GW843682X / GSK - LARVOL DELTA

In vitro targeting of polo-like kinase 1 in bladder carcinoma: Comparative effects of four potent inhibitors (Cancer Biol Ther) - PMID: 23792639; “PLK1 inhibition prevented cell proliferation and clonogenicity, causing significant inhibition of invasion of tumor cells, though modest differences were observed between drugs. Moreover, all PLK1 inhibitors induced G 2/M arrest, with the subsequent induction of death in all three cell lines.”

Preclinical • Oncology