lisinopril / Generic mfg. - LARVOL DELTA

ACEIs versus ARBs, how to choose? (PubMed, Rev Med Suisse) - "Angiotensin converting enzyme inhibitors, particularly lisinopril, are prescribed more frequently than angiotensin receptor blockers for several reasons. However, current data show similar efficacy between the two classes, with notable differences in terms of action duration, side effects, and costs. This article reviews the factors that may influence the choice between these treatments."

Clinical • Journal • Review • Cardiovascular • Hypertension

An Uncommon Case of Bowel Angioedema Due to Lisinopril. (PubMed, Cureus) - "He was started on a lisinopril-hydrochlorothiazide combination two days before the presentation. The patient was ultimately treated for bowel angioedema successfully with dexamethasone, diphenhydramine, and famotidine, and his lisinopril was discontinued. This case report aims to discuss and evaluate bowel angioedema in the setting of ACEi use and how it should be considered as a differential for an acute abdomen and its relevant empirical management with steroids due to the indistinguishable etiology of histamine or bradykinin mediated."

Journal • Allergy • Cardiovascular • Hypertension • Immunology • Pain

Role of Lisinopril in Preventing the Progression of Non-Alcoholic Fatty Liver Disease, RELIEF-NAFLD Study (clinicaltrials.gov) - P2 | N=45 | Active, not recruiting | Sponsor: Northwestern University | Trial primary completion date: Dec 2025 ➔ Aug 2025

Trial primary completion date • Hepatocellular Cancer • Hepatology • Metabolic Dysfunction-Associated Steatohepatitis • Metabolic Dysfunction-Associated Steatotic Liver Disease • Oncology • Solid Tumor • CXCL8

Statin-Associated Headache: A Rare and Underrecognized Clinical Presentation: A Case Report. (PubMed, Reports (MDPI)) - "In this case, the patient was taking metoprolol succinate, lisinopril, simvastatin, clopidogrel, and tamsulosin. Clinicians should remain vigilant about the possibility of statin-induced headache, even in long-term users. Early recognition can prevent unnecessary diagnostic investigations, expedite symptom resolution, and support optimal management of both cardiovascular risk and treatment-related adverse effects."

Journal • Cardiovascular • Musculoskeletal Pain • Pain

Selection for Postponed Senescence in Drosophila melanogaster Reveals Distinct Metabolic Aging Trajectories Modifiable by the Angiotensin-Converting Enzyme Inhibitor Lisinopril. (PubMed, Aging Cell) - "This suggests that ACE inhibition may buffer against age-associated increases in metabolic rate and contribute to enhanced metabolic stability. Our results show that selection for delayed reproduction and increased lifespan modifies age-related metabolic trajectories and modulates physiological responses to pharmacological intervention."

Journal • Metabolic Disorders

Combined RAS Modulation: The Effect on Plasma and Tissue Angiotensin Peptide Levels. (PubMed, Physiol Res) - "We investigated hemodynamics and circulating and tissue angiotensin peptide profile in spontaneously hypertensive rats (SHR) treated with lisinopril, olmesartan and aliskiren and their dual combinations. Tissue analyses revealed minimal intrinsic Ang II synthesis in the left ventricle, consistent with AT?-dependent uptake of circulating Ang II, while renal peptide profiles indicated some local enzymatic activity with differential reliance on ACE and neprilysin. Our results advocate a cautious, mechanism-aware approach to combination RAS blockade and support therapeutic strategies that balance blood pressure lowering with preservation of the Ang 1-7 axis."

Journal • Cardiovascular • Hypertension • ANGPT1

Emotional and autoimmune triggers in Takotsubo cardiomyopathy: A case report of a young female with systemic lupus erythematosus. (PubMed, Medicine (Baltimore)) - "This case reinforces the importance of evaluating TCM in young SLE patients with acute chest pain, particularly when emotional stress is involved. Excluding coronary artery disease is essential, and effective management requires a multidisciplinary approach that treats both cardiac and autoimmune components. Preventing recurrence demands integrating emotional and psychological support into the care of chronically ill individuals."

Journal • Acute Coronary Syndrome • Cardiomyopathy • Cardiovascular • Coronary Artery Disease • Immunology • Inflammatory Arthritis • Lupus • Mood Disorders • Pain • Psychiatry • Systemic Lupus Erythematosus

STABILIZE-CKD: A Study to Evaluate the Effect of Sodium Zirconium Cyclosilicate on Chronic Kidney Disease (CKD) Progression in Participants With CKD and Hyperkalaemia or at Risk of Hyperkalaemia (clinicaltrials.gov) - P3 | N=1112 | Terminated | Sponsor: AstraZeneca | N=716 ➔ 1112

Enrollment change • Chronic Kidney Disease • Nephrology • Renal Disease

Myocardial Infarction, Pulmonary Embolism, and Deep Vein Thrombosis Following Testosterone Cypionate Use: A Pharmacovigilance Study. (PubMed, Curr Drug Saf) - "Based on the current FAERS data, testosterone cypionate does not appear to increase the risk of major cardiovascular events more than expected. Still, serious outcomes can and do happen, especially in patients with more complex medical histories. These results highlight the importance of evaluating each patient's individual risk and show why post-marketing surveillance remains such an important tool for tracking drug safety in real-world clinical settings."

Adverse events • Journal • Cardiovascular • Endocrine Disorders • Hematological Disorders • Myocardial Infarction • Pulmonary Embolism • Respiratory Diseases • Venous Thromboembolism

Synergistic antimigraine effects of lisinopril and memantine associated with an improved therapeutic index (EHF-EHC 2025) - "Lisinopril and memantine exhibit strong pharmacodynamic synergy in migraine models without adverse or amplifying cardiovascular effects. This combination may offer enhanced efficacy with a favourable side effect profile, supporting its potential utility in migraine prophylaxis."

Cardiovascular • CNS Disorders • Migraine • Pain

Fabrication and characterization of taste-masked core-shell nanofibre mats for dual drug delivery of antihypertensives in pediatrics. (PubMed, Int J Pharm) - "With pediatric hypertension on the rise worldwide, this study investigated the use of electrospinning to create a novel taste-masked, fixed-dose combination of lisinopril dihydrate (LIS) and amlodipine besylate (AML) for paediatric use. The e-tongue mean sensor response plot showed the nanofibre mats achieved a statistically significant enhanced taste-masking (p < 0.0001) compared to raw amlodipine which registered a high bitterness reading of 87 mV. This study therefore indicates that coaxial electrospinning may be used to produce a fixed-dose taste masked nanofibre mat of LIS and AML that can potentially be used to improve adherence in children."

Journal • Acute Myelogenous Leukemia • Cardiovascular • Gastrointestinal Disorder • Hypertension • Pediatrics

Postpartum management of the hypertensive disorders of pregnancy: systematic review and meta-analysis. (PubMed, Am J Obstet Gynecol) - "While diuretics may aid in BP control, they cannot be recommended as monotherapy. Evidence guiding the optimal choice of antihypertensive agents remains limited. Of greatest relevance to practice is the effectiveness of: enalapril or amlodipine (vs. nifedipine) in controlling BP; and BP self-measurement/management or lifestyle change (vs. usual care) in preventing longer-term cardiovascular outcomes."

Journal • Retrospective data • Review • Cardiovascular • Hypertension

Association of impaired medication adherence with subsequent clinical recognition of dementia or cognitive impairment in older veterans. (PubMed, Eur Geriatr Med) - "Among veterans without clinically recognized DCI, lower baseline medication adherence was associated with an increased risk for future clinically recognized DCI. Further studies should seek to disentangle whether low adherence is a risk factor for future DCI or an indicator of existing but not yet recognized DCI and whether this can inform clinical practice decisions."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia

The use and efficacy of angiotensin-converting enzyme inhibitors for treatment of hypertension in young children following paediatric cardiac surgery: a case control comparison. (PubMed, Cardiol Young) - "High and medium dose angiotensin-converting enzyme inhibitor therapy had a greater effect in decreasing mean arterial pressure when compared to low dose."

Journal • Cardiovascular • Hypertension • Pediatrics

Mechanistic insights into angiotensin-converting enzyme inhibition by Apium graveolens through an integrative in silico-in vitro study. (PubMed, Int J Biol Macromol) - "Molecular docking identified bergapten and myrcene as top candidates with binding affinities comparable to lisinopril, and molecular dynamics simulations confirmed stable ligand-enzyme interactions with favourable energetics, supported by MM-GBSA analysis...Enzyme kinetic analyses revealed a non-competitive inhibition pattern for bergapten and myrcene, while the crude extract showed a mixed-type mechanism, suggesting synergistic modulation by multiple phytochemicals. Collectively, these findings highlight the mechanistic basis of ACE inhibition by A. graveolens and underscore its potential as a natural and safer therapeutic candidate for hypertension management."

Journal • Preclinical • Asthma • Cardiovascular • Cough • Dyslipidemia • Hypertension • Immunology • Pulmonary Disease • Respiratory Diseases

Targeted Therapy or Tension: A Case of Tyrosine Kinase Inhibitor-Mediated Hypertensive Crisis in a Patient with Advanced Renal Cell Carcinoma (KIDNEY WEEK 2025) - "Case Description A 71-year-old woman with well-controlled hypertension on lisinopril 20 mg daily and prior RCC treated by radical nephrectomy and short-lived pembrolizumab (stopped for immune polyarthritis) began cabozantinib 40 mg daily for progression...Twelve weeks after stopping cabozantinib, she remained markedly hypertensive despite four agents (lisinopril 40 mg qd, nifedipine 120 mg qd, chlorthalidone 25 mg qd, spironolactone 25 mg qd)...Since then, she has been receiving Belzutifan (HIF-2α inhibitor) without adverse effects. ( Ref Fig1 ) Discussion Grade 1-3 HTN was observed in about 37% of patients in the METEOR Trial (Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma), but frank hypertensive crisis (grade 4) and true resistant hypertension are very uncommon (<1 %). Presentation with hypertensive crisis prompts discontinuation of the TKI therapy."

Clinical • Metastases • Cardiovascular • Genito-urinary Cancer • Hypertension • Immunology • Oncology • Renal Cell Carcinoma • Renal Disease • Solid Tumor • EPAS1

Association Between Common Systemic Medications and the Presence and Severity of Furcation Involvement: A Cross-Sectional Study. (PubMed, Healthcare (Basel)) - "The use of certain systemic medications, particularly for cardiovascular conditions, is independently associated with both a higher likelihood and increased severity of furcation involvement, highlighting the critical need for dental professionals to consider a patient's medication profile as an integral part of periodontal risk assessment."

Journal • Observational data • Cardiovascular • Dental Disorders • Periodontitis

FARFOOD: a database of potential interactions between food compounds and drugs. (PubMed, BioData Min) - No abstract available

Journal

Natriuretic Response to an Acute Oral Potassium Load in Healthy Individuals and Patients with Chronic Kidney Disease: A Randomized Controlled Trial. (PubMed, Nephrol Dial Transplant) - "These findings indicate that in CKD, potassium-induced natriuresis does not occur and oral potassium loading is accompanied by an increased risk of hyperkalemia."

Journal • Chronic Kidney Disease • Nephrology • Renal Disease

Acute Interstitial Nephritis and Liver Injury After Long-Term Semaglutide Use (KIDNEY WEEK 2025) - "Long term medications included semaglutide, lisinopril, and allopurinol. Aspirin and atorvastatin were recently initiated for a transient ischemic attack...Prednisone dose was increased, and she was slowly tapered off steroids with Cr remaining stable at 1.6 mg/dL...Figure - The interstitium shows severe inflammatory infiltrates including lymphocytes, plasma cells, and numerous eosinophils in clusters (up to > 100 eosinophils per HPF). Tubules show focally severe tubulitis."

Acute Kidney Injury • Anorexia • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Eosinophilia • Genetic Disorders • Glomerulonephritis • Hepatology • Hypertension • Liver Failure • Metabolic Disorders • Nephrology • Obesity • Renal Disease • Type 2 Diabetes Mellitus

Pembrolizumab and Nonsteroidal Anti-Inflammatory Drug (NSAID)-Induced Acute Tubular Necrosis and Acute Tubulointerstitial Nephritis: A Diagnostic and Therapeutic Challenge (KIDNEY WEEK 2025) - "She had a past medical history of hypertension and metastatic adenocarcinoma of the lung on maintenance therapy with pemetrexed and pembrolizumab...She continued taking lisinopril, despite being put on hold for low blood pressure. She had persistent periumbilical pain and left lower quadrant abdominal pain, and continued taking ibuprofen 800 mg three times/day...She was started on Prednisone 60 mg daily initially and increased to 75 mg daily...Identification and elimination of causative agents is a mainstay of treatment. This case underscores the importance of being vigilant for immune therapy-related interstitial nephritis, especially when other nephrotoxic drugs are co-administered."

Acute Kidney Injury • Amyloidosis • Cardiovascular • Eosinophilia • Hypertension • Hypotension • Lung Adenocarcinoma • Lung Cancer • Metabolic Disorders • Nephrology • Non Small Cell Lung Cancer • Pancreatitis • Renal Disease • Solid Tumor

The impact of dose and discontinuation timing of preoperative ACE inhibitors on survival outcomes in cardiac surgery: A MIMIC-IV database analysis. (PubMed, PLoS One) - "Continuing preoperative ACEI use on the day of surgery was associated with significantly reduced postoperative mortality. Medium-dose lisinopril was associated with the most consistent reduction in postoperative mortality, although patients with malignancy may require individualized assessment. These findings suggest that evidence-based perioperative ACEI management may be beneficial and warrant further investigation."

Journal • Cardiovascular • Oncology

A Pilot Study for the Kidney Effects of Voxelotor in Sickle Cell Anemia (ASH 2023) - P1/2 | "The median age of the enrolled cohort was 36 (27 - 63) years, 4 were male, 4 were on stable doses of hydroxyurea (median dose 1000mg/day; 500 - 1500mg/day) and 2 were on stable doses of lisinopril (5, 20mg/day) for at least 90 days before screening. This pilot study demonstrates that SCA patients with hemoglobinuria and early stages of CKD treated with voxelotor may have significant improvements in urine ACR and proteinuria after 24 - 48 weeks of therapy. These preliminary results support the concept that improving hemolytic anemia could be a targeted therapeutic approach to reduce biomarkers of kidney dysfunction, and they warrant larger, prospective clinical studies."

Clinical • Anemia • Chronic Kidney Disease • Genetic Disorders • Hematological Disorders • Nephrology • Renal Disease • Sickle Cell Disease • CST3

Delayed Presentation of IgG4-Related Disease and Subsequent Lymphoma in Phospholipase A2 Receptor (PLA2R)(-) Membranous Nephropathy (KIDNEY WEEK 2025) - "He was treated as low-risk PLA2R(-) primary MN with lisinopril...He was given rasburicase for spontaneous tumor lysis, then polatuzumab, rituximab, cyclophosphamide, doxorubicin, and prednisolone chemoimmunotherapy...In this case, the submandibular gland, commonly involved in IgG4-RD, retained IgG4-rich features at DLBCL diagnosis. Alternatively, he may have had indolent lymphoma mimicking IgG4-RD, which transformed into DLBCL."

Acute Kidney Injury • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Fibrosis • Glomerulonephritis • Hematological Malignancies • Immunology • Indolent Lymphoma • Lymphoma • Nephrology • Non-Hodgkin’s Lymphoma • Renal Disease

Effect of Sequential Targeted-Release Formulation (TRF)-Budesonide and Sparsentan Therapy in a Patient with IgAN: Can Histopathology Predict Therapeutic Response? (KIDNEY WEEK 2025) - "He was treated with Losartan 100 mg a day and Lisinopril 20 mg twice a day for many years In 2021, his UPC ratio was 2.4-3 mg/mg. He was started on Empagliflozin in July 2021 and Lisinopril decreased to 20 mg a day...The new guidelines have distinguished this and can help guide appropriate effective therapies based on histological variables. Improvement of UPCR with supportive therapies"

Clinical • Glomerulonephritis • IgA Nephropathy • Renal Disease