clindamycin/tretinoin / Generic mfg. - LARVOL DELTA

Unilateral acneiform eruption in a patient with contralateral Horner syndrome: A neurocutaneous observation (EADV 2025) - "She had been receiving trastuzumab, pertuzumab, and vinorelbine on a triweekly schedule, with the last dose five weeks before the eruption. Dexamethasone 8 mg IV was administered one day before onset...Topical clindamycin and tretinoin 0.05% led to gradual improvement... This case expands the differential diagnosis and pathophysiological understanding of acneiform eruptions. The contralateral pattern in a patient with Horner syndrome suggests sympathetic innervation may be essential for maintaining sebogenesis and inflammatory responsiveness. This observation aligns with emerging evidence of neuroimmune control over sebaceous glands, including melanocortin pathways and neuropeptide signaling."

Clinical • Acne Vulgaris • Breast Cancer • CNS Disorders • Dermatology • HER2 Breast Cancer • HER2 Positive Breast Cancer • Hidradenitis Suppurativa • Immunology • Mood Disorders • Solid Tumor • HER-2

Comparison of tretinoin-clindamycin gel and emulgel formulations for treating mild to moderate acne vulgaris: A randomized biometric study (EADV 2025) - "The findings suggest that both formulations are effective and safe, with the emulgel offering potential advantages in reducing bacterial activity and erythema"

Clinical • Acne Vulgaris • Dermatology

Comparison of topical dapsone + tretinoin and clindamycin + tretinoin combination in terms of effectiveness in the treatment of mild and moderate acne vulgaris: a retrospective analysis. (PubMed, Arch Dermatol Res) - No abstract available

Journal • Retrospective data • Acne Vulgaris • Dermatology

Improvement of Fox-Fordyce disease with botulinum toxin type A (EADV 2024) - "Treatment with methylprednisolone aceponate 1mg/g ointment and clindamycin 1% gel yielded no improvement after 3 months. Due to concomitant hyperhidrosis, she received one session of intradermal injection of 75 U botulinum toxin type A (BTX-A, Botox®, Allergan, Inc) into each axilla...Other modalities with varying success rates include topical calcineurin inhibitors, tretinoin, clindamycin, oral contraceptives, laser therapy, surgical excision, and phototherapy... A 36-year-old pre-menopausal woman presented with a four-year history of multiple mildly itchy papules in both axillae. She had no significant medical history and denied previous laser hair removal or use of topical products/fragrances. Physical examination revealed multiple firm, non-tender, skin-colored follicular papules grouped in the bilateral axilla."

Aesthetic Medicine • Dermatology • Pruritus

Efficacy of topical treatments for mild-to-moderate acne: A systematic review and meta-analysis of randomized control trials. (PubMed, J Eur Acad Dermatol Venereol) - "Adapalene-benzoyl peroxide (BPO), clindamycin-BPO and clindamycin-tretinoin demonstrated the greatest reduction in non-inflammatory (ratio of means [RoM] 1.76; 95% CI [1.46; 2.12], RoM 1.70; 95% CI [1.44; 2.02] and RoM 1.87; 95% CI [1.53; 2.30], respectively), inflammatory (RoM 1.56; 95% CI [1.44; 1.70], RoM 1.49; 95% CI [1.39; 1.60] and RoM 1.48; 95% CI [1.36; 1.61], respectively) and total lesion count (ROM 1.67; 95% CI [1.47; 1.90], RoM 1.59; 95% CI [1.42; 1.79] and RoM 1.64; 95% CI [1.42; 1.89], respectively) compared to placebo. All single agents outperformed placebo except tazarotene, which did not significantly outperform placebo for inflammatory and non-inflammatory lesion count reduction...There was no significant difference amongst most single agents when evaluating lesion count reduction. Combination agents are generally most effective for mild-to-moderate acne; however for non-inflammatory acne, the addition of clindamycin in topical regimens is unnecessary..."

Clinical • Journal • Retrospective data • Review • Acne Vulgaris • Dermatology

Drugs for acne. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Acne Vulgaris

Hidradenitis suppurativa in children and young adults: a retrospective cross-sectional observational study in the United Kingdom. (PubMed, Int J Dermatol) - "This group had a female predominance with an apparent strong genetic predisposition which is seen in other HS CYA cross-sectional research. Treatment was varied in this cohort, however long courses of antibiotics, including combined therapy with rifampicin and clindamycin, were the mainstay of treatment, similar to management in the adult population. This study therefore adds to the limited information on the demographics and management of the HS CYA population."

Journal • Observational data • Retrospective data • Dermatology • Hidradenitis Suppurativa • Immunology

A multicenter, randomized, double-blind, parallel, three-arm, active- and placebo-controlled therapeutic equivalence for the comparison of clindamycin + tretinoin/Verisfield gel (1+0.025)% with Acnatac®/Meda gel [clindamycin + tretinoin (1+0.025)%] in the treatment of acne vulgaris (clinicaltrialsregister.eu) - P3 | N=600 | Ongoing | Sponsor: Verisfield S.M.S.A.

New P3 trial • Acne Vulgaris • Dermatology • Rheumatology

Enhancing Topical Pharmacotherapy for Acne and Rosacea: Vehicle Choices and Outcomes. (PubMed, J Clin Aesthet Dermatol) - "One of the latest vehicle technologies in acne and rosacea to enhance efficacy, stability, and tolerability is microencapsulation of benzoyl peroxide and tretinoin, which resulted in significant efficacy and good tolerability in patients with each of these two diseases. Other new vehicle technologies include a polymeric form of tretinoin and a microsphere product that combines tretinoin plus clindamycin...This review summarizes drug delivery systems that have been developed with the aim of improving outcomes for patients being treated for either acne or rosacea. It also focuses, where possible, on formulations that have been evaluated in clinical studies."

Journal • Review • Acne Vulgaris • Dermatology • Rosacea

Tretinoin/benzoyl peroxide cream (Twyneo) for acne. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Acne Vulgaris

Clascoterone cream (Winlevi) for acne. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Acne Vulgaris

Co-delivery of isotretinoin and clindamycin by phospholipid-based mixed micellar system confers synergistic effect for treatment of acne vulgaris. (PubMed, Expert Opin Drug Deliv) - "The testosterone induced acne model proved superior pharmacodynamic efficacy of lab developed formulation vis-à-vis marketed products of both the drugs. The results were further confirmed by the histopathological studies of respective skin samples treated with different formulations. The lab developed lipid-based micellar formulation of ITR and CLIN offers a better strategy for the combined delivery of unstable molecules like ITR and CLIN in acne management."

Journal • Acne Vulgaris • Dermatology

Tolerability and Efficacy of Clindamycin/Tretinoin versus Adapalene/Benzoyl Peroxide in the Treatment of Acne Vulgaris. (PubMed, J Drugs Dermatol) - "2021;20(3):295-301. doi:10.36849/JDD.2021.5641."

Clinical • Journal • Acne Vulgaris • Dermatology

Drugs for acne. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Acne Vulgaris • Infectious Disease • Novel Coronavirus Disease

Efficacy and tolerability of short contact therapy with tretinoin, clindamycin and glycolic acid gel in acne: A randomised, controlled, assessor-blinded two-centre trial: The MASCOTTE study. (PubMed, Dermatol Ther) - "This tretinoin, clindamycin, glycolic acid gel, applied as short contact therapy, has shown a better skin tolerability and at least a comparable clinical efficacy in comparison with the standard application modality in the treatment of mild-to-moderate acne. The SCT therefore could be an effective treatment strategy which could improve subjects' compliance and adherence."

Clinical • Journal • Acne Vulgaris • Contact Dermatitis • Dermatitis • Dermatology • Immunology

[VIRTUAL] The risk of oral or topical antimicrobials for the development of Clostridium difficile colitis (CDI) (ASHP 2020) - "Control topicals included benzoyl peroxide/clindamycin (0.1%), erythromycin (0.02%), and clindamycin/tretinoin (0.02%). Control orals included doxycycline (40%), minocycline (35%), cephalexin (0.1%), and azithromycin (0.1%)... CDI is associated with high morbidity and mortality. Understanding the associated risk factors is essential in preventing patients from developing CDI. Although it is well-known that antimicrobial use is a risk factor for CDI, different antimicrobial classes and administration routes are associated with varying degrees of risk."

Acne Vulgaris • Gastroenterology • Gastrointestinal Disorder • Immunology

Urinogenital Myiasis From Blow Fly in a Pakistani Child. (PubMed) - J Coll Physicians Surg Pak - "The larvae were identified as Chrysomya bezziana(Villeneuve), using Light and Scanning Electron microscopic techniques. The study brings into focus the subject of human myiasis, about which little is known in Pakistan."

Journal • Biosimilar

Chemical Composition and Antinociceptive Potential of Campomanesia reitziana Fruits. (PubMed) - J Med Food - "Compound 1 caused dose-dependent inhibition of abdominal constrictions, with a calculated ID50 value of 8.1 (6.5-10.1) μmol/kg (i.p.), being about 16-fold more potent than two reference analgesic drugs. Methanolic extract and 1 were also effective against the formalin model, inhibiting both phases of pain, causing reductions of 39.9% and 26.8% (extract, 10 mg/kg) and 52.9% and 57.6% (compound 1, 5 mg/kg) for the first and second phases, respectively."

Journal • Biosimilar • Pain

Trifarotene (Aklief) - a new topical retinoid for acne. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal