with penicillin in the treatment of neonatal sepsis and its effect on the level of immunity in pediatric patients. (PubMed, Pak J Pharm Sci) - "No obvious differences of recurrence rate among both groups (P>0.05) were found. This combined therapy has a remarkable curative effect, which is worthy of popularization and use in the clinic."

Journal • Infectious Disease • Pediatrics • Septic Shock

Incidence and antimicrobial resistance of nontyphoidal SalmonellaNTS in children under five years of age in a peri-urban area of Ouagadougou in Burkina Faso. (ASTMH 2025) - "The highest incidence was among children aged 12–23 months (10.3; 95% CI: 6.7–15.6).All isolates were susceptible to imipenem, ciprofloxacin, ceftriaxone, and aztreonam. High susceptibility (≥99%) was seen for ceftazidime, cefotaxime, chloramphenicol, cefepime, and tobramycin. Resistance was low for amoxicillin-clavulanic acid (2.1%), gentamicin (3.1%), streptomycin (6.2%), nalidixic acid (5.2%), and trimethoprim-sulfamethoxazole (4.1%)...However, high resistance to tetracycline suggests the presence of circulating resistant strains. Continued AMR surveillance is essential to inform treatment policies."

Clinical • Late-breaking abstract • Infectious Disease

Characterizing the MDR Klebsiella pneumoniae from Ghanaian Hospital Isolates. (ASTMH 2025) - "The resistance rate was highest for Cefotaxime (89%) followed by trimethoprim-sulfamethoxazole (87.5%). Meropenem-vaborbactam (98%), amikacin (81%), and ceftazidime-avibactam (76%) exhibited high susceptibility levels...The dominance ST15 and ST147, coupled with bla-CTX-M-15, bla-NDM-1 underscores a threat to antimicrobial efficacy. The findings Highlights the need for targeted infection control and genomic surveillance in low-resource settings."

Clinical • Late-breaking abstract • Infectious Disease • Pneumonia

Genomic characterization of Vibrio cholerae Isolated from Clinical and Environmental sources during the 2022-2023 cholera outbreak in Kenya (ASTMH 2025) - "Clinical isolates carried key virulence genes (ctxA, ctxB7, hlyA) and were 100% resistant to multiple antibiotics (ampicillin, cefotaxime, cefpodoxime) but remained susceptible to gentamicin and chloramphenicol. In contrast, environmental isolates lacked ctxB gene but harbored toxR and hlyA, showing variable antibiotic resistance (59% to ampicillin and 41% to trimethoprim-sulfamethoxazole)...While the role of environmental reservoirs as a source of human infection remains unclear in our study, environmental isolates possess virulent and antimicrobial resistance genes that may spread via horizontal gene transfer. This highlights the need for continuous genomic surveillance to monitor V. cholerae evolution, track transmission patterns, and mitigate the spread of antimicrobial resistance."

Clinical • Cholera • Gene Therapies • Infectious Disease

Characterization of Cefotaxime-Resistant Klebsiella pneumoniae from Courtyard and Home Environmental Samples in Rural Bangladesh (ASTMH 2025) - "All 33 isolates were multidrug-resistant and 100% resistant to ampicillin, aztreonam, cefepime, ceftazidime, cefotaxime, cefuroxime and ciprofloxacin. Further research on host-pathogen interactions and environmental persistence could provide valuable insights into the transmission dynamics of K. pneumoniae. Given the rapid emergence of resistance, ongoing genomic surveillance is crucial to monitor evolving resistance patterns and tailor public health interventions."

Infectious Disease • Pneumonia

Enterobacterial Profiling and Molecular Studies of Resistant Isolates Among Food Handlers in Selected Restaurants in Nnewi Metropolis (ASTMH 2025) - "The results showed that food handlers represent a frequent source of bacterial strains exhibiting high resistance to several antibiotics, including cefotaxime, ampicillin + cloxacillin, and amoxicillin + clavulanic acid. Genetic sequencing identified the isolates with their accession number, and a phylogenetic tree was used to visualize their genetic relatedness. This study has revealed a high prevalence of ESBL-producing Enterobacteriaceae in food handlers, highlighting a potential route for the transmission of antibiotic-resistant pathogens through the food chain, which has important implications for public health, emphasizing the need for continuous surveillance and targeted interventions to mitigate the spread of antibiotic resistance."

Burden of Malaria-Typhoid Co-infection and Associated Antimicrobial Resistance in a Resource-Limited Setting (ASTMH 2025) - "Salmonella isolates showed high susceptibility to cefotaxime, ceftriaxone, ciprofloxacin, and amikacin (>90%), but significant resistance to ampicillin, tetracycline, co-trimoxazole, gentamicin, cefuroxime, chloramphenicol, and meropenem (resistance rates >50%, p<0.001). This study reveals a high prevalence of malaria-typhoid co-infection and concerning antimicrobial resistance patterns in northern Ghana. These findings underscore the need for accurate diagnostic methods and targeted antimicrobial therapy to combat the dual burden of these infections effectively"

Infectious Disease • Malaria

Development and application of a wipe sampling method for detection of antibiotic surface contamination in hospital wards. (PubMed, Ann Work Expo Health) - "A widespread environmental contamination of antibiotics was observed in hospital wards that potentially can contribute to the development of antibiotic-resistant bacteria as well as health impacts of exposed personnel. Probable sources include compounding, handling and administration of drug tablets, antibiotic contaminated waste as well as other sources such as excretions from patients and contaminated drug vials. Current surface cleaning routines do not sufficiently reduce spills and leakage regardless of source."

Journal • Immunology • Infectious Disease

Microbial spectrum and emerging antibiotic sensitivity patterns in explanted scleral buckle elements-a 12 year retrospective analysis. (PubMed, Int Ophthalmol) - "In contrast to previous studies, a preponderance of Nocardia species as the most commonly isolated pathogen was studied. A paradigm shift in antibiotic sensitivity pattern with an emerging resistance to Vancomycin and decreasing efficacy of Amikacin was demonstrated."

Journal • Observational data • Retrospective data • Infectious Disease • Retinal Disorders

Clinical characteristics and carbapenem resistance gene of Klebsiella pneumonia isolates from children in Chongqing region from 2019 to 2024 (PubMed, Zhonghua Yu Fang Yi Xue Za Zhi) - "The majority were from sputum (59.2%, 2 970/5 020), followed by pus (17.1%, 857), urine (9.7%, 487), venous blood (6.5%, 326), secretions (2.6%, 130), and other specimens (5.0%, 250).The lowest resistance rate was to amikacin (3.8%), followed by levofloxacin (10.9%), imipenem (19.1%), and meropenem (19.9%). Resistance rates to cefoperazone/sulbactam (χ²=9.982 0, P=0.001 6), piperacillin/tazobactam (χ²=10.110 0, P=0.001 5), ceftazidime (χ²=3.849 0, P=0.049 8), cefotaxime (χ²=7.605 0, P=0.005 8), cefepime (χ²=13.510 0, P=0.000 2), aztreonam (χ²=6.457 0, P=0.011 1), imipenem (χ²=4.672 0, P=0.030 7), and levofloxacin (χ²=7.555 0, P=0.006 0) showed an annual increasing trend...Patients with KPC-KP were older than those with NDM-KP. NDM-KP predominated in neonatal wards, while KPC-KP predominated in ICUs, with KPC-KP showing higher antimicrobial resistance."

Journal • Retrospective data • Infectious Disease • Pediatrics • Pneumonia • Respiratory Diseases

Extended spectrum β-lactamase and integron genes among Shigella flexneri and Shigella sonnei isolated from children with diarrhea in shiraz, Southwest Iran. (PubMed, BMC Pediatr) - "Resistance rates of 100% were observed against cefotaxime, ceftriaxone, streptomycin, and trimethoprim/sulfamethoxazole in all S. flexneri and S. sonnei isolates, with all isolates exhibiting multidrug resistance (MDR). The high prevalence of MDR Shigella spp. isolates in our region underscores the critical need to address the spread of antibiotic resistance and integrons in Shigella spp., making it an urgent priority."

Journal • Gastrointestinal Disorder • Infectious Disease

Colistin- and cefotaxime-resistant Shiga toxin-producing Escherichia coli (STEC) in buffalo meat. (PubMed, Sci Rep) - "The isolates showed high resistance rates against Erythromycin (100%), Clindamycin (86.7%), Nalidixic acid (84.4%), Cefepime (73.4%), and Ampicillin (62.7%), Cefazolin (53.2%) and Tetracycline (51.7%) and most of the isolates (73%) were classified as multi-drug resistant (MDR). The emergence of virulent and multidrug-resistant E. coli strains in food seriously threatens human health. This highlights the need for antimicrobial stewardship programs in developing countries like Egypt to minimize the spread and emergence of these strains and prevent their dissemination to humans."

Journal • Infectious Disease