ulinastatin injection / Generic mfg. - LARVOL DELTA

Retraction: Associations of MMP-2 and MMP-9 gene polymorphism with ulinastatin efficacy in patients with severe acute pancreatitis. (PubMed, Biosci Rep) - No abstract available

Journal • Pancreatitis • MMP2 • MMP9

Efficacy of high-dose ulinastatin in adult sepsis with systemic inflammatory response syndrome: a multi-centre randomised controlled trial with precision subgroup insights (ESCMID Global 2026) - No abstract available

Clinical • Immunology • Infectious Disease • Inflammation • Septic Shock • Systemic Inflammatory Response Syndrome

EFFICACY AND SAFETY OF NEUTROPHIL ELASTASE INHIBITORS (SIVELESTAT AND ULINASTATIN) FOR POSTOPERATIVE LUNG INJURY AFTER AORTIC DISSECTION SURGERY: A SYSTEMATIC REVIEW AND META-ANALYSIS (ACC 2026) - "Sivelestat and Ulinastatin do not reduce mortality but improve postoperative oxygenation and inflammation and may facilitate recovery. Larger high-quality trials are required to define itsclinical role."

Retrospective data • Review • Surgery • Inflammation • Respiratory Diseases • ELANE • IL6

Streptococcus suis meningitis in an elderly man: a case report. (PubMed, Front Med (Lausanne)) - "Therefore, the patient received antibiotic treatment with vancomycin (1 g) intravenously every 12 h. Concurrently, he was administered mannitol to reduce intracranial pressure and ulinastatin for anti-inflammatory effects and immune enhancement. It was also pointed out that Metagenomic Capture sequencing can reduce host gene interference and increase the detection rate of pathogens. This case aims to enhance clinicians' understanding of the disease and provide a reference for early identification and standardized treatment."

Journal • Ataxia • CNS Disorders • Infectious Disease • Movement Disorders • Pneumococcal Infections • Pneumonia • Septic Shock

Ulinastatin relieves sepsis-associated dysmotility via IL-1β-related enteric neuroprotection. (PubMed, Eur J Pharmacol) - "UTI confers broad and integrated protection of the intestine during sepsis. These findings suggest that IL-1β-mediated inflammatory signaling plays a key role in UTI-induced enteric neuroprotection and restoration of intestinal motility."

Journal • Infectious Disease • Oncology • Septic Shock • CLDN1 • IL1B • IL6 • TNFA

LncRNA NR_190073.1 Mediates the Cardioprotective Effect of Ulinastatin in Sepsis through Notch Signaling. (PubMed, Eur J Pharmacol) - "Notably, in contrast to direct TLR4 inhibition, the cardioprotective effects of ulinastatin appear to be primarily mediated through Notch-dependent lncRNA regulatory mechanisms. This study delineates an NR_190073.1-mediated therapeutic pathway of ulinastatin, offering a novel target for SIMI treatment exploration."

Journal • Infectious Disease • Inflammation • Septic Shock • HES1 • IL1B • NICD • TLR4 • TNFA

A case report of acute hyperlipidemic pancreatitis after blastocyst transfer and literature review. (PubMed, Front Med (Lausanne)) - "Medications administered included fenofibrate, ulinastatin, latamoxef (moxalactam), and the traditional Chinese medicine Mirabilite (Glauber's salt). Two days later, the patient's relevant indicators decreased significantly and symptoms improved. The patient was subsequently transferred to the general ward for continued treatment."

Journal • Diabetes • Hepatology • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • Pain • Pancreatitis • Type 1 Diabetes Mellitus

Continuous renal replacement therapy combined with ulinastatin in acute respiratory distress syndrome: A systematic review and meta-analysis. (PubMed, Ann Thorac Med) - "Overall, current evidence of limited quality suggests that CRRT combined with ulinastatin may improve short-term clinical outcomes in patients with ARDS. Future rigorous, large-scale, multicenter randomized controlled trials are essential to verify these findings."

Journal • Retrospective data • Review • Acute Respiratory Distress Syndrome • Critical care • Pulmonary Disease • Respiratory Diseases

Ulinastatin-somatostatin combination for acute severe pancreatitis: enhanced clinical efficacy and reduced serum inflammation. (PubMed, Am J Transl Res) - "UTI+SS for SAP is effective in clinical efficacy enhancement and serum inflammation suppression."

Journal • Diabetes • Inflammation • Oncology • Pancreatitis • Renal Disease • CRP • IL6 • TNFA

A risk prediction model for medication safety: assessing cardiopulmonary adverse outcomes in 11,252 patients treated with ulinastatin. (PubMed, Front Pharmacol) - "The implementation of such a tool represents a tangible step towards enhancing medication safety protocols and promoting safer prescribing behaviors in clinical practice. https://www.chictr.org.cn/showproj.html?proj=11439."

Adverse events • Journal • Critical care

AI-assisted Subtyping-directed Precision Treatment in Acute Aortic Dissection (clinicaltrials.gov) - P=N/A | N=300 | Not yet recruiting | Sponsor: Nanjing Medical University

New trial • Cardiovascular

Immune homeostasis regulatory therapy in elderly sepsis patients: A multicenter, randomized, double-blind Pilot study (ChiCTR) - P2 | N=60 | Not yet recruiting | Sponsor: The First Affiliated Hospital, Sun Yat-sen University; The First affiliated hospital, sun yat-sen university

New P2 trial • Infectious Disease • Septic Shock

Phenotypic impact on coat color and uterine development in mice carrying a missense mutation associated with bovine White Heifer Disease. (PubMed, J Vet Med Sci) - "The roan locus was reported to affect coat color and fertility...KI mice carrying compound mutations mimicking bovine transmembrane domain showed moderate coat color change, but single missense mutation KI did not. None of them exhibited uterine abnormalities, suggesting that localized gene modification may not fully affect murine KITL function."

Journal • Preclinical

Effect of octreotide combined with ulinastatin on the creatinine-to-albumin ratio and systemic immune-inflammation index in patients with severe acute pancreatitis. (PubMed, Am J Transl Res) - "The addition of ulinastatin to octreotide therapy in SAP significantly reduces inflammation and organ injury, improving short-term survival and decreasing mid-term recurrence. CAR and SII are promising prognostic biomarkers."

Journal • Critical care • Inflammation • Pancreatitis • CRP • IL6

Efficacy and Safety Comparison of Ulinastatin versus Flurbiprofen Axetil for Preemptive Analgesia in Reducing Opioid Burden After Total Knee Arthroplasty: A Randomized Controlled Trial [Response to Letter]. (PubMed, J Pain Res) - No abstract available

Journal • Orthopedics • Pain

Fever in a patient with mild acute pancreatitis caused by ulinastatin injection: A case report. (PubMed, Medicine (Baltimore)) - "This case highlights the importance of considering drug-induced fever in clinical practice. Recognizing it promptly and discontinuing the drug can prevent unnecessary interventions and improve outcomes."

Journal • Infectious Disease • Pancreatitis

Comment on "Efficacy and Safety Comparison of Ulinastatin versus Flurbiprofen Axetil for Preemptive Analgesia in Reducing Opioid Burden After Total Knee Arthroplasty: A Randomized Controlled Trial" [Letter]. (PubMed, J Pain Res) - No abstract available

Journal • Orthopedics • Pain

Immunomodulatory Therapy and Mortality in Patients with Sepsis: A Meta-Analysis. (PubMed, Int Arch Allergy Immunol) - "Immunomodulatory therapy can reduce the risk of death in patients with sepsis, but there is moderate heterogeneity, and its efficacy may be affected by factors such as the type of specific immunomodulatory therapy."

Journal • Retrospective data • Review • Infectious Disease • Septic Shock

Ulinastatin mitigates protamine-induced hypotension during cardiac surgery: A retrospective observational study using propensity score matching. (PubMed, Medicine (Baltimore)) - "While the continuous cardiac index was comparable between the groups after protamine administration, systemic vascular resistance index was significantly higher in the ulinastatin group than in the control group (2090.1 [342.5] vs 1616.2 [644.4] dynes*sec/cm5/m2, mean [standard deviation], P = .022). Ulinastatin mitigates protamine-induced hypotension, maintaining systemic vascular resistance."

Journal • Observational data • Retrospective data • Cardiovascular • CNS Disorders • Depression • Hypotension • Psychiatry

Deriving consensus sepsis clusters via goal-directed subgroup identification in multi-omics study. (PubMed, Nat Commun) - "Patients stratified by GD-SI-derived benefit scores for restrictive versus liberal fluid resuscitation exhibited marked survival differences, with similar advantages observed for ulinastatin immunomodulation...This framework reconciles biological heterogeneity with clinical actionability, offering a scalable infrastructure for precision trial design and personalized sepsis management. Our findings underscore the translational potential of omics-driven, goal-directed stratification to overcome decades of therapeutic stagnation in critical care."

Journal • Critical care • Immunology • Infectious Disease • Septic Shock

Ulinastatin Reduces Postoperative Pulmonary Complications in Cardiac Surgery (clinicaltrials.gov) - P=N/A | N=4540 | Completed | Sponsor: Qin Zhang

New trial • Real-world evidence • Cardiovascular

Ulinastatin Attenuates Lipopolysaccharide-Induced Microglia Activation and Cognitive Deficits Via a MAPKs/JAK-STATs Dependent Manner. (PubMed, Neurochem Res) - "UTI treatment suppressed LPS-induced microglial activation by modulating these pathways, reduced pro-inflammatory cytokine production, and attenuated spatial memory impairment. Notably, our findings provide new evidence that UTI exerts anti-inflammatory and neuroprotective effects by targeting MAPK/JAK-STAT-mediated microglial activation, suggesting its potential as a therapeutic agent for neuroinflammatory and neurodegenerative diseases."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Inflammation • IL1B • TNFA

Absence of Internal Low Echoes Can Be an Important Diagnostic Clue for Intraductal Tubulopapillary Carcinomas of the Pancreas: A Case Report. (PubMed, Cureus) - "The patient received ulinastatin and antibiotic therapy for pancreatic head tumor-induced acute pancreatitis...Diagnostic physicians should note that ITPNs have distinct margins, enhanced posterior echoes, and no internal low echoes due to their pathological structures. In addition, it is also important for diagnostic physicians to note that ITPN patients less often develop icterus due to both the mass softness and the lack of mucin production."

Journal • Oncology • Pain • Pancreatic Cancer • Pancreatitis • Small Intestinal Carcinoma • CCND1 • MUC2 • MUC5AC

Ecological Composite Materials Based on Polylactide (PLA) and Organic Fillers: Coffee Grounds and Hen Eggshells Produced by the FDM Method: Mechanical, Thermal Properties, Stress Relaxation and Creep. (PubMed, Materials (Basel)) - "The structure of polylactide enriched with hen eggshells is characterized by roan and irregular shapes, which can cause a high tendency to form a concentration of cracks in these areas...The polymer composition of coffee grounds and eggshells shows a tendency to creep faster than pure polylactide and with different degrees of infill. Voids reduce the strength of composite materials, which increases the creep potential of samples with incomplete degrees of infill."

Journal

Efficacy and Safety Comparison of Ulinastatin Versus Flurbiprofen Axetil for Preemptive Analgesia in Reducing Opioid Burden After Total Knee Arthroplasty: A Randomized Controlled Trial. (PubMed, J Pain Res) - "Total knee arthroplasty (TKA) poses a significant challenge for acute pain. Single preoperative UTI significantly reduced postoperative morphine consumption (~48%) and adverse reaction risks compared with FA and control by modulating the balance of proinflammatory and anti-inflammatory factors (IL-6 and IL-10). UTI provides an efficient and safe alternative, supporting its inclusion in enhanced recovery after surgery (ERAS) analgesia strategies."

Clinical • Journal • CNS Disorders • Gastrointestinal Disorder • Orthopedics • Pain • IL10 • IL6