GS-5801 / Gilead - LARVOL DELTA

Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus. (PubMed, PLoS One) - "Evaluation of GS-5801 antiviral activity in a humanized mouse model of HBV infection, however, did not result in antiviral efficacy, despite achieving pharmacodynamic levels of H3K4me3:H3 predicted to be efficacious from the in vitro model. Here we discuss potential reasons for the disconnect between in vitro and in vivo efficacy, which highlight the translational difficulties of epigenetic targets for viral diseases."

Journal • Hepatitis B • Hepatology • Infectious Disease • Inflammation

The pleiotropic association between IL-10 levels and CVD prognosis: Evidence from a meta-analysis. (PubMed, Cytokine) - "Data from the GSE58015 dataset were used to investigate the levels of IL-10 under certain conditions...Furthermore, our data mining analysis supported our findings. Our analysis showed that IL-10 levels may be pleiotropically associated with the CVD prognosis possibly based on the type of pathology, disease stage and levels of other proinflammatory factors, such as IL-6."

Journal • Retrospective data • Cardiovascular