ceftriaxone/sulbactam / Generic mfg. - LARVOL DELTA

Molecular and phylogenetic characterization of Staphylococcus aureus isolated from primary pyoderma in a goat from tropical India: an emerging zoonotic threat. (PubMed, Vet Res Commun) - "The isolate was catalase positive and exhibited sensitivity to tetracycline, gentamicin, amoxicillin-sulbactam, ceftriaxone-tazobactam, and streptomycin, but showed resistance to multiple antibiotics. The genetic proximity to human pathogenic strains across diverse regions highlighted the broad host range of the bacterium. The findings of present study underscore the need for molecular surveillance, antimicrobial stewardship, and integrated One Health strategies to mitigate emerging zoonotic threats, particularly in regions with frequent human-livestock contact."

Journal • Infectious Disease • Septic Shock • CAT

PREVALENCE, PATTERNS, AND FACTORS ASSOCIATED WITH BLOODSTREAM INFECTIONS IN CHILDREN WITH MALIGNANCIES AT BUGANDO CANCER CENTRE, MWANZA, . TANZANIA (SIOP 2025) - "Gram-positive bacteria were uniformly susceptible to vancomycin and linezolid, while Gram-negative bacteria were all susceptible to meropenem, amikacin, and ceftriaxone sulbactam. Gram-positive bacteria were commonly found to cause BSI, which was significantly associated with neutropenia. There is a need for routine blood cultures among pediatric cancer patients to provide more data to guide appropriate antibiotic treatment in this vulnerable population."

Clinical • Infectious Disease • Neutropenia • Oncology • Pediatrics

Antimicrobial susceptibility profiling of caprine clinical mastitis pathogens in Punjab, India. (PubMed, Ann Med Surg (Lond)) - "Milk samples were collected aseptically from the cases of clinical mastitis in goats followed by bacterial isolation and antibiotic susceptibility testing for amikacin, amoxicillin, amoxyclav, ampicillin, ampicillin-sulbactam, cefoperazone, cefoperazone-tazobactam, ceftizoxime, ceftriaxone, ceftriaxone-sulbactam, ceftriaxone-tazobactam, ciprofloxacin, colistin, doxycycline, enrofloxacin, erythromycin, gentamicin, moxifloxacin, ofloxacin, oxytetracycline, penicillin-G, streptomycin and tetracycline. As the antimicrobial susceptibility was found to vary among the goats suffering from mastitis as well as the bacteria involved, the antimicrobial susceptibility testing prior to treatment initiation would be crucial in limiting the development of resistance in goats and potentially in human beings as well. The antimicrobial susceptibility profiling in caprine mastitis revealed the multidrug resistant bacterial isolates."

Journal

Abnormal coagulation indicators associated with β-lactamantibacterial drug: a pharmacovigilance study based on the FAERS database. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "β-Lactam antibacterial drug may be associated with various abnormal coagulation indicators, particularly cephalosporins such as cefoperazone/sulbactam, ceftriaxone, and cefotaxime. In the process of clinical use, it is necessary to pay close attention to the elderly, liver and kidney dysfunction, and high risk population with a history of blood clotting. The findings from this study can provide valuable insights for enhancing the safe use of β-lactam drugs, particularly in populations at high risk for coagulation abnormalities, thereby guiding clinical practice."

Adverse events • Journal • Nephrology • Renal Disease • Thrombosis

Point-Prevalence Survey of Antimicrobial Use in Benin Hospitals: The Need for Antimicrobial Stewardship Programs. (PubMed, Antibiotics (Basel)) - "In four prescriptions, hospital A used a non-recommended association of antibiotics, such as ceftriaxone + sulbactam and ofloxacin + ornidazole. While hospital A prescribed predominantly amoxicillin + clavulanic acid (19/92; 21%) and ceftriaxone (14/92; 15%), hospital B prescribed ampicillin (24/120; 20%) and cefuroxime (14/120; n = 12%)...In patients in intensive care units, prolonged prophylaxis (>1 day, SP3) accounted for all postoperative prescriptions. These findings highlight the critical need for implementing antimicrobial stewardship programs, expanding diagnostic laboratory capacity to minimize empirical prescribing, and strengthening medical student training to ensure quality and rational antibiotic use, thereby addressing the growing challenge of resistance in resource-limited settings."

Journal • Critical care

Real world in vitro synergy to doxycycline, ceftriaxone/sulbactam/edetate, and chloramphenicol in ceftazidime/avibactam-resistant, aztreonam synergy-negative isolates from a tertiary referral centre in southern India (ESCMID Global 2025) - No abstract available

Preclinical • Real-world • Real-world evidence

Effectiveness of Ampicillin-Sulbactam Versus Ceftriaxone for the Initial Treatment of Community-Acquired Pneumonia in Older Adults: A Target Trial Emulation Study. (PubMed, Open Forum Infect Dis) - "The study included patients aged ≥65 years, admitted to Diagnosis Procedure Combination hospitals for CAP, who received either ampicillin-sulbactam or ceftriaxone as the initial treatment. These results were consistent among patients with risk factors for aspiration. In older patients with CAP, initial treatment with ampicillin-sulbactam was associated with higher mortality compared to treatment with ceftriaxone."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

Risk factors for drug-resistant pathogens in community-acquired pneumonia: systematic review and meta-analysis. (PubMed, Eur Respir Rev) - "To our knowledge, this is the first systematic review focused on CAP-DRP. Unlike previous reviews, the all-patient and culture-positive pneumonia cohorts were analysed separately. Findings from the all-patient cohort are particularly relevant for guiding initial antimicrobial selection in clinical practice. Furthermore, the abovementioned factors should be considered when developing prediction models for CAP-DRPs."

Clinical • Journal • Retrospective data • Review • Chronic Obstructive Pulmonary Disease • CNS Disorders • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Determination of the Common Microorganisms Present in the Intensive Care Unit of Federal Teaching Hospital Owerri, Southeast Nigeria: A Prospective, Descriptive Cross-sectional Study. (PubMed, Niger Postgrad Med J) - "The bacteria contamination rate in the ICU was relatively high, mostly by Gram-negative organisms. Frequent profiling and sensitivity testing of the microbial load in the ICU are advocated to guide treatment."

Journal • Observational data • Critical care • Infectious Disease

Microbial Pathogen Spectrum in Anastomotic Leaks after Ivor-Lewis Esophagectomy. (PubMed, Surg Infect (Larchmt)) - "Expected failure of empiric antibiotic treatment was <10% for piperacillin-tazobactam, meropenem, and tigecycline (each combined with an echinocandin) but not for ampicillin-sulbactam, ceftriaxone plus metronidazole, moxifloxacin, or gentamicine plus clindamycin. There is a broad microbial pathogen spectrum in anastomotic leaks after esophagectomy. Implications for empiric antimicrobial treatment arise from enterobacterales, enterococci, and yeasts."

Journal • Infectious Disease

AN UNEXPECTED LOVEBUG: PNEUMONIA SECONDARY TO NEISSERIA WEAVERI (CHEST 2024) - "The patient was treated initially with vancomycin and cefepime, but was transitioned to ampicillin-sulbactam and ceftriaxone after culture sensitivities resulted...Therapeutic anticoagulation with apixaban was started and deep venous thrombosis was ruled out...Successful treatment options of N. weaveri described in the literature include beta-lactams such as ampicillin-sulbactam, ceftriaxone, and amoxicillin-clavulanate, and one case treated effectively with ofloxacin. Neisseria weaveri is an infrequent cause of pneumonia. Contact with dogs is an important risk factor."

Acute Kidney Injury • Bronchiectasis • Cardiovascular • Diabetes • Hematological Disorders • Infectious Disease • Metabolic Disorders • Nephrology • Obstructive Sleep Apnea • Pneumonia • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Sleep Disorder • Thrombosis • Type 2 Diabetes Mellitus • Venous Thromboembolism

An uncommon case of follicular occlusion triad with challenging treatment outcome: a case report (EADV 2024) - "The patient was managed with medications that included oral and parenteral antibiotics (intravenous ceftriaxone- sulbactam, oral clindamycin, oral dapsone) , oral isotretinoin, and oral prednisolone. FOT presents a significant clinical challenge due to its chronic, debilitating nature and association with psychosocial distress. Despite advancements in therapy, management remains unsatisfactory compared to the treatment of individual components. This case highlights the incidence of this uncommon syndrome and the need for more research into therapeutic options specifically tailored to address FOT and its associated comorbidities, aiming to improve patient outcomes and quality of life."

Case report • Clinical • Acne Vulgaris • Alopecia • Anemia • CNS Disorders • Dermatology • Hematological Disorders • Hepatitis B • Hepatology • Hidradenitis Suppurativa • Immunology • Infectious Disease • Inflammation • Pain

Concomitant use of lansoprazole and ceftriaxone is associated with an increased risk of ventricular arrhythmias and cardiac arrest in a large Japanese hospital database. (PubMed, J Infect) - "Oral and intravenous lansoprazole may increase the risk of ventricular arrhythmia and cardiac arrest in patients who are receiving ceftriaxone."

Journal • Atrial Fibrillation • Cardiovascular

High risk and low prevalence diseases: Acute mastoiditis. (PubMed, Am J Emerg Med) - "An understanding of acute mastoiditis can assist emergency clinicians in diagnosing and managing this potentially deadly disease."

Journal • Review • Cardiovascular • CNS Disorders • Dermatology • Epilepsy • Hematological Disorders • Infectious Disease • Inflammation • Otorhinolaryngology • Pediatrics • Thrombosis

Dosage Forms Suitability in Pediatrics: Acceptability of Antibiotics in a German Hospital. (PubMed, Antibiotics (Basel)) - "Four antibiotics assessed in this study were formulated as preparations for injection (ampicillin, ampicillin/sulbactam, ceftriaxone, and gentamicin) and one as a powder for oral liquid suspension (co-amoxiclav). These findings are important in improving knowledge on acceptability drivers and might help in formulating and prescribing better medicines for children. The study highlights the need for healthcare professionals to have knowledge about the acceptability of different products to select the best-adapted product for each patient."

Journal • Pediatrics

In Vitro Susceptibility of Clinical Isolates to Ceftriaxone Alone and Ceftriaxone in Combination With Sulbactam or Tazobactam: A Comparative Study of Broad-Spectrum β-Lactam Antibiotics in India. (PubMed, Cureus) - "Ceftriaxone, ceftriaxone + sulbactam, and ceftriaxone + tazobactam had ER >10 against 78%, 100%, and 90% of K. pneumoniae isolates, while the corresponding percentages for cefotaxime, piperacillin + tazobactam, and cefepime were 100%, 64%, and 80%, respectively. Conclusions Ceftriaxone and ceftriaxone in combination with sulbactam and tazobactam are promising antibiotics to explore against prevalent infectious microorganisms such as E. coli and K. pneumoniae. Ceftriaxone + tazobactam also holds promise against ESBL-producing variants."

Combination therapy • Journal • Preclinical • Infectious Disease • Pneumonia

Drug Utilization and Evaluation of Antibiotics in Pre and Post Operative Obstetrics Ward at a Tertiary Care Hospital (ISPOR-EU 2023) - "The most commonly prescribed antibiotic was a combination of Ceftriaxone and Sulbactam (302 gms), whose DDD was found to be 151 gms. And on further evaluation DDD/100 HOSPITALIZED DAYS was found to be 83.88 gms followed by Ceftriaxone 56.5 grams and 31.38 grams, whereas, Cefuroxime axetil was used in the minimum amount i.e., 1 gram whose DDD was found to be 0.5 gram and DDD/100 BED DAYS was 1.11 gram respectively... Third generation cephalosporins, i.e., ceftriaxone was the most frequently prescribed antibiotics and every antibiotic given was of brand name. All the antibiotics which were prescribed during the study that were according to the essential drugs list. All though the present study provides valuable insight about the overall pattern of drug use profile in pre and post-operative patients in the obstetrics unit."

Clinical • Gynecology • Obstetrics

Clinical and microbiological characterization of Salmonella spp. isolates from patients treated in a university hospital in South America between 2012-2021: a cohort study. (PubMed, BMC Infect Dis) - "Despite improved availability of antibiotics for the treatment of salmonellosis in the past decades, mortality due to salmonellosis continues occurring in children and adults, mainly in patients with hematological malignancies and bacteremia. Antibiotic resistance rates have increased significantly over the last 10 years. Public health strategies for the control of this disease should be strengthened, especially in vulnerable populations."

Journal • Hematological Disorders • Hematological Malignancies • Infectious Disease • Oncology • Pain

Evaluation of active microorganisms and antibiotic susceptibility in community-acquired intraabdominal infections in children. (PubMed, Ann Ital Chir) - "In our study, ESBL-resistant gram-negative microorganisms in CA-IAIs presented as primary agents to be considered. Ampicillin-sulbactam, ceftriaxone and cefotaxime should not be preferred in the monotherapy of complicated CA-IAIs due to their high resistance rates, but they can be combined with aminoglycosides. Quinolones can be included in the treatment because of their low resistance rates. It is considered that routine intraoperative culture and evaluation of antibiotic susceptibility in complicated CA-IAIs will provide an insight into the outcomes of empirical treatment."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

Using Culture Sensitivity Reports to Optimize Antimicrobial Therapy: Findings and Implications of Antimicrobial Stewardship Activity in a Hospital in Pakistan. (PubMed, Medicina (Kaunas)) - "Most of the gram-negative isolates were found to be resistant to ampicillin and co-amoxiclav...The most widely used antibiotics for empiric therapy were cefoperazone plus sulbactam, ceftriaxone, amikacin, vancomycin, and metronidazole whereas high use of linezolid, clindamycin, meropenem, and piperacillin + tazobactam was seen in definitive treatment... Culture sensitivity reports helped reduced antibiotic utilization and costs as well as helped select the most appropriate treatment. We also found an urgent need for implementing antimicrobial stewardship programs in hospitals and the development of hospital antibiotic guidelines to reduce unnecessary prescribing of broad-spectrum antibiotics."

Journal • Infectious Disease

Burkholderia cepacia infection in children without cystic fibrosis: a clinical analysis of 50 cases. (PubMed, Front Pediatr) - "It indicated that B. cepacia was the most sensitive to ceftazidime (95.65%), followed by trimethoprim-sulfamethoxazole (88.68%), meropenem (82.98%), cefepime (77.78%), and levofloxacin (55.85%). The drug resistance rate of piperacillin-tazobactam, minocycline, aztreonam, cefoperazone-sulbactam and ceftriaxone was higher than 55%...The surveillance of B. cepacia infections including changing epidemiology and increasing resistance of the microorganism is still very important. Treatment with effective antibiotics such as ceftazidime, meropenem, trimethoprim-sulfamethoxazole is associated with a favorable prognosis."

Journal • Cardiovascular • Critical care • Cystic Fibrosis • Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Oncology • Pediatrics • Pulmonary Disease • Respiratory Diseases

Characterisation of genes encoding for extended spectrum β-lactamase in Gram-negative bacteria causing healthcare-associated infections in Mwanza, Tanzania. (PubMed, Afr J Lab Med) - "Extended spectrum β-lactamase genes, particularly bla , are common among ceftriaxone-resistant GNB causing HCAIs. This study revealed the distribution of genes (bla , bla and bla ) coding for ESBL production among ceftriaxone resistant GNB causing HCAIs However, all ESBL producing GNB were susceptible towards ceftriaxone-sulbactam indicating that ceftriaxone-sulbactam may be empirically prescribed for treating patients with HCAIs."

Gram negative • Journal • Infectious Disease

Not recommended fixed-dose antibiotic combinations in low- and middle-income countries - the example of Tanzania. (PubMed, Antimicrob Resist Infect Control) - "There is an urgent need for monitoring consumption of non-recommended FDC-AB in low- and middle-income countries, particular in Sub-Saharan Africa. A multinational and multisectoral antimicrobial stewardship strategy is needed in order to abolish the use of non-recommended FDC-AB."

Journal • Review • Infectious Disease • Malaria • Pediatrics • Pulmonary Disease • Respiratory Diseases • Tuberculosis

An In Vitro Susceptibility Study of Cefotaxime-Sulbactam on Clinical Bacterial Isolates From Various Regions in India: A Comparison With Ceftriaxone-Sulbactam. (PubMed, Cureus) - "Conclusions The in vitro effect of cefotaxime-sulbactam on organisms is similar to that of ceftriaxone-sulbactam in terms of MIC, ZOI, and proportion of sensitivity based on our study involving clinical isolates from various parts of India. Cefotaxime-sulbactam may be preferred in the empirical management of various clinical infections."

Journal • Preclinical • Infectious Disease

EFFICACY OF TARGETED VS. NONTARGETED BETA-LACTAM THERAPY FOR MSSA BACTEREMIA: A MATCHED COHORT STUDY (SCCM 2023) - "Patients were identified retrospectively through the electronic medical record and must have received either a NT (ampicillin/sulbactam, ceftriaxone, cefepime, piperacillin/tazobactam, meropenem) or TT. The TT cohort included the receipt of or de-escalation to nafcillin or cefazolin within 72 hours of antibiotic initiation... ICU patients who received TT or NT had similar duration of bacteremia, hospital LOS, and ICU LOS. Exposure to NT was associated with increased mortality. Although these results should be validated prospectively, clinicians should be cognizant of this risk when evaluating those with MSSA bacteremia and consider de-escalation to TT as soon as clinically appropriate."

Clinical • Critical care • Infectious Disease