CS2015 / CStone Pharma - LARVOL DELTA

CS2015 A TSLP/OX40L Bispecific Antibody As A Potential Novel Therapeutic Agent For Type2 Inflammation Diseases (ACAAI 2025) - "In the MC903-induced atopic dermatitis model (OX40/OX40L and TSLP/TSLPR humanized mice), treatment with K19YTE and K19LS reduced skin lesion severity, including ear and epidermal thickening. K19YTE and K19LS exhibited favorable PK profile in mice and cynomolgus monkeys, further supporting the development of a subcutaneous injection formulation with extended dosing intervals. Conclusion CS2015, a novel TSLP/OX40L bispecific antibody, represents a potential best-in-class therapeutic candidate for Type2 inflammatory diseases."

IO biomarker • Asthma • Atopic Dermatitis • Dermatitis • Dermatology • Inflammation • Respiratory Diseases • CD4 • CRLF2 • IL4 • TNFSF4 • TSLP

Expanding into Autoimmunity & Inflammation | CStone Unveils Two Novel Bispecific Antibody Targets for Autoimmune/Inflammatory Diseases (CStone Pharma Press Release) - "CStone...announced the first disclosure of the targets for two internally developed bispecific antibodies, aiming to address autoimmune/inflammatory diseases: CS2013 (B-cell-Activating Factor [BAFF]/ A Proliferation-Inducing Ligand [APRIL]); CS2015 (OX40 Ligand [OX40L]/ Thymic Stromal Lymphopoietin [TSLP])...Both have best-in-class (BIC)/first-in-class (FIC) potential and have advanced to the preclinical candidate (PCC) nomination stage, preclinical data will be disclosed at international academic conferences. In addition, the Investigational New Drug (IND)-enabling studies are expected to commence in H2 2025...CS2013 targets B-cell-mediated autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), IgA nephropathy (IgAN)...CS2015, a potential FIC bispecific antibody....provides a strategic approach for type 2 inflammatory diseases including atopic dermatitis (AD), asthma, etc."

Pipeline update • Preclinical • Asthma • Atopic Dermatitis • IgA Nephropathy • Inflammation • Rheumatoid Arthritis • Systemic Lupus Erythematosus