lisinopril / Generic mfg. - LARVOL DELTA

Unmasking the Unexpected: Renal Arteriovenous Malformation in a Young Puerto Rican Patient With Persistent Hypertension. (PubMed, Cureus) - "We present the case of a 20-year-old woman with hypertension that remained elevated despite treatment with lisinopril and extended-release nifedipine. This case highlights the importance of considering uncommon renal vascular abnormalities in young patients with severe hypertension and renal asymmetry when the initial evaluation is inconclusive. Selective renal angiography can provide detailed anatomic characterization while simultaneously offering an opportunity for targeted endovascular therapy."

Journal • Cardiovascular • CNS Disorders • Hypertension

Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease (clinicaltrials.gov) - P2 | N=60 | Recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center | Not yet recruiting ➔ Recruiting

Enrollment open • Breast Cancer • Cardiovascular • Esophageal Cancer • Heart Failure • Lung Cancer • Oncology • Solid Tumor • Thoracic Cancer

Drugs for prevention of migraine. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Migraine • Pain

SEVERE LATE-ONSET LISINOPRIL-INDUCED ANGIOEDEMA WITH RAPID AIRWAY COMPROMISE AFTER 12 YEARS OF THERAPY: A CASE REPORT (CHEST 2026) - No abstract available

Case report • Clinical • Cardiovascular

Target-dose vs below-target-dose lisinopril and fosinopril in HFrEF with advanced CKD. (PubMed, Eur J Heart Fail) - No abstract available

Journal • Cardiovascular

Comparative Effectiveness Of Losartan Versus Lisinopril On New-onset Heart Failure In Hypertension: A Propensity-matched Analysis [Poster no. 629] (HFSA 2026) - No abstract available

HEOR • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension

A SHAP-Informed Formal Feature Attribution Framework for Drug-Drug Interaction Risk in Large-Scale Claims Data. (PubMed, Clin Transl Sci) - "FFA flagged 115 synergistic pairs and 312 high-confidence triplets (e.g., furosemide + hydrochlorothiazide + lisinopril; digoxin + furosemide + amiodarone, IE = 8.7). Top Intervention Rate drugs included simvastatin, furosemide, and alprazolam. Moderate preventive Z-code monitoring (Q2) was protective (OR = 0.25; 95% CI 0.18-0.34) versus no monitoring, while fragmented high-intensity monitoring (Q4) was not. The framework prioritizes medication combinations for pharmacist review in claims data; it does not replace pharmacokinetic confirmation or prove that changing a drug caused fewer ED visits."

Journal

IgA Nephropathy Associated With Long-Term Infliximab Therapy in a Young Patient With Crohn's Disease: A Case Report (ACG 2026) - "Transition to an IL-23 antagonist was recommended; however, the patient insisted on continuing anti-TNF-α therapy as she remained in remission while being treated with lisinopril for IgAN by her nephrologist. Prompt referral to nephrology for expedited renal biopsy and tissue diagnosis is necessary. Switching class of advanced therapy is indicated; however, supportive nephroprotective measures, including renin-angiotensin-aldosterone system blockade, may be reasonable alternatives in patients who decline advanced therapy class switching."

Case report • Clinical • Cardiovascular • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Glomerulonephritis • Hypertension • IgA Nephropathy • Immunology • Inflammatory Bowel Disease • Lupus Nephritis • Nephrology • Renal Disease • IL23A

Esophageal Lichen Planus With an Esophageal Stricture: A Rare Lichen Planus Manifestation (ACG 2026) - "Management included omeprazole for 8 weeks and swallowed fluticasone for 4 weeks...Drug-induced etiology was considered, as the patient was taking possible causative medications including etanercept and lisinopril...ELP remains underdiagnosed due to variable presentation and subtle endoscopic findings, our case highlights the need for increased vigilance in selected populations. Figure: Figure 1: Esophageal stricture (EGD 1) Figure: Figure 2: Endoscopic appearance following 12mm dilation (EGD 2), crepe paper like mucosa in upper third of the esophagus"

Dermatology • Dermatopathology • Esophageal Squamous Cell Carcinoma • Gastrointestinal Disorder • Immunology • Inflammatory Arthritis • Lichen Planus • Rheumatoid Arthritis • Squamous Cell Carcinoma

Wheat a Minute! A Case Series Expanding the Differential for Chronic Diarrhea Beyond Celiac Disease (ACG 2026) - "A 56-year-old male with prostate cancer presented with persistent iron deficiency anemia who was found to likely have Lisinopril-induced enteropathy Case 3...Case 2 (top right) showing increased markedly increased intraepithelial lymphocytes (red arrows). Case 4 (bottom right) with a great decrease in goblet and Paneth cells and increased crypt apoptoses (red arrows)."

Clinical • Celiac Disease • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Genito-urinary Cancer • Hematological Malignancies • Immunology • Inflammatory Bowel Disease • Lymphoma • Metabolic Disorders • Prostate Cancer • Psoriasis • Solid Tumor • Vitiligo

Fruquintinib-Induced Hypertensive Crisis in a 23-Year-Old With Early-Onset Metastatic Rectal Adenocarcinoma (ACG 2026) - "The day before, he started lisinopril, clonidine, and tramadol for suspected drug-induced and pain-related hypertension. He completed two weeks of fruquintinib (previously on FOLFOXIRI)...Clinicians should suspect fruquintinib toxicity if HTN-C occurs. Holding therapy may be needed while evaluating end-organ injury."

Metastases • Colorectal Adenocarcinoma • Colorectal Cancer • Hepatocellular Cancer • Hypertension • Oncology • Pulmonary Disease • Rectal Adenocarcinoma • Solid Tumor

Suspected Delayed ACE-Inhibitor Angioedema with Anticipated Difficult Airway (ASA 2026) - "A 36-year-old man (BMI 46.9) with asthma, suspected OSA, uncontrolled diabetes on tirzepatide presented with facial angioedema and difficulty breathing four days after stopping lisinopril and shortly after other drug exposure...Other airway issues included limited mouth opening, Mallampati IV, large neck circumference, short thyromental distance, difficult front-of-neck access, reduced FRC and concern for delayed gastric emptying because of GLP-1 use and diabetes. This case highlights suspicion of late-onset angioedema and emphasizes the importance of timely and algorithmic treatment to prevent life threatening deterioration."

Asthma • Cardiovascular • CNS Disorders • Diabetes • Immunology • Metabolic Disorders • Obstructive Sleep Apnea • Respiratory Diseases

Acute Bilateral Vocal Cord Immobility Secondary to Acute Myopathy. (PubMed, Ear Nose Throat J) - "A 47-year-old female with tuberous sclerosis, lymphangioleiomyomatosis, and a recent upper respiratory infection, taking atorvastatin and, until recently, everolimus, presented with several weeks of myalgias and 10 days of dyspnea...Treatment included high-dose dexamethasone, racemic epinephrine, albuterol, intravenous fluids, a temporary feeding tube, and discontinuation of atorvastatin and lisinopril...Recovery was sustained at seven months. This case suggests pharyngolaryngeal musculature can be preferentially affected in acute myopathy."

Journal • Gastrointestinal Disorder • Immunology • Infectious Disease • Musculoskeletal Pain • Myositis • Otorhinolaryngology • Pain • Pulmonary Disease • Respiratory Diseases • Rheumatology • Solid Tumor

The Effect Of Lisinopril On Polycythemia (clinicaltrials.gov) - P4 | N=30 | Recruiting | Sponsor: Mayo Clinic | Not yet recruiting ➔ Recruiting

Enrollment open

Not Just Another Allergic Reaction: Postoperative Bradykinin-Mediated Angioedema (ASA 2026) - "A 45-year-old woman with obesity (BMI 43) and hypertension on lisinopril underwent robotic pyeloplasty with uneventful atraumatic airway management...Despite treatment with epinephrine, steroids, and antihistamines, swelling progressed...Subsequent CT imaging confirmed diffuse upper airway edema with complete epiglottic effacement. Findings were consistent with bradykinin-mediated angioedema, likely from ACE inhibitor use, highlighting the importance of early recognition and intervention."

Allergy • Cardiovascular • Genetic Disorders • Hypertension • Obesity

Delayed Airway Catastrophe in ACE-Inhibitor-Induced Angioedema Despite ICU Monitoring (ASA 2026) - "A 46-year-old male on chronic lisinopril presented with recurrent lingual angioedema without initial respiratory distress. Despite treatment with corticosteroids, antihistamines, tranexamic acid, and icatibant, he had persistent severe swelling with Mallampati IV airway, voice changes, and secretion intolerance requiring ICU monitoring...Return of spontaneous circulation was achieved after prolonged resuscitation. This case highlights the risk of delayed airway compromise in ACE inhibitor-induced angioedema despite close observation."

Cardiovascular • Pulmonary Disease

Not All Tongue Swelling Is an Allergy: Postoperative Angioedema in a Patient on Lisinopril (ASA 2026) - "There was no rash, wheezing, or evidence of trauma. Although concerning for angiotensin-converting enzyme inhibitor-associated angioedema, symptoms improved after antihistamines and steroids, highlighting diagnostic uncertainty and importance of airway monitoring in the PACU."

Clinical • Allergy • Cardiovascular • Immunology • Mood Disorders

Analysis of real water samples with AQbD microextraction using thymol-based NADES: implications of uncontrolled hypertension risk in Egypt. (PubMed, Anal Methods) - "This work developed a green analytical method for the simultaneous determination of three model antihypertensive agents from distinct classes, namely, furosemide, atenolol, and lisinopril, in water samples. A comprehensive greenness assessment using the GAPI, AGREE, BAGI, and EVG tools confirmed strong alignment with sustainable chemistry principles. By enabling multi-class extraction of antihypertensive drugs with a low-ecological-footprint NADES-based protocol, this method addresses a critical gap as no prior NADES-based method exists for these three therapeutic classes together, supporting environmental monitoring and clean water objectives."

Journal • Cardiovascular • Hypertension

Mitral valve posteromedial papillary muscle head rupture presenting after liposomal doxorubicin chemotherapy for metastatic lung liposarcoma: a case report. (PubMed, Eur Heart J Case Rep) - "Her acute heart failure was optimized medically with intravenous loop diuretics, low-dose lisinopril for afterload reduction, and metoprolol succinate, while home amlodipine and hydrochlorothiazide were discontinued. We present this 'two-hit' model as a hypothesis-generating observation, suggesting that chemotherapy-induced structural changes might compound underlying ischaemic or radiation-induced vulnerabilities. As such, advanced imaging modalities may offer value in future efforts to implement risk-adapted surveillance."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Liposarcoma • Oncology • Pulmonary Disease • Sarcoma • Solid Tumor

Digital pharmacoepidemiology of angiotensin-converting enzyme inhibitors in Russia. (PubMed, Front Pharmacol) - "Search queries were analyzed for six major ACE inhibitors (captopril, enalapril, lisinopril, perindopril, ramipril, fosinopril), as well as for their brand names (21 drugs in total). The identified digital patterns may indirectly reflect medication-related information needs and potential gaps in the population's health literacy. The infodemiological approach represents a promising tool for monitoring patients' information needs and optimizing clinical communication and preventive programs."

Journal • Cardiovascular • Hypertension

VEGFR1-Blocking Antibody Improves Endothelial Structure, Kidney Function, and GFR in Diabetic Mice. (PubMed, J Am Soc Nephrol) - "An anti-VEGFR1 antibody restored VEGFA activity, endothelial health, and GFR in severe murine DKD. This effect was via a mechanism distinct from lisinopril."

Journal • Preclinical • Nephrology • Renal Disease • ESM1 • FLT1

Assessing the readability of AI-generated medication counseling for common Medicaid drug classes: metformin, lisinopril, and atorvastatin. (PubMed, Proc (Bayl Univ Med Cent)) - "This article exclusively addresses readability. Pharmacists and prescribers should endorse reputable websites that provide suitable assistance; grade-level prompts may facilitate patient comprehension of AI-generated summaries."

Journal • Reimbursement • US reimbursement

Evaluating AT1R expression and the effects of renin-angiotensin system inhibition in a mouse model of cerebral amyloid angiopathy. (PubMed, Brain Res) - "Regional brain AT1R levels were not significantly dysregulated in Tg-SwDI mice compared to wild-type mice. Additionally, drug treatment with sub-depressor doses of the AT1R antagonist, telmisartan, or the ACE inhibitor, lisinopril, caused no significant brain AT1R alterations in Tg-SwDI mice. This suggests that pathophysiological changes in the brain renin-angiotensin system do not mediate the cognitive impairments and neuropathological changes associated with CAA in Tg-SwDI mice."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • Hypotension • Vascular Neurology

Decoding cytokine interactions for psoriasis therapy through computational repurposing of antihypertensive drugs. (PubMed, Sci Rep) - "Lisinopril, Ramipril, Amlodipine, and Atenolol emerged as top candidates based on docking scores and pharmacokinetic profiles. Among them, Lisinopril exhibited the strongest binding affinity across all four cytokines, comparable to or exceeding that of Apremilast...However, these results are purely predictions and should be viewed with caution, especially considering reports of potential ACE inhibitor-related psoriasis worsening. Further thorough laboratory, animal, and clinical studies are necessary to assess its practical application and safety in treating psoriasis."

Journal • Dermatology • Immunology • Inflammation • Psoriasis • IFNG • IL17A • IL1B • IL6

Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease (clinicaltrials.gov) - P2 | N=60 | Not yet recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center

New P2 trial • Breast Cancer • Cardiovascular • Esophageal Cancer • Heart Failure • Lung Cancer • Oncology • Solid Tumor • Thoracic Cancer