aceclofenac / Generic mfg. - LARVOL DELTA

Development and characterization of aceclofenac-LDH/alginate porous microspheres for pH-responsive drug release. (PubMed, RSC Adv) - "In vitro drug release was studied in PBS (pH 7.4 and 4.0) at 37 °C. Compared with the physical mixture and ACF-LDH nanohybrids, ACF release from the porous LDH/Alg microspheres was 50% (pH 4.0) within 16 h, whereas 62% of the drug was released at pH 7.4, indicative of a sustained and pH-responsive drug release profile."

Journal

Sustainable miniaturized smartphone-coupled TLC platform for innovative cleaning validation: application to tizanidine combinations under challenging concentration ratios. (PubMed, Sci Rep) - "To address this need, a portable at-line analytical platform was developed for TZN determination in combination with aceclofenac (ACF), ibuprofen (IBF), and paracetamol (PRC). Validation according to ICH guidelines demonstrated good linearity and high sensitivity for the investigated drugs, with quantitation limits below established acceptance limits. Multidimensional sustainability was confirmed using moGAPI, CACI, VIGI, and RGB-12 assessments, highlighting the method as a novel sustainable tool for reliable cleaning validation of TZN combinations."

Journal • CNS Disorders • Psychiatry

Spectral, Electrochemical and Molecular Docking Studies Over Effects of Interaction Between Two Different NSAIDs With BSA and DNA Base. (PubMed, Luminescence) - "The role of two different non-steroidal anti-inflammatory drugs, namely, mefenamic acid (MA) (2-[(2,3-dimethylphenyl)amino]benzoic acid) and aceclofenac (ACF) (2-[(2,6-dichlorophenyl)amino]phenyl acetoxyacetic acid), and their electrostatic interactions with bovine serum albumin (BSA) and adenine model systems have been studied. The free energy, van der Waals and hydrogen-bonding interaction values of BSA with the drugs are determined. In order to assess the electrochemical process, the scan rate is another important parameter, which has been determined by using cyclic voltammograms."

Journal

Novel nanostructured carrier for effective management of Rheumatoid Arthritis by Topical delivery (EAACI 2026) - "The aim of the study was to develop and characterize Aceclofenac loaded solid lipid nanoparticles (SLN) and nanostructure lipid carriers(NLC) to study the skin permeation profile and deposition kinetics for its topical delivery as a possible treatment of rheumatic arthritis to provide a constant effect over prolonged period of time...Permeation studies through human cadaver skin and clinical implication of data are required to develop topical drug delivery system. Nevertheless, further specialized studies are required to confirm the present hypothesis and to better investigate the role of nanoparticulate carriers for controlling and sustaining the release of the drug."

Ankylosing Spondylitis • Immunology • Inflammatory Arthritis • Osteoarthritis • Rheumatoid Arthritis • Rheumatology • Seronegative Spondyloarthropathies

Preemptive Analgesia With Steroidal and Nonsteroidal Anti-Inflammatory Drugs in Dental Implant Surgeries: A Systematic Review. (PubMed, J Oral Implantol) - "Seven RCTs (n = 589 patients) evaluated aceclofenac 100 mg (in combination with acetaminophen), dexamethasone 4 mg, dexketoprofen 25 mg, etoricoxib 90 mg, ibuprofen 600 mg, ketorolac 10 mg, meloxicam 15 mg, nimesulide 100 mg, piroxicam 40 mg, and tenoxicam 20 mg. Owing to the heterogeneity in protocols, drug regimens, and outcome measures, definitive conclusions regarding the most effective and safest preemptive agents could not be drawn. Future trials should emphasize methodological standardization and focus on widely used drugs to support evidence-based decisions in implant dentistry."

Clinical • Journal • Review • Pain

Intra-articular platelet-rich plasma demonstrates superior clinical and serum biomarker outcomes compared with corticosteroids and NSAIDs in late-stage knee osteoarthritis: a randomised controlled trial. (PubMed, J Orthop Surg Res) - "Two PRP injections demonstrated greater 6-month clinical and biomarker improvements compared to CS and NSAIDs in late-stage KOA, supporting PRP as a safe bridge therapy prior to arthroplasty."

Biomarker • Journal • Immunology • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Osteoarthritis • Pain • Rheumatology • BDNF • CCL2 • COMP • CX3CL1 • IL18 • IL6 • MMP3 • TGFB1 • TNFA

The Effect of Pregabalin and Aceclofenac on Testicular Tissue of Adult Albino Rats: Evaluation of Toxicity and Potential Reversibility of Toxic Effects. (PubMed, J Appl Toxicol) - "In conclusion, aceclofenac and pregabalin significantly impair testicular function, with combined administration exacerbating damage through synergistic oxidative and inflammatory mechanisms. Although pregabalin-induced effects appear largely reversible, aceclofenac causes more persistent structural and ultrastructural damage to testicular tissue and sperm cells."

Journal • Preclinical • Pain • KIT • PCNA • TNFA

Mechanistic enhancement of oral bioavailability through a coamorphous apremilast-aceclofenac systems: integrated LC-MS/MS Bioanalysis, in vivo pharmacokinetics, and PBPK modeling. (PubMed, Eur J Pharm Biopharm) - "Physiologically based pharmacokinetic (PBPK) modeling incorporating the Advanced Compartmental Absorption and Transit (ACAT) framework, along with formulation-specific dissolution inputs, accurately predicted plasma concentration-time profiles and regional gastrointestinal absorption, confirming dissolution-driven absorption enhancement. This integrated in vitro-in vivo-in silico investigation establishes coamorphization as a validated strategy to overcome dissolution-limited absorption, identifying AA12 as the optimized CAMS for combined APR-ACF delivery."

Journal • PK/PD data • Preclinical

Ufasome-based transdermal dual-vesicular gel of febuxostat and aceclofenac for sustained gout therapy: formulation optimization and pharmacodynamic evaluation. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "These findings suggest that the FEB-ACE ufasomal transdermal gel offers a sustained delivery platform that may improve therapeutic outcomes and patient compliance in gout therapy. The novelty of this work lies in the dual-drug ufasomal transdermal system integrating urate-lowering and anti-inflammatory therapy in a single formulation, offering a potential alternative to conventional oral treatment for gout management with improved therapeutic convenience."

Journal • PK/PD data • Gout • Inflammatory Arthritis • Rheumatology

Hot melt extrusion-driven cocrystallization of aceclofenac with nicotinamide: A strategy to enhance solubility, bioavailability, and therapeutic effect. (PubMed, J Pharm Sci) - "The in vivo anti-arthritic activity also demonstrated significant improvement when compared to pure ACF. ACF-nicotinamide cocrystals prepared by hot melt extrusion achieved remarkable gains in solubility, bioavailability, and therapeutic efficacy, providing a promising strategy to overcome ACF's clinical limitations."

Journal

A multihued sustainable appraisal of the electrochemical method for synchronized micro-estimation of the household drug Paracetamol with Aceclofenac or Dicyclomine. (PubMed, Sci Rep) - "The results demonstrate that the proposed voltammetric approach is simple, rapid, cost-effective and suitable for routine quality control analysis of paracetamol-based binary mixtures. The online version contains supplementary material available at 10.1038/s41598-026-41215-w."

Journal • Pain

Thermosensitive in-situ gel based on halloysite nanotube/chitosan for site-specific delivery of aceclofenac. (PubMed, J Pharm Sci) - "The in vitro release studies revealed a sustained drug release profile, following zero-order and Korsmeyer-Peppas kinetics, indicative of a Super Case-II transport mechanism. This novel, thermoresponsive local drug delivery system shows strong potential to improve the clinical management of periodontitis by providing prolonged therapeutic action, targeted delivery, and improved patient compliance."

Journal • Dental Disorders • Inflammation • Periodontitis

Mechanistic insights into carbon dot-aceclofenac interactions: An experimental and theoretical approach. (PubMed, J Mol Graph Model) - "These analyses provide detailed mechanistic insights into non-covalent interactions, electronic perturbations, hydrogen bonding, charge transfer, and stabilization mechanisms in the AC complex. These findings offer a foundational mechanistic and analytical understanding that can guide future studies on ACE delivery and formulation optimization, highlighting the potential of green CDs as sustainable nanocarriers for therapeutic agents."

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Acute Exacerbation of Chronic Periapical Pathology in a Dentist: An Autobiographical Case Report. (PubMed, Cureus) - "Self-medication began with paracetamol, escalating to ibuprofen, aceclofenac, and etoricoxib, when pain worsened. Amoxicillin and metronidazole were also taken for infection control...Timely endodontic intervention remains the cornerstone of treatment for acute periapical abscesses. Analgesic prescribing should be individualized and symptom-based rather than fixed-duration, with rotation considered selectively."

Journal • Anesthesia • Infectious Disease • Mood Disorders • Pain

Population pharmacokinetic model-based IVIVC incorporating active metabolite kinetics: Application to aceclofenac sustained-release formulations. (PubMed, Int J Pharm) - "This study successfully established a population pharmacokinetic model-based IVIVC that predicts the pharmacokinetics of both parent drug and active metabolite from in vitro dissolution data. This approach provides a practical framework for developing SR formulations of drugs with active metabolites."

Journal • PK/PD data

An open-label observational study of the efficacy and tolerability of rapidly dissolving forms of aceclofenac and nimesulide for oral use in the treatment of patients with acute non-specific low back pain (ASTRA study) (PubMed, Zh Nevrol Psikhiatr Im S S Korsakova) - "The use of aceclofenac and nimesulide in a rapidly dissolving form for the preparation of a suspension for oral administration is an effective and safe option for the treatment of ANLP. Rapid onset of effect, ease of administration, and a favorable safety profile are important advantages of this NSAID formulation for patients. Aceclofenac in the form of a powder for the preparation of a suspension for oral administration is superior to rapidly dissolving nimesulide in the speed of pain relief and can be considered as a first-line treatment for patients with ANLP."

Journal • Observational data • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

Effect of Occlusal Reduction on Post-operative Pain in Diabetic and Non-diabetic Patients With Symptomatic Apical Periodontitis in a Single Visit: An In Vivo Study. (PubMed, Cureus) - "Both diabetic and non-diabetic groups showed significant pain reduction over 72 hours, with the most substantial decrease within the first 48 hours. The pain patterns were comparable between groups except at 1 hour, where non-diabetics reported higher pain."

Journal • Preclinical • Dental Disorders • Diabetes • Infectious Disease • Inflammation • Metabolic Disorders • Pain • Periodontitis

Unveiling the Pharmacological Promise of Rondeletia leucophylla: A Multidimensional Approach. (PubMed, Biomed Res Int) - "The anti-inflammatory results showed that the 400 mg/kg dose stopped paw edema by 49.01%, which is close to aceclofenac's 65.19% reduction...Molecular docking revealed strong binding affinities of selected compounds to key oxidative stress-related targets, exceeding standard benchmarks, while ADMET profiling indicated favorable drug-like properties and low toxicity. This study supports the traditional use of R. leucophylla, highlighting its antioxidant, thrombolytic, antimicrobial, antidiarrheal, anti-inflammatory, and hypoglycemic potentials, warranting further pharmacological exploration."

Journal

Vitamin B supplementation enhances the efficacy of non-steroidal anti-inflammatory drugs in patients with painful foot and ankle conditions: A multicenter, prospective, randomized controlled trial. (PubMed, PLoS One) - "Combining vitamin B complex with anti-inflammatory drugs effectively reduces pain and improves function in patients with chronic foot disorders. This combination therapy offers a promising strategy for improving pain control and functional outcomes in orthopaedic outpatient settings."

Clinical • Journal • Immunology • Inflammation • Musculoskeletal Diseases • Orthopedics • Pain • Rheumatology

Erythema Annulare Centrifugum: A Dermatologic Suspicion for Malignancy (ACG 2025) - "Although the pathogenesis of EAC is not currently fully understood, it is commonly characterized as a hypersensitivity reaction that occurs in congruence with a multitude of different entities: infectious diseases (viruses, bacteria and parasites) and drugs (chloroquine, cimetidine, aceclofenac). It is of utmost importance for the PCP to recognize this malignant association, relay the importance of proper cancer screening, and refer the patient for a prompt dermatology follow-up. With an early detection of PEACE, the underlying cancer can be detected at an earlier stage of the disease ultimately resulting in a better long-term prognosis for the patient.Figure: Paraneoplastic Erythema Annulare Centrifugum Eruption shown on the torso from the initial presentationFigure: Resolution of previously seen Paraneoplastic Erythema Annulare Centrifugum Eruption after resection of his colorectal adenocarcinoma (as evidenced by abdominal surgical scar)"

Colorectal Adenocarcinoma • Colorectal Cancer • Dermatology • Immunology • Infectious Disease • Oncology • Solid Tumor

Formulation and In-Vivo Evaluation of Aceclofenac and Quercetin Nanoemulsion-Based Gel Against Rheumatoid Arthritis. (PubMed, Immunol Invest) - "In-vivo studies showed 50.89% reduction in paw volume (p<0.0001) with better anti-arthritic effects.  . The study substantiated combinatorial NE-gel formulation with advanced permeation characteristics which can be an efficient alternative for topical delivery in RA."

Journal • Preclinical • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Assessment of Prescription Writing Pattern in a Tertiary Care Center and Hospital at Vidisha Madhya Pradesh: A Prospective Study. (PubMed, J Pharm Bioallied Sci) - "The average number of drugs per prescription was 3.28 prescriptions, and the fixed drug combinations (FDC) mostly of ibuprofen or aceclofenac combined with paracetamol generic prescribing was 100%. This study has shown the need of changes in current prescribing patterns in tertiary care teaching government medical colleges. Regarding the legibility of the prescription, it requires awareness programs for doctors to improve the quality of prescriptions."

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A Data-Driven Workflow for Nanomedicine Optimization Using Active Learning and Automated Experimentation. (PubMed, Mol Pharm) - "To overcome these challenges, this study introduces a data-driven workflow that integrates active learning with experimental automation to rapidly identify optimal nanoformulations, using aceclofenac as a model drug with poor solubility...Through this workflow, a panel of high-performing lead nanoformulations was identified within a few weeks, demonstrating improved solubility, small and uniform particle size, and stability during storage. These findings highlight the power of combining AI-driven design with automation to accelerate nanomedicine development and lay the groundwork for more efficient formulation development."

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Integrated experimental, computational and machine learning approaches for the development of Apremilast-Aceclofenac coamorphous systems. (PubMed, Int J Pharm) - "Accelerated stability testing (40 °C/75 % RH) showed sustained amorphous stability, while forced degradation studies revealed lower degradation rates. This integrative framework provides a predictive, mechanistic basis for CAMs design and offers a broadly applicable strategy for dual-drug delivery in inflammatory disorders such as psoriasis."

Journal • Dermatology • Immunology • Inflammation • Psoriasis • IL17A • IL23A • TNFA

Afebrile vancomycin-induced delayed hypersensitivity suggestive of incomplete drug rash with eosinophilia and systemic symptoms syndrome: a case report. (PubMed, J Med Case Rep) - "This case highlights an atypical presentation of vancomycin-induced delayed hypersensitivity with incomplete drug reaction with eosinophilia and systemic symptoms syndrome due to the absence of fever, potentially masked by nonsteroidal anti-inflammatory drug treatment. Clinicians should remain vigilant for atypical presentations of drug hypersensitivity reactions, especially in patients concurrently taking nonsteroidal anti-inflammatory drugs that can suppress fever."

Journal • Dermatology • Eosinophilia • Immunology • Infectious Disease • Pruritus