cefotaxime / Generic mfg. - LARVOL DELTA

A Case of Fatal Cupriavidus gilardii Sepsis Following Cord Blood Transplantation: Pitfalls of Novel Antimicrobial Agents. (PubMed, Int J Infect Dis) - "Cefiderocol (CFDC) is a novel antimicrobial agent that exhibits activity against carbapenem-resistant non-fermenting gram-negative bacilli, such as resistant Pseudomonas aeruginosa and Stenotrophomonas maltophilia, and has thus attracted considerable attention. Herein, we report a case in which a patient who was undergoing cord blood transplantation developed gram-negative rod sepsis after meropenem administration...The causative organism was later identified as Cupriavidus gilardii, which was resistant to novel antimicrobial agents, including CFDC, ceftazidime/avibactam, and ceftolozane/tazobactam. However, it was susceptible to cefepime and cefotaxime, suggesting a potential pitfall in the sole reliance on novel antibacterial drugs...This is the first reported case in the context of hematopoietic cell transplantation and the second diagnosed case using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Moreover, this report presents a..."

Journal • Hematological Disorders • Infectious Disease • Neutropenia • Septic Shock • Transplantation

Assessment of Escherichia coli as an indicator of antimicrobial resistance and monitoring of ESBL/AmpC-Producing Enterobacteriaceae in retail seafood commonly consumed in Italy. (PubMed, Int J Food Microbiol) - "Cefotaxime-resistant E. coli isolates were identified at low but relevant frequencies, especially in bivalves, and were characterised phenotypically and by whole-genome sequencing...Overall, our findings support the suitability of E. coli as an AMR indicator organism for retail bivalves and crustaceans. The detection of ESBL-producing strains, carrying important plasmid-borne resistance determinants, highlights the need to strengthen AMR surveillance in these seafood commodities."

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An Efficient and Streamlined System for In Vitro Regeneration and Genetic Transformation of Paper Mulberry (Broussonetia papyrifera). (PubMed, Life (Basel)) - "After co-cultivation, explants were transferred sequentially to callus induction, shoot induction, shoot multiplication, and rooting media supplemented with 250 mg·L-1 cefotaxime and 200 mg·L-1 Timentin, as well as 5.0 mg·L-1 hygromycin at a concentration that completely suppressed regeneration of non-transformed explants...The integration and expression of the transgene were further confirmed by PCR and quantitative reverse transcription PCR (qRT-PCR) after the resistant calli developed into plantlets. Collectively, this streamlined protocol provides a practical platform for functional genomics and genetic improvement of B. papyrifera."

Journal • Preclinical • Gene Therapies

Occurrence and Antimicrobial Susceptibility of Major Bacterial Pathogens Associated with Subclinical Mastitis in Dairy Cows in Western Romania. (PubMed, Microorganisms) - "Among S. aureus, the highest resistance rates were to fosfomycin (58.3%), penicillin (44.4%), clindamycin (44.4%), and tetracycline (41.7%), with 47.2% MDR isolates...coli showed resistance to amoxicillin/clavulanic acid (88.9%), ampicillin (55.6%), and cefotaxime (55.6%), with 66.6% MDR...aureus remains the leading cause of subclinical mastitis in Western Romania. The high MDR rates highlight the need for targeted antimicrobial stewardship, culture-based therapy, and continuous AMR monitoring under the "One Health" framework."

Journal • Infectious Disease • Pneumonia

Dual Core-Shell Loaded Lipid-Polymer Hybrid Nanoparticles as Combination Anti-Infective Delivery Platforms. (PubMed, Pharmaceutics) - " LPHNPs containing the antibiotic cefotaxime within a chitosan polymer core and the novel antimicrobial peptide RN7IN6 within a bacteria-mimicking lipid shell were produced by microfluidic mixing, and optimized with respect to parameters including total flow rate, flow rate ratio, and lipid concentration... The current findings clearly demonstrate the feasibility of formulating LPHNPs for core-shell co-encapsulation and delivery of anti-infectives. The promising antibacterial efficacy of co-loaded LPHNPs warrants further in-depth investigation to determine the extent of co-loaded LPHNP applications as combination anti-infective delivery platforms."

Journal • Infectious Disease

Clonal and Plasmid-Mediated Dissemination of Multidrug-Resistant Salmonella Enteritidis in Chicken Production, Northeastern Thailand. (PubMed, Pathogens) - "These findings indicate that MDR Salmonella dissemination is driven by two synergistic mechanisms: the clonal expansion of fit lineages and the horizontal transfer of conjugative plasmids harboring β-lactamase genes. We identified IncI-gamma-K1 and Col-related plasmids as key vectors in this process. This study advocates for targeted interventions, guided by a One Health approach, that specifically aim to disrupt plasmid transmission at critical control points, such as slaughterhouses, to curb the spread of antimicrobial resistance."

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Design, Synthesis, Antimicrobial Activity and Molecular Docking of New 1,2,4-Triazepine, 1,3,4,6-Oxatriazepine and Pyridazino[1,2-a] Pyrimidine Derivatives. (PubMed, Pharmaceuticals (Basel)) - "These compounds demonstrated consistently superior binding affinities compared to control drugs cefotaxime and nystatin across a range of enzymes essential for pathogen viability and virulence. Molecular docking analysis indicated that the in silico results strongly suggest that compounds (6, 8, 9, and 10) are promising multi-target agents capable of disrupting essential bacterial processes and critical fungal pathways, making them excellent candidates for the development of novel antimicrobial therapeutics. These consistent findings support the conclusion that both practical and theoretical studies of the new compounds align with their antimicrobial effectiveness."

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High Prevalence of Multidrug-Resistant Haemolytic Escherichia coli in Colombian Pig Farms. (PubMed, Antibiotics (Basel)) - "All isolates exhibited resistance to at least three antimicrobial classes (MDR), with high levels of resistance to tetracycline (98.0%), neomycin (97.3%), chloramphenicol (95.9%), sulfamethoxazole (93.9%), trimethoprim (91.9%), ampicillin (91.9%), nalidixic acid (82.4%), and ciprofloxacin (79.7%). Colistin resistance was observed in 5.4% of isolates, mediated by mcr1 or mcr3, while cefotaxime resistance (8.8%) was extensively associated with blaCTX-M. These findings reveal a concerning burden of MDR E. coli in Colombia's pig-producing regions and indicate that haemolysis alone is a poor indicator of ETEC. Integrating farm-level antimicrobial use data with genomic analyses will be essential to identify drivers of AMR and guide effective stewardship in the Colombian pig industry."

Journal • Hematological Disorders

International maritime organization, we may have a problem - ballast water treatment triggers global concerns with antimicrobial resistant bacteria. (PubMed, Mar Pollut Bull) - "The results of the disk diffusion method indicated an increase in resistance to ampicillin, ceftazidime, and the highest increase occurred in resistance to cefotaxime. The number of multi-drug resistant isolates decreased substantially in the discharged water. BWMS effectively eliminate plankton, while UV water treatment causes different negative changes in bacteria, introducing new threats to human health (microbiome to accumulate resistance genes) and aquaculture (increase diversity and volume of antibiotics used, lower seafood production), hence opening a new issue in global discharges of ballast water."

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Efficacy of InP/ZnSe/ZnS Quantum Dots with Antibiotics in the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Keratitis: Preclinical Studies. (PubMed, Exp Eye Res) - "aeruginosa bacteria are resistant to cefotaxime in vitro but are susceptible to the QD solutions used in conjugates with an antibiotic. QD conjugates with tobramycin increase the effectiveness of keratitis treatment from 32±2% to 88±3% and accelerate the symptom reversal rate compared to standard antibacterial therapy with tobramycin."

Journal • Preclinical • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Orbital cellulitis with emm1-type M1UK sublineage group A Streptococcus detected in a blood culture: a case report. (PubMed, J Infect Chemother) - "The patient was initially treated with a combination of cefotaxime (CTX) and clindamycin (CLDM). We changed antibiotics from CTX to ampicillin after susceptibility results were known. After discharge, oral clavulanic acid/amoxicillin was continued as an oral medication, and antibiotics were administered for a total of 21 days...This case is unusual in that it involved bloodstream infection in a pediatric orbital cellulitis, and M1UK's highly toxin-producing and highly transmissible may have been implicated. In rapidly exacerbating orbital cellulitis, iGAS infection should be considered."

Journal • Dermatology • Infectious Disease • Ocular Infections • Ocular Inflammation • Pediatrics

WGS analysis and virulence of Streptococcus suis serotype 4 ST1689 isolated from an asymptomatic pig, Thailand. (PubMed, Microb Pathog) - "This strain was multidrug resistant with resistance to penicillin, cefepime, cefotaxime, azithromycin, erythromycin, and tetracycline. These results suggested that the highly virulent S. suis serotype 4-ST1689 strain induced high levels of pro-inflammatory mediators and invasion of multiple organs, subsequence leading to high mortality. These results should provide important insights into the development of control strategies for transmission of S. suis serotype 4 ST1689 in public and pig farms."

Journal • Infectious Disease • IL1B • IL6 • TNFA

Pediatric Salmonella Poona gastroenteritis with bacteremia linked to exposure to a pet turtle: a case report. (PubMed, J Rural Med) - "The patient made a full recovery following a 14-day course of intravenous cefotaxime and ampicillin. To our knowledge, this is the first reported case in Japan of S. Poona infection with microbiological confirmation of the source animal. This case highlights the importance of strict hygiene practices when handling reptiles and cleaning their habitats, particularly in homes with young children or other vulnerable individuals."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pediatrics

Prior culture-guided prediction of antibiotic susceptibility in recurrent respiratory tract infections: a retrospective cohort analysis. (PubMed, Front Cell Infect Microbiol) - "Prior cultures had good predictive value (>70%) for detecting future resistance to 22 antibiotics, with ciprofloxacin, levofloxacin, cefuroxime, cefotaxime, ampicillin, ampicillin/sulbactam, and ceftriaxone showing excellent predictive values (≥85%). Additionally, prior cultures had excellent predictive value (≥85%) for detecting future susceptibility to imipenem, amikacin, tobramycin, meropenem, minocycline, and tigecycline. Considerable antibiotic resistance was detected among isolates in patients with RRTIs. Using a prior culture as a guide can enhance the probability of selecting an effective empirical agent."

Journal • Retrospective data • Infectious Disease • Pneumonia • Respiratory Diseases

Epidemiology, changing resistance trends and serotypes of Streptococcus pneumoniae in children in Chongqing, China, 2019-2024: a multicenter study. (PubMed, Front Cell Infect Microbiol) - "Except for vancomycin and linezolid...The resistance rates to trimethoprim/sulfamethoxazole, levofloxacin, and moxifloxacin were higher in non-IPD group than in IPD group, whereas chloramphenicol resistance was lower...PCV7, PCV10, and PCV13 covered 388 (64.6%), 440 (73.3%), and 501 (83.5%) strains, respectively. The resistance rates of S. pneumoniae to penicillin, trimethoprim/sulfamethoxazole, erythromycin, clindamycin, cefotaxime, and cefepime show significant downward trends over the six-year study period. The pneumococcal conjugate vaccine PCV13 can effectively cover the major drug-resistant serotypes in China, and PCV 13 is therefore recommended for the prevention of S. pneumoniae infection. These findings contribute to informed and clinical policy decisions for prevention and treatment."

Clinical • Journal • Infectious Disease • Novel Coronavirus Disease • Pneumococcal Infections • Pneumonia

Dynamic signature of activity-stability tradeoff in lactamase evolution. (PubMed, Nat Commun) - "During the evolution of cefotaxime resistance, the initial mutation reorganizes the active site, introducing a new function conformation. Stability defects associated with initial mutations are not evenly disseminated but are clustered at specific distal scaffold elements. The capacity of mutants to independently modulate the populations of individual active site walls and scaffold regions through narrow residue networks, produces conformational epistasis and a combinatorial set of cefotaximase states, which enables local compensation of scaffold defects."

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Unveiling the synergistic enhancement of cefotaxime efficacy with magnetic iron nanoparticles using co-culture technique and tooth model: a promising approach to combat antibiotic resistance. (PubMed, 3 Biotech) - "SEM imaging of a tooth biofilm model revealed pronounced biofilm disruption after treatment with MNPs-conjugated CTX. These findings highlight MNPs-conjugated CTX as a promising nanoformulation for treating drug-resistant E. coli infections and support its potential for future biomedical applications."

Journal • Infectious Disease

Antibiogram profiles and genetic characteristics of Streptococcus pneumoniae clinical isolates from Pakistan. (PubMed, Pak J Pharm Sci) - "These findings underscore the growing prevalence of antibiotic-resistant S. pneumoniae in Pakistan and highlight the urgent need for enhanced antimicrobial stewardship, improved surveillance systems and preventive measures to address the rising threat of resistant strains and shifting serotype distribution."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia

Evaluation of serum interleukin-6 level in diabetic patients with urinary tract infections. (PubMed, Egypt J Immunol) - "Group C showed the highest antibiotic sensitivity, notably to meropenem (91.4%), polymyxin B (82.9%), and amikacin (80.0%). Group B exhibited the highest resistance rates to cefotaxime (79.5%), norfloxacin (61.5%), azithromycin (59%), and cotrimoxazole (56%). In conclusion, diabetic patients, especially those with uncontrolled diabetes, showed higher bacterial loads, more mixed and fungal infections, increased antibiotic resistance, and elevated serum IL-6 levels compared to non-diabetic individuals."

Journal • Diabetes • Infectious Disease • Inflammation • Metabolic Disorders • Nephrology • Type 2 Diabetes Mellitus • IL6

Agrobacterium-mediated genetic transformation and stable transgene expression in Muscat Ottonel grape (Vitis vinifera). (PubMed, Braz J Biol) - "The transformed explants were selected on media with 30 mg/L kanamycin and 200 mg/L cefotaxime...The absence of a hypersensitive response in Muscat Ottonel during transformation contributed to the efficiency. This protocol is valuable for future grapevine genetic studies and breeding programs to introduce beneficial traits, like disease resistance, into elite cultivars."

Journal • Gene Therapies

Associations between Water Supply Interruptions and Water Use, Drinking Water Quality, Child Health, and Caregiver Stress in Peri-Urban Malawi. (PubMed, Environ Sci Technol) - "Among 237 households in Malawi, we conducted a cross-sectional questionnaire and tested drinking water for generic and cefotaxime-resistant Escherichia coli (CREC)...Our findings highlight respiratory risks from water interruptions and suggest that interruption frequency and duration may influence enteric vs respiratory pathogen transmission through distinct mechanisms. Prospective studies should validate these associations and evaluate mitigation strategies."

Journal • Infectious Disease • Respiratory Diseases

Clinical implications of differences in the pharmacokinetic and pharmacodynamic profiles of ceftriaxone and cefotaxime: A narrative review. (PubMed, Adv Clin Exp Med) - "Although cefotaxime and ceftriaxone share a similar antibacterial spectrum, antibiotic selection should always be individualized according to the patient's clinical status and treatment context. A direct comparison of their clinical efficacy undoubtedly warrants further investigation, as suggested by the clear differences in their pharmacokinetic profiles."

Journal • PK/PD data • Review

Molecular and Microbiological Characteristics of Uropathogenic Escherichia coli Harboring CTX-M-55. (PubMed, Ann Lab Med) - "CTX-M-55 showed (P >0.05) a trend toward increased resistance to aztreonam, cefotaxime, ceftazidime, and cefepime, while showing decreased resistance to amoxicillin/clavulanate and piperacillin/tazobactam. Virulence factors and coexisting resistance genes did not significantly differ. Our findings suggest that, given its increased resistance to ceftazidime and cefepime, CTX-M-55 should be considered when treating UTIs in Korea."

Journal • Infectious Disease • Nephrology

Synergistic effects of gentamicin, levofloxacin, and cefotaxime against Aeromonas salmonicida: In vitro and In vivo evaluation. (PubMed, Bioorg Chem) - "These findings highlight the superior protective efficacy of antibiotic combinations, particularly GENTA with CFT, in improving survival, alleviating tissue damage, and modulating host immune responses during AS infection in rainbow trout. The study underscores the potential of rational combination therapy as a strategy to overcome antimicrobial resistance, enhance treatment outcomes, and reduce the impact of pathogens on host health."

Journal • Preclinical • Infectious Disease • Inflammation

Multidrug-Resistant and Potentially Pathogenic Escherichia coli Prevalent in Samples of Different Types of Raw Meat Sold in Informal Markets in Luanda, Angola. (PubMed, Foods) - "The results also showed high resistance to cefotaxime (67.7%), ampicillin (56.7%) and amoxicillin/clavulanic acid (56.6%). The presence of multidrug-resistant and potentially pathogenic E. coli strains in raw meat sold in informal markets in Luanda represents a significant threat to public health. These findings underscore the urgent need to improve surveillance, hygiene practices, and antimicrobial use regulation policies in animal production in Angola."

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