CNS-5161
/ PAION
- LARVOL DELTA
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October 23, 2018
Comment on " In Vivo [F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates".
(PubMed, ACS Chem Neurosci)
- "Prior data suggest that the uptake of disubstituted arylguanidine-based ligands such as GE-179 can be reduced by phencyclidine binding site antagonists, if injection is performed in the absence of ketamine and isoflurane anesthesia, e.g., with GE-179's antecedent, CNS 5161 ( Biegon et al. 36 , 1111 - 1121 ). However, the extent of nonspecific uptake remains uncertain."
Journal • Preclinical
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