Eroxon (MED3000) / Futura Medical - LARVOL DELTA

Unmet needs in the treatment of erectile dysfunction and a place for topical treatments in the therapeutic landscape. (PubMed, J Sex Med) - "Overall, the statements supported in this Delphi initiative may provide a framework for more detailed recommendations that could be incorporated into treatment guidelines. In addition, the statements for which unanimous support could not be achieved help to identify evidence gaps that are targets for future research."

Journal • Erectile Dysfunction

Integration of hydrodynamic cavitation and preozonation: a physicochemical strategy for effectively addressing intracellular odorants from filamentous cyanobacteria. (PubMed, Bioresour Technol) - "Unlike conventional peroxone preozonation, which fails to degrade cell-bound odorants and requires unstable hydrogen peroxide handling, HCPO employs a Venturi-based HC unit to physically enhance the disruption of cyanobacterial cells while upgrading ozone dispersion and radical generation...Critically, HCPO minimized bromate formation (<10 ppb) through optimized oxidant utilization and reduced ozone dosage (30-50% lower), yielding operational costs of 0.17-0.25 kWh/m3. This innovation resolves a significant limitation in drinking water treatment by concurrently addressing dissolved and cell-bound contaminants, offering a scalable, safety-enhanced alternative that aligns with sustainable water purification frameworks."

Journal

Microwave-assisted electro-peroxone process for rapid removal of high-concentration recalcitrant dye solutions. (PubMed, iScience) - "The degradation followed first-order kinetics. These findings highlight the applicability of the MW-EP process for treating high-concentration dye-containing wastewater."

Journal

Local microenvironment regulation with co nanoparticles/ single-atoms sites to drive two-electron oxygen reduction catalysis for efficient adsorption-electroperoxone water purification. (PubMed, Water Res) - "Overcoming the inherent trade-off between pollutant adsorption and catalytic site utilization remains a critical challenge in electrochemical advanced oxidation processes (EAOPs). The developed cathode achieves over 80% total organic carbon (TOC) removal for carbamazepine in surface water with low electric energy consumption at 0.21 kWh•g-1 TOC (5.2 kWh•m-3), and maintains stable performance in carbamazepine removal over 100 h of operation. These results demonstrate its practical applicability for decentralized remediation of pharmaceutical-contaminated water."

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Significant enhancement of electro-peroxone system for complexed Ni decomplexation and recovery from complicated wastewater by synergizing anodic 1O2 with cathodic ·OH. (PubMed, Environ Res) - "A preliminary life cycle assessment suggested lower environmental impacts per unit Ni recovered under the selected system boundary, while ozone utilization and electrode preparation remain targets for further optimization. The new synergistic 1O2-·OH process offers a selective, robust pathway for coupled decomplexation and resource recovery from complex wastewaters."

Journal

PLEASURE (Pleasing Lovers, Efficacy, Arousal, Satisfaction, and Uptake Research on Eroxon) (clinicaltrials.gov) - P4 | N=30 | Not yet recruiting | Sponsor: University of Miami

New P4 trial • Diabetes • Erectile Dysfunction • Metabolic Disorders • Type 2 Diabetes Mellitus

Electron transfer drives hydroxyl radical formation in peroxone reactions. (PubMed, Environ Sci Ecotechnol) - "We also determine the pK a of the hydroxyl radical precursor hydrotrioxide as approximately 6.15 and quantify the long-disputed hydroxyl radical-ozone reaction rate constant as 1.1 × 108 M-1 s-1. These results revise classical ozonation and peroxone mechanisms and provide a mechanistic foundation for optimizing ozone-based advanced oxidation technologies for water purification."

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A Robust Cost-Effective Spectrophotometric Method for Nb Determination in Refractory Nb-doped Gadolinium Zirconate: Overcoming Matrix Dissolution Challenges. (PubMed, Anal Sci Adv) - "Subsequent to dissolution of highly refractory solid matrices, a one-step spectrophotometric method for Nb determination based on the formation of peroxoniobium complex in sulfuric acid medium was optimised and developed...The recovery of Nb from spiked samples at a 50 ppm level is greater than 98% and, thereby validating the proposed method. Furthermore, the proposed method is independently authenticated using total reflection X-ray fluorescence/energy-dispersive X-ray fluorescence techniques, with the results showing good agreement within the 95% confidence interval."

HEOR • Journal

In brief: Vybrique - sildenafil oral film for erectile dysfunction. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Erectile Dysfunction

Interfacial electron modulation and molecular passivation: Suppression mechanisms of microplastics on dual oxidation pathways in peroxone reaction. (PubMed, Water Res) - "Crucially, the O3/H2O2 system maintained high pollutant removal efficiency in real water matrices despite MPs-induced inhibition, and also exhibited no ecotoxicity in plant growth assays and yielded favorable life cycle outcomes. This study establishes a mechanistic foundation for optimizing advanced oxidation in microplastic-coexisted environments and demonstrated the practical feasibility of the O3/H2O2 system for such applications."

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Comparative Assessment of 2-MIB and Geosmin Removal Techniques using Multi-Criteria Decision Analysis. (PubMed, Integr Environ Assess Manag) - "This study employs a multi-criteria decision-making (MCDM) approach, integrating the Analytic Hierarchy Process (AHP), Technique for Order Preference by Similarity to Ideal Solution (TOPSIS), VlseKriterijumska Optimizacija I Kompromisno Resenje (VIKOR) and Stochastic Multicriteria Acceptability Analysis (SMAA), to evaluate five treatment alternatives: activated carbon adsorption (A1), modified activated carbon adsorption (A2), peroxone oxidation (A3), integrated original activated carbon and peroxone process (A4), and integrated modified activated carbon and peroxone process (A5)...These findings underscore the importance of a hybrid evaluation framework in selecting effective water treatment strategies. Future studies should explore the integration of machine learning techniques to enhance decision-making reliability."

Journal

Degradation of methylene blue using inutile LCD panels as novel anodes: A potential replacement for platinum-based electrodes. (PubMed, J Environ Manage) - "Real wastewater treatment further demonstrated the effectiveness of the system, achieving 30% TOC mineralization, a 75% reduction in COD, an 80% reduction in turbidity, and a 57% reduction in TSS in 6 h. Overall, the results demonstrated that the LCD-RVC electro-peroxone system provided robust pollutant removal, confirming LCD as a promising low-cost electrode material for advanced oxidation applications."

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Trace Mn(II)-Mediated Peroxone Process Boosts Oxidative Capacity for Electron-Deficient Pollutant Removal: Key Role of Transient Mn(III) and Overcoming pH Limitations. (PubMed, Environ Sci Technol) - "Ecotoxicity assays (plant germination, zebrafish embryo development, and bacterial proliferation) and life cycle assessment confirmed lower environmental risks than O3 and Fenton processes. These results establish transient Mn(III) as a pivotal HO•-generating species and provide a robust, pH-resilient, and environmentally compatible framework for next-generation AOPs targeting persistent organic pollutants in diverse water matrices."

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Comprehensive and sludge-free treatment of raw landfill leachate wastewaters using electro-peroxone. (PubMed, Waste Manag) - "The particle distribution analysis before and after treatment clearly indicated the reduction in particle size and substantiated the reduction in TSS and turbidity, and increase in soluble TOC. Finally, mechanisms for contaminant abatement and the novel phenomenon of particulate organic matter mineralization are proposed, demonstrating electro-peroxone as a sustainable, chemical-free, zero-sludge treatment option for complex landfill leachates."

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Vinyl Chloride Degradation Using Ozone-Based Advanced Oxidation Processes: Bridging Groundwater Treatment and Machine Learning for Smarter Solutions. (PubMed, Molecules) - "Decreasing VC concentration below the parametric value of 0.5 µg/L requires application of the peroxone process or photodegradation by O3/H2O2/UV for groundwater with higher levels of interfering compounds...An ensemble of Random Forest and Neural Network predictions yielded the best performance (R2 = 0.99; Mean Squared Error = 10.8), demonstrating the effectiveness of ensemble approaches for complex chemical prediction tasks and highlighting areas for further refinement to improve interpretability and predictive consistency of AOP treatment outcomes. This study not only aligns with the current momentum in AI-assisted AOP research but also advances it by delivering a generalizable, reproducible, and interpretable ensemble model trained on experimentally diverse datasets."

Journal

Boosting NO Oxidation in the Catalytic Peroxone Process over TiO2: The Key Role of Surface Sulfate. (PubMed, ACS Omega) - "In addition, sulfates also inhibit the accumulation of oxidation product nitrates on the catalyst surface, thereby improving catalytic stability. This work reveals the promotion mechanism of SO4 2- on the catalytic peroxone process from multiple perspectives."

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MED3000 Topical Gel for On-Demand Treatment of Post-Radical Prostatectomy Erectile Dysfunction (clinicaltrials.gov) - P=N/A | N=20 | Completed | Sponsor: Brigham and Women's Hospital | Recruiting ➔ Completed

Trial completion • Erectile Dysfunction

Pilot study of MED3000 in treatment of erectile dysfunction after bilateral nerve-sparing radical prostatectomy. (PubMed, J Sex Med) - No abstract available

Journal • Erectile Dysfunction

Insight into the Al-Fe dual-anode hybridperoxicoagulation-ozonation process for landfill leachate wastewater treatment: Quantitative analysis of reaction pathways and synergistic mechanism. (PubMed, Water Res) - "Quantitative reactive oxygen species (ROS) trapping revealed that organic pollutants degradation was driven by multi-pathway •OH generation, dominated by electro-peroxone (EP) and synergistic effects between ozone and coagulants (SOC)...After 3 h treatment, the effluent COD (<60 mg/L) and color met the Standard for Pollution Control on domestic waste landfills (GB 16,889-2024). Compared with other traditional processes, the PCOAl-Fe process exhibited accelerated degradation rates for efficient contaminant removal, 36 %-78 % lower energy demand and 56 %-88 % reduction in operating costs, offering a cost-effective solution for refractory wastewater."

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Electrochemical ozone generation reaction (OZER) for drinking water treatment (ACS-Fall 2025) - "Third, the OZER anode was combined with UV or H2O2 generating cathode to degrade recalcitrant pollutants with .OH in terms of E-UV/O3 or E-peroxone process. Lastly, the NSS/SiOx anode was integrated into a membrane electrode assembly (MEA) for drinking water treatment with negligible electrical conductivity. The findings of this study would broaden the applications of electrochemical advanced oxidation processes."

Surface Coordination and Radical Binding Induce Efficient Decomposition of Chlorinated Organophosphate Flame Retardants during Catalytic Ozonation. (PubMed, Environ Sci Technol) - "Conventional AOPs, e.g., the benchmark O3/H2O2 (peroxone), are not efficient in removing them from water/wastewater, because of their relatively low reaction rates with hydroxyl radical (•OH)...The O3/ZnO was most effective at neutral pH for TCEP removal and can achieve partial mineralization and detoxification of the compound. This work highlights the importance of surface reaction in removing the highly refractory Cl-OPFRs."

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An efficient sequential method for enhanced landfill leachate treatment and detoxification: Electrocoagulation/permanganate, peroxymonosulfate-based process, and electro-peroxone. (PubMed, J Environ Manage) - "The BOD5/COD ratio improved to 0.55, indicating that the treated leachate is suitable for biological treatment processes with significantly reduced toxicity. Overall, the sequence of treatment processes yielded promising results."

Journal

Addressing unmet needs for patients with erectile dysfunction: a narrative review of topical therapies. (PubMed, Sex Med) - "These actions have been demonstrated by a new over-the-counter agent, MED3000, authorized by the United States Food and Drug Administration, and for topical alprostadil, which is available with a prescription in the European Union...However, the heterogeneity of studies evaluated creates difficulties in directly comparing results from different studies. The results of this analysis show that current topical therapies can provide statistically and clinically significant improvements in erectile function in men with ED and may provide an effective alternative to PDE5i in men who require or prefer an alternative therapy."

Journal • Review • Erectile Dysfunction • Sexual Disorders • Urology

Pilot Study of MED3000 for Treatment of Erectile Dysfunction After Bilateral Nerve-Sparing Radical Prostatectomy (AUA 2025) - "In this pilot study, our findings show MED3000 was well tolerated but did not demonstrate efficacy in improving EF in post-bnsRP patients with predominantly severe ED."

Clinical • Erectile Dysfunction • Infectious Disease • Prostate Cancer

Enhanced peroxone reaction with amphoteric oxide modulation for efficient decontamination of challenging wastewaters: Comparative performance, economic evaluation, and pilot-scale implementation. (PubMed, Water Res) - "A detailed comparison of reaction systems with conventional technologies using Electrical Energy per Order (EE/O) and Life Cycle Assessment (LCA) further highlighted the advantages. This investigation offers a groundbreaking solution for the treatment of complex wastewater, showcasing the substantial promise of ZnO-catalyzed peroxone for practical wastewater treatment applications."

HEOR • Journal