NWL-283 / New World Labs - LARVOL DELTA

Primitive and Definitive Neural Precursor Cells Are Present in Human Cerebral Organoids. (PubMed, Int J Mol Sci) - "The drug NWL283, an inhibitor of apoptosis, reduced cell death in COs but did not improve NSC survival. Metformin, a drug used to treat type II diabetes that is known to promote NSC activation in mice, was found to expand human NSC pools. Together, these findings are the first to identify and characterize human pNSCs, advancing our understanding of the human NSC lineage and highlighting drugs that enhance their activity."

Journal • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Inhibition of Apoptosis in a Model of Ischemic Stroke Leads to Enhanced Cell Survival, Endogenous Neural Precursor Cell Activation and Improved Functional Outcomes. (PubMed, Int J Mol Sci) - "Coincident with NWL283 delivery for 8 days, stroke-injured mice exhibited improved functional outcomes that persisted following cessation of the drug. Therefore, we propose that NWL283 is a promising therapeutic warranting further investigation to enhance stroke recovery."

Journal • Cardiovascular • Ischemic stroke • CASP3 • CASP7