CM-10 / Merck (MSD) - LARVOL DELTA

Bremsstrahlung cannon design for shock ignition relevant regime. (PubMed, Rev Sci Instrum) - "In this regime with laser intensities of 10 W/cm-10 W/cm, fast electrons with energies ≤100 keV are expected to be generated through Stimulated Raman Scattering (SRS) and Two Plasmon Decay (TPD) instabilities. The main purpose of the BSC in our experiment is to identify the contribution to x-ray emission from bremsstrahlung of fast electrons originating from SRS and TPD, with expected temperatures of 40 keV and 95 keV, respectively. Data analysis and reconstruction of the distributions of x-ray photons incident on the BSC are described."

Journal

Preliminary dosimetric analysis of DOTA-folate radiopharmaceutical radiolabelled with Sc produced through V(p,x)Sc cyclotron irradiation. (PubMed, Phys Med Biol) - "For such a reason, the absorbed dose contributions to healthy organs and the effective dose contributions by the three radioisotopes, Sc, Sc and Sc, were evaluated using DOTA-folate conjugate (cm10) as an example of radiopharmaceutical product. Considering as acceptable the limits of 99% for the radionuclidic purity and 10% for the contribution of radioactive Sc-contaminants to the total effective dose after Sc-cm10 injection, it was obtained that proton beam energies below 35 MeV must be used to produce Sc through irradiation of a V target."

Journal • Oncology

Combination of lyophilized adipose-derived stem cell concentrated conditioned medium and polysaccharide hydrogel in the inhibition of hypertrophic scarring. (PubMed, Stem Cell Res Ther) - "Altogether, ADSCC-CM can downregulate the expression of α-SMA due to its anti-fibrosis effect and promote the rearrangement of collagen fibres, which is integral to scar precaution. The in situ cross bonding of ADSCC-CM and polysaccharide hydrogel could remarkably enhance the therapeutic outcomes in inhibiting scar proliferation. Hence, the alliance of ADSCC-CM and hydrogel may become a potential alternative in hypertrophic scar prophylaxis."

Journal • Fibrosis • Immunology

Experimental and theoretical investigation of resonances in low-energy NO-H collisions. (PubMed, J Chem Phys) - "In this report, we continue these investigations by measuring the scattering behavior of the NO-H system in the previously unexplored 0.4 cm-10 cm region for the parity changing de-excitation channel of NO...We furthermore identify the partial wave contributions to these resonances and investigate the nature of the differences between collisions with para- and ortho-H. Additionally, we tune the energy spreads in the experiment to our advantage to probe scattering behavior at energies beyond our mean experimental limit."

Journal

Screening of serum protein biomarkers in hemorrhagic cerebral infarction by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) technology. (PubMed, Ann Transl Med) - "Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) and CM10 ProteinChip can be used to screen serum protein markers in patients with HCI. Mass-to-charge ratio of 3,495.2, 8,941.0, 15,890.4, and 2,941.3 may be potential protein biomarkers of HCI and used to distinguish HCI patients from HCs and CI."

Biomarker • Journal • CNS Disorders • Hematological Disorders

[VIRTUAL] The Prognostic Validity of the Acute Myeloid Leukemia Composite Model in Predicting Risks of One-Year Mortality Among Patients in Atlantic Canada: A Multi-Centre Experience (ASH 2020) - "The most frequently used regimen was the standard 3+7 regimen (daunorubicin and cytarabine). The AML-CM was predictive of 8-week mortality, odds ratio 12 (95%CI 3.15-45.75) AML-CM 10+ vs AML-CM 1-4, (p-value 0.0003) and 1-year mortality, odds ratio 11.76 (95% CI 2.45-56.51) AML-CM 10+ vs AML-CM 1-4 (p-value 0.0021)...Additionally, the AML-CM could be utilized to adjust for the impact of comorbidities in clinical trials investigating newer intensive AML therapies. Figure 1: Overall survival by AML-CM score range"

Clinical • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology

[VIRTUAL] Single Operator Per-Oral Cholangioscopy-Assisted Endoscopic Transpapillary Gallbladder Drainage in a High Surgical Risk Patient With Acute Calculous Cholecystitis and Choledocholithiasis (ACG 2020) - "Repeat ERCP was done with removal of an occluded CBD stent, stone extraction, dilation of the distal CBD stricture comprised of a fibrinous clot, SOC-assisted placement of 15 cm 7 Fr double pigtail stent in the cystic duct, placement of 7 cm 10 Fr plastic stent in the common hepatic duct, and removal of PC drain...This patient’s distal CBD stricture prevented successful cystic duct cannulation. This case demonstrates that SOC-assisted ETGS should be considered among high-risk patients with acute cholecystitis with a difficult-to-visualize cystic duct."

Clinical • Cardiovascular • Gastroenterology • Hepatology • Pulmonary Embolism • Sickle Cell Disease

Preliminary dosimetric analysis of DOTA-folate radiopharmaceutical radiolabelled withSc produced throughV(p,x)Sc cyclotron irradiation. (PubMed, Phys Med Biol) - "For such a reason, the absorbed dose contributions to healthy organs and the effective dose contributions by the three radioisotopes,Sc,Sc andSc, were evaluated using DOTA-folate conjugate (cm10) as an example of radiopharmaceutical product. Considering as acceptable the limits of 99% for the radionuclidic purity and 10% for the contribution of radioactive Sc-contaminants to the total effective dose afterSc-cm10 injection, it was obtained that proton beam energies below 35 MeV must be used to produceSc through irradiation of aV target."

Journal • Oncology

Clinical-pathological issues in thyroid pathology: study on the routine application of NIFTP diagnostic criteria. (PubMed, Sci Rep) - "The average diameter of the lesion was 1.7 cm (0.1 cm-10 cm)...Multifocality is part of the spectrum of NIFTPs, that can arise in a multinodular background with variable sizes from microscopic lesions to very large ones. Cytopathological criteria such as an evaluation of the nuclear score may help the pathologists in promoting a NIFTP diagnosis in the preoperative setting."

Clinical • Journal • Oncology

A novel simple experimental model for low-osmolar contrast-induced acute kidney injury using different definitions based on the levels of serum creatinine and cystatin C. (PubMed, BMC Nephrol) - "A simple and reliable animal model for low osmolality contrast medium-induced AKI was established, which is similar to clinical CI-AKI based on different definitions for AKI."

Journal • Acute Kidney Injury • Nephrology • Renal Disease

[VIRTUAL] The Prognostic Validity of the Acute Myeloid Leukemia Composite Model in Predicting Risks of One-Year Mortality among Patients in Atlantic Canada: A Multi-Centre Experience (SOHO 2020) - "The most frequently used regimen was the standard 3+7 regimen (daunorubicin and cytarabine). The AML-CM was predictive of 8-week, odds ratio 2.39 (95%CI 1.09-5.239) AML-CM 7-9 vs AML-CM 1-4, (p-value 0.0284) and 1-year mortality, odds ratio 11.76 (95% CI 2.45-56.51) AML-CM 10+ vs AML-CM 1-4 (p-value 0.0021)... The AML-CM is a valid prognosticator for early and late mortality in our patient population. Our findings emphasize the significance of comorbidities assessment prior to induction therapy for AML and the potential use in tailoring targeted interventions to mitigate their risks alongside leukemia treatments. Additionally, the AML-CM could be utilized to adjust for the impact of comorbidities in clinical trials investigating newer intensive AML therapies."

Clinical • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology

Validation of ICD-10-CM Codes for Identifying Cases of Chlamydia and Gonorrhea. (PubMed, Sex Transm Dis) - "Disease specific ICD-10-CM codes accurately identify persons with chlamydia and gonorrhea. However, low sensitivities suggest that most individuals could not be identified in administrative data alone without laboratory test results."

Clinical • Journal

First Report of Anthracnose on Ctenanthe oppenheimiana Caused by Colletotrichum siamense in China. (PubMed, Plant Dis) - "Round brown necrotic lesions in the middle of the leaves grew in the inoculated wounded leaves 5 days after inoculation and brown necrotic lesions developed into large brown lesions of 2.2-3.6 cm 10 days after inoculation whilethere were no symptoms in the negative controls...To our knowledge, this is the first report of anthracnose on C. oppenheimiana caused by C. siamense in China. Identification of the pathogen of this disease is essential for the development of effective and economical management practices."

Journal

[APPLICATION OF FREE BILOBED MEDIAL SURAL ARTERY PERFORATOR FLAP FOR REPAIRING PENETRATING WOUND OF FOOT]. (PubMed) - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi - "The free BMSAP flap is very suitable to repair penetrating wound of the foot. The flap has the advantages of repairing the two wounds at the same time and reconstructing skin sensation as well."

Journal • Biosimilar • Immunology

[Reconstruction of postburn facial scar contracture deformity with expanded flap containing cervical cutaneous branch of transverse cervical artery]. (PubMed) - Zhonghua Shao Shang Za Zhi - "Expanded flap containing cervical cutaneous branch of TCA is a good choice for reconstruction of postburn facial scar contracture deformity because of its good texture and color, thin thickness, as well as it can provide large avaliable area while causing less injury to the donor site."

Journal • Biosimilar

A functional genomics screen identifies an Importin-α homolog as a regulator of stem cell function and tissue patterning during planarian regeneration. (PubMed) - "Through this work, we described the roles of several previously uncharacterized genes in planarian regeneration and implicated nuclear import in this process. We have additionally created an online database to house our in situ and RNAi data to make it accessible to the planarian research community."

Journal • Biosimilar

Effects of flap or myocutaneous flap combined with fascia lata or composite mesh on repairing severe high-voltage electrical burn wounds in abdomen of patients (PubMed, Zhonghua Shao Shang Za Zhi) - "During follow-up of 6 month to 1 year, flaps or myocutaneous flaps were in good appearance, with no ankylenteron or abdominal wall hernia. Flap or myocutaneous flap combined with fascia lata or composite mesh can achieve good effects on repairing severe high-voltage electrical burn wounds in abdomen."

Journal • Biosimilar • Complement-mediated Rare Disorders • Rare Diseases

Effects of axial vascular network flap of scalp or anterolateral thigh perforator flap with fascia lata on repairing defects after radical resection of scalp carcinoma in patients (PubMed, Zhonghua Shao Shang Za Zhi) - "The appearance of thigh donor site of flap and skin was good, with normal muscle strength and movement of lower limbs. Patients with scalp carcinoma were performed with radical resection of carcinoma, and axial vascular network flap of scalp or anterolateral thigh perforator flap with fascia lata were applied to repair the postoperative defects, with good appearance of head operation area and no local recurrence or distant metastasis of carcinoma."

Journal • Biosimilar • Oncology

Health Care Costs and Utilization among Adult Patients with Immune Thrombocytopenia (ITP) Enrolled in Texas Medicaid (AMCP 2020) - "ITP patients aged from 19 to 63 years were identified using ICD-CM-9 code 287.31 and ICD-CM-10 code D69.3, with a requirement of two claims for ITP separated by at least 30 days...A total of 68 (44%) patients received first-line therapies for ITP, including corticosteroids and IVIG; 17 (11%) patients received second-line therapies, including rituximab, TPO-RAs, immunosuppressants and splenectomies... There was a large variation in health care costs among adult ITP patients in Texas Medicaid. Hospitalization and drug therapies were major contributions to ITP-related costs. ITP- related ER visits were rare in adult patients."

Clinical • HEOR • Medicaid • Reimbursement • Hematological Disorders • Thrombocytopenia • Thrombocytopenic Purpura

Anti-inflammatory and healing effects of pulsed ultrasound therapy on fibroblasts. (PubMed, Am J Phys Med Rehabil) - "Low-intensity pulsed ultrasound therapy had a biostimulatory effect on semi-confluent in vitro L929 fibroblast cells, where the group with a dose of 0.2 W/cm-10% (G2) presented higher responses, in all the analyzed aspects, towards the dose pulsed to 20%, confirming its therapeutic properties related to the initial phases of tissue healing."

Journal

The histone methylation readers MRG1/MRG2 and the histone chaperones NRP1/NRP2 associate in fine-tuning Arabidopsis flowering time. (PubMed, Plant J) - "In contrast, NRP1/2 and MRG1/MRG2 act together, likely in a multiprotein complex manner, in promoting transcription of FLOWERING LOCUS C (FLC) via increase of both H4K5ac and H3K9ac in the FLC chromatin. Because the expression pattern of FLC represents the major category of differentially expressed genes identified by genome-wide RNA-seq analysis in the mrg1 mrg2, nrp1 nrp2 and mrg1 mrg2 nrp1 nrp2 mutants, it is reasonable to speculate that the NRP1/2-MRG1/MRG2 complex may be involved in transcriptional activation of genes beyond FLC and flowering time control."

Journal • NRP1 • NRP2

MRG1/2 histone methylation readers and HD2C histone deacetylase associate in repression of the florigen gene FT to set a proper flowering time in response to day-length changes. (PubMed, New Phytol) - "More importantly, HD2C competes with CO for the binding of MRG2, and the accumulation of HD2C at the FT locus occurs at the end of the day. Our findings not only reveal a histone deacetylation mechanism contributing to prevent FT overexpression and precocious flowering, but also support the model in which the histone methylation readers MRG1/2 provide a platform on chromatin for connecting regulatory factors involved in activating FT expression in response to daylight and decreasing FT expression around dusk in long days."

Journal

[VIRTUAL] HEALTH CARE COST AND UTILIZATION AMONG CHILDREN WITH IMMUNE THROMBOCYTOPENIA ENROLLED IN TEXAS MEDICAID (ISPOR 2020) - "ITP patients aged 18 or under were identified using ICD-CM-9 code 287.31 and ICD-CM-10 code D69.3, with a requirement of two claims for ITP separated by at least 30 days...More than half (55%) of non-drug medical costs were attributed to office visits, followed by hospitalizations (23%) and outpatient visits (20%); 40% of drug costs were attributed to IVIG, followed by rituximab (30%) and thrombopoietin receptor agonists (TPO-RAs) (18%)... Office visits were the biggest contribution to ITP-related costs in children. ITP- related ER visits in children were more common compared to adults."

Clinical • HEOR • Medicaid • Reimbursement • Hematological Disorders • Thrombocytopenia • Thrombocytopenic Purpura

Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei. (PubMed, Nature) - "This suggests that the spatial organization of chromatin in C. elegans is regulated both by the direct perinuclear attachment of silent chromatin, and by an active retention of CBP-1/p300 in euchromatin. The two pathways contribute differentially in embryos and larval tissues, with CBP-1 sequestration by MRG-1 having a major role in differentiated cells."

Journal

Characterization of aldehyde dehydrogenase 1A (ALDH1A) inhibitors for cancer treatment (ACS-Sp 2020) - "This study focused on developing structure-activity relationships for ALDH1A inhibitors, based on our initial hit compound, CM10, using enzyme kinetics assays, structural biology and cell culture experiments...These findings are consistent with prior survey of compounds from this same chemical series and extend the findings into novel chemical entities. The development of these ALDH1A inhibitors are leads toward potential treatments that could improve of patient outcomes for solid tumors that develop resistance to standard therapies."