CIT-110 / Cureimmune Therap - LARVOL DELTA

Activity of LpxC inhibitors on carbapenemase producing Citrobacter spp. clinical isolates. (PubMed, J Glob Antimicrob Resist) - "strains, with low (Cit 52) and high (Cit 110) LpxC inhibitor MIC values...Although LpxC-4 had a lower MIC90 value compared to CHIR-090, CHIR-090 showed a bactericidal effect at short times and prevented the regrowth of both isolates in time-kill assays. In terms of cross resistance, all three structurally similar LpxC inhibitors showed a moderate positive correlation between their activity."

Journal • Infectious Disease