CNS-5161 / PAION - LARVOL DELTA

Comment on " In Vivo [F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates". (PubMed, ACS Chem Neurosci) - "Prior data suggest that the uptake of disubstituted arylguanidine-based ligands such as GE-179 can be reduced by phencyclidine binding site antagonists, if injection is performed in the absence of ketamine and isoflurane anesthesia, e.g., with GE-179's antecedent, CNS 5161 ( Biegon et al. 36 , 1111 - 1121 ). However, the extent of nonspecific uptake remains uncertain."

Journal • Preclinical