trisoralen / Generic mfg. - LARVOL DELTA

DNA Aptamers with Chemically Locked Ends for Virus Infection Inhibition. (PubMed, ACS Appl Mater Interfaces) - "Diagonal T-T bases were designed in the ends of aptamers and could be chemically cross-linked with trioxsalen via photocatalyzed cycloaddition...Notably, in the application exploration, the terminal locked aptamers, which bound to receptor-binding domains on SARS-CoV-2, showed superior performance in virus infection inhibition. This work puts forward a paradigm to develop a biological regulation pattern for aptamers based on chemical terminal manipulation of DNA, potentially promoting the clinical applications of nucleic acid drugs."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Comparison of Radio- and Phototoxicity in Association with an Enhancing Effect of the Photosensitizers Psoralen, Trioxsalen and Ortho-Iodo-Hoechst33258 on FaDu, PC-3, 4T1 and B16-F10 Cells. (PubMed, Biomedicines) - " Thus, an enhancing effect of photosensitizers (PS) in combination with UVA could be demonstrated in some cases. However, this is cell- and dose-dependent."

Journal

Investigation of Photodynamic Therapy Promoted by Cherenkov Light Activated Photosensitizers - New Aspects and Revelations (EANM 2024) - "An absorbance measurement shows that daylight does not induce a psoralen/trioxsalen reaction. The expected therapeutic effect of CL-activated PSs in radionuclide therapy could only be demonstrated on a non-significant basis in cells. The plasmid DNA data should shed light on this."

Oncology

Innovative Tools for DNA Topology Probing in Human Cells Reveal a Build-Up of Positive Supercoils Following Replication Stress at Telomeres and at the FRA3B Fragile Site. (PubMed, Cells) - "Indeed, the few tools available currently could only investigate unwound (Trioxsalen) or overwound (GapR) DNA topology (variations in twist) but not the variations in writhe (supercoils and plectonemes)...TRF2 depletion caused both telomere relaxation and an increase in positive supercoils while the inhibition of Histone Deacetylase I and II by TSA only caused telomere relaxation. Moving outside telomeres, we also observed a build-up of positive supercoils on the FRA3B fragile site following replication stress, suggesting a topological model of DNA fragility for this site."

Journal • TERF2

Investigation of Photodynamic Therapy Promoted by Cherenkov Light Activated Photosensitizers-New Aspects and Revelations. (PubMed, Pharmaceutics) - "Here, the CL for the activation of the PSs (psoralen and trioxsalen) is generated by the ionizing radiation from rhenium-188 (a high-energy beta-emitter, Re-188). The CL spectrum of Re-188 was measured. Fluctuating inconclusive results from clonogenic assays were found."

Journal

Benzopyrone, a privileged scaffold in drug discovery: An overview of FDA-approved drugs and clinical candidates. (PubMed, Med Res Rev) - "One of the pioneering anticoagulant drugs, warfarin approved in 1954 bears a benzo-α-pyrone (coumarin) nucleus. The widely investigated psoriasis drugs, methoxsalen, and trioxsalen, also contain a benzo-α-pyrone nucleus...The role of the pyrone core in biological activity has also been discussed. The present review unravels the potential of benzopyrone core in medicinal chemistry and drug development."

FDA event • Journal • Review • Asthma • Dermatology • Immunology • Psoriasis • Pulmonary Disease • Respiratory Diseases

Unique Crosslinking Properties of Psoralen-conjugated Oligonucleotides developed by Novel Psoralen N-Hydroxysuccinimide Esters. (PubMed, Chembiochem) - "Psoralens and their derivatives, such as trioxsalen, have unique crosslinking features to DNA. We found that the introduction of an oligonucleotide via a linker at the C-5 position of psoralen can promote favorable crosslinking to target double-stranded DNA. We believe our findings are essential information for the development of Ps-Oligos as novel gene regulation tools."

Journal

Deciphering the Biomolecules from Bacillus atrophaeus NMB01 Untangles the Anti-Oomycetes Action of Trioxsalen and Corynan-17-ol, Against Phytophthora infestans Inciting Late Blight of Potato. (PubMed, Indian J Microbiol) - "From the present study, we conclude that the biomolecules, trioxsalen and corynan-17-ol, can be explored for the management of P. infestans, the incitant of late blight of potato. The online version contains supplementary material available at 10.1007/s12088-022-01044-7."

Journal

Design and Application of Mini-libraries of the miRNA Probes for an Efficient and Versatile miRNA-mRNA Cross-linking. (PubMed, Chemistry) - "The new strategy is based on the utilization of a controlled mixture of probes for a chosen miRNA, in which the trioxsalen moiety is introduced at the N 4 -position of a selected cytidine through short oligoethylene glycol-based linkers. In vitro photo-cross-linking experiments with mini-libraries of probes for microRNAs of interest showed variable cross-linking efficiencies, giving strong evidence for the general applicability of the presented approach."

Journal