Zioptan (tafluprost) / Santen, Merck (MSD) - LARVOL DELTA

Contamination Rates and Economic Evaluation of Reusing Medicated, Preservative-Free, Single-Use Eye Drops. (PubMed, Ophthalmic Physiol Opt) - "Within this hypothetical economic model, reusing single-use vials within 24 h demonstrated potential cost savings independent of the instillation technique. Further real-world studies are warranted as actual experienced patients are expected to provide pragmatic conclusions."

HEOR • Journal • Glaucoma • Infectious Disease • Ophthalmology

Prostaglandin Analogues Attenuate Hyaluronan Accumulation in Orbital Fibroblast Cultures (ETA 2026) - "Cells were cultured in the presence or absence of PGAs: latanoprost, tafluprost or bimatoprost, or prostaglandin F2 (PF2), with or without PDGF-BB (10 ng/ml) stimulation of HA synthesis. PGAs modulate HA levels in orbital fibroblasts not only by suppressing synthesis but also by promoting degradation. This dual action may offer therapeutic benefits in TED, where the progression of the disease is driven by pathological HA accumulation."

Glaucoma • Ophthalmology • Thyroid Eye Disease • CEMIP • HAS 3 • HAS1 • HAS2 • HYAL1

Omidenepag isopropyl (Omlonti) for glaucoma. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Glaucoma • Ophthalmology

A Comprehensive Review of the Clinical Evidence Comparing Benzalkonium Chloride-Preserved and Benzalkonium Chloride-Free Latanoprost in the Treatment of Primary Open-Angle Glaucoma and Ocular Hypertension. (PubMed, Clin Ophthalmol) - "Inclusion criteria were peer-reviewed clinical trials and meta-analyses comparing latanoprost with placebo or other treatments (eg. bimatoprost, travoprost, tafluprost, latanoprostene bunod)...Comparative studies indicate that latanoprost achieves a good balance between IOP reduction and tolerability compared to bimatoprost, travoprost, tafluprost, and unoprostone...Latanoprost remains a first-line therapy for POAG and OHT due to its efficacy, safety, and patient adherence. The availability of BAK-free formulations enhances its therapeutic profile, with reduced corneal toxicity making it a preferred choice for long-term glaucoma management."

Clinical • Journal • Review • Cardiovascular • Dermatology • Glaucoma • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain

Prostaglandin analogues in cosmetic products formulated for eyelash lengthening. (PubMed, Ann Pharm Fr) - "Six prostaglandin analogues were found, including bimatoprost and norbimatoprost. The most common are ethyl tafluprostamide, also known as dechloro dihydroxy difluoro ethyl cloprostenolamine (DDDE), and isopropyl cloprostenate...Conclusion : Serums containing prostaglandin analogues are therefore available on the market and are promoted as eyelash growth treatments. They pose a number of problems as they are not regulated for use in cosmetic products."

Journal

Efficacy and safety of netarsudil compared with prostaglandin-based therapies: a Bayesian network meta-analysis. (PubMed, Int Ophthalmol) - "The study aimed to compare the efficacy and safety of netarsudil (NET), alone or in fixed-dose combinations (FDC), in comparison with prostaglandin analogues (PGAs: bimatoprost [BIM], latanoprost [LAT], travoprost [TRA], and tafluprost [TAF]) for the treatment of primary open-angle glaucoma (POAG) or ocular hypertension. Although NET ranked lower in IOP-lowering efficacy compared to most PGAs and FDC, it demonstrated a favorable safety profile, particularly with a relatively lower incidence of conjunctival hyperemia than TAF and FDC. These findings suggest that NET may serve as a valuable alternative in patients who are intolerant to PGAs or require adjunctive therapy, warranting further investigation in targeted populations."

Clinical • Journal • Retrospective data • Cardiovascular • Glaucoma • Ophthalmology

Post-Marketing Surveillance Reveals Amplified Adverse Event Burden Across Topical Pharmacotherapies for Primary Open-Angle Glaucoma (ARVO 2026) - "The FDA-approved drugs evaluated included bimatoprost, tafluprost, travoprost, latanoprost, omidenepag, timolol, brimonidine, brinzolamide, dorzolamide, netarsudil, brinzolamide-brimonidine, and brimonidine-timolol. With average trial lengths of 15 months versus chronic real-world use, post-marketing data reveal multisystem and mortality-associated safety signals not detected pre-approval. These findings highlight gaps in the POAG trial safety reporting and may support the need for extended pharmacovigilance beyond formal trial periods."

Adverse events • P4 data • Glaucoma • Ophthalmology

Effect of prostaglandin analogues on hyaluronan production of orbital fibroblasts (ARVO 2026) - "Cells were treated with 40 µM prostaglandin F2α (PF2α) and PGAs: latanoprost, tafluprost, or bimatoprost for 72 hours. Conclusions PGAs affect HA production in OFs by inhibiting HA synthesis and by facilitating degradation. This may be beneficial in the treatment of TED related secondary glaucoma, where abnormal HA accumulation contributes to disease progression."

Glaucoma • Ophthalmology • CEMIP • HAS 3 • HAS1 • HAS2

Polyketal-conjugated tafluprost microparticles enable long-acting glaucoma therapy. (PubMed, Nat Commun) - "Tafluprost-polyketal conjugate microparticles that further encapsulate unconjugated tafluprost reduce intraocular pressure for approximately 3 months after subconjunctival injection in ocular normotensive female rats, exhibiting a low grade of tissue reaction, no retinal abnormalities or systemic side effects, and enhanced intraocular pressure-lowering efficacy compared with a long-acting bimatoprost-loaded biodegradable implant in an ocular hypertensive rat model. Our findings have broad implications in advancing extended drug delivery systems."

Journal • Glaucoma • Ophthalmology

Regional variation and trends in prostaglandin analogue prescribing for glaucoma in England 2019-2024. (PubMed, Eye (Lond)) - "Regional variation in PGA prescribing exists in England. Further investigation is required to determine the primary cause for the reported differences. Reducing variations so that prescribing clinicians are directed towards the most cost-effective PGA choice has the potential for considerable cost savings to NHS budgets."

Journal • Glaucoma • Ophthalmology

Comparison of Circadian Efficacy of Tafluprost Eye Drops (Taflotan Sine®) with Latanoprost Eye Drops (Xalatan®) in the Treatment of Open-Angle Glaucoma and Ocular Hypertension. (PubMed, J Clin Med) - "PF tafluprost eye drops remain a useful treatment option as long as the patient's individual target pressure is achieved. Furthermore, according to the literature, it is also a treatment option for patients with symptoms of ocular surface disease and other side effects affecting the ocular surface while receiving preservative-containing topical therapy."

Journal • Cardiovascular • Glaucoma • Ophthalmology

The Effect of Preoperative Use of High- vs. Low-PAP-Inducing-Potential FP Agonists on the Surgical Outcomes of Trabeculectomy and AGV Implantation. (PubMed, J Clin Med) - "The eyes were stratified by preoperative FP agonist use into the high-PAP-inducing-potential (bimatoprost or travoprost) and low-PAP-inducing-potential (latanoprost or tafluprost) groups. Although the effect on AGV implantation appears limited, it may still influence early postoperative results. These findings underscore the need to consider PAP risk and medication history when selecting surgical procedures for glaucoma."

Journal • Glaucoma • Ophthalmology

Pseudoexfoliation Glaucoma Selective Laser for Trabeculoplasty Treatment in Vietnam. (PubMed, Endocr Metab Immune Disord Drug Targets) - "SLT can be effectively used as a primary treatment for PXG. In cases of recurrent IOP elevation, a second SLT procedure can be administered alone or in combination with other medications."

Journal • Glaucoma • Ophthalmology

assessment of the role of patch testing in diagnosing allergic contact dermatitis linked to ophthalmic products: a retrospective review of 28 patients (EADV 2025) - "These included one positive result each to latanoprost, tafluprost, polymyxin B, and a hydrating product (Parpadual® gel-cream). Identification of the allergen is the cornerstone of treatment for allergic contact dermatitis related to ophthalmic products. However, in these patients, performing diagnostic patch testing can be challenging due to the lack of individual test substances and potential confounding factors such as cosmetic products, airborne allergens, and the pharmacological vehicle. The literature highlights the need to standardize and enhance the sensitivity of patch testing in ophthalmology; our case series supports this observation, as we found relevant positive results in only 14% of the patients studied (4 out of 28)"

Retrospective data • Review • Atopic Dermatitis • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Ophthalmology

Efficacy and safety of prostaglandin drugs for elevated intraocular pressure: a Bayesian network meta-analysis. (PubMed, Front Med (Lausanne)) - "To evaluate and compare the effectiveness and safety of latanoprost, bimatoprost, travoprost, and tafluprost in lowering intraocular pressure (IOP) in individuals with glaucoma or ocular hypertension. Latanoprost and tafluprost offered balanced efficacy with better tolerability, making them suitable for patients with mild disease. https://www.crd.york.ac.uk/PROSPERO/view/CRD420251034803."

Journal • Retrospective data • Review • Cardiovascular • Glaucoma • Ophthalmology

A study of the efficacy and treatment adherence of preservative-free tafluprost based on an electronic patient reporting system (ChiCTR) - P=N/A | N=60 | Completed | Sponsor: Changsha Aier Eye Hospital; Changsha Aier Eye Hospital

New trial • Glaucoma • Ophthalmology

Incidence of and factors associated with brimonidine allergy. (PubMed, PLoS One) - "Approximately 5.5% of brimonidine users developed brimonidine allergy, which typically manifested at 32 weeks. Concurrent artificial tear and tafluprost use increased brimonidine allergy risk, whereas topical steroids' concomitant use reduced the risk."

Journal • Retrospective data • Allergy • Immunology

HPLC method for detecting prostaglandin F2α analogs in cosmetics: Optimization for chromatographic separation and sample preparation. (PubMed, J Pharm Biomed Anal) - "Some prostaglandin F2α (PGF2α) analogs, including bimatoprost and tafluprost, are pharmaceutical substances known to cause specific abnormal reactions that promote eyelash growth. The verified analytical method was applied to eyelash serums currently available in the market, and norbimatoprost was detected in one product. The HPLC method proposed in this study may help prevent the distribution of cosmetics containing illegal PGF2α analogs."

Journal

ENDOSafe: Comparing the Safety and Efficacy in the Use of Hormonal Therapy on Endometriosis Patients After Conservative Surgery (clinicaltrials.gov) - P3 | N=80 | Completed | Sponsor: Universitas Diponegoro | Recruiting ➔ Completed | Trial completion date: Apr 2024 ➔ Nov 2024 | Trial primary completion date: Mar 2024 ➔ Aug 2024

Surgery • Trial completion • Trial completion date • Trial primary completion date • Endometriosis • Gynecology • Women's Health • TNFA

Changes in prostaglandin-associated periorbital syndrome: a self-controlled and prospective study. (PubMed, Cutan Ocul Toxicol) - P4 | "Bilateral instillation of bimatoprost, travoprost, latanoprost, or tafluprost was conducted (treatment, 3-6 months). Bimatoprost caused the most severe PAPS, and latanoprost caused the least severe PAPS. The study was registered at www.chictr.org.cn on 15 April 2021, under the identifier ChiCTR2100045465."

Journal • Cardiovascular • Glaucoma • Ophthalmology

Green extraction of prostaglandin analogs in cosmetics using deep eutectic solvents and detection via LC-MS/MS. (PubMed, J Chromatogr A) - "Prostaglandin analogs (bimatoprost, travoprost, tafluprost, etc.) have similar effects to prostaglandins and are effective drugs for treating glaucoma. Additionally, using the Analytical GREEnness calculator and complex green analytical procedure index tools, we confirmed that the method using the DES was greener than the other methods. In this study, we developed an analytical method for illicit compounds contained in eyelash growth serums, offering an eco-friendly approach for the prevention of the distribution of illegal cosmetics."

Journal • Dry Eye Disease • Glaucoma • Ophthalmology

RTA408 alleviates retinal ganglion cells damage in mouse glaucoma by inhibiting excessive autophagy. (PubMed, PLoS One) - "Autophagy mediates the occurrence of glaucoma in mice, promoting RGC apoptosis. RTA408 alleviates RGCs damage by inhibiting excessive autophagy in the context of glaucoma."

Journal • Preclinical • Glaucoma • Ophthalmology

Adverse events of topical ocular prostaglandin medications for glaucoma treatment: a pharmacovigilance study based on the FAERS database. (PubMed, Ther Adv Drug Saf) - "We screened and analyzed the generic and brand names of latanoprost, bimatoprost, travoprost, and tafluprost in the FAERS database and summarized and cleaned the baseline information of subjects receiving the above-mentioned drugs. Although signal detection analysis based on the FAERS database cannot establish a definitive causal relationship, our study found that FP receptor agonists used in glaucoma can cause various adverse events. Assessing their clinical suitability and potential side effects is crucial for providing personalized treatment and ensuring medication safety."

Adverse events • Journal • Glaucoma • Immunology • Ophthalmology

Prostaglandin analogues signal detection by data mining in the FDA Adverse Event Reporting System database. (PubMed, BMJ Open Ophthalmol) - "Our findings have revealed a potential relationship due to the biological plausibility among malignant mediastinal neoplasm, full blood count abnormal, blood immunoglobulin E increased, diabetes mellitus, blepharospasm, cataracts, chest discomfort and dry mouth; therefore, it is relevant to continue investigating the possible drug-event association, whether to refute the safety signal or identify a new risk."

Adverse events • Journal • Cataract • CNS Disorders • Diabetes • Glaucoma • Metabolic Disorders • Oncology • Ophthalmology • Xerostomia

Photocrosslinkable Sericin Hydrogel Injected into the Anterior Chamber of Mice with Chronic Ocular Hypertension Efficacy, Medication Sensitivity, and Material Safety. (PubMed, Bioengineering (Basel)) - "Two common drugs (tafluprost eye drops and timolol eye drops) were provided for one week after four weeks of stable IOP, and IOP changes were assessed to determine the drug sensitivity of the mouse model of chronic ocular hypertension...The model can simulate the structural and functional changes of glaucoma and can effectively reduce IOP after the action of most antihypertensive drugs, and it is highly sensitive to drugs. Sericin has no obvious toxic effect on cells and has high safety."

Journal • Preclinical • Cardiovascular • Cataract • Glaucoma • Ocular Infections • Ocular Inflammation • Ophthalmology