GCC-4401C / GC Biopharma - LARVOL DELTA

Oxidative stress and impaired insulin secretion in cystic fibrosis pig pancreas. (PubMed, Adv Redox Res) - "CF pig pancreas demonstrated increased DHE oxidation (as a surrogate marker of superoxide) in situ compared to non-CF and this was inhibited by a SOD-mimetic (GC4401)...These results are consistent with the hypothesis that CF pig pancreas is under significant oxidative stress as a result of increased O and peroxides combined with reduced antioxidant defenses against reactive oxygen species (ROS). We speculate that insulin secretory defects in CF may be due to oxidative stress."

Journal • Cystic Fibrosis • Diabetes • Fibrosis • Genetic Disorders • Immunology • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases • CAT

Current and Emerging Direct Oral Anticoagulants: State-of-the-Art. (PubMed, Semin Thromb Hemost) - "Several drugs (apixaban [BMS-562247], dabigatran [BIBR953], edoxaban [DU-1766], rivaroxaban [BAY 59-7939]) have already received widespread approval by national or supranational medicinal agencies. This narrative article provides a state-of-the-art for these and for several other DOACs at different stages of clinical evaluation (betrixaban, darexaban, eribaxaban, letaxaban, nokxaban), and certain others whose development has been discontinued (AZD-0837, fidexaban, LY517717, odiparcil, otamixaban, TTP889, and ximelagatran)...These factors contribute to challenging the minds of physicians, who may find difficulty navigating their way through multiple indications, different pharmacological profiles, various side effects, and specific drug-to-drug interactions. Such considerations also burden laboratory professionals, who may face organizational and economic challenges in developing and/or implementing multiple assays to assess the pharmacodynamics (effect on coagulation) or..."

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