E2307 / Eisai - LARVOL DELTA

Biomarkers. (PubMed, Alzheimers Dement) - "This data suggests that the amygdala is a robust region for detecting early tau aggregation by MK6240 PET and that a rise in plasma pTau217 is associated with early formation of NFT rather than a direct physiological response to brain Aβ plaques prior to NFT formation. Figure 1 legend: Modeling of 18F-MK6240 quantification and pTau217 as a function of Centiloid. Biomarker values Z-scored using the results from Aβ- cognitively unimpaired to define the normal range for p217+tau level and each tau PET ROI SUVR. The horizontal line is +2 standard deviations (SD). 1Doré V, Doecke JD, …, Rowe CC. Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum. Alzheimers Dement (Amst). 2022 Apr 5;14(1):e12307. doi: 10.1002/dad2.12307. PMID: 35415202; PMCID: PMC8984092."

Biomarker • Journal • Alzheimer's Disease • CNS Disorders

Alzheimer's Imaging Consortium. (PubMed, Alzheimers Dement) - "This data suggests that the amygdala is a robust region for detecting early tau aggregation by MK6240 PET and that a rise in plasma pTau217 is associated with early formation of NFT rather than a direct physiological response to brain Aß plaques prior to NFT formation. Figure 1 legend: Modeling of 18F-MK6240 quantification and pTau217 as a function of Centiloid. Biomarker values Z-scored using the results from Aß- cognitively unimpaired to define the normal range for p217+tau level and each tau PET ROI SUVR. The horizontal line is +2 standard deviations (SD). 1Doré V, Doecke JD, …, Rowe CC. Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum. Alzheimers Dement (Amst). 2022 Apr 5;14(1):e12307. https://doi.org/10.1002/dad2.12307. PMID: 35415202; PMCID: PMC8984092."

Biomarker • Journal • Alzheimer's Disease • CNS Disorders

Plasma phospho-tau 217 rises with and not before early tau aggregation measured by MK6240 PET (AAIC 2024) - "2022 Apr 5;14(1):e12307. This data suggests that the amygdala is a robust region for detecting early tau aggregation by MK6240 PET and that a rise in plasma pTau217 is associated with early formation of NFT rather than a direct physiological response to brain Aβ plaques prior to NFT formation. Figure 1 legend: Modeling of 18 F-MK6240 quantification and pTau217 as a function of Centiloid. Biomarker values Z-scored using the results from Aβ- cognitively unimpaired to define the normal range for p217+tau level and each tau PET ROI SUVR."

Alzheimer's Disease • CNS Disorders

Plasma phospho-tau 217 rises with and not before early tau aggregation measured by MK6240 PET (AAIC 2024) - "2022 Apr 5;14(1):e12307. This data suggests that the amygdala is a robust region for detecting early tau aggregation by MK6240 PET and that a rise in plasma pTau217 is associated with early formation of NFT rather than a direct physiological response to brain Aß plaques prior to NFT formation. Figure 1 legend: Modeling of 18F-MK6240 quantification and pTau217 as a function of Centiloid. Biomarker values Z-scored using the results from Aß- cognitively unimpaired to define the normal range for p217+tau level and each tau PET ROI SUVR."

Alzheimer's Disease • CNS Disorders

Major R&D Pipeline - Eisai (Eisai Press Release) - "Development has been discontinued for the Alzheimer’s disease indication for E2307 at the Phase I stage."

Discontinued • Alzheimer's Disease