ceftriaxone/sulbactam / Generic mfg. - LARVOL DELTA

The impact of intraoperative peritoneal fluid cultures on empirical antibiotic therapy and postoperative complications in pediatric perforated appendicitis. (PubMed, Turk J Pediatr) - "aeruginosa: ampicillin/sulbactam 8%, ceftriaxone 16%, cefotaxime 0%, amikacin 99%. Postoperative modification of empirical therapy was required in 102 cases (66.2%) Conclusions. High resistance rates to commonly used empirical antibiotics were observed among isolated microorganisms, highlighting the need for regular revision of empirical treatment protocols and greater reliance on intraoperative culture results in pediatric perforated appendicitis."

Journal • Retrospective data • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pediatrics • Pneumonia

Comparison of effectiveness and safety of cefoperazone-sulbactam versus ceftriaxone and flomoxef in acute cholangitis: a multicenter retrospective study. (PubMed, Antimicrob Agents Chemother) - "Although outcomes were statistically similar to those of ceftriaxone and flomoxef, the underpowered between-group comparisons preclude definitive conclusions regarding comparative efficacy. These findings support its continued clinical use while awaiting confirmation in larger randomized trials."

Journal • Retrospective data • Infectious Disease • Oncology

Staphylococcus aureus prostatic abscess in a young diabetic patient: a case report and literature review. (PubMed, Int J Surg Case Rep) - "Was initially diagnosed with acute prostatitis and initiated on intravenous ceftriaxone sulbactam with no improvement...This case underscores the need to consider this diagnosis in patients with persistent or worsening symptoms despite appropriate initial therapy. Early imaging, recognition of atypical pathogens such as S. aureus, and prompt culture-directed antibiotics with minimally invasive drainage are essential for optimal outcomes."

Journal • Diabetes • Infectious Disease • Metabolic Disorders

Narrowing the Spectrum: Empiric Antibiotic Regimens and Clinical Outcomes in Pediatric Orbital Cellulitis (PAS 2026) - "Ampicillin/sulbactam or ceftriaxone, sometimes combined with metronidazole, clindamycin, or vancomycin, are commonly used. Non-inferiority of ceftriaxone monotherapy (Group 1) will be evaluated by comparing surgical rates to other regimens (Groups 2–5) with a 10% non-inferiority margin and 90% confidence interval. Data collection has been completed, and analyses will be finalized by January 31, 2026."

Clinical • Clinical data • Dermatology • Infectious Disease • Ocular Infections • Ocular Inflammation • Pediatrics

Critical Analysis of Fixed-Dose Antibiotic Combinations Sold in Kinshasa-Democratic Republic of the Congo. (PubMed, Antibiotics (Basel)) - "For injectable FDAC, for example, the combination Ceftriaxone-Sulbactam was represented by eight medications. For oral FDACs, the combination Sulfamethoxazole-Trimethoprim was represented by seven medications... Fifteen varieties of FDACs were available in Kinshasa, most of which (80%) were unsuitable. It is important that public health authorities address this situation and develop stricter guidelines for granting marketing authorizations, particularly for FDACs."

Journal • Infectious Disease • Malaria • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Comparative efficacy of andrographolide and hordenine in the treatment of methicillin resistant Staphylococcus aureus infected wounds: a multifaceted approach. (PubMed, J Ayurveda Integr Med) - "Andrographolide and hordenine exhibited wound healing activity in MRSA-infected wounds, promotes fibroblast proliferation and migration, as well as fostering angiogenesis."

Journal • Infectious Disease

Distribution and antibiotic resistance of Gram-negative bacteria from blood cultures before and during the COVID-19 pandemic. (PubMed, J Infect Dev Ctries) - "K. pneumoniae remained the most frequently isolated bacterium in both periods, while A. baumannii showed a significant increase during the pandemic. The 2.6-fold increase in A. baumannii may have been caused by the increased use of broad-spectrum antibiotics during the pandemic. These findings reflect data from a single hospital and should be validated by further multicenter studies."

Journal • Retrospective data • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

"In vitro evaluation of sulbactam combination therapies for Acinetobacter baumannii". (PubMed, Indian J Med Microbiol) - "Combining sulbactam with β-lactams, particularly cefepime, significantly reduced sulbactam MICs. However, the β-lactam MICs themselves remained largely within not-susceptible ranges, highlighting that the observed benefit was confined primarily to sulbactam rather than the companion β-lactams. These findings supported further clinical studies of high-dose sulbactam-β-lactam combinations to optimize the pharmacodynamic efficacy of sulbactam against CRAB strains with elevated MICs."

Journal • Preclinical • Infectious Disease • Pneumonia • Respiratory Diseases

Molecular and phylogenetic characterization of Staphylococcus aureus isolated from primary pyoderma in a goat from tropical India: an emerging zoonotic threat. (PubMed, Vet Res Commun) - "The isolate was catalase positive and exhibited sensitivity to tetracycline, gentamicin, amoxicillin-sulbactam, ceftriaxone-tazobactam, and streptomycin, but showed resistance to multiple antibiotics. The genetic proximity to human pathogenic strains across diverse regions highlighted the broad host range of the bacterium. The findings of present study underscore the need for molecular surveillance, antimicrobial stewardship, and integrated One Health strategies to mitigate emerging zoonotic threats, particularly in regions with frequent human-livestock contact."

Journal • Infectious Disease • Septic Shock • CAT

PREVALENCE, PATTERNS, AND FACTORS ASSOCIATED WITH BLOODSTREAM INFECTIONS IN CHILDREN WITH MALIGNANCIES AT BUGANDO CANCER CENTRE, MWANZA, . TANZANIA (SIOP 2025) - "Gram-positive bacteria were uniformly susceptible to vancomycin and linezolid, while Gram-negative bacteria were all susceptible to meropenem, amikacin, and ceftriaxone sulbactam. Gram-positive bacteria were commonly found to cause BSI, which was significantly associated with neutropenia. There is a need for routine blood cultures among pediatric cancer patients to provide more data to guide appropriate antibiotic treatment in this vulnerable population."

Clinical • Infectious Disease • Neutropenia • Oncology • Pediatrics

Antimicrobial susceptibility profiling of caprine clinical mastitis pathogens in Punjab, India. (PubMed, Ann Med Surg (Lond)) - "Milk samples were collected aseptically from the cases of clinical mastitis in goats followed by bacterial isolation and antibiotic susceptibility testing for amikacin, amoxicillin, amoxyclav, ampicillin, ampicillin-sulbactam, cefoperazone, cefoperazone-tazobactam, ceftizoxime, ceftriaxone, ceftriaxone-sulbactam, ceftriaxone-tazobactam, ciprofloxacin, colistin, doxycycline, enrofloxacin, erythromycin, gentamicin, moxifloxacin, ofloxacin, oxytetracycline, penicillin-G, streptomycin and tetracycline. As the antimicrobial susceptibility was found to vary among the goats suffering from mastitis as well as the bacteria involved, the antimicrobial susceptibility testing prior to treatment initiation would be crucial in limiting the development of resistance in goats and potentially in human beings as well. The antimicrobial susceptibility profiling in caprine mastitis revealed the multidrug resistant bacterial isolates."

Journal

Abnormal coagulation indicators associated with β-lactamantibacterial drug: a pharmacovigilance study based on the FAERS database. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "β-Lactam antibacterial drug may be associated with various abnormal coagulation indicators, particularly cephalosporins such as cefoperazone/sulbactam, ceftriaxone, and cefotaxime. In the process of clinical use, it is necessary to pay close attention to the elderly, liver and kidney dysfunction, and high risk population with a history of blood clotting. The findings from this study can provide valuable insights for enhancing the safe use of β-lactam drugs, particularly in populations at high risk for coagulation abnormalities, thereby guiding clinical practice."

Adverse events • Journal • Nephrology • Renal Disease • Thrombosis

Point-Prevalence Survey of Antimicrobial Use in Benin Hospitals: The Need for Antimicrobial Stewardship Programs. (PubMed, Antibiotics (Basel)) - "In four prescriptions, hospital A used a non-recommended association of antibiotics, such as ceftriaxone + sulbactam and ofloxacin + ornidazole. While hospital A prescribed predominantly amoxicillin + clavulanic acid (19/92; 21%) and ceftriaxone (14/92; 15%), hospital B prescribed ampicillin (24/120; 20%) and cefuroxime (14/120; n = 12%)...In patients in intensive care units, prolonged prophylaxis (>1 day, SP3) accounted for all postoperative prescriptions. These findings highlight the critical need for implementing antimicrobial stewardship programs, expanding diagnostic laboratory capacity to minimize empirical prescribing, and strengthening medical student training to ensure quality and rational antibiotic use, thereby addressing the growing challenge of resistance in resource-limited settings."

Journal • Critical care

Real world in vitro synergy to doxycycline, ceftriaxone/sulbactam/edetate, and chloramphenicol in ceftazidime/avibactam-resistant, aztreonam synergy-negative isolates from a tertiary referral centre in southern India (ESCMID Global 2025) - No abstract available

Preclinical • Real-world • Real-world evidence

Effectiveness of Ampicillin-Sulbactam Versus Ceftriaxone for the Initial Treatment of Community-Acquired Pneumonia in Older Adults: A Target Trial Emulation Study. (PubMed, Open Forum Infect Dis) - "The study included patients aged ≥65 years, admitted to Diagnosis Procedure Combination hospitals for CAP, who received either ampicillin-sulbactam or ceftriaxone as the initial treatment. These results were consistent among patients with risk factors for aspiration. In older patients with CAP, initial treatment with ampicillin-sulbactam was associated with higher mortality compared to treatment with ceftriaxone."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

Risk factors for drug-resistant pathogens in community-acquired pneumonia: systematic review and meta-analysis. (PubMed, Eur Respir Rev) - "To our knowledge, this is the first systematic review focused on CAP-DRP. Unlike previous reviews, the all-patient and culture-positive pneumonia cohorts were analysed separately. Findings from the all-patient cohort are particularly relevant for guiding initial antimicrobial selection in clinical practice. Furthermore, the abovementioned factors should be considered when developing prediction models for CAP-DRPs."

Clinical • Journal • Retrospective data • Review • Chronic Obstructive Pulmonary Disease • CNS Disorders • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Determination of the Common Microorganisms Present in the Intensive Care Unit of Federal Teaching Hospital Owerri, Southeast Nigeria: A Prospective, Descriptive Cross-sectional Study. (PubMed, Niger Postgrad Med J) - "The bacteria contamination rate in the ICU was relatively high, mostly by Gram-negative organisms. Frequent profiling and sensitivity testing of the microbial load in the ICU are advocated to guide treatment."

Journal • Observational data • Critical care • Infectious Disease

Microbial Pathogen Spectrum in Anastomotic Leaks after Ivor-Lewis Esophagectomy. (PubMed, Surg Infect (Larchmt)) - "Expected failure of empiric antibiotic treatment was <10% for piperacillin-tazobactam, meropenem, and tigecycline (each combined with an echinocandin) but not for ampicillin-sulbactam, ceftriaxone plus metronidazole, moxifloxacin, or gentamicine plus clindamycin. There is a broad microbial pathogen spectrum in anastomotic leaks after esophagectomy. Implications for empiric antimicrobial treatment arise from enterobacterales, enterococci, and yeasts."

Journal • Infectious Disease

AN UNEXPECTED LOVEBUG: PNEUMONIA SECONDARY TO NEISSERIA WEAVERI (CHEST 2024) - "The patient was treated initially with vancomycin and cefepime, but was transitioned to ampicillin-sulbactam and ceftriaxone after culture sensitivities resulted...Therapeutic anticoagulation with apixaban was started and deep venous thrombosis was ruled out...Successful treatment options of N. weaveri described in the literature include beta-lactams such as ampicillin-sulbactam, ceftriaxone, and amoxicillin-clavulanate, and one case treated effectively with ofloxacin. Neisseria weaveri is an infrequent cause of pneumonia. Contact with dogs is an important risk factor."

Acute Kidney Injury • Bronchiectasis • Cardiovascular • Diabetes • Hematological Disorders • Infectious Disease • Metabolic Disorders • Nephrology • Obstructive Sleep Apnea • Pneumonia • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Sleep Disorder • Thrombosis • Type 2 Diabetes Mellitus • Venous Thromboembolism

An uncommon case of follicular occlusion triad with challenging treatment outcome: a case report (EADV 2024) - "The patient was managed with medications that included oral and parenteral antibiotics (intravenous ceftriaxone- sulbactam, oral clindamycin, oral dapsone) , oral isotretinoin, and oral prednisolone. FOT presents a significant clinical challenge due to its chronic, debilitating nature and association with psychosocial distress. Despite advancements in therapy, management remains unsatisfactory compared to the treatment of individual components. This case highlights the incidence of this uncommon syndrome and the need for more research into therapeutic options specifically tailored to address FOT and its associated comorbidities, aiming to improve patient outcomes and quality of life."

Case report • Clinical • Acne Vulgaris • Alopecia • Anemia • CNS Disorders • Dermatology • Hematological Disorders • Hepatitis B • Hepatology • Hidradenitis Suppurativa • Immunology • Infectious Disease • Inflammation • Pain

Concomitant use of lansoprazole and ceftriaxone is associated with an increased risk of ventricular arrhythmias and cardiac arrest in a large Japanese hospital database. (PubMed, J Infect) - "Oral and intravenous lansoprazole may increase the risk of ventricular arrhythmia and cardiac arrest in patients who are receiving ceftriaxone."

Journal • Atrial Fibrillation • Cardiovascular

High risk and low prevalence diseases: Acute mastoiditis. (PubMed, Am J Emerg Med) - "An understanding of acute mastoiditis can assist emergency clinicians in diagnosing and managing this potentially deadly disease."

Journal • Review • Cardiovascular • CNS Disorders • Dermatology • Epilepsy • Hematological Disorders • Infectious Disease • Inflammation • Otorhinolaryngology • Pediatrics • Thrombosis

Dosage Forms Suitability in Pediatrics: Acceptability of Antibiotics in a German Hospital. (PubMed, Antibiotics (Basel)) - "Four antibiotics assessed in this study were formulated as preparations for injection (ampicillin, ampicillin/sulbactam, ceftriaxone, and gentamicin) and one as a powder for oral liquid suspension (co-amoxiclav). These findings are important in improving knowledge on acceptability drivers and might help in formulating and prescribing better medicines for children. The study highlights the need for healthcare professionals to have knowledge about the acceptability of different products to select the best-adapted product for each patient."

Journal • Pediatrics

In Vitro Susceptibility of Clinical Isolates to Ceftriaxone Alone and Ceftriaxone in Combination With Sulbactam or Tazobactam: A Comparative Study of Broad-Spectrum β-Lactam Antibiotics in India. (PubMed, Cureus) - "Ceftriaxone, ceftriaxone + sulbactam, and ceftriaxone + tazobactam had ER >10 against 78%, 100%, and 90% of K. pneumoniae isolates, while the corresponding percentages for cefotaxime, piperacillin + tazobactam, and cefepime were 100%, 64%, and 80%, respectively. Conclusions Ceftriaxone and ceftriaxone in combination with sulbactam and tazobactam are promising antibiotics to explore against prevalent infectious microorganisms such as E. coli and K. pneumoniae. Ceftriaxone + tazobactam also holds promise against ESBL-producing variants."

Combination therapy • Journal • Preclinical • Infectious Disease • Pneumonia

Drug Utilization and Evaluation of Antibiotics in Pre and Post Operative Obstetrics Ward at a Tertiary Care Hospital (ISPOR-EU 2023) - "The most commonly prescribed antibiotic was a combination of Ceftriaxone and Sulbactam (302 gms), whose DDD was found to be 151 gms. And on further evaluation DDD/100 HOSPITALIZED DAYS was found to be 83.88 gms followed by Ceftriaxone 56.5 grams and 31.38 grams, whereas, Cefuroxime axetil was used in the minimum amount i.e., 1 gram whose DDD was found to be 0.5 gram and DDD/100 BED DAYS was 1.11 gram respectively... Third generation cephalosporins, i.e., ceftriaxone was the most frequently prescribed antibiotics and every antibiotic given was of brand name. All the antibiotics which were prescribed during the study that were according to the essential drugs list. All though the present study provides valuable insight about the overall pattern of drug use profile in pre and post-operative patients in the obstetrics unit."

Clinical • Gynecology • Obstetrics