Undisclosed LAG-3 targeted IL15/IL15Rα-Fc therapeutic / Xencor - LARVOL DELTA

LAG3-targeted IL15/IL15Rα-Fc (LAG3 x IL15) fusion proteins for preferential TIL expansion via cis delivery of IL15 to LAG3+ cells (SITC 2022) - "In NHP, LAG3 x IL15 has superior PK compared to native IL15-Fc and showed selective targeting of LAG3+ peripheral T cells. Conclusions LAG3 x IL15 shows a promising profile of selective delivery to LAG3+ cells with minimal peripheral activity and may help to preferentially expand LAG3+ TIL in patients with cancer, while potentially avoiding systemic toxicity due to off-target activation and expansion of peripheral lymphocytes."

IO biomarker • Oncology • CD4 • CD8 • IL15 • IL2 • LAG3