VS-505 / Vidasym - LARVOL DELTA

Diagnostic accuracy of stereomicroscopy assessment of invasion depth in ex vivo specimens of early gastric cancer. (PubMed, World J Gastroenterol) - "Stereomicroscopy is an effective diagnostic tool for determining the EGC invasion depth, particularly in non-ulcerated lesions. These findings could inform clinical practice and ESD treatment strategy optimization for EGC."

Journal • Preclinical • Retrospective data • Gastric Cancer • Oncology • Solid Tumor

Severe obesity associates with maladaptive glomerular haemodynamics clustered with insulin resistance and endothelial dysfunction. (PubMed, Clin Kidney J) - "Across tertiles, mGFR did not differ, but ERPF declined (756 ± 113 vs 505 ± 130 mL/min, P = .001) and of filtration fraction increased (16 ± 3% vs 26 ± 5%, P = .001) from the lowest to the highest tertile...Endothelial function was reduced in the highest vs lowest tertile (3.44 ± 1.49 vs 6.21 ± 1.76%, P = .014), while responses to nitroglycerin did not differ...A maladaptive phenotype characterized by elevated filtration fraction relative to renal plasma flow clustered with insulin resistance and endothelial dysfunction, whereas mGFR alone failed to capture these relationships. Comprehensive haemodynamic profiling may help to refine risk stratification in obesity."

Journal • Chronic Kidney Disease • Genetic Disorders • Glomerulonephritis • Nephrology • Obesity • Renal Disease

Fluidized Catalytic Oxidation of Ultralow Concentration Methane: A Pilot-Scale Study. (PubMed, ACS Omega) - "In the stability test, methane conversion decreased from 97.4 to 90% in the initial 22 h. It was found that ∼35.6 wt % of the catalysts was blown out of the reactor during the reaction due to the low separation efficiency of the used cyclone, causing the conversion rate to decrease. After the reaction, the active component MnO2 in the natural ore was partially converted to Mn2O3 with less surface oxygen vacancies, which also contributed to the decreased activity since the methane catalytic activity was much lower on Mn2O3 than that on MnO2 (T 90 = 795 vs 505 °C)."

Journal

Getting More Out of the 6-minute Walk Test Through Metabolic and Heart Rate Monitoring (ATS 2024) - "The healthy control had a further 6-minute walk distance and lower Cardiac Effort compared to the PE recovered group (612 m vs 505 m and 1...Fourteen patients who recovered from acute PE and nine healthy controls completed one 6MWT wearing Cosmed K5 Wearable Metabolic System and Fourth Frontier X2 heart rate monitor. The PE recovered group were 71% male, median age of 66 years old (58, 70), and median BMI of 34 kg/m2 (30, 38). The healthy control group were 78% male, median age of 30 years old (24, 39), and a median BMI of 23 kg/m2 (22, 27)."

Respiratory Diseases

Efficacy, tolerability, and safety of the oral phosphate binder VS-505 (AP301). (PubMed, Nephrol Dial Transplant) - P2 | "VS-505, a novel phosphate binder, was well tolerated with a manageable safety profile, and effectively and dose-dependently reduced serum phosphorus in CKD patients with hyperphosphatemia receiving MHD. Clinical Trial registration number: NCT04551300."

Journal • Chronic Kidney Disease • Gastroenterology • Gastrointestinal Disorder • Metabolic Disorders • Nephrology • Renal Disease

Different timing for abdominal paracentesis catheter placement and drainage in severe acute pancreatitis complicated by intra-abdominal fluid accumulation. (PubMed, World J Gastrointest Surg) - "Percutaneous catheter drainage for the treatment of SAP complicated by intra-abdominal fluid accumulation is most effective when performed within 2 d of onset."

Journal • Oncology • Pancreatitis • CRP • IL6 • TNFA

Meta-analysis of Major Congenital Anomaly Outcomes Following Prenatal Exposure to Monotherapy Antiseizure Medications. (AES 2022) - "The evidence for lamotrigine (LTG) and levetiracetam (LEV) is presented here. Fifteen cohort studies and eight studies using routine health record data were identified to include pregnancies exposed to LTG, with eleven cohort studies and one routine health record data study identified for LEV...The MCA risk was significantly higher for exposure to carbamazepine (CBZ) in comparison to LTG from cohort studies (n=4018 vs. 4550, RR 1.37, 95% CI 1.06 to 1.77, p=0.02), but not from routine health record studies (n=1755 vs. 1906, RR 1.31, 95% CI 0.91 to 1.88, p=0.14)...Exposure to LTG had a lower MCA risk in comparison to topiramate (TPM) in cohort study data (n=4275 vs 505, RR 0.59, 95% CI 0.36 to 0.96, p=0.03), but data was limited for routine health record studies...There was no significant difference between the MCA risk for LTG exposure in comparison to oxcarbazepine (OXC) for cohort study data (n=2208 vs. 333, RR 0.73, 95% CI 0.33 to 1.62, p=0.44) or routine health record..."

Late-breaking abstract • Monotherapy • Retrospective data • CNS Disorders • Epilepsy

A Dose Escalation Study to Evaluate the Tolerability, Safety, and Efficacy of VS-505 in Hemodialysis Patients With Hyperphosphatemia (KIDNEY WEEK 2022) - "No SAE was related to VS-505 as assessed by the investigator. Conclusion VS-505, a novel non-absorbed phosphate binder, was safe and well tolerated and showed great effect on lowering serum phosphorus in HD patients with hyperphosphatemia."

Clinical • Gastrointestinal Disorder • Metabolic Disorders • Nephrology • Renal Disease

A Phase 2 Dose Ranging Study to Evaluate the Efficacy, Tolerability, and Safety of VS-505 in Hemodialysis Patients With Hyperphosphatemia (KIDNEY WEEK 2022) - P2 | "Table 1. Change in serum phosphorus from baseline to end of treament"

Clinical • P2 data • Metabolic Disorders • Nephrology • Renal Disease

The association of new-onset diabetes with subsequent diagnosis of pancreatic cancer-novel use of a large administrative database. (PubMed, J Public Health (Oxf)) - "NoD was independently associated with subsequent diagnosis of PDAC within 3 years. Future studies should evaluate the feasibility and benefit of PDAC screening in patients with NoD."

Journal • Chronic Obstructive Pulmonary Disease • Diabetes • Gastrointestinal Cancer • Hepatology • Immunology • Metabolic Disorders • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Pulmonary Disease • Respiratory Diseases • Solid Tumor • Type 2 Diabetes Mellitus

A Phase 2 Study to Evaluate the Safety and Efficacy of VS-505(AP301) to Treat Hyperphosphatemia in Hemodialysis Patients (clinicaltrials.gov) - P2 | N=158 | Completed | Sponsor: Shanghai Alebund Pharmaceuticals Limited | Active, not recruiting ➔ Completed

Trial completion • Chronic Kidney Disease • Metabolic Disorders • Nephrology • Renal Disease

Lung-function trajectories in COVID-19 survivors after discharge: A two-year longitudinal cohort study. (PubMed, EClinicalMedicine) - "Dyspnea (mMRC≥1) generally decreased over time (23.3% [61/262] for 6-month, 27.9% [67/240] for 1-year, 13.4% [35/261] for 2-year), and 6MWD increased continuously (500.0 m vs 505.0 m vs 525.0 m)...The relatively fast decline trend of PFTs from 1 year to 2 years needs to be paid attention and further validated in the future follow-up study. This work was supported by Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (CIFMS 2021-I2M-1-048) and the National Key Research and Development Program of China (2021YFC0864700)."

Journal • Infectious Disease • Novel Coronavirus Disease • Pulmonary Disease

The potential value of low-level serum interleukin-38 for the clinical diagnosis and risk prediction of hyperuricemia. (PubMed, Int Immunopharmacol) - "Low level of serum IL-38 shows some potential in the clinical diagnosis and risk prediction of HUA. In addition, as a novel biomarker of HUA, serum IL-38 would contribute to the in-depth study of its pathogenesis in the future."

Biomarker • Journal • Immunology • Inflammation

A Phase 2 Study to Evaluate the Safety and Efficacy of VS-505(AP301) to Treat Hyperphosphatemia in Hemodialysis Patients (clinicaltrials.gov) - P2 | N=158 | Active, not recruiting | Sponsor: Shanghai Alebund Pharmaceuticals Limited | Trial completion date: Aug 2022 ➔ Dec 2022

Trial completion date • Chronic Kidney Disease • Metabolic Disorders • Nephrology • Renal Disease

Biomechanical Comparison of Three Suspensory Techniques for all Soft Tissue Central Quadriceps Tendon Graft Fixation. (PubMed, Arthrosc Sports Med Rehabil) - "Similar failure loads were observed for the BTB CON and the BTB RS (446.4 ± 151.46 N vs 505.74 ± 131.41 N; P = .99) Failure testing was not feasible for the BTB CL and BTB EB preparation methods...It remains unknown which method of soft-tissue suspensory provides optimal fixation. As these autografts become more common, it is essential to evaluate which fixation methods provide superior outcomes."

Journal

Analysis of the effect of gene mutations on the efficacy of ruxolitinib in patients with myelofibrosis based on second-generation sequencing technology (PubMed, Zhonghua Xue Ye Xue Za Zhi) - "Moreover, patients carrying ASXL1 and EZH2 mutations had significantly shorter TTF [ASXL1: 360 (55-1270) d vs 440 (55-1268) d, z=-3.115, P=0.002; EZH2: 327 (55-975) d vs 404 (50-1270) d, z=-3.219, P=0.001], and significantly shorter PFS compared to non-carriers [ASXL1: 457 (50-1331) d vs 574 (55-1437) d, z=-3.219, P=0.001) ; 428 (55-1331) d vs 505 (55-1437) d, z=-2.576, P=0.008]. The type and number of mutations carried by patients with myelofibrosis and HMR impact the efficacy of ruxolitinib."

Journal • Hematological Disorders • Hematological Malignancies • Immunology • Myelofibrosis • Oncology • Polycythemia Vera • Thrombocytosis • ASXL1 • SRSF2

A Phase 2 Study to Evaluate the Safety and Efficacy of VS-505 to Treat Hyperphosphatemia in Hemodialysis Patients (clinicaltrials.gov) - P2 | N=158 | Active, not recruiting | Sponsor: Shanghai Alebund Pharmaceuticals Limited | Recruiting ➔ Active, not recruiting

Enrollment closed • Chronic Kidney Disease • Metabolic Disorders • Nephrology • Renal Disease

Rectal washout has no impact on the oncological outcome in abdominoperineal resection for rectal cancer. (PubMed, Colorectal Dis) - "Our results do not support routine rectal washout during abdominoperineal resection in order to improve the oncological outcome."

Journal • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Rectal Cancer • Solid Tumor

[VIRTUAL] PREVALENCE AND CLINICAL CHARACTERISTICS OF SARS-COV-2 CONFIRMED AND NEGATIVE KAWASAKI DISEASE PATIENTS DURING THE PANDEMIC IN SPAIN. (ESPID 2021) - "CoV+ patients were significantly older (7.5 vs 2.5yr), mainly non-Caucasian (64 vs 29%), had incomplete KD presentation (73 vs 32%), lower leucocyte (9.5 vs 15.5x109) and platelet count (174 vs 423x109/L), higher inflammatory markers (C-Reactive Protein 18.5 vs 10.9 mg/dl) and terminal segment of the natriuretic atrial peptide (4766 vs 505 pg/ml), less aneurysm development (3.8 vs 11.1%) and more myocardial dysfunction (30.8 vs 1.6%) than PreCoV patients... The KD CoV+ patients mostly meet PIMS-TC and MIS-C criteria. Around half of the KD patients presenting during the pandemic had confirmed SARS-COV-2 infection. Whether this is a novel entity or the same disease on different ends of the spectrum is yet to be clarified."

Clinical • Cardiovascular • Critical care • Immunology • Infectious Disease • Inflammation • Novel Coronavirus Disease • Pediatrics • Respiratory Diseases • CRP

[VIRTUAL] QUINOLINIC ACID IS ASSOCIATED WITH CAROTID INTIMA-MEDIA THICKNESS IN HIV (CROI 2021) - "HIV duration (4 yrs) and HIV-1 RNA (2461 copies/ml) were similar among HIV+, but nadir CD4+ was lower in HIV+ initiating ART (340 vs 505 cells/mm3; p<0.01)... QA, but not KA, was associated with both CCA and bulb IMT, and inflammatory and coagulation markers appear to mediate these effects. Also, TRYP metabolites were associated more closely with bulb IMT, the site with the highest inflammatory milieu. ART initiation appears to impact TRYP metabolite levels."

Cardiovascular • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • CD4 • ICAM1 • IL6 • VCAM1

Physical Activity, Dietary Habits and Sleep Quality Before and During COVID-19 Lockdown: A Longitudinal Study. (PubMed, Appetite) - "These participants spent a total of 48 days locked at home, a period during which a significant worsening in all the variables assessed except for the risk of developing eating disorders, was observed: weight (kg), 67.3 ± 14.8 vs 67.7 ± 15.1, p = 0.012; physical activity (MET minutes per week), 8515.7 ± 10260.0 vs 5053.5 ± 5502.0, p < 0.001; sleep problems (total score), 6.2 ± 3.5 vs 7.2 ± 3.9, p < 0.001; self-perceived well-being (score), 4 (3-4) vs 3 (3-4), p < 0.001...Findings from this longitudinal study indicate that a lockdown period due to COVID-19 had a negative impact on the physical activity levels, sleep quality and well-being in a group of physically active Spanish adults. Public health authorities should be aware that people who usually lead an active lifestyle, might be particularly susceptible to such disruptions."

Journal • Observational data • Infectious Disease • Novel Coronavirus Disease • Sleep Disorder

A Phase 2 Study to Evaluate the Safety and Efficacy of VS-505 to Treat Hyperphosphatemia in Hemodialysis Patients (clinicaltrials.gov) - P2; N=175; Recruiting; Sponsor: Shanghai Alebund Pharmaceuticals Limited; Not yet recruiting ➔ Recruiting

Clinical • Enrollment open • Chronic Kidney Disease • Metabolic Disorders • Nephrology • Renal Disease

A Phase 2 Study to Evaluate the Safety and Efficacy of VS-505 to Treat Hyperphosphatemia in Hemodialysis Patients (clinicaltrials.gov) - P2; N=175; Not yet recruiting; Sponsor: Shanghai Alebund Pharmaceuticals Limited

Clinical • New P2 trial • Chronic Kidney Disease • Metabolic Disorders • Nephrology • Renal Disease

Establishing an electronic health record-supported approach for outreach to and recruitment of persons at high risk of type 2 diabetes in clinical trials: The vitamin D and type 2 diabetes (D2d) study experience. (PubMed, Clin Trials) - "Establishing electronic health record-supported recruitment approaches across a multicenter prediabetes/diabetes trial is feasible and can be adopted by diverse clinical environments."

Clinical • Journal • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

NSCLC patient "migration" for treatment: A retrospective analysis of patient characteristics, travel patterns, and survival differences. (PubMed, Curr Probl Cancer) - "This analysis demonstrates a survival benefit for initially untreated patients with advanced disease who migrate to another hospital for treatment. Migration was associated with having private insurance, thus making it noteworthy of the relationship between NSCLC survival benefit and insurance status."

Journal • Retrospective data • Review