lactobacillus salivarius CECT5713 / Kerry - LARVOL DELTA

Ligilactobacillus salivarius CECT5713 Increases Term Pregnancies in Women with Infertility of Unknown Origin: A Randomized, Triple-Blind, Placebo-Controlled Trial. (PubMed, Nutrients) - "The probiotic intervention improved both vaginal and semen immunological profiles, with no substantial changes observed in their microbial composition. These preliminary findings support the potential of L. salivarius CECT5713 supplementation to enhance fertility outcomes in couples with unexplained infertility."

Clinical • Journal • Gynecology • Infertility • Sexual Disorders

Modulation of Reproductive Microbiota by Ligilactobacillus Salivarius CECT5713 (clinicaltrials.gov) - P=N/A | N=72 | Completed | Sponsor: Biosearch S.A.

New trial • Infertility • Sexual Disorders

Insights into the mechanisms of L. salivarius CECT5713 resistance to freeze-dried storage. (PubMed, Cryobiology) - "We confirmed that a matrix with a glass transition temperature at least 50 °C higher than the storage temperature is crucial for L. salivarius CECT5713 storage stability. In addition, this work explored promising FTIR methods for a better understanding of the protection mechanisms involved."

Journal

Modulation of Reproductive Microbiota by Ligilactobacillus Salivarius CECT5713 (clinicaltrials.gov) - P=N/A | N=70 | Active, not recruiting | Sponsor: Universidad Complutense de Madrid

New trial • Infertility • Sexual Disorders

Effect of protective agents on the storage stability of freeze-dried Ligilactobacillus salivarius CECT5713. (PubMed, Appl Microbiol Biotechnol) - "• Freeze-drying and storage mainly altered cell proteins, peptidoglycans, and nucleic acids. • A glassy matrix containing maltodextrin and an antioxidant ensured the highest storage stability."

Journal

Application of Ligilactobacillus salivarius CECT5713 to Achieve Term Pregnancies in Women with Repetitive Abortion or Infertility of Unknown Origin by Microbiological and Immunological Modulation of the Vaginal Ecosystem. (PubMed, Nutrients) - "The probiotic intervention modified key microbiological, biochemical, and immunological parameters in women who got pregnant. In conclusion, L. salivarius CECT5713 has proved to be a good candidate to improve reproductive success in women with reproductive failure."

Clinical • Journal • Immunology • Infertility • Sexual Disorders

Intestinal anti-inflammatory effects of probiotics in DNBS-colitis via modulation of gut microbiota and microRNAs. (PubMed, Eur J Nutr) - "Among the probiotics assayed, Lactobacillus fermentum CECT5716 and Escherichia coli Nissle 1917 appear to present the best intestinal anti-inflammatory effects, being the latter one of the few probiotics with reputed efficacy in human IBD. Therefore, Lactobacillus fermentum CECT5716 could be considered as a complementary nutritional strategy for IBD treatment."

Journal • Gastroenterology • Gastrointestinal Disorder • Inflammatory Bowel Disease

Application of Lactobacillus Salivarius CECT5713 in Infertility of Unknown Origin (clinicaltrials.gov) - P2; N=58; Completed; Sponsor: Universidad Complutense de Madrid

Clinical • New P2 trial • Infertility • Long-acting Reversible Contraceptives • Sexual Disorders