CAR peptide / Vascular BioSci - LARVOL DELTA

CAR Peptide Targeted Liposomes Loaded With an Admixture of Fasudil and DETA Nonoate for the Treatment of Pulmonary Arterial Hypertension (ATS 2024) - "In sum, this research has exhibited the potential medical benefits of fasudil and DN, either separately or combined, administered through the trachea in CAR-modified lipid mixtures, in a Su/Hx-induced PAH rat model. This study underscores the potential of combination therapy and targeted drug delivery in PAH treatment, laying the groundwork for future investigations into the optimization of these treatments, their long-term safety and efficacy, and the underlying mechanism of action of the proposed therapy."

Late-breaking abstract • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Intratracheally Administered Peptide-Modified Lipid Admixture Containing Fasudil and/or DETA NONOate Ameliorates Various Pathologies of Pulmonary Arterial Hypertension. (PubMed, Pharmaceuticals (Basel)) - "The findings reveal that fasudil, DN, and their combination in a CAR-modified lipid mixture improved pulmonary hemodynamics, RV functions, and pathological alterations in the pulmonary vasculature. This study underscores the potential of combination therapy and targeted drug delivery in PAH treatment, laying the groundwork for future investigations into the optimization of these treatments, their long-term safety and efficacy, and the underlying mechanism of action of the proposed therapy."

Journal • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases