MT-4561 / Mitsubishi Tanabe - LARVOL DELTA

A novel BRD4 degrader, MT-4561, degrades the BRD4-NUT fusion protein in vitro and induces complete tumor regression in a subcutaneous NUT carcinoma xenograft model (AACR-NCI-EORTC 2025) - " In vitro studies: MT-4561 demonstrated potent antitumor activity against Ty-82 cells, a NUT carcinoma cell line harboring the BRD4-NUT fusion protein, and showed greater efficacy than the BET inhibitor JQ1. MT-4561 exhibited potent antitumor efficacy against NUT carcinoma in both in vitro and in vivo studies. Notably, MT-4561 demonstrated activity not only against BRD4-NUT cells but also against BRD3-NUT cell lines. This effect is considered to be mediated through suppression of c-MYC (expression)."

Preclinical • NUT Midline Carcinoma • Oncology • BRD3 • BRD4 • MYC • NUTM1

A Study of MT-4561 in Patients With Various Advanced Solid Tumors (clinicaltrials.gov) - P1/2 | N=27 | Recruiting | Sponsor: Mitsubishi Tanabe Pharma America Inc. | Not yet recruiting ➔ Recruiting

Enrollment open • Biliary Cancer • Breast Cancer • Cervical Cancer • Endocrine Cancer • Endometrial Cancer • Esophageal Cancer • Gastric Cancer • Genito-urinary Cancer • Head and Neck Cancer • Lung Cancer • Neuroendocrine Tumor • Non Small Cell Lung Cancer • Oncology • Ovarian Cancer • Pancreatic Cancer • Prostate Cancer • Sarcoma • Soft Tissue Sarcoma • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • Urothelial Cancer