Z160 / Sun Pharma - LARVOL DELTA

Comparative pharmacokinetics of four major compounds after oral administration of Mori Cortex total flavonoid extract in normal and diabetic rats. (PubMed, Front Pharmacol) - "The transitions of m/z 300.9→107.1, m/z 419.3→297.1, m/z 160.9→77.0, m/z 567.1→243.2 and m/z 283.1→268.2 were selected for morin, morusin, umbelliferone, mulberroside A and internal standard, respectively...For umbelliferone and mulberroside A, the AUC and C also increased significantly in diabetic rats (p < 0.05). The validated method was successfully applied to the pharmacokinetic study in normal and diabetic rats."

Journal • PK/PD data • Preclinical • Diabetes • Metabolic Disorders

Development of Flow Injection Analysis Method for the Second-Tier Estimation of Succinylacetone in Dried Blood Spot of Newborn Screening. (PubMed, Indian J Clin Biochem) - "Detection and quantification was performed by the mass spectrometer using multiple reaction monitoring mode at m/z 155.1 → 109.1 for SUAC and m/z 160.1 → 114.1 for the SUAC IS...The accuracy also ranged between 101.2 and 103.87%.This method provided the necessary sensitivity, precision, accuracy, recovery and linearity and hence, has the potential to reduce the false positive, false negative results which significantly minimise the cost involved in the screening and follow up of TYR1 patients. The online version of this article (10.1007/s12291-020-00944-z) contains supplementary material, which is available to authorized users."

Journal • Metabolic Disorders

Identification of New Psychoactive Tryptamines 4-OH-MET and 4-AcO-DMT Using High Resolution Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy (PubMed, Fa Yi Xue Za Zhi) - "The main ions in the secondary mass spectrum under the collision-induced dissociation （CID） mode were m/z 160.076 3 and 72.080 8...NIST 17 library retrieval and H-NMR confirmed that the white powder and brown powder contained new psychoactive tryptamines 4-OH-MET and 4-AcO-DMT, respectively. Conclusion GC-QTOF-MS, UPLC-LTQ-Orbitrap MS and H-NMR can be used together to identify unknown new psychoactive substances."

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Profiling of Volatile Organic Compounds in Wild Indigenous Medicinal Ginger (Zingiber barbatum Wall.) from Myanmar. (PubMed, Metabolites) - "Four accessions (ZO191, ZO223, ZO217, and the control accession ZO105) collected from the Shan State and Mandalay region of Myanmar were found to share a similar VOC profile, while two accessions (ZO64 and ZO160) collected from the Bago region were found to vary in their VOC profiles compared with the control accession. The two identified compounds, i.e., α-bergamotene and β-(E)-guaiene may serve as discriminative chemical markers for the characterization of Z. barbatum species collected in these three geographical regions of Myanmar. This study represents a first attempt to identify and describe the VOCs in the medicinal species Z. barbatum that have not been reported to date."

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Zalicus secures new $25 million funding commitment from Lincoln Park capital (Businesswire) - "This arrangement with Lincoln Park is an attractive financing alternative for Zalicus at this time because it provides us with flexible access to capital...as we work to obtain the results from the clinical trials of our lead product candidates Z160 and Z944 later this year."

Financing • Pain

Zalicus reports financial results for the fourth quarter and year end 2012 (Zalicus) - "Advanced Z160...into the second of two Phase 2a clinical trials for the potential treatment of chronic neuropathic pain, including lumbosacral radiculopathy which began in the third quarter of 2012 and postherpetic neuralgia which began in the fourth quarter of 2012. Top line data from both studies are expected to be available late in the second half of 2013...Advance Z944 through further clinical development including completing one experimental medicine clinical study in 2013."

Anticipated P2 data • Anticipated trial completion date • Pain

Zalicus’ Z160 for chronic neuropathic pain selected as a top 10 project to watch (Zalicus) - "Zalicus...announced that Z160...has been chosen by Windhover as one of the Top 10 Neuroscience Projects to Watch. Mark Corrigan, MD, CEO of Zalicus, will provide a summary of Z160 during his presentation at the Windhover 2012 Therapeutic Area Partnership meeting being held at the Westin Copley Place Boston at 1:30 p.m. ET on Thursday, November 29, 2012 during the Top 10 Neuroscience Projects to Watch session."

Conference • Pain

Zalicus initiates the second of two phase 2a studies with Z160 (Zalicus) - P2a, N=140; NCT01757873; "Zalicus Inc...has initiated the second of two Phase 2a clinical studies with Z160...Top line data from both studies are expected to be available late in the second half of 2013."

Anticipated P2 data • Trial initiation date • Pain

Zalicus successfully completes phase 1 clinical study with reformulated Z160 (Businesswire) - In the study, Z160 demonstrated substantial bioavailability and solubility improvements using a novel, proprietary formulation technology; Based on the data from this study, Zalicus plans to advance Z160 into P2 clinical development for the treatment of neuropathic pain in the H2 2012

Anticipated P2 study • P1 completion • Pain

The Entner-Doudoroff and Nonoxidative Pentose Phosphate Pathways Bypass Glycolysis and the Oxidative Pentose Phosphate Pathway in Ralstonia solanacearum. (PubMed, mSystems) - "solanacearum F1C1 cells fed with [C]glucose (99% [1-C]glucose or 99% [1,2-C]glucose or 40% [C]glucose) followed by gas chromatography-mass spectrometry (GC-MS)-based labeling analysis of fragments from amino acids, glycerol, and ribose provided clear evidence that rather than glycolysis and the OxPPP, the ED pathway and non-OxPPP are the main routes sustaining metabolism in R. solanacearum The C incorporation in the mass ions of alanine (m/z 260 and m/z 232), valine (m/z 288 and m/z 260), glycine (m/z 218), serine (m/z 390 and m/z 362), histidine (m/z 440 and m/z 412), tyrosine (m/z 466 and m/z 438), phenylalanine (m/z 336 and m/z 308), glycerol (m/z 377), and ribose (m/z 160) mapped the pathways supporting the observations...The outcomes help better define the central carbon metabolic network of R. solanacearum that can be integrated with C metabolic flux analysis as well as flux balance analysis studies for defining the metabolic phenotypes. The study highlights the..."

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Urban wastewater photobiotreatment with microalgae in a continuously operated photobioreactor: growth, nutrient removal kinetics and biomass coagulation-flocculation. (PubMed, Environ Technol) - "...Four coagulants (aluminium sulphate, ferric sulphate, ferric chloride and polyaluminium chloride (PAC)) and five flocculants (Chemifloc CM/25, FO 4498SH, cationic polymers Zetag (Z8165, Z7550 and Z8160)) were tested to determine the optimal dosage to reach 90% of biomass recovery...Results indicated that the removal of total dissolved nitrogen and total dissolved phosphorous under continuous operation were greater than 99%. PAC, Fe2(SO4)3 and Al2(SO4)3 were the best options from an economical point of view for microalgae harvesting."

Journal

Prognostic Metabolite Biomarkers for Soft Tissue Sarcomas Discovered by Mass Spectrometry Imaging. (PubMed, J Am Soc Mass Spectrom) - "FTICR-MSI identified m/z 241.0118 as inositol cyclic phosphate and m/z 160.8417 as carnitine. Graphical Abstract ᅟ."

Biomarker • Journal

Real-Time Quantitative Analysis of Valproic Acid in Exhaled Breath by Low Temperature Plasma Ionization Mass Spectrometry. (PubMed, J Am Soc Mass Spectrom) - "...In particular, the effect of working conditions and geometry of the LTP source on the ions of interest, protonated molecular ion at m/z 143 and ammonium adduct ion at m/z 160, were systematically characterized...Our results show that LTP-MS is a powerful analytical platform with high sensitivity for quantitative analysis of volatile organic compounds in human breath, and can have potential applications in pharmacokinetics or for patient monitoring and treatment. Graphical Abstract ᅟ."

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