Indaflex (indomethacin transdermal) / UMeWorld, Grunenthal - LARVOL DELTA

Hyaluronan-modified transfersomes based hydrogel for enhanced transdermal delivery of indomethacin. (PubMed, Drug Deliv) - "In addition, IND-HTs/Gel showed significant analgesic activity in hot plate test and no potentially hazardous skin irritation. This study indicated that the developed IND-HTs/Gel could be a promising alternative to conventional oral delivery of IND by topical administration."

Journal • Pain

Energy-Dependent Endocytosis Is Responsible for Skin Penetration of Formulations Based on a Combination of Indomethacin Nanoparticles and l-Menthol in Rat and Göttingen Minipig. (PubMed, Int J Mol Sci) - "On the other hand, the treatment of nystatin and dynasore decreased the transdermal penetration of indomethacin in rats and Göttingen minipigs treated with N-IND/MEN. In addition, this study suggests that the SC-passed IND-NPs are absorbed into the skin tissue by energy-dependent endocytosis (CavME, CME, and/or MP pathways) on the epidermis under the SC, resulting in an enhancement in transdermal penetration of IND-NPs. These findings provide significant information for the design of nanomedicines in transdermal formulations."

Journal • Preclinical

Combination with l-Menthol Enhances Transdermal Penetration of Indomethacin Solid Nanoparticles. (PubMed, Int J Mol Sci) - "In addition, the energy-dependency of the skin penetration of IMC solid nanoparticles was demonstrated. These findings suggest the utility of a transdermal drug delivery system to provide the easy application of solid nanoparticles (SNPs)."

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