Eroxon (MED3000) / Futura Medical - LARVOL DELTA

MED3000 Topical Gel for On-Demand Treatment of Post-Radical Prostatectomy Erectile Dysfunction (clinicaltrials.gov) - P=N/A | N=20 | Completed | Sponsor: Brigham and Women's Hospital | Recruiting ➔ Completed

Trial completion • Erectile Dysfunction

Pilot study of MED3000 in treatment of erectile dysfunction after bilateral nerve-sparing radical prostatectomy. (PubMed, J Sex Med) - No abstract available

Journal • Erectile Dysfunction

Insight into the Al-Fe dual-anode hybridperoxicoagulation-ozonation process for landfill leachate wastewater treatment: Quantitative analysis of reaction pathways and synergistic mechanism. (PubMed, Water Res) - "Quantitative reactive oxygen species (ROS) trapping revealed that organic pollutants degradation was driven by multi-pathway •OH generation, dominated by electro-peroxone (EP) and synergistic effects between ozone and coagulants (SOC)...After 3 h treatment, the effluent COD (<60 mg/L) and color met the Standard for Pollution Control on domestic waste landfills (GB 16,889-2024). Compared with other traditional processes, the PCOAl-Fe process exhibited accelerated degradation rates for efficient contaminant removal, 36 %-78 % lower energy demand and 56 %-88 % reduction in operating costs, offering a cost-effective solution for refractory wastewater."

Journal

Electrochemical ozone generation reaction (OZER) for drinking water treatment (ACS-Fall 2025) - "Third, the OZER anode was combined with UV or H2O2 generating cathode to degrade recalcitrant pollutants with .OH in terms of E-UV/O3 or E-peroxone process. Lastly, the NSS/SiOx anode was integrated into a membrane electrode assembly (MEA) for drinking water treatment with negligible electrical conductivity. The findings of this study would broaden the applications of electrochemical advanced oxidation processes."

Surface Coordination and Radical Binding Induce Efficient Decomposition of Chlorinated Organophosphate Flame Retardants during Catalytic Ozonation. (PubMed, Environ Sci Technol) - "Conventional AOPs, e.g., the benchmark O3/H2O2 (peroxone), are not efficient in removing them from water/wastewater, because of their relatively low reaction rates with hydroxyl radical (•OH)...The O3/ZnO was most effective at neutral pH for TCEP removal and can achieve partial mineralization and detoxification of the compound. This work highlights the importance of surface reaction in removing the highly refractory Cl-OPFRs."

Journal

An efficient sequential method for enhanced landfill leachate treatment and detoxification: Electrocoagulation/permanganate, peroxymonosulfate-based process, and electro-peroxone. (PubMed, J Environ Manage) - "The BOD5/COD ratio improved to 0.55, indicating that the treated leachate is suitable for biological treatment processes with significantly reduced toxicity. Overall, the sequence of treatment processes yielded promising results."

Journal

Addressing unmet needs for patients with erectile dysfunction: a narrative review of topical therapies. (PubMed, Sex Med) - "These actions have been demonstrated by a new over-the-counter agent, MED3000, authorized by the United States Food and Drug Administration, and for topical alprostadil, which is available with a prescription in the European Union...However, the heterogeneity of studies evaluated creates difficulties in directly comparing results from different studies. The results of this analysis show that current topical therapies can provide statistically and clinically significant improvements in erectile function in men with ED and may provide an effective alternative to PDE5i in men who require or prefer an alternative therapy."

Journal • Review • Erectile Dysfunction • Sexual Disorders • Urology

Pilot Study of MED3000 for Treatment of Erectile Dysfunction After Bilateral Nerve-Sparing Radical Prostatectomy (AUA 2025) - "In this pilot study, our findings show MED3000 was well tolerated but did not demonstrate efficacy in improving EF in post-bnsRP patients with predominantly severe ED."

Clinical • Erectile Dysfunction • Infectious Disease • Prostate Cancer

Enhanced peroxone reaction with amphoteric oxide modulation for efficient decontamination of challenging wastewaters: Comparative performance, economic evaluation, and pilot-scale implementation. (PubMed, Water Res) - "A detailed comparison of reaction systems with conventional technologies using Electrical Energy per Order (EE/O) and Life Cycle Assessment (LCA) further highlighted the advantages. This investigation offers a groundbreaking solution for the treatment of complex wastewater, showcasing the substantial promise of ZnO-catalyzed peroxone for practical wastewater treatment applications."

HEOR • Journal

Fluorescence sensor enabled control of contaminants of emerging concern in reclaimed wastewater using ozone-based treatment processes. (PubMed, Water Res) - "Furthermore, real-time fluorescence data were successfully used to predict observed pseudo-first-order rate constants of CEC with O3 or O3/H2O2. Obtained results suggest that real-time fluorescence monitoring is an excellent tool to control CEC removal during O3-based AOPs and monitor the transferred ozone in wastewater (R2≥0.94), contributing to the optimization of reagent dose, energy and costs."

Journal

The role of TiO2 and gC3N4 bimetallic catalysts in boosting antibiotic resistance gene removal through photocatalyst assisted peroxone process. (PubMed, Sci Rep) - "Furthermore, Polymerase Chain Reaction-Denaturing Gradient Gel Electrophoresis (PCR-DGGE) analysis reveals challenges in eradicating GC-rich bacteria with TiO2 and g-C3N4 processes, while slight differences in Cu/Pd loadings suggest g-C3N4-based ozonation improved antibacterial effectiveness. Terminal Restriction Fragment Length Polymorphism analysis highlights the efficacy of the photocatalyst-assisted peroxone process in treating diverse samples."

Journal

Using green nanocomposite containing eggshell in the electroperoxone process in a baffled reactor to remove the emerging tetracycline pollutant. (PubMed, Environ Res) - "Additionally, the reusability of the nanocomposite was evaluated over five usage periods, during which the process efficiency decreased from 95.9% to 83.1%. In short, this study proved that EMAC/Fe3O4 nanocomposites are promising electroperoxone catalysts due to their low cost, excellent stability and reusability, environmental compatibility, and superior catalytic activity for TCH antibiotics removal."

Journal

Scoping review exploring advancements in topical agent therapies for erectile dysfunction. (PubMed, Sex Med Rev) - "Topical agents via various mechanisms are effective and well-tolerated treatments for ED. A fast-acting drug that significantly reduces side effects as compared with other options has been discovered. However, its efficacy relative to current first-line therapies remains unclear. Topical agents present a viable therapeutic alternative for individuals who are unable or unwilling to take oral phosphodiesterase 5 inhibitors."

Journal • Review • Erectile Dysfunction

Formation of chlorinated disinfection byproducts in textile industry waste water: Emerging concerns and current issues (ACS-Fall 2024) - "Study findings revealed that conventionally treated effluents contained higher levels of DBPs, emphasizing the need for more eco-friendly treatment approaches. The application of electroperoxone not only demonstrated superior color removal but also offered a more environmentally responsible solution for the textile industry."

Defluorination of PFOA in trickle bed electrochemical reactor with intensified absorption of bubble (ACS-Fall 2024) - "Subsequently, ●OH generated via peroxon reaction (of O3 and H2O2) can further oxidize the mono-defluorination intermediates...This trickle bed enhanced with electrochemical processes provides a new approach for effective PFOA degradation and defluorination in drinking water. experimental setup"

Balancing organic pollutant removal and bromate formation during peroxone treatment of bromide containing waters (ACS-Fall 2024) - "The influence of O3(g) interphase mass transfer rate and mixing within the reactor on the overall performance of the process will also be discussed. Simulation of reactor performance using modelling tools such as computation fluid dynamics incorporating both multiphase flow and reactions kinetics describing ozone decay, hydroxyl radical generation and organic oxidation will also be presented."

E-peroxone with a novel GDE decorated with hydrophobic membrane for the degradation of pyridine: Stability, byproducts and toxicity. (PubMed, Chemosphere) - "The toxicity variation along the degradation progress was evaluated with microbial respiration tests and Toxicity Estimation Software Tool (T.E.S.T.) calculation and an efficient detoxification capacity of E-peroxone was observed. This research provides a theoretical basis and technical support for the development of highly efficient and stable E-peroxone system for the elimination of toxic organic contaminants."

Journal

High-efficiently utilizing micro-nano ozone bubbles to enhance electro-peroxone process for rapid removal of trace pharmaceutical contaminants from hospital wastewater. (PubMed, Water Res) - "Consequently, the EP process under MNBs aeration significantly enhanced ozone-resistant ibuprofen (IBU) removal, achieving a removal rate of 98.4 ± 1.5 %, far exceeding the 47.3 ± 4.7 % observed with conventional aeration...As a result, over 97 % removal efficiency was achieved for five representative pharmaceutical pollutants (sulfamethoxazole, ribavirin, norfloxacin, tetracycline and ampicillin) in just 1 min. Furthermore, when applied to real hospital wastewater, the MNBs-O3-E treatment system reduced all 15 detected trace pharmaceutical compounds to below 10 ng L-1 and achieved 14 types of pollutants with removal rates of over 85 % within 15 min, resulting in an ultrahigh total removal rate of 98.6 %, from an initial total concentration of 2108 ng L-1 to less than 30 ng L-1. Thus, micro-nano aeration endowed the EP process as a promising advanced oxidation system for rapid and highly-effective removal of trace pharmaceutical contaminants from hospital..."

Journal

Ozone and peroxone disinfection of Toxocara canis eggs in water. (PubMed, Trop Biomed) - "The synergistic effect of ozone combined with hydrogen peroxide allows higher helminth egg inactivation rates, demonstrating that advanced oxidation processes are a real alternative to apply in the inactivation of Toxocara canis eggs. The results obtained in this study show that the ozone and peroxone treatment could be a useful disinfection process to destroy or inactivate Toxocara canis eggs in processes commonly applied in water treatment."

Journal

Efficacy and safety of MED3000, a novel topical therapy for the treatment of erectile dysfunction (AUA 2024) - "In a second multi-center, randomized, open-label, parallel-group study (FM71), MED3000 was compared with 5 mg oral tadalafil over 24 weeks in 96 men with ED. The data from these pivotal studies resulted in the approval of MED3000 in the United States. MED3000 met the MCID for improving erectile function with a favorable safety profile. This novel topical agent may be useful for men with ED who are not candidates for a PDE5 inhibitor, who cannot tolerate adverse events associated with these agents, or who have suboptimal responses to them."

Clinical • Erectile Dysfunction

Simultaneous electrocoagulation and E-peroxone coupled with ultrafiltration membrane for shale gas produced water treatment. (PubMed, Chemosphere) - "Mechanism study indicated that ECP could realize the simultaneous coagulation, H2O2 generation and activation by O3, facilitating the enhancement of ·OH and Alb production and therefore beneficial for improved water quality and UF fouling mitigation. Therefore, the ECP-UF process emerges as a highly efficient and space-saving approach, yielding a synergistic effect in mitigating UF fouling for SGPW recycling."

Journal

Insight into roles of carbon anodes for removal of refractory organic contaminants in electro-peroxone system: Mechanism, performance and stability. (PubMed, J Hazard Mater) - "In this work, the EP system with graphite felt anode (EP-GF) and activated carbon fiber anode (EP-ACF) was developed to enhance ibuprofen (IBP) removal. The three degradation pathways of IBP were proposed, and the toxicity of intermediates were evaluated. In general, carbon anodes have a good application prospect in the removal of ROCs in EP systems."

Journal

Crystal Plane Regulation Promotes the Oriented Conversion of Radicals in Heterogeneous Persulfate Catalyzed Oxidation Process. (PubMed, Small) - "The presence of Ov not only facilitates the adsorption of PMS molecules but also enhances electron transfer from Co2+ to PMS, leading to directed formation and efficient transformation of radicals. This study presents a novel strategy for promoting efficient radical formation in persulfate-activated systems."

Heterogeneity • Journal

Kinetic modelling assisted balancing of organic pollutant removal and bromate formation during peroxone treatment of bromide-containing waters. (PubMed, J Hazard Mater) - "For pollutants with low reactivity towards O3/•OH, high O3 (O3:DOC>>1 g/g) and high H2O2 dosages (O3:H2O2 ∼1 (g/g)) are required for minimizing BrO3- formation along with effective pollutant removal which may result in a very high residual of H2O2 in the effluent, causing secondary pollution. On balance, we conclude that the peroxone process is not effective for the removal of low reactivity micropollutants if minimization of BrO3- formation is also required."

Journal

Comparative study of different ultrasound based hybrid oxidation approaches for treatment of real effluent from coke oven plant. (PubMed, J Environ Manage) - "High-resolution liquid chromatography mass spectrometry (HR-LCMS) analysis was also performed to establish intermediate compounds. Overall, the coupling of ultrasound with oxidation processes produced better results with US + Peroxone established as best treatment approach for coke plant effluent."

Journal