cefoperazone/sulbactum / Generic mfg. - LARVOL DELTA

Identification of Pantoea agglomerans in a patient with chronic abdominal sinus. (PubMed, J Family Med Prim Care) - "The organism was sensitive to most antibiotics, and the patient responded well to empirical treatment with cefoperazone/sulbactum...Accurate identification using the VITEK system and successful treatment with cefoperazone/sulbactam highlight the importance of advanced diagnostics and appropriate antibiotic therapy. This case highlights the importance of considering opportunistic pathogens like Pantoea agglomerans in chronic infections, emphasizing accurate microbial identification and susceptibility testing for effective therapy and optimal outcomes."

Journal • Immunology • Infectious Disease • Inflammation • Nephrology • Pain • Pneumonia • Pulmonary Disease • Respiratory Diseases • Rheumatology • Tuberculosis

A Rare Case of False Positive Bronchoalveolar Lavage Galactomannan (ATS 2024) - "False positive results have been reported due to cross reactivity with intravenous antibiotics usage - piperacillin tazobactum, cefoperazone sulbactum, co-amoxiclav; colonization of aspergillus; inhaled colistin. Now this case adds to the literature for another potential cause of false-positive BAL galactomannan. Also, a contrast CT would give a clue to the diagnosis of a pneumonia that is not responding to broad spectrum antibiotics."

Clinical • Esophageal Cancer • Gastroenterology • Infectious Disease • Oncology • Pneumonia • Pulmonary Disease • Respiratory Diseases • Septic Shock • Squamous Cell Carcinoma • Tuberculosis

Treatment Cost Along With Pattern of Disease and Therapy in the Intensive Care Unit of a Tertiary Care Teaching Hospital in India. (PubMed, Cureus) - "Cefoperazone/sulbactum, ceftriaxone, and piperacillin/tazobactam were the most utilized antibiotics with 8, 16, and 6 DDD/100 bed-days, respectively, while proton pump inhibitors, analgesics, and anti-epileptics were the most frequently prescribed non-antimicrobial drug class. Conclusion Drug utilization assessment provides crucial information for understanding the usage of drugs in the settings of the ICU, and should be conducted regularly to help in the proper planning and implementation of rational drug use. Treatment costs reflect the high economic burden seen in ICU admissions."

Journal • Treatment costs • Cardiovascular • Critical care • Epilepsy • Pain • Pediatrics

Drug-induced hemolytic anemia due to cefoperazone-sulbactum: Challenges in reaching diagnosis. (PubMed, J Postgrad Med) - No abstract available

Journal • Anemia • Hematological Disorders

Ralstonia mannitolilytica: an emerging multidrug-resistant opportunistic pathogen in a tertiary care hospital setting. (PubMed, Access Microbiol) - "Patients received treatment with cefoperazone/sulbactum and meropenem or ceftazidime. R. mannitolilytica is resistant to many routinely used antibiotics, including carbapenems."

Journal • Diabetes • Infectious Disease • Metabolic Disorders

Chronic wound isolates and their minimum inhibitory concentrations against third generation cephalosporins at a tertiary hospital in Uganda. (PubMed, Sci Rep) - "Generally, most isolates were susceptible to cefoperazone + sulbactum 2 g (Sulcef) and ceftriaxone 1 g (Epicephin). The overall prevalence of isolates in chronic wound infection among patients admitted in the surgical ward of MRRH was 92% and the most prevalent isolates were Staphylococcus aureus, Klebsiella species and proteus species respectively. The observed MIC values were higher than the CLSI clinical breakpoint, implying a decreasing trend in susceptibility of chronic wound isolates to third generation cephalosporins."

Journal • Infectious Disease

Pattern of Bacterial Infections in Indian Bone Marrow Transplant Patients - Experience from Chennai India (ASH 2021) - "Cefoperazone Sulbactum and Amikacin were started empirically as first line in all. Culture positivity rate was 22.7% of which 60% were multi-drug resistant gram negative bacilli which were sensitive only to Colistin / Fosfomycin / Tigecycline...This made us to change antibiotic stewardship policy to Colistin / Fosfomycin / Ceftazidime avibactum very early in course in case of second fever / Hypotension or tachycardia...The rate of gram positive bacteremia is only 2% and this makes us think of avoiding drugs like Teicoplanin / Glycopeptides in first line empirical therapy... This seven year study had shown 22.7% culture positivity rate in febrile neutropenia transplant patients of which 60% are multi-drug resistant bacteria which is highly contrary to western literature. The rate of gram positive culture growth is only 2% which is lower than western literature. This study implies the importance of region and center specific antibiotic policy for febrile neutropenia and a..."

Clinical • Bone Marrow Transplantation • Cardiovascular • Febrile Neutropenia • Hematological Disorders • Hypotension • Infectious Disease • Neutropenia • Septic Shock • Transplantation

Clinical correlation and antimicrobial susceptibility pattern of Chryseobacterium spp.: A three year prospective study. (PubMed, Intractable Rare Dis Res) - "Susceptibility to rifampicin was observed at a maximum (75%) followed by piperacillin-tazobactum (45%). Susceptibility against imipenem, meropenem, cotrimoxazole and cefoperazone-sulbactum were observed approximately 33%. Amikacin, cefotaxime and ceftazidime showed least susceptibility results. Further clinical correlation was established."

Clinical • Journal • Infectious Disease

Antimicrobial susceptibility patterns among community and health care acquired carbapenem resistant Enterobacteriaceae, in a tertiary care hospital of Lahore. (PubMed, J Pak Med Assoc) - "There was low antimicrobial resistance in community acquired carbapenem-resistant enterobacteraceae isolates."

Clinical • Journal • Complement-mediated Rare Disorders

CTX-M type extended-spectrum β-lactamase in Escherichia coli isolated from extra-intestinal infections in a tertiary care hospital in south India. (PubMed, Indian J Med Res) - "Most (91%) of the isolates positive for bla were sensitive to meropenem. Our findings showed bla to be the dominant gene. Based on the data on antimicrobial susceptibility, cefoperazone-sulbactum could be an antimicrobial of choice."

Clinical • Journal

Microbiological profile of non cystic fibrosis bronchiectasis patients at rural tertiary care centre of Western Uttar Pradesh (NAPCON 2019) - "The commonest organisms identified in bronchiectasis patients in our study were gram negative bacilli. The commonest isolate was Klebsiella followed by E.coli. Initial empirical antibiotic therapy in bronchiectasis can be started with a combination of Cefoperazone-Sulbactum with Aminoglycoside."

Clinical