RK-023 / Mallinckrodt - LARVOL DELTA

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications (AES 2025) - P | "Our findings firstly revealed that fever-related seizure frequency reduction is the distinctive and prevalent genotype-phenotype for CDD, thereby providing evidence to support the development of innovative therapeutic strategies and to further fundamental research for patients."

CNS Disorders • Epilepsy • Genetic Disorders

Quantum-Hall Spectroscopy of Elliptically Deformed Graphene Nanobubble Qubits. (PubMed, J Phys Condens Matter) - "We found that the single and double QD show distinguished behavior with regard to the direction of the elliptical deformation. While the single QD (SQD) levels are substantially affected by the $y$-directional deformation, the double QD (DQD) levels are largely shifted by the $x$-directional deformation."

Journal

HUMAN INDUCED PLURIPOTENT STEM CELL -DERIVED ASTROCYTES FROM ALZHEIMER´S DISEASE PATIENTS SHOW A PRO -INFLAMMATORY AND SENESCENT PHENOTYPE (ADPD 2025) - "Our preliminary data suggest that astrocytes derived from AD patients present an intrinsic pro-inflammatory and senescent phenotype which compromise their functionality. Elucidating the mechanisms inducing these processes and their functional consequences should help for a better understanding of role that astrocytes play in AD, by direct functioning and also through their interactions with neurons and the other glial cells. This should lead to potential therapeutic targets for future AD treatments."

Clinical • Alzheimer's Disease • CNS Disorders

Design of Extracranial-Intracranial Bypass Surgery for Symptomatic Chronic Middle Cerebral Artery Occlusion Trial (CMOSS-2) (ISC 2025) - P=N/A | "Patients will be randomized to EC-IC bypass surgery plus medical treatment or medical treatment alone.Study outcomes: The primary outcome is the ischemic stroke in territory of qualifying artery within 2 years after randomization. Key secondary outcomes are: Any stroke or death within 30 days after randomization, ischemic stroke in territory of qualifying artery beyond 30 days to 2 years after randomization, any stroke or death within 30 days, or ischemic stroke in territory of qualifying artery beyond 30 days to 2 years after randomization.Sample size estimates: The estimated difference is 10% in proportions of the primary outcome between the EC-IC bypass group and medical group, which requires 420 (210 per group) participants to provide valid data to achieve a statistical power of 80% and two-tailed alpha of 5% significance after 10% loss to follow-up or early withdrawal. CMOSS-2 study is expected to confirm the effect of EC-IC bypass surgery for symptomatic..."

Surgery • Ischemic stroke

Accelerated biological aging increases the risk of short- and long-term stroke prognosis in patients with ischemic stroke or TIA. (PubMed, EBioMedicine) - "In this prospective cohort study, BA acceleration, particularly PhenoAge, may help identify stroke patients with risks of short- and long-term poor outcomes, potentially enabling subclinical prevention and early intervention."

Journal • Cardiovascular • Ischemic stroke

Extracranial-intracranial Bypass Surgery Versus Medical Treatment Alone For Symptomatic Chronic Middle Cerebral Artery Occlusion: The Ongoing CMOSS-2 Trial (ISC 2024) - P=N/A | "Medical treatment includes antiplatelet therapy and stroke risk factor control, including low-density lipoprotein cholesterol level and hypertension control with medications as needed, smoking and excess weight control.Outcomes: The primary outcome is ischemic stroke in territory of qualifying artery within 2 years after randomization. There are 9 secondary outcomes, including a composite of any stroke or death within 30 days, or ischemic stroke in territory of qualifying artery beyond 30 days to 2 years after randomization.Trial Status: The study has been registered on ClinicalTrials.gov (Identifier: NCT05899582) and enrollment is ongoing.Sponsor: Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support (ZLRK202320)."

Surgery • Atherosclerosis • Cardiovascular • Dyslipidemia • Hypertension • Ischemic stroke

"#AAD23 was so good! Roses, I’m throwing roses to the cast and crew. 🌹🌹#artafterdark2023" (@queenie4c)

WRKY genes family study reveals tissue-specific and stress-responsive TFs in wild potato species. (PubMed, Sci Rep) - "Those WRKYs were further studied through interactome analysis allowing the identification of potential co-expression relationships between ScWRKYs/SchWRKYs and genes of various pathways. Overall, this study enabled the discrimination of WRKY genes that could be considered as potential candidates in both breeding programs and functional studies."

Journal • Immunology • GEP