cyclophilin D inhibitor / Cypralis, J&J - LARVOL DELTA

The Novel Cyclophilin D Inhibitor CC-2055 Exerts Anti-Seizure Effects in the Mouse Pilocarpine Model of Epilepsy Via Rescue of Hippocampal Parvalbumin-Positive Interneurons (AES 2022) - "Earlier, we reported that pharmacological inhibition of CypD with cyclosporin A or N-methyl-4-isoleucine-cyclosporin (NIM811) renders anti-seizure effects in epileptic Kcna1-null mice (PMID: 25899847). The novel CypD antagonist, CC-2055, induces anti-seizure effects in the mouse pilocarpine model of epilepsy. CC-2055 also appears to restore PV+ interneuron numbers in CA1 hippocampus and reverses the electrophysiological changes in CA1 pyramidal cells from pilocarpine-treated mice. Taken together, our preliminary results further support the scientific rationale for the development of CypD antagonists as novel anti-seizure medications."

Late-breaking abstract • Preclinical • CNS Disorders • Epilepsy • PPIF