Gammaraas (human immunoglobulin (pH4) intravenous) / Shanghai RAAS - LARVOL DELTA

Intravenous immunoglobulin protects the integrity of the intestinal epithelial barrier and inhibits ferroptosis induced by radiation exposure by activating the mTOR pathway. (PubMed, Int Immunopharmacol) - "Rapamycin, which is a potent inhibitor of the mTOR protein, significantly abolished the protective effect of IVIg against radiation-induced damage to intestinal epithelial tight junctions. Overall, IVIg can prevent RE-induced damage to the intestinal epithelial barrier and inhibit ferroptosis by activating the mTOR pathway; this study provides a new treatment strategy for patients with RE caused by radiotherapy or accidental nuclear exposure."

Journal • Gastrointestinal Disorder

Sexual dimorphism in gut microbiota dictates therapeutic efficacy of intravenous immunoglobulin on radiotherapy complications. (PubMed, J Adv Res) - "IVIg battles against radiation injuries in a sex-specific, gut microbiome-dependent way through Lachnospiraceae/hypoxanthine/PLD1 axis. Our findings provide a sex-precise therapeutic avenue to improve the prognosis of cancer patients with radiotherapy in pre-clinical settings."

Journal • Gastrointestinal Disorder • Immunology • Oncology

Impact of cytokine storm on severity of COVID-19 disease in a private hospital in West Jakarta prior to vaccination. (PubMed, PLoS One) - "Factors influencing the development of a cytokine storm include age, duration of treatment, comorbidity, symptoms, type of admission ward and severity of infection. Most patients (76.92%) with cytokine storm who received Gammaraas®/Actemra®, survived although they were in the severe and critical levels (87.17%). Overall, based on the treatment duration and survival rate, the most effective therapy was a combination of oseltamivir + favipiravir + hydroxychloroquine + antibiotics + vitamins/minerals."

Cytokine storm • Journal • Critical care • Diabetes • Fatigue • Hypertension • Infectious Disease • Metabolic Disorders • Novel Coronavirus Disease • Respiratory Diseases