aceclofenac / Generic mfg. - LARVOL DELTA

A multihued sustainable appraisal of the electrochemical method for synchronized micro-estimation of the household drug Paracetamol with Aceclofenac or Dicyclomine. (PubMed, Sci Rep) - "The results demonstrate that the proposed voltammetric approach is simple, rapid, cost-effective and suitable for routine quality control analysis of paracetamol-based binary mixtures. The online version contains supplementary material available at 10.1038/s41598-026-41215-w."

Journal • Pain

Thermosensitive in-situ gel based on halloysite nanotube/chitosan for site-specific delivery of aceclofenac. (PubMed, J Pharm Sci) - "The in vitro release studies revealed a sustained drug release profile, following zero-order and Korsmeyer-Peppas kinetics, indicative of a Super Case-II transport mechanism. This novel, thermoresponsive local drug delivery system shows strong potential to improve the clinical management of periodontitis by providing prolonged therapeutic action, targeted delivery, and improved patient compliance."

Journal • Dental Disorders • Inflammation • Periodontitis

Mechanistic insights into carbon dot-aceclofenac interactions: An experimental and theoretical approach. (PubMed, J Mol Graph Model) - "These analyses provide detailed mechanistic insights into non-covalent interactions, electronic perturbations, hydrogen bonding, charge transfer, and stabilization mechanisms in the AC complex. These findings offer a foundational mechanistic and analytical understanding that can guide future studies on ACE delivery and formulation optimization, highlighting the potential of green CDs as sustainable nanocarriers for therapeutic agents."

Journal

Acute Exacerbation of Chronic Periapical Pathology in a Dentist: An Autobiographical Case Report. (PubMed, Cureus) - "Self-medication began with paracetamol, escalating to ibuprofen, aceclofenac, and etoricoxib, when pain worsened. Amoxicillin and metronidazole were also taken for infection control...Timely endodontic intervention remains the cornerstone of treatment for acute periapical abscesses. Analgesic prescribing should be individualized and symptom-based rather than fixed-duration, with rotation considered selectively."

Journal • Anesthesia • Infectious Disease • Mood Disorders • Pain

Population pharmacokinetic model-based IVIVC incorporating active metabolite kinetics: Application to aceclofenac sustained-release formulations. (PubMed, Int J Pharm) - "This study successfully established a population pharmacokinetic model-based IVIVC that predicts the pharmacokinetics of both parent drug and active metabolite from in vitro dissolution data. This approach provides a practical framework for developing SR formulations of drugs with active metabolites."

Journal • PK/PD data

An open-label observational study of the efficacy and tolerability of rapidly dissolving forms of aceclofenac and nimesulide for oral use in the treatment of patients with acute non-specific low back pain (ASTRA study) (PubMed, Zh Nevrol Psikhiatr Im S S Korsakova) - "The use of aceclofenac and nimesulide in a rapidly dissolving form for the preparation of a suspension for oral administration is an effective and safe option for the treatment of ANLP. Rapid onset of effect, ease of administration, and a favorable safety profile are important advantages of this NSAID formulation for patients. Aceclofenac in the form of a powder for the preparation of a suspension for oral administration is superior to rapidly dissolving nimesulide in the speed of pain relief and can be considered as a first-line treatment for patients with ANLP."

Journal • Observational data • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

Effect of Occlusal Reduction on Post-operative Pain in Diabetic and Non-diabetic Patients With Symptomatic Apical Periodontitis in a Single Visit: An In Vivo Study. (PubMed, Cureus) - "Both diabetic and non-diabetic groups showed significant pain reduction over 72 hours, with the most substantial decrease within the first 48 hours. The pain patterns were comparable between groups except at 1 hour, where non-diabetics reported higher pain."

Journal • Preclinical • Dental Disorders • Diabetes • Infectious Disease • Inflammation • Metabolic Disorders • Pain • Periodontitis

Unveiling the Pharmacological Promise of Rondeletia leucophylla: A Multidimensional Approach. (PubMed, Biomed Res Int) - "The anti-inflammatory results showed that the 400 mg/kg dose stopped paw edema by 49.01%, which is close to aceclofenac's 65.19% reduction...Molecular docking revealed strong binding affinities of selected compounds to key oxidative stress-related targets, exceeding standard benchmarks, while ADMET profiling indicated favorable drug-like properties and low toxicity. This study supports the traditional use of R. leucophylla, highlighting its antioxidant, thrombolytic, antimicrobial, antidiarrheal, anti-inflammatory, and hypoglycemic potentials, warranting further pharmacological exploration."

Journal

Vitamin B supplementation enhances the efficacy of non-steroidal anti-inflammatory drugs in patients with painful foot and ankle conditions: A multicenter, prospective, randomized controlled trial. (PubMed, PLoS One) - "Combining vitamin B complex with anti-inflammatory drugs effectively reduces pain and improves function in patients with chronic foot disorders. This combination therapy offers a promising strategy for improving pain control and functional outcomes in orthopaedic outpatient settings."

Clinical • Journal • Immunology • Inflammation • Musculoskeletal Diseases • Orthopedics • Pain • Rheumatology

Erythema Annulare Centrifugum: A Dermatologic Suspicion for Malignancy (ACG 2025) - "Although the pathogenesis of EAC is not currently fully understood, it is commonly characterized as a hypersensitivity reaction that occurs in congruence with a multitude of different entities: infectious diseases (viruses, bacteria and parasites) and drugs (chloroquine, cimetidine, aceclofenac). It is of utmost importance for the PCP to recognize this malignant association, relay the importance of proper cancer screening, and refer the patient for a prompt dermatology follow-up. With an early detection of PEACE, the underlying cancer can be detected at an earlier stage of the disease ultimately resulting in a better long-term prognosis for the patient.Figure: Paraneoplastic Erythema Annulare Centrifugum Eruption shown on the torso from the initial presentationFigure: Resolution of previously seen Paraneoplastic Erythema Annulare Centrifugum Eruption after resection of his colorectal adenocarcinoma (as evidenced by abdominal surgical scar)"

Colorectal Adenocarcinoma • Colorectal Cancer • Dermatology • Immunology • Infectious Disease • Oncology • Solid Tumor

Formulation and In-Vivo Evaluation of Aceclofenac and Quercetin Nanoemulsion-Based Gel Against Rheumatoid Arthritis. (PubMed, Immunol Invest) - "In-vivo studies showed 50.89% reduction in paw volume (p<0.0001) with better anti-arthritic effects.  . The study substantiated combinatorial NE-gel formulation with advanced permeation characteristics which can be an efficient alternative for topical delivery in RA."

Journal • Preclinical • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Assessment of Prescription Writing Pattern in a Tertiary Care Center and Hospital at Vidisha Madhya Pradesh: A Prospective Study. (PubMed, J Pharm Bioallied Sci) - "The average number of drugs per prescription was 3.28 prescriptions, and the fixed drug combinations (FDC) mostly of ibuprofen or aceclofenac combined with paracetamol generic prescribing was 100%. This study has shown the need of changes in current prescribing patterns in tertiary care teaching government medical colleges. Regarding the legibility of the prescription, it requires awareness programs for doctors to improve the quality of prescriptions."

Journal

A Data-Driven Workflow for Nanomedicine Optimization Using Active Learning and Automated Experimentation. (PubMed, Mol Pharm) - "To overcome these challenges, this study introduces a data-driven workflow that integrates active learning with experimental automation to rapidly identify optimal nanoformulations, using aceclofenac as a model drug with poor solubility...Through this workflow, a panel of high-performing lead nanoformulations was identified within a few weeks, demonstrating improved solubility, small and uniform particle size, and stability during storage. These findings highlight the power of combining AI-driven design with automation to accelerate nanomedicine development and lay the groundwork for more efficient formulation development."

Journal

Integrated experimental, computational and machine learning approaches for the development of Apremilast-Aceclofenac coamorphous systems. (PubMed, Int J Pharm) - "Accelerated stability testing (40 °C/75 % RH) showed sustained amorphous stability, while forced degradation studies revealed lower degradation rates. This integrative framework provides a predictive, mechanistic basis for CAMs design and offers a broadly applicable strategy for dual-drug delivery in inflammatory disorders such as psoriasis."

Journal • Dermatology • Immunology • Inflammation • Psoriasis • IL17A • IL23A • TNFA

Afebrile vancomycin-induced delayed hypersensitivity suggestive of incomplete drug rash with eosinophilia and systemic symptoms syndrome: a case report. (PubMed, J Med Case Rep) - "This case highlights an atypical presentation of vancomycin-induced delayed hypersensitivity with incomplete drug reaction with eosinophilia and systemic symptoms syndrome due to the absence of fever, potentially masked by nonsteroidal anti-inflammatory drug treatment. Clinicians should remain vigilant for atypical presentations of drug hypersensitivity reactions, especially in patients concurrently taking nonsteroidal anti-inflammatory drugs that can suppress fever."

Journal • Dermatology • Eosinophilia • Immunology • Infectious Disease • Pruritus

Development and characterization of sodium tripolyphosphate-crosslinked Echinochloa esculenta (Ghingora) starch microspheres as potential drug carrier. (PubMed, Int J Biol Macromol) - "This study aimed to address these issues by developing sodium tripolyphosphate (STPP) treated Ghingora (Echinochloa esculenta) starch and its application in development of aceclofenac loaded microspheres via the solvent evaporation method...This study highlights the potential of modified Ghingora starch as a sustainable and cost-effective alternative to synthetic polymers in drug delivery applications. By overcoming the limitations of native starch, this study presents a biocompatible system that facilitates targeted delivery, prolonged release, reduced side effects, and improved therapeutic outcomes particularly for inflammatory conditions."

Journal

Hot Melt Extruded Aceclofenac-Soluplus® Solid Dispersion: Mechanistic View of Miscibility and Drug-Carrier Interactions for Enhanced Dissolution. (PubMed, AAPS PharmSciTech) - "Leveraging the hydrophilic nature of the SOLP, the solid dispersion demonstrated enhanced dissolution of ACF, while HME synergistically reinforced the combination. This approach presents a compelling alternative to traditional methods, unlocking new possibilities for formulating poorly soluble drugs."

Journal

Synthesis of aceclofenac and L-Arginine salt, characterization and Bioactivities. (PubMed, J Pharm Sci) - "Furthermore, the synthesized salt showed potent anti-inflammatory and cytotoxic activities. It can be concluded that drug co-crystallization using conformer is a new era for the exploration of drug pharmacokinetics."

Journal

Nano-Engineered Hybridized Polymeric Framework for Chronic Wound Management. (PubMed, AAPS PharmSciTech) - "The designed scaffold is composed of a Polyvinylidene fluoride (PVDF) nanofibrous mat, a Collagen/Polyvinyl Alcohol (PVA) composite loaded with metformin hydrochloride, and polyhydroxybutyrate (PHB) embedded with aceclofenac. The HPF scaffold had displayed 93.5% cell viability, 98.7% hemocompatibility, 73.9% in-vitro wound contraction and an improved anti-oxidant activity, that supports the tissue repair in chronic wounds. Thus, the developed hybrid scaffold highlights its potential as an advanced holistic solution for chronic wound management."

Journal • Diabetes • Metabolic Disorders

Enzymatic Removal of Diclofenac and Aceclofenac from Water by Soybean Peroxidase. (PubMed, Molecules) - "Mass spectrometric analysis of the enzymatic treatment products of DCF revealed the formation of an oxidative tetramer. The SBP-catalyzed reaction is a highly effective method for removing DCF and ACF from synthetic wastewater, highlighting its potential for environmental cleanup of pharmaceutical contaminants."

Journal

ULTRASOUND-GUIDED COMMON PERONEAL NERVE BLOCK AND SCAR INFILTRATION FOR CHRONIC POSTOPERATIVE NEUROPATHIC PAIN: A CASE REPORT (ASRA-SPRING 2025) - "Minimal residual pain at the nailing site wasmanaged conservatively with oral analgesics (T.Amitriptyline 5 mg at bedtime for 5 days, followed by 10mg at bedtime, and Tablet with combination of 100 mg ofaceclofenac, 325 mg of paracetamol, and 15mg ofserratiopeptidase for 3 days) and physiotherapy.Follow-up at three months confirmed sustained pain reliefand functional improvement.ResultsThis case underscores the efficacy of ultrasound-guided nerve blocksand scar infiltration in addressing chronic postoperative neuropathicpain. Ultrasound-guided peripheralnerve blocks and scar infiltration have been explored as effectiveinterventional strategies to alleviate chronic postoperative pain. Thiscase report discusses a patient with chronic neuropathic painfollowing tibia and fibula fracture surgery, emphasizing the role oftargeted pain management techniques."

Case report • Clinical • Fibrosis • Immunology • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Neuralgia • Orthopedics • Pain

The efficacy of pre-operative oral aceclofenac and intra-ligamentary mepivacaine on the success of failed inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, randomised, double-blinded clinical trial. (PubMed, PeerJ) - "Based on the pre-operative medication and the intra-ligamentary injection received, the patients were categorized into the following four groups: two groups received 4% articaine with 1:100,000 epinephrine as an intra-ligamentary injection with or without aceclofenac as the pre-operative medication (Group 1 and Group 2, respectively), and two other groups received 3% plain mepivacaine with or without aceclofenac (Group 3 and Group 4, respectively). Mandibular molars with symptomatic irreversible pulpitis are associated with a high anaesthetic failure rate of a single primary IANB injection during endodontic treatment. Adding an oral pre-operative aceclofenac medication and a supplemental intra-ligamentary injection, augments the anaesthetic efficacy in such cases."

Clinical • Journal • Anesthesia • Dental Disorders • Pain

Multimodal evaluation of lipoxygenase-targeting NSAIDs using integrated in vitro, SAR, in silico, cytotoxicity towards MCF-7 cell line, DNA docking and MD simulation approaches. (PubMed, Int J Biol Macromol) - "We reported earlier that several NSAIDs, including naproxen, aspirin and acetaminophen, inhibited lipoxygenase (LOX) enzyme at sub-micromolar concentrations...Aceclofenac (IC50 0.85 ± 0.06 μM) was the most active drug, followed by indomethacin (IC50 1.13 ± 0.07 μM), meloxicam (IC50 1.94 ± 0.07 μM) and ketorolac (IC50 9.26 ± 0.82 μM). Celecoxib (IC50 15.81 ± 0.71 μM), lornoxicam (IC50 16.54 ± 0.28 μM) and nimesulide (IC50 19.87 ± 0.85 μM) showed excellent inhibitory profiles. Flurbiprofen (IC50 21.73 ± 0.93 μM) and etoricoxib (IC50 24.93 ± 0.64 μM) moderately inhibited the target enzyme...Density functional theory (DFT) and ESP studies, MD simulations and MMPBSA free energy calculations further reiterated the stability of ligand-receptor complexes. Overall, these findings highlight the potential of targeted NSAIDs as dual COX/LOX inhibitors with broader therapeutic relevance in inflammatory disorders."

Journal • Preclinical • Breast Cancer • Oncology • Solid Tumor

Anti-inflammatory drugs as potential antimicrobial agents: a review. (PubMed, Front Pharmacol) - "NSAIDs, namely aceclofenac, diclofenac, and ibuprofen, were tested in clinical trials with patients diagnosed with uncomplicated urinary tract infections (UTIs) and cellulitis...Similarly, aspirin caused a high survival rate in M. tuberculosis-infected mice and strong to moderate in vitro activity against E. coli, B. cereus, P. aeruginosa, Enterobacter aerogenes, Klebsiella pneumoniae and Salmonella choleraesuis (MIC 1.2-5 mg/L). Moreover, topical application of celecoxib resulted in a high reduction in MRSA burden in mice...These data suggest that certain non-steroidal anti-inflammatory drugs (NSAIDs) are promising drug candidates for the development of dual-action drugs for the potential treatment of combined infectious and inflammatory diseases such as tuberculosis, musculoskeletal infections and UTIs. Nevertheless, future clinical trials must be conducted to ascertain the antibacterial effect of these NSAIDs before their practical use."

Journal • Review • Cholera • Dermatology • Immunology • Infectious Disease • Inflammation • Musculoskeletal Diseases • Nephrology • Pneumonia • Pulmonary Disease • Respiratory Diseases • Rheumatology • Tuberculosis • GDF15

Overall compilation of adverse effects of non-steroidal anti-inflammatory drugs: a hypothesis-free systematic investigation using a nationwide cohort study. (PubMed, Front Pharmacol) - "Further, we assessed the association between five NSAID subtypes (aceclofenac, meloxicam, loxoprofen, celecoxib, and naproxen) and AEs, and compared their adjusted hazard ratios (aHRs) with each other. Our findings enhance the understanding of NSAID safety profiles by identifying dose-response and duration-time AEs. They also contribute to better diagnosis and management of AEs while providing valuable guidelines for both patients and clinicians."

Adverse events • Journal • Hematological Disorders • Immunology • Nephrology • Osteoarthritis • Pain • Rheumatology