lisinopril / Generic mfg. - LARVOL DELTA

Association of impaired medication adherence with subsequent clinical recognition of dementia or cognitive impairment in older veterans. (PubMed, Eur Geriatr Med) - "Among veterans without clinically recognized DCI, lower baseline medication adherence was associated with an increased risk for future clinically recognized DCI. Further studies should seek to disentangle whether low adherence is a risk factor for future DCI or an indicator of existing but not yet recognized DCI and whether this can inform clinical practice decisions."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia

The use and efficacy of angiotensin-converting enzyme inhibitors for treatment of hypertension in young children following paediatric cardiac surgery: a case control comparison. (PubMed, Cardiol Young) - "High and medium dose angiotensin-converting enzyme inhibitor therapy had a greater effect in decreasing mean arterial pressure when compared to low dose."

Journal • Cardiovascular • Hypertension • Pediatrics

Mechanistic insights into angiotensin-converting enzyme inhibition by Apium graveolens through an integrative in silico-in vitro study. (PubMed, Int J Biol Macromol) - "Molecular docking identified bergapten and myrcene as top candidates with binding affinities comparable to lisinopril, and molecular dynamics simulations confirmed stable ligand-enzyme interactions with favourable energetics, supported by MM-GBSA analysis...Enzyme kinetic analyses revealed a non-competitive inhibition pattern for bergapten and myrcene, while the crude extract showed a mixed-type mechanism, suggesting synergistic modulation by multiple phytochemicals. Collectively, these findings highlight the mechanistic basis of ACE inhibition by A. graveolens and underscore its potential as a natural and safer therapeutic candidate for hypertension management."

Journal • Preclinical • Asthma • Cardiovascular • Cough • Dyslipidemia • Hypertension • Immunology • Pulmonary Disease • Respiratory Diseases

Synergistic antimigraine effects of lisinopril and memantine associated with an improved therapeutic index (EHF-EHC 2025) - "Lisinopril and memantine exhibit strong pharmacodynamic synergy in migraine models without adverse or amplifying cardiovascular effects. This combination may offer enhanced efficacy with a favourable side effect profile, supporting its potential utility in migraine prophylaxis."

Cardiovascular • CNS Disorders • Migraine • Pain

Targeted Therapy or Tension: A Case of Tyrosine Kinase Inhibitor-Mediated Hypertensive Crisis in a Patient with Advanced Renal Cell Carcinoma (KIDNEY WEEK 2025) - "Case Description A 71-year-old woman with well-controlled hypertension on lisinopril 20 mg daily and prior RCC treated by radical nephrectomy and short-lived pembrolizumab (stopped for immune polyarthritis) began cabozantinib 40 mg daily for progression...Twelve weeks after stopping cabozantinib, she remained markedly hypertensive despite four agents (lisinopril 40 mg qd, nifedipine 120 mg qd, chlorthalidone 25 mg qd, spironolactone 25 mg qd)...Since then, she has been receiving Belzutifan (HIF-2α inhibitor) without adverse effects. ( Ref Fig1 ) Discussion Grade 1-3 HTN was observed in about 37% of patients in the METEOR Trial (Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma), but frank hypertensive crisis (grade 4) and true resistant hypertension are very uncommon (<1 %). Presentation with hypertensive crisis prompts discontinuation of the TKI therapy."

Clinical • Metastases • Cardiovascular • Genito-urinary Cancer • Hypertension • Immunology • Oncology • Renal Cell Carcinoma • Renal Disease • Solid Tumor • EPAS1

Association Between Common Systemic Medications and the Presence and Severity of Furcation Involvement: A Cross-Sectional Study. (PubMed, Healthcare (Basel)) - "The use of certain systemic medications, particularly for cardiovascular conditions, is independently associated with both a higher likelihood and increased severity of furcation involvement, highlighting the critical need for dental professionals to consider a patient's medication profile as an integral part of periodontal risk assessment."

Journal • Observational data • Cardiovascular • Dental Disorders • Periodontitis

FARFOOD: a database of potential interactions between food compounds and drugs. (PubMed, BioData Min) - No abstract available

Journal

Natriuretic Response to an Acute Oral Potassium Load in Healthy Individuals and Patients with Chronic Kidney Disease: A Randomized Controlled Trial. (PubMed, Nephrol Dial Transplant) - "These findings indicate that in CKD, potassium-induced natriuresis does not occur and oral potassium loading is accompanied by an increased risk of hyperkalemia."

Journal • Chronic Kidney Disease • Nephrology • Renal Disease

Acute Interstitial Nephritis and Liver Injury After Long-Term Semaglutide Use (KIDNEY WEEK 2025) - "Long term medications included semaglutide, lisinopril, and allopurinol. Aspirin and atorvastatin were recently initiated for a transient ischemic attack...Prednisone dose was increased, and she was slowly tapered off steroids with Cr remaining stable at 1.6 mg/dL...Figure - The interstitium shows severe inflammatory infiltrates including lymphocytes, plasma cells, and numerous eosinophils in clusters (up to > 100 eosinophils per HPF). Tubules show focally severe tubulitis."

Acute Kidney Injury • Anorexia • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Eosinophilia • Genetic Disorders • Glomerulonephritis • Hepatology • Hypertension • Liver Failure • Metabolic Disorders • Nephrology • Obesity • Renal Disease • Type 2 Diabetes Mellitus

Pembrolizumab and Nonsteroidal Anti-Inflammatory Drug (NSAID)-Induced Acute Tubular Necrosis and Acute Tubulointerstitial Nephritis: A Diagnostic and Therapeutic Challenge (KIDNEY WEEK 2025) - "She had a past medical history of hypertension and metastatic adenocarcinoma of the lung on maintenance therapy with pemetrexed and pembrolizumab...She continued taking lisinopril, despite being put on hold for low blood pressure. She had persistent periumbilical pain and left lower quadrant abdominal pain, and continued taking ibuprofen 800 mg three times/day...She was started on Prednisone 60 mg daily initially and increased to 75 mg daily...Identification and elimination of causative agents is a mainstay of treatment. This case underscores the importance of being vigilant for immune therapy-related interstitial nephritis, especially when other nephrotoxic drugs are co-administered."

Acute Kidney Injury • Amyloidosis • Cardiovascular • Eosinophilia • Hypertension • Hypotension • Lung Adenocarcinoma • Lung Cancer • Metabolic Disorders • Nephrology • Non Small Cell Lung Cancer • Pancreatitis • Renal Disease • Solid Tumor

The impact of dose and discontinuation timing of preoperative ACE inhibitors on survival outcomes in cardiac surgery: A MIMIC-IV database analysis. (PubMed, PLoS One) - "Continuing preoperative ACEI use on the day of surgery was associated with significantly reduced postoperative mortality. Medium-dose lisinopril was associated with the most consistent reduction in postoperative mortality, although patients with malignancy may require individualized assessment. These findings suggest that evidence-based perioperative ACEI management may be beneficial and warrant further investigation."

Journal • Cardiovascular • Oncology

A Pilot Study for the Kidney Effects of Voxelotor in Sickle Cell Anemia (ASH 2023) - P1/2 | "The median age of the enrolled cohort was 36 (27 - 63) years, 4 were male, 4 were on stable doses of hydroxyurea (median dose 1000mg/day; 500 - 1500mg/day) and 2 were on stable doses of lisinopril (5, 20mg/day) for at least 90 days before screening. This pilot study demonstrates that SCA patients with hemoglobinuria and early stages of CKD treated with voxelotor may have significant improvements in urine ACR and proteinuria after 24 - 48 weeks of therapy. These preliminary results support the concept that improving hemolytic anemia could be a targeted therapeutic approach to reduce biomarkers of kidney dysfunction, and they warrant larger, prospective clinical studies."

Clinical • Anemia • Chronic Kidney Disease • Genetic Disorders • Hematological Disorders • Nephrology • Renal Disease • Sickle Cell Disease • CST3

Delayed Presentation of IgG4-Related Disease and Subsequent Lymphoma in Phospholipase A2 Receptor (PLA2R)(-) Membranous Nephropathy (KIDNEY WEEK 2025) - "He was treated as low-risk PLA2R(-) primary MN with lisinopril...He was given rasburicase for spontaneous tumor lysis, then polatuzumab, rituximab, cyclophosphamide, doxorubicin, and prednisolone chemoimmunotherapy...In this case, the submandibular gland, commonly involved in IgG4-RD, retained IgG4-rich features at DLBCL diagnosis. Alternatively, he may have had indolent lymphoma mimicking IgG4-RD, which transformed into DLBCL."

Acute Kidney Injury • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Fibrosis • Glomerulonephritis • Hematological Malignancies • Immunology • Indolent Lymphoma • Lymphoma • Nephrology • Non-Hodgkin’s Lymphoma • Renal Disease

Effect of Sequential Targeted-Release Formulation (TRF)-Budesonide and Sparsentan Therapy in a Patient with IgAN: Can Histopathology Predict Therapeutic Response? (KIDNEY WEEK 2025) - "He was treated with Losartan 100 mg a day and Lisinopril 20 mg twice a day for many years In 2021, his UPC ratio was 2.4-3 mg/mg. He was started on Empagliflozin in July 2021 and Lisinopril decreased to 20 mg a day...The new guidelines have distinguished this and can help guide appropriate effective therapies based on histological variables. Improvement of UPCR with supportive therapies"

Clinical • Glomerulonephritis • IgA Nephropathy • Renal Disease

Autosomal Dominant Alport Syndrome in a Patient with Familial Thin Basement Membrane Nephropathy: Expanding the Phenotypic Spectrum of COL4A4 Mutations (KIDNEY WEEK 2025) - "She was started on lisinopril...It emphasizes the critical role of genetic testing in differentiating these conditions and guiding family screening. Early identification allows for closer monitoring and potential interventions to delay disease progression."

Clinical • Genetic Disorders • Glomerulonephritis • Nephrology • Otorhinolaryngology • Renal Disease • COL4A5

Treatment with Either SGLT2 Inhibitors or GLP-1 Receptor Agonists Rescues GFR Decline in a Multifactorial Cardiovascular-Kidney-Metabolic Syndrome Mouse Model (KIDNEY WEEK 2025) - "Therapeutic efficacy of standard-of-care therapy with either the ACE-inhibitor Lisinopril, the SGLT2-inhibitor Dapagliflozin or the GLP1 receptor agonist Semaglutide was studied on kidney function and cardiac pathology. Semaglutide also reduced body weight gain. These effects of the standard-of-care compounds indicates the clinal relevance of the model demonstrating that it is suitable for compound efficacy studies in both early and more advanced stages of CKM syndrome."

Preclinical • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Diabetic Nephropathy • Genetic Disorders • Heart Failure • Hypertension • Metabolic Disorders • Nephrology • Obesity • Renal Disease

Importance of Genetic Testing in Candidate Kidney Transplant Recipients and Donors (KIDNEY WEEK 2025) - "The patient developed moderate albuminuria with a UACR of 240mg/g which was treated initially with lisinopril and subsequently dapagliflozin. Guidelines recognize the variability in severity common in some monogenic forms of CKD, such as ADAS, allowing more effective risk stratification. Genetic testing in a related donor scenario provides great value and should be standardized for every patient considering kidney donation."

Clinical • Chronic Kidney Disease • Genetic Disorders • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Nephrology • Renal Disease • Transplantation

Acute T Cell-Mediated Rejection in a Kidney Transplant Patient Receiving Teclistamab (KIDNEY WEEK 2025) - "He was treated with complement blockade, dexamethasone and teclistamab (Fig 1)...He was treated with steroids, mycophenolate, lisinopril and dapagliflozin...While definite causality is not confirmed, rejection raises concerns about off-target alloimmune T-cell activation. This underscores the need for further investigation in this population."

Clinical • Acute Kidney Injury • Complement-mediated Rare Disorders • Glomerulonephritis • Hematological Malignancies • Infectious Disease • Lupus Nephritis • Monoclonal Gammopathy • Multiple Myeloma • Nephrology • Transplant Rejection • Transplantation

Docking-MD Polypharmacy Screening Study of Loop D of Human Aquaporin 1 (KIDNEY WEEK 2025) - "The results necessitate experimental validation but could represent new adjunctive options in the treatment of some cancers and compounds to avoid in peritoneal dialysis. The best docked position of famotidine (A), carbidopa (B), lisinopril (C), and bendroflumethiazide (D) with loop D of human AQP1."

AQP1

Two Cases of IgAN in Healthy Adult Male Bodybuilders Using Testosterone Replacement Therapy (KIDNEY WEEK 2025) - "Case Description Patient A is a 45-year-old gentleman with a medical history of hypertension on valsartan and hypogonadism secondary to anabolic steroid use treated with topical testosterone for the last ten years evaluated for worsening creatinine and proteinuria...Patient B is a 39-year-old gentleman with a medical history of hypertension on lisinopril and hypogonadism secondary to anabolic steroid use treated with testosterone injections for seven months evaluated for worsening serum creatinine...In these adult men, use of testosterone replacement therapy and anabolic androgenic steroids may have affected liver function impairing the clearance of these abnormal IgA immune complexes and leading to the development of IgA nephropathy. This underscores the importance of screening patients using testosterone replacement therapy for bodybuilding."

Clinical • Cardiovascular • Celiac Disease • Chronic Kidney Disease • Endocrine Disorders • Fibrosis • Glomerulonephritis • Hepatology • Hypertension • IgA Nephropathy • Immunology • Infectious Disease • Inflammation • Liver Failure • Nephrology • Renal Disease

Pericarditis as the Initial Manifestation of IgA Vasculitis with Concurrent IgAN (KIDNEY WEEK 2025) - "She was managed with dapagliflozin 10 mg daily, lisinopril 10 mg daily, colchicine 0.3 mg daily, and a prednisone taper. Early recognition and appropriate immunosuppressive therapy proved beneficial towards recovery of renal function. Diffuse ST segment elevation and PR interval depression, consistent with acute pericarditis."

Cardiovascular • Chronic Kidney Disease • CNS Disorders • Depression • Fibrosis • Glomerulonephritis • IgA Nephropathy • Immunology • Lupus Nephritis • Nephrology • Psychiatry • Renal Disease • Vasculitis

More than Skin Deep: Successful Management of Rare IgA Vasculitis with Kidney Involvement (KIDNEY WEEK 2025) - "Diagnosed with IgAV with IgA dominant glomerulonephritis, she was started on prednisone, mycophenolate mofetil (MMF), and lisinopril. RAAS blockade, corticosteroids and cyclophosphamide or MMF are mainstay of treatment, but newer drugs like sparsentan and iptacopan, specifically targeting the immune system, have shown promise. From left to right: Gross specimen minimal interstitial fibrosis, IF granular mesangial IgA deposition, LM IgA-dominant mesangial deposits with mesangial hypercellularity and crescent."

Fatigue • Fibrosis • Glomerulonephritis • IgA Nephropathy • Immunology • Lupus Nephritis • Musculoskeletal Pain • Nephrology • Renal Disease • Vasculitis

IgA Vasculitis Triggered by Semaglutide (KIDNEY WEEK 2025) - "She was initiated on a prednisone taper, lisinopril, and later started on empagliflozin, with complete resolution of the proteinuria and the rash. This is especially relevant in LCV, where vascular injury is driven by neutrophil infiltration and the subsequent release of proteolytic enzymes. As GLP-1RA use expands, clinicians should be aware of this potential, albeit rare, complication."

Cardiovascular • Dyslipidemia • Genetic Disorders • Glomerulonephritis • Hepatitis B • Hepatitis C • Hepatology • Human Immunodeficiency Virus • Hypertension • IgA Nephropathy • Infectious Disease • Inflammation • Influenza • Obesity • Renal Disease • Respiratory Diseases • Type 2 Diabetes Mellitus • Vasculitis

Anti-Tumor Necrosis Factor-Associated IgAN (KIDNEY WEEK 2025) - "On Humira since 2017, switched to Hyrimoz in 2024, with no Crohn’s flares since 2017...Anemic (Hb 10 g/dL) with worsening microscopic hematuria and new proteinuria (2g/g, improved to 1.3g/g with Lisinopril)...Infliximab has also been known to cause IgA Nephropathy in patient with Pustular Psoriasis as well as Ankylosing Spondylitis. It is important for a patient treated with Adalimumab for Crohn's Disease to have frequent follow ups with their renal function tests to monitor for TNF alpha inhibitor induced renal dysfunction, early diagnosis and treatment of which can be life saving."

Ankylosing Spondylitis • Back Pain • Chronic Kidney Disease • Crohn's disease • Dermatology • Gastroenterology • Glomerulonephritis • IgA Nephropathy • Immunology • Inflammatory Arthritis • Inflammatory Bowel Disease • Lumbar Back Pain • Musculoskeletal Pain • Nephrology • Oncology • Pediatrics • Psoriasis • Pustular Psoriasis • Renal Disease • Rheumatoid Arthritis • Rheumatology • Seronegative Spondyloarthropathies • TNFA

Refractory Hypokalemia in a Middle-Aged Woman: Unraveling the Mystery (KIDNEY WEEK 2025) - "She denied diarrhea, autoimmune history or diuretic use, stopped using Topamax and Ketorolac for the migraine, denied recent change in dietary habits...Started on KCL 40 mEq twice daily, and Lisinopril switched to Spironolactone 12.5 mg daily to be titrated as tolerated. The rheumatology considered Early Rheumatoid arthritis and started on Methotrexate 10 mg weekly...Discussion Our patient presented with debilitating symptoms of hypokalemia, posing significant challenges in the management, this case highlights the importance of investigating the autoimmune and genetic causes mainly in refractory hypokalemia cases, although genetically not fulfilling the criteria of Autosomal recessive disease, or classic RTA 1-Linked to patients with Rheumatoid Arthritis, It is hard to conclude the coexistence of a heterozygous SLC12A3 variant and Rheumatoid Arthritis played synergistic role or confounded one another in our patient leading to resistant hypokalemia case. Further research..."

Clinical • CNS Disorders • Fatigue • Immunology • Inflammatory Arthritis • Migraine • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Rheumatoid Arthritis • Rheumatology • SLC2A3