IRAK4 inhibitor / Amgen - LARVOL DELTA

Immune complexes-mediated activation of neutrophils in systemic lupus erythematosus is dependent on RNA recognition by toll-like receptor 8. (PubMed, Front Immunol) - "Blocking FcγRIIA, targeting RNA sensing by adding RNase, or blocking TLR7/8, TLR8 only, or IRAK4, decreased plasma-mediated neutrophil activation (p<0.05)...The data support IC-driven RNA-sensing by TLR8 in neutrophils is a key mechanism of neutrophil activation in SLE. Patients with elevated neutrophil activation and presence of RNA-containing ICs, may benefit from TLR8 inhibition and other strategies targeting RNA removal."

IO biomarker • Journal • Immunology • Inflammatory Arthritis • Lupus • Systemic Lupus Erythematosus • CEACAM8 • IRAK4 • ITGAM • TLR8