curcumin/doxorubicin (iMX-110) / Immix Biopharma - LARVOL DELTA

Coencapsulation of doxorubicin and curcumin in liposomes modified with folic acid for reversal of drug resistance in glioma. (PubMed, Front Oncol) - "Mechanistic analysis confirmed that Cur effectively suppressed P-gp expression, thereby restoring Dox sensitivity. This FA-functionalized codelivery system combines active targeting with MDR reversal, showing improved cellular uptake in vitro and antitumor efficacy in subcutaneous xenografts, with potential for BBB penetration as suggested by in vitro models."

Journal • Brain Cancer • Glioma • Oncology • Solid Tumor

Design, synthesis, anticancer, antioxidant and computational evaluation of curcumin-benzodiazepine derivatives. (PubMed, 3 Biotech) - "and tested derivatives 3d (2.85 ± 0.57), 3e (4.26 ± 0.82), and 3c (5.64 ± 1.09) showed comparable activities to the reference Doxorubicin (1.80 ± 0.21)...The molecular dynamic simulation investigated for structural dynamic determination of proteins interaction with ligands at an atomic level. The online version contains supplementary material available at 10.1007/s13205-026-04823-x."

Journal • Breast Cancer • Oncology • Solid Tumor

Combined Curcumin and Doxorubicin Induce Apoptosis via JNK-Dependent MAPK Signaling Independent of TXNDC5 in Human Osteosarcoma Cells. (PubMed, Nutrients) - "These findings indicate that combined curcumin and doxorubicin induce apoptosis primarily through JNK-dependent MAPK signaling, accompanied by stress-associated cellular responses."

Journal • Oncology • Osteosarcoma • Sarcoma • Solid Tumor • HSPA5 • MAPK8

Studies on the anti-tumor effects of curcumin synergizing with doxorubicin in inducing immunogenic cell death. (PubMed, Nanomedicine) - "Moreover, they effectively promote CRT exposure, HMGB1 release, and ATP secretion in 4T1 cells. Furthermore, in a murine breast cancer model, CMCS-D + C/NPs significantly upregulate the expression of proteins such as CD8 and Caspase-3, cytokines (IFN-γ and IL-6), and Granzyme B, demonstrating favorable antitumor efficacy."

Journal • Breast Cancer • Oncology • Solid Tumor • CASP3 • CD8 • GZMB • HMGB1 • IFNG • IL6

Curcumin Synergistically Sensitizes Multidrug-Resistant Lung Cancer to Doxorubicin Through Ferroptosis-Associated Oxidative Stress. (PubMed, Antioxidants (Basel)) - "Molecular docking analyses supported the binding of CUR and DOX to key ferroptosis regulators. This study shows the potential of CUR to sensitize DOX-resistant cancer cells through ferroptosis-linked-oxidative stress targeting."

Journal • Hematological Disorders • Lung Cancer • Metabolic Disorders • Oncology • Solid Tumor • CASP3

Chemoresistance mitigation of dual drug-loaded nanoparticles with doxorubicin and curcumin. (PubMed, Cytotechnology) - "This study investigates the characterization and biological effects of Dual Drug-Loaded Nanoparticles on HepG2/doxorubicin (DOX) cells, focusing on the anti-cancer ability of Doxorubicin/Curcumin-Polyethylene Glycol-Polycaprolactone Nanoparticles (DOX/Cur-PEG-PCL-NPs)...These results demonstrate that DOX/Cur-PEG-PCL-NPs effectively reverse chemoresistance and suppress tumor progression through modulation of the Nrf2 pathway and apoptosis induction, offering a promising strategy for targeted liver cancer therapy. The online version contains supplementary material available at 10.1007/s10616-025-00855-y."

Journal • Liver Cancer • Oncology • Solid Tumor • ABCB1 • ABCC1 • BAX • CASP3 • HMOX1 • KEAP1 • NQO1

Towards implementing optimized methodologies and in-depth molecular profiling to assess the pharmacological potential of human lung fibroblast exosomes as bio-shuttles for cancer therapeutics. (PubMed, Eur J Pharm Sci) - "This study aims to: (a) identify the optimal methodology for isolating intact MRC-5 cell-derived exosomes with high purity and integrity suitable for drug delivery applications, (b) elucidate the global miRNA and proteomic profile of the isolated exosomes using high-throughput methodologies and bioinformatics, (c) investigate the exosome uptake capacity towards the "autologous" normal MRC-5, and "heterologous" malignant human lung adenocarcinoma A549 and tongue squamous HSC-3 cells, (d) evaluate the pharmacological profile of doxorubicin (DOX)- and curcumin (CUR)- loaded exosomes towards the normal and tumorigenic cells in vitro...Exosomal CUR and exosomal DOX inhibited tumor cell proliferation more efficiently than free drugs, with synergistic effects upon co-administration. This study provides a comprehensive morphological, physicochemical and molecular characterization of MRC-5 cell-derived exosomes and validates the "intrinsic" tropism..."

Journal • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor

Emerging nanostructure-based strategies for breast cancer therapy: innovations, challenges, and future directions. (PubMed, Med Oncol) - "Nanostructures encapsulating anticancer agents such as doxorubicin, curcumin, paclitaxel, erlotinib, and docetaxel enhance the therapeutic efficacy of these agents and promote targeted drug delivery. Further research should focus on optimizing these nanoparticles to enhance the targeted drug delivery and address multi-drug resistance. Our review underscores recent developments in nanostructures, their therapeutic potential, and the challenges that need to be addressed for more effective breast cancer treatment."

Journal • Review • Breast Cancer • Oncology • Solid Tumor

Fmoc-FF Nanogel-Mediated Delivery of Doxorubicin and Curcumin in Thyroid Cancer Cells. (PubMed, Pharmaceutics) - "Comparative studies with CUR-loaded NGs revealed similar internalization and delayed nuclear uptake, highlighting the efficacy of Fmoc-FF NGs in delivering hydrophobic agents. Overall, the data suggest that Fmoc-FF NGs represent a promising strategy for delivering agents with diverse physicochemical properties in TC, enhancing their efficacy and safety and warranting further investigation."

Journal • Endocrine Cancer • Oncology • Solid Tumor • Thyroid Gland Carcinoma

Mitigating doxorubicin-induced hepatotoxicity in male rats: The role of aerobic interval training and curcumin supplementation in reducing oxidative stress, endoplasmic reticulum stress and apoptosis. (PubMed, Sci Rep) - "Both curcumin and AIT significantly reduced DOXO-triggered oxidative damage, ER stress, and apoptosis (P < 0.05), with the latter showing slightly higher effectiveness. Consequently, the combination of AIT with curcumin supplementation exhibits protective effects against chronic hepatotoxicity induced by DOXO, with AIT demonstrating relatively greater efficacy in increasing antioxidant capacity and reducing ER stress and apoptosis."

Journal • Preclinical • Hepatology

A nano drug delivery system loading drugs and chlorin e6 separately to achieve photodynamic-chemo combination therapy. (PubMed, Nanomedicine (Lond)) - "Doxorubicin (DOX) was loaded into the pores of MSNs...Additionally, in vitro experiments suggested that the nanoparticles had pleasing toxicity to various tumor cells and equally positive therapeutic effect when curcumin replaced DOX. Our work suggests that the nanoparticles designed by our strategy have satisfactory combination therapy performance and can enable more chemotherapy drugs to be used in photodynamic-chemo combination therapy."

Journal • Oncology

Liposomal Codelivery of Doxorubicin and Curcumin Sensitizes Antitumor Activity and Reduces Tumor Metastasis. (PubMed, ACS Appl Bio Mater) - "Compared to the conventional DOX treatment, the dual-drug treatment exhibits a significantly improved anticancer effect. In the murine metastasis 4T1 IP tumor model, the dual-drug-encapsulating liposomes successfully suppressed tumor growth and reversed the tumoral effect (omental tumor metastasis, fat, and muscle weight loss) into a normal state."

Journal • Oncology

Human and canine osteosarcoma cell lines: How do they react upon incubation with calcium phosphate-coated lipid nanoparticles carrying doxorubicin and curcumin? (PubMed, Int J Pharm) - "Additionally, the combination treatment led to a further increase in C12DOXO retention when cells were also treated with the P-gp inhibitor verapamil, indicating enhanced efficacy against MDR mechanisms. Notably, canine OSA cells exhibited a distinct response pattern, suggesting the presence of species-specific differences that warrant further investigation."

Journal • Preclinical • Oncology • Osteosarcoma • Sarcoma • Solid Tumor

Fabrication of curcumin-loaded nano-micelles based on quercetin-quarternary ammonium-chitosan (Qu-QCS) conjugate and evaluation of synergistic effect with doxorubicin against breast cancer. (PubMed, Int J Biol Macromol) - "Moreover, the co-treatment of dox with cur-loaded Qu-QCS nano-micelles showed increased anticancer activity and reduced cardiotoxicity. Overall, this study suggests the potential applications of cur-loaded Qu-QCS micelles in the delivery of chemotherapeutic agents and complementary support in combination with chemotherapeutic agents."

Journal • Breast Cancer • Cardiovascular • Oncology • Solid Tumor

Conquering dual challenges: A sialic-modified liposome for targeting activated neutrophils to tackle comorbid lung inflammation and cancer metastasis. (PubMed, J Control Release) - "In this context, we introduce a novel therapeutic approach involving a sialic acid-lipid derivative (SA-PG10-C18) modified doxorubicin-curcumin co-loaded liposome (DOX/CUR-SAL)...The treated animals demonstrated favorable survival conditions, persisting beyond 45 days. This innovative therapeutic strategy offers a novel concept and reference for treating comorbid conditions of tumors and inflammation, thus breaking the clinical impasse where lung inflammation and cancer metastasis have been treated separately."

Journal • Acute Lung Injury • Infectious Disease • Lung Cancer • Oncology • Pneumonia • Respiratory Diseases

Exploiting lignin-based nanomaterials for enhanced anticancer therapy: A comprehensive review and future direction. (PubMed, Int J Biol Macromol) - "Lignin nanoparticles loaded with drugs like curcumin, doxorubicin, camptothecin, and resveratrol have demonstrated the ability to improve drug efficacy, selectively target cancer cells, overcome multidrug resistance, and minimize toxicity in both in vitro and in vivo studies...Future research directions include optimizing lignin nanoparticle formulations for clinical applications, refining targeted delivery mechanisms to cancer cells, and conducting thorough biocompatibility and toxicity assessments. Overall, this review highlights the significant progress made in utilizing lignin-based nanomaterials for cancer therapy and outlines promising areas for further exploration in this rapidly evolving field."

Journal • Review • Oncology

Cytotoxicity of Doxorubicin-Curcumin Nanoparticles Conjugated with Two Different Peptides (CKR and EVQ) against FLT3 Protein in Leukemic Stem Cells. (PubMed, Polymers (Basel)) - "Moreover, DCM-C + E and CM-C + E showed the highest toxicity in KG-1a and EoL-1 cells. Using two peptides likely improves the probability of micelles binding to the FLT3 receptor and induces cytotoxicity in leukemic stem cells."

Journal • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology • FLT3

Investigation of green synchronous spectrofluorimetric approach for facile sensitive estimation of two co-administered anti-cancer drugs; curcumin and doxorubicin in their laboratory-prepared mixtures, human plasma, and urine. (PubMed, BMC Chem) - "It showed a high percentage of recoveries with minimal RSD values. Additionally, three different tools were utilized to evaluate the greenness of the proposed approach."

Journal • Oncology

Harnessing the therapeutic potential of phytochemicals in neuroblastoma. (PubMed, Biofactors) - "Several studies have used plant-derived bioactive compounds such as phenolics and flavonoids, suggesting modulation of biomolecules and signal transduction pathways involved in neuroblastoma. We reviewed the findings of recent preclinical and clinical studies demonstrating the effects of phytochemicals on neuroblastoma, shedding light on their molecular mechanism of action and potential therapeutic applications."

Journal • Review • CNS Tumor • Neuroblastoma • Oncology • Pediatrics • Solid Tumor

Reduction-Responsive Polyprodrug Nanoplatform Based on Curcumin for Tumor-Targeted Therapy. (PubMed, Curr Drug Deliv) - "The prepared reduction-responsive targeted polymer nanomedical DOX/HAPCS NPs exhibited a synergistic anti-cancer effect, with high drug loading capacity and the ability to release drugs in proportion, making it a promising polymer nanoparticle drug delivery system."

Journal • Oncology

Dual-Drug Loaded Nanobubbles Combined with Sonodynamic and Chemotherapy for Hepatocellular Carcinoma Therapy. (PubMed, Int J Nanomedicine) - "We developed curcumin/doxorubicin-cis-aconitic anhydride-polyethylene glycol nanobubble (C/DCNB) surface modified with acid-sensitive polyethylene glycol (PEG)...In vitro and vivo experiments demonstrate that C/DCNB can facilitate contrast-enhanced ultrasound imaging while simultaneously delivering drugs, enabling both imaging and treatment. The combination of C/DCNB and ultrasound provides an effective strategy for improving the efficiency of HCC therapy and imaging."

Journal • Gastrointestinal Cancer • Hepatocellular Cancer • Oncology • Solid Tumor

Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative Stress, preventing inflammation and apoptosis: Ultrastructural and computational approaches. (PubMed, Heliyon) - "In cardiac tissue, CMN significantly increased the concentrations of SOD and CAT and significantly decreased the concentrations of MDA and TNF-α. Biochemical and histological studies have demonstrated that CMN has a heart-protective effect that might be related to its antioxidant and anti-inflammatory capabilities."

Journal • Cardiovascular • Inflammation • Oncology • CAT • TNFA

Dual centrifugation as a novel and efficient method for the preparation of lipodisks. (PubMed, Int J Pharm) - "Furthermore, our investigations confirm the efficacy of DC in formulating curcumin and doxorubicin within these lipodisks. For doxorubicin, careful control and optimization of the experimental conditions resulted in formulations displaying an encouraging encapsulation efficiency of 84 % and a favourable drug-to-lipid ratio of 0.13 in the disks."

Journal

Long-Acting Nanohybrid Hydrogel Induces Persistent Immunogenic Chemotherapy for Suppressing Postoperative Tumor Recurrence and Metastasis. (PubMed, Mol Pharm) - "Here, we constructed an injectable curcumin/doxorubicin-loaded nanoparticle (NanoCD) hydrogel, which could effectively inhibit tumor regrowth and metastasis via reshaping the tumor immune microenvironment (TIME) for highly effective postsurgical cancer treatment...Upon being injected into the tumor cavity after resection, the in situ-generated NanoCD@Gel allowed the local release of CUR and DOX in a controlled manner to induce local chemotherapy and persistently activate the antitumor immune response, thereby achieving enhanced immunogenic chemotherapy with reduced systemic toxicity. Our work provides an elegant strategy for persistently stimulating effective antitumor immunity to prevent postsurgical tumor recurrence and metastasis."

Journal • Oncology

A PHASE 1/2A OPEN-LABEL, DOSE-ESCALATION/DOSE EXPANSION SAFETY, TOLERABILITY AND PHARMACOKINETIC STUDY OF IMX-110 IN PATIENTS WITH ADVANCED SOLID TUMORS (CTOS 2023) - "N/A This abstract is submitted under Trials in Progress"

Clinical • Metastases • P1/2 data • PK/PD data • Oncology • Solid Tumor • STAT3