Zenavod (doxycycline) / Dr. Reddy’s - LARVOL DELTA

Visible-light enhanced tetracycline degradation via SnO2/TiO2-Ni@rGO ternary heterostructures. (PubMed, Luminescence) - "The SnO2/TiO2-Ni@rGO composite also exhibited excellent reusability, maintaining high catalytic performance over four consecutive cycles. These findings suggest that the SnO2/TiO2-Ni@rGO nanocomposite is a promising candidate for the efficient and sustainable photocatalytic degradation of persistent organic pollutants like TC, offering significant potential for environmental remediation applications."

Journal

Review on antibiotic pollution dynamics: insights to occurrence, environmental behaviour, ecotoxicity, and management strategies. (PubMed, Environ Sci Pollut Res Int) - "Fluoroquinolones, macrolides, tetracyclines, and sulphonamides have emerged as prevalent contaminants in environmental matrices worldwide...It also advocates for the development and implementation of tailored national action plans that consider specific environmental conditions and factors. Thus, an approach is crucial for safeguarding both public health and the delicate balance of our natural ecosystems."

Journal • Review

Efficiency and Mechanistic Insights of Photocatalytic Decomposition of Tetracycline and Rhodamine B utilizing Z-scheme g-C3N4/SnWO4 Heterostructures under Visible Light Irradiation. (PubMed, Environ Res) - "Attributed to its unique structural features, and effective separation of charge carriers, the Z-scheme gCNSW-7.5 heterostructure photocatalyst exhibits significant promise as an exceptionally efficient catalyst for the degradation of pollutants. This positions it as a prospective material with considerable potential across various environmental applications."

Journal

Dr. Reddy's Laboratories Announces the Launch of Doxycycline Capsules, 40 mg in the U.S. (Businesswire) - "Dr. Reddy's Laboratories Ltd...announced its launch of Doxycycline Capsules, 40 mg in the U.S. market, a therapeutic generic equivalent of ORACEA (doxycycline, USP) Capsules, 40 mg approved by the U.S. Food and Drug Administration (USFDA). Dr. Reddy’s Doxycycline Capsules, 40 mg, are supplied in bottle counts of 30....Each capsule contains: 26 mg immediate-release pellets and 14 mg delayed-release pellets equivalent to 40 mg of anhydrous doxycycline, USP."

Generic launch • Oncology

2D g-CN nanosheets functionalized with nickel-doped ZrO nanoparticles for synergistic photodegradation of toxic chemical pollutants. (PubMed, Chemosphere) - "The synthesized photocatalyst degraded rhodamine B (RhB) and tetracycline (TC) with ∼92% and ∼89% degradation efficiency, respectively...The radical scavenging experiments suggested that O and OH radicals contributed substantially to the dye elimination activity of the composite. Therefore, the synthesized novel nanohybrid catalysts in this study present an efficient and straightforward synthesis method for the efficient removal of toxins from wastewater under visible light irradiation."

Journal

Experimental and numerical elucidation of the fate and transport of antibiotics in aquatic environment: A review. (PubMed, Environ Monit Assess) - "Among all, tetracycline was found to more unstable (log K =  - 0.62 to - 1.12) that can readily undergo photolysis and hydrolysis; whereas macrolides were more stable (log K = 3.06 to 4.02) that are prone to biodegradation...Addressing these aspects collectively is the key to exploring the emergence of antimicrobial resistance. Therefore, a comprehensive model involving antimicrobial resistance parameters like fitness cost, bacterial population dynamics, conjugation transfer efficiency, etc. is required to predict the fate of antibiotics."

Journal • Review

Phytotoxic Effects of Tetracycline and its Removal Using Canna indica in a Hydroponic System. (PubMed, Bull Environ Contam Toxicol) - "These findings emphasize the importance of monitoring tolerance levels induced by antibiotics in plant species. Thus, monitoring the antibiotic-induced-tolerance levels in plant species is crucial for maintaining plant health and effectively managing abiotic stress, ensuring efficient recovery and facilitating an effective wetland treatment system."

Journal

Synthesis of transition metal ions doped-ZrO nanoparticles supported g-CN hybrids for solar light-induced photocatalytic removal of methyl orange and tetracycline pollutants. (PubMed, Chemosphere) - "It was further revealed that the development of heterojunctions between g-CN and Fe-doped ZrO nanoparticles effectively reduced the recombination rate of electron and hole pairs within the photocatalyst system, resulting in improved photocatalytic activity. Previous studies have pointed at the superoxide radical anions (˙O) and (OH·) as being primarily responsible for the degradation of MO and TC species, leading us to hypothesize that the g-FZ composite works via a possible free-radical based catalytic mechanism to support the photodegradation process."

Journal

Vachellia schaffneri leaves: A forestry waste or a sustainable resource of antibacterial compounds against foodborne pathogens? (ACS-Fall 2022) - "As a part of our ongoing research on investigating phytoceuticals from forestry waste, we have carried out a bioactivity-guided cold extraction of Vachellia schaffneri leaves in water and evaluated the antibacterial activity of our extract against Listeria innocua, Salmonella typhimurium, and Escherichia coli O157:H7 by antibiotic disc diffusion assay using tetracycline (20 mg/disc) as a positive control...This study indicates that Vachellia schaffneri leaf extract has antimicrobial properties against the tested foodborne pathogens. Further investigation confirmed the presence of antibacterial compounds in the extract."

Novel Z-scheme Binary Zinc Tungsten Oxide/Nickel Ferrite Nanohybrids for Photocatalytic Reduction of Chromium (Cr (VI)), Photoelectrochemical Water Splitting and Degradation of Toxic Organic Pollutants. (PubMed, J Hazard Mater) - "Herein, we evaluated the photocatalytic removal of Cr(VI), and degradation of tetracycline (TC) and methylene blue (MB) by the nanocomposite, as well as its ability to split water...The photoelectrochemical analysis confirmed that NiFeO-ZnWO exhibited minor charge-transfer resistance and large photocurrents. We propose a novel and efficient approach for designing a coupled heterostructured nanocomposites with a significant solar light ability for ecological conservation and water splitting."

Journal

[VIRTUAL] Esophageal Actinomycosis Presenting as Persistent Dysphagia in an Immunocompromised Host (ACG 2020) - "He was initially treated with PO Cefdinir for 4 weeks without resolution of symptoms, then started on Augmentin, again without any relief...Actinomyces remain highly sensitive to Penicillin however if allergy is present, tetracyclines, clindamycin, and macrolides are alternative options. In some cases, surgical drainage may be required."

Allergy • Gastrointestinal Disorder • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Mood Disorders • Oncology • Tuberculosis

[VIRTUAL] CDK5 DRIVES THE PHOSPHOPROTEOMICS OF PANCREATIC NEUROENDOCRINE TUMORS AND IS A THERAPEUTIC TARGET (APCM 2020) - "p25 overexpression was induced with dietary doxycycline (dox) at 24 weeks... Aberrant Cdk5 activity is seen in all hPNET and is a potential therapeutic target. We have created the first transgenic model of PNET that behaves like human disease and have identified molecular pathways that are being activated in PNET. This mouse is a powerful tool that can be used to interrogate the biological systems driving these tumors."

Anaplastic Thyroid Cancer • Medullary Thyroid Cancer • Neuroendocrine Tumor • Oncology • Pancreatic Cancer • Retinal Disorders • Solid Tumor • Thyroid Cancer • CDK4 • LRIG1

SELECTION OF AN APROPRIATE HELICOBACTER PYLORI ERADICATION REGIMEN IN AN URBAN POPULATION: A QUALITY IMPROVEMENT PROJECT (POSTER PRESENTATION) (DDW 2020) - "In the US, most commonly used therapies for H. pylori eradication include clarithromycin-based triple therapy (PPI, clarithromycin, and amoxicillin) and quadruple therapy (PPI, bismuth, metronidazole, and tetracycline)... Treatment failure rate with clarithromycin-based triple therapy was > 15 % in our urban population. Educational conferences and reminders resulted in 98 % increase in appropriate selection of quadruple therapy for H. pylori eradication"

Clinical • Gastric Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Oncology • Peptic Ulcer • Solid Tumor

FACTORS PREDICTIVE OF HELICOBACTER PYLORI INFECTION RECURRENCE: A SINGLE CENTER EXPERIENCE (DDW 2020) - "In the US, most commonly used therapies for H. pylori eradication include clarithromycin-based triple therapy (PPI, clarithromycin, and amoxicillin) and quadruple therapy (PPI, bismuth, metronidazole, and tetracycline)... Quadruple therapy is superior to triple therapy and associated with lower rates of H. pylori recurrent infection. In areas suspected of having a high resistance to H. pylori, or patients with a history of clarithromycin exposure, clinicians should strongly consider the use of quadruple therapy as a first line regimen"

Clinical • Gastric Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Oncology • Peptic Ulcer • Solid Tumor

Target site pharmacokinetics of doxycycline for rosacea in healthy volunteers is independent of food-effect (PI Markus Zeitlinger). (PubMed, Br J Clin Pharmacol) - "At steady state, doxycycline concentrations in skin of fed and fasting healthy volunteers were comparable. Doxycycline's efficacy in rosacea is possibly due to considerable dermal accumulation of unbound doxycycline and is independent of food-effect. EudraCT registration number 2016-001622-34."

Clinical • Journal • PK/PD data