ulinastatin injection / Generic mfg. - LARVOL DELTA

Immunomodulatory Therapy and Mortality in Patients with Sepsis: A Meta-Analysis. (PubMed, Int Arch Allergy Immunol) - "Immunomodulatory therapy can reduce the risk of death in patients with sepsis, but there is moderate heterogeneity, and its efficacy may be affected by factors such as the type of specific immunomodulatory therapy."

Journal • Retrospective data • Review • Infectious Disease • Septic Shock

Ulinastatin mitigates protamine-induced hypotension during cardiac surgery: A retrospective observational study using propensity score matching. (PubMed, Medicine (Baltimore)) - "While the continuous cardiac index was comparable between the groups after protamine administration, systemic vascular resistance index was significantly higher in the ulinastatin group than in the control group (2090.1 [342.5] vs 1616.2 [644.4] dynes*sec/cm5/m2, mean [standard deviation], P = .022). Ulinastatin mitigates protamine-induced hypotension, maintaining systemic vascular resistance."

Journal • Observational data • Retrospective data • Cardiovascular • CNS Disorders • Depression • Hypotension • Psychiatry

Deriving consensus sepsis clusters via goal-directed subgroup identification in multi-omics study. (PubMed, Nat Commun) - "Patients stratified by GD-SI-derived benefit scores for restrictive versus liberal fluid resuscitation exhibited marked survival differences, with similar advantages observed for ulinastatin immunomodulation...This framework reconciles biological heterogeneity with clinical actionability, offering a scalable infrastructure for precision trial design and personalized sepsis management. Our findings underscore the translational potential of omics-driven, goal-directed stratification to overcome decades of therapeutic stagnation in critical care."

Journal • Critical care • Immunology • Infectious Disease • Septic Shock

Ulinastatin Reduces Postoperative Pulmonary Complications in Cardiac Surgery (clinicaltrials.gov) - P=N/A | N=4540 | Completed | Sponsor: Qin Zhang

New trial • Real-world evidence • Cardiovascular

Ulinastatin Attenuates Lipopolysaccharide-Induced Microglia Activation and Cognitive Deficits Via a MAPKs/JAK-STATs Dependent Manner. (PubMed, Neurochem Res) - "UTI treatment suppressed LPS-induced microglial activation by modulating these pathways, reduced pro-inflammatory cytokine production, and attenuated spatial memory impairment. Notably, our findings provide new evidence that UTI exerts anti-inflammatory and neuroprotective effects by targeting MAPK/JAK-STAT-mediated microglial activation, suggesting its potential as a therapeutic agent for neuroinflammatory and neurodegenerative diseases."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Inflammation • IL1B • TNFA

Absence of Internal Low Echoes Can Be an Important Diagnostic Clue for Intraductal Tubulopapillary Carcinomas of the Pancreas: A Case Report. (PubMed, Cureus) - "The patient received ulinastatin and antibiotic therapy for pancreatic head tumor-induced acute pancreatitis...Diagnostic physicians should note that ITPNs have distinct margins, enhanced posterior echoes, and no internal low echoes due to their pathological structures. In addition, it is also important for diagnostic physicians to note that ITPN patients less often develop icterus due to both the mass softness and the lack of mucin production."

Journal • Oncology • Pain • Pancreatic Cancer • Pancreatitis • Small Intestinal Carcinoma • CCND1 • MUC2 • MUC5AC

Ecological Composite Materials Based on Polylactide (PLA) and Organic Fillers: Coffee Grounds and Hen Eggshells Produced by the FDM Method: Mechanical, Thermal Properties, Stress Relaxation and Creep. (PubMed, Materials (Basel)) - "The structure of polylactide enriched with hen eggshells is characterized by roan and irregular shapes, which can cause a high tendency to form a concentration of cracks in these areas...The polymer composition of coffee grounds and eggshells shows a tendency to creep faster than pure polylactide and with different degrees of infill. Voids reduce the strength of composite materials, which increases the creep potential of samples with incomplete degrees of infill."

Journal

Efficacy and Safety Comparison of Ulinastatin Versus Flurbiprofen Axetil for Preemptive Analgesia in Reducing Opioid Burden After Total Knee Arthroplasty: A Randomized Controlled Trial. (PubMed, J Pain Res) - "Total knee arthroplasty (TKA) poses a significant challenge for acute pain. Single preoperative UTI significantly reduced postoperative morphine consumption (~48%) and adverse reaction risks compared with FA and control by modulating the balance of proinflammatory and anti-inflammatory factors (IL-6 and IL-10). UTI provides an efficient and safe alternative, supporting its inclusion in enhanced recovery after surgery (ERAS) analgesia strategies."

Clinical • Journal • CNS Disorders • Gastrointestinal Disorder • Orthopedics • Pain • IL10 • IL6

Ulinastatin attenuates perioperative nitric oxide surge and postoperative delirium in cardiac surgery: a prospective cohort study with molecular docking and experimental validation. (PubMed, Int J Surg) - "Dynamic perioperative NO surges independently predict POD and postoperative mortality in cardiac surgery. Ulinastatin mitigates this risk by suppressing pathological NO elevation and preserving endothelial integrity, supporting a biomarker-guided neuroprotection strategy."

Journal • Cardiovascular • CNS Disorders • Cognitive Disorders • Inflammation • CTSD • MMP3 • PACERR • PTGS2 • SIRT1

Efficacy and Safety of Ulinastatin in Post-traumatic Sepsis: A Randomized Controlled Trial. (PubMed, Drugs R D) - "While the 28-day mortality rate did not differ significantly between the two groups, ulinastatin was associated with shorter ICU and hospital stays, improvements in inflammatory markers and organ function, and demonstrated a favorable safety profile."

Journal • Infectious Disease • Septic Shock • CRP • IL6

Clinical efficacy of ulinastatin and budesonide combination therapy in pelvic fracture complicated by pulmonary contusion. (PubMed, Eur J Med Res) - "The combination of ulinastatin and budesonide demonstrated significant efficacy in improving lung function indices, modulating immune responses, and reducing inflammation and oxidative stress in individuals with pelvic fractures complicated by pulmonary contusion. The combination therapy exhibited a favorable safety profile, may serve as a potential treatment approach."

Clinical • Journal • Inflammation • Musculoskeletal Diseases • Orthopedics

The application of Da Cheng Qi Decoction in improving gastrointestinal dysfunction in acute pancreatitis through ultrasound-mediated electroconductive targeted acupoint transdermal drug delivery (ChiCTR) - P=N/A | N=80 | Not yet recruiting | Sponsor: Kunshan Traditional Chinese Medicine Hospital; Kunshan Hospital of Traditional Chinese Medicine

New trial • Pancreatitis

Ulinastatin improves sepsis associated organ damage in children: a prospective multicenter randomized controlled clinical trial (ChiCTR) - P4 | N=364 | Recruiting | Sponsor: Children's Hospital of Soochow University; Children's Hospital of Soochow University

New P4 trial • Infectious Disease • Pediatrics • Septic Shock

Ecotone Might Provide Key Refugium for Sky Island Mammals in the Southern Appalachian Mountains. (PubMed, Ecol Evol) - "We conducted livetrapping, camera trapping, and ultrasonic acoustic surveys to characterize mammal diversity across the spruce-fir-northern hardwood forest gradient on Grandfather Mountain and Roan Mountain Highlands in western North Carolina, USA...Next, the abundance of small mammals associated with spruce-fir was higher in the spruce-fir and ecotone forests for one of the three species we were able to estimate. Together, our results suggest that the spruce-fir-northern hardwood ecotone might serve as refugium for mammal species that are associated with spruce-fir sky islands in the Southern Appalachian Mountains and mammalian conservation efforts in this biodiversity hotspot should consider focusing on the ecotone in addition to the adjacent spruce-fir ecosystem."

Journal

Development of an 11-oxoetiocholanolone mini-kit for the quantification of faecal glucocorticoid metabolites in various wildlife species. (PubMed, Conserv Physiol) - "This mini-kit was used to quantify glucocorticoid metabolites with a 5β-3α-ol-11-one structure in faecal extracts from 23 species: African and Asian elephants, Alpine chamois, American bison, Bengal tiger, blue wildebeest, blue-and-yellow macaw, brushtail possum, cape buffalo, fat-tailed dunnart, Florida manatee, ghost bat, giraffe, golden langur, Gould's wattled bat, hippopotamus, Leadbeater's possum, mandrill, okapi, roan antelope, samango monkey, short-beaked echidna, and western lowland gorilla...This assay provides a valuable new option for assessing adrenal activity across taxa using a group-specific antibody. Future studies should put similar emphasis on validation to determine optimal assay choice for measuring fGCMs in a variety of species."

Journal • Endocrine Disorders

Expression of Concern: Associations of MMP-2 and MMP-9 gene polymorphism with ulinastatin efficacy in patients with severe acute pancreatitis. (PubMed, Biosci Rep) - No abstract available

Journal • Pancreatitis • MMP2 • MMP9

Expression of Concern: Associations of MMP-2 and MMP-9 gene polymorphism with ulinastatin efficacy in patients with severe acute pancreatitis. (PubMed, Biosci Rep) - No abstract available

Journal • Pancreatitis • MMP2 • MMP9

Ulinastatin protects against cisplatin-induced ovarian damage via Nrf2/Keap1 pathway. (PubMed, J Ovarian Res) - "Keap1 silencing enhanced the protective effects of ulinastatin, whereas Keap1 overexpression attenuated these effects, confirming that the Nrf2/Keap1 pathway is the key mediator of ulinastatin's protective role in the ovary. These findings underscore the dual function of ulinastatin in repairing cisplatin-induced ovarian damage and provide a promising therapeutic strategy for preserving fertility in female cancer patients undergoing chemotherapy."

IO biomarker • Journal • Fibrosis • Immunology • Oncology • Women's Health • BCL2 • CASP3

Pancreatic panniculitis associated with presumed advanced pancreatic tumor: A case report and literature review. (PubMed, Pathol Res Pract) - "Despite sequential anti-infectives, glucocorticoids, Octreotide, Somatostatin, Ulinastatin, and Cimetidine, her condition deteriorated, culminating in death...Controlling panniculitis fundamentally requires treating the primary tumor: surgical resection (including metastases) significantly improves survival; platinum-based chemotherapy (e.g., FOLFOX/FOLFIRINOX) is preferred for ACC; and molecular profiling (BRCA/RAF/NTRK) guided targeted therapy is promising. Prognosis is poor; early recognition via clinician vigilance for unexplained panniculitis and pathologist identification of "ghost cells", coupled with multidisciplinary collaboration and aggressive tumor-directed therapy, is essential for improving outcomes."

Journal • Hepatology • Musculoskeletal Pain • Oncology • Pain • Pancreatic Cancer • Solid Tumor • BRCA • NTRK

Arthritis associated with Kawasaki disease after initial combination therapy with cyclosporine: a case report. (PubMed, Transl Pediatr) - "This study reports a case of KD that required initial treatment with cyclosporine A (CyA) followed by additional infliximab (IFX) and secondary to reactive arthritis. A 5-year-old boy met diagnostic criteria for KD on day 5 of fever and had an intravenous immunoglobulin (IVIG) refractory predictive score of 8 (≥5) was administered ulinastatin, IFX, and three IVIG doses in combination with CyA...Subsequently, acetylsalicylic acid was changed to flurbiprofen and then to dipyridamole due to suspicion of a drug rash...No recurrence of joint symptoms or coronary artery lesions was observed after tapering off of PSL. Based on the evaluation at the start of treatment, although CyA is initially administered in potential IVIG-resistant patients, attention must be paid to secondary reactive arthritis if the patient becomes resistant to treatment and requires IFX treatment."

Journal • Immunology • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain • Rheumatology • Seronegative Spondyloarthropathies

Retraction Note: Ulinastatin attenuates renal fibrosis by regulating AMPK/HIF-1α signaling pathway-mediated glycolysis. (PubMed, Sci Rep) - No abstract available

Journal • Fibrosis • Immunology • HIF1A

Ulinastatin for the treatment of severe acute pancreatitis: a systematic review and meta-analysis. (PubMed, BMC Gastroenterol) - "Ulinastatin, administered either alone or in combination with other therapeutic agents, was associated with significant improvements in clinical outcomes and reduced mortality rates in patients with severe acute pancreatitis."

Clinical • Journal • Retrospective data • Review • Oncology • Pain • Pancreatic Cancer • Pancreatitis • CRP • IL6 • TNFA

Identification of a Novel Haplotype Associated with Roan Coat Color in American Quarter Horses. (PubMed, Animals (Basel)) - "In our sample set of horses, these three haplotypes account for more than 95% of the American Quarter Horse population studied and about 50-60% of roan horses in other breeds. Using whole genome sequencing of distantly related animals with a particular phenotype, together with a larger number of control horses, improves the odds of finding linked and/or causative variants."

Journal

Inhibition of Ferroptosis by Serine Protease Inhibitor Attenuates Acute Respiratory Distress Syndrome. (PubMed, Arch Biochem Biophys) - "Inhibition of ferroptosis is a novel mechanism underpinning UTI's lung-protective effect against ARDS. UTI potentially regulates the KEAP1-NRF2 interaction through direct binding to KEAP1, offering a new molecular-level explanation for its mechanism of action."

Journal • Acute Respiratory Distress Syndrome • Hematological Disorders • Inflammation • Pulmonary Disease • Respiratory Diseases • GPX4 • IL1B • IL6 • KEAP1 • TNFA

Effect of vascular endothelial membrane protection on the incidence of systemic inflammatory response syndrome after off-pump coronary artery bypass transplantation (ChiCTR) - P=N/A | N=152 | Recruiting | Sponsor: Beijing Chaoyang Hospital Affiliated to Capital Medical University; Beijing ChaoYang Hospital Affiliated to Capital Medical University | Not yet recruiting ➔ Recruiting | N=284 ➔ 152

Enrollment change • Enrollment open • Immunology • Inflammation • Systemic Inflammatory Response Syndrome • Transplantation • SDC1