Tmi-018 / Translatum Medicus - LARVOL DELTA

Transcriptional regulation of immunometabolism modulates macrophage (M0) behaviour and protects against the onset and expansion of atrophy in a rodent model of age related macular degeneration (AMD) with geographic atrophy (GA) (ARVO 2023) - "Treatment with intravitreal (IVT) TMi-018 (0.2-100ug/eye), an indazole derivative, and BMS309403 (30ug/eye), a known FABP4 inhibitor, were compared against IVT saline...We show that this novel approach dampens unwanted inflammation and directly protects stressed and vulnerable cells. Accordingly, we suggest that modulation of 'immunometabolism' by molecules that mimic fatty acids may be effective in reducing GA formation and expansion in patients with AMD."

Preclinical • Age-related Macular Degeneration • Dry Age-related Macular Degeneration • Macular Degeneration • Ophthalmology • Retinal Disorders • CCL2 • CD36 • FABP4 • IL6 • PPARG • TNFA