NV 52 / Kazia - LARVOL DELTA

Accelerometer-Based Navigation in Primary TKA Leads to Improved Alignment but No Change in PROs. (PubMed, J Arthroplasty) - "Accelerometer-based navigation is valuable in its ability to improve postoperative alignment, but does not improve complication rates or patient reported functional outcomes."

Journal • Anesthesia • Orthopedics • Pain

"Perceived regulatory complexity is a key driver of supply chain vulnerabilities for medicinal products, according to a European Commission staff working document created. https://t.co/rbvSsnVD07" (@RAPSorg)

European regulatory

"yo this is cool @chengk40682163 @DianeArlotta @KhoachDong43245 @RohanV35291770 @bantai @GlopesMd @donkeyfly2 @MoutHave_co @NFTHorrorPunk @FlornesHenrik @rogrroman @DimasJulian01 @nikolasav06 @LineWooo" (@BahramNurettin)

Huntington's disease phenotypes are improved via mTORC1 modulation by small molecule therapy. (PubMed, PLoS One) - "Further, the heart contractility, heart fibrosis, and survival were improved in response to the cardiac stressor isoprenaline when compared to vehicle-treated mice. Cummulatively, these data support mTORC1 activation as a therapeutic target in HD and consolidates NV-5297 as a promising drug candidate for treating central and peripheral HD phenotypes and, more generally, mTORC1-deficit related diseases."

Journal • Cardiovascular • CNS Disorders • Congestive Heart Failure • Fibrosis • Heart Failure • Huntington's Disease • Immunology • Infectious Disease • Movement Disorders • Pneumonia • Respiratory Diseases

"Single cell characterization of the cellular landscape of acral melanoma identifies novel targets for IO - in CCR congrats Drs Li, Chen and Smalley ⁦@InnaSmalley⁩ ⁦@LabSmalley⁩ ⁦@MoffittNews⁩ thanks for letting me be a part of the project https://t.co/Nv5079g6j4" (@jzager99)

Melanoma • Oncology • Solid Tumor

"$GE GE Healthcare to Acquire BK Medical, Expanding Ultrasound Portfolio into Surgical Visualization https://t.co/YbNVs07m3L" (@stock_titan)

Isolation of Outer Membrane Vesicles from Helicobacter pylori. (PubMed, Methods Mol Biol) - "Additional measures may be adopted to further size-fractionate the population of OMV including gel filtration or density gradient ultra-centrifugation in order to facilitate differentiation between the activities of small versus large OMV, as recent studies have demonstrated differential modes of entry into host cells as well as size-dependent differences in the OMV proteome (Turner et al., Front Immunol 9:1466, 2018). The OMV from H. pylori harbor many of the virulence factors associated with gastric disease including the CagA oncoprotein, the cytotoxin VacA, and the HtrA protease (Olofsson et al., mBio 5:e00979-14, 2014; Mullaney et al., Proteomics Clin Appl 3:785-96, 2009) and their close association with areas of cell-cell contact and efficient endocytosis supports a role for these complexes in gastric disease (Turkina et al., FEMS Microbiol Lett 362:fnv076, 2015)."

Journal • Infectious Disease

Identification of the functional regions of the viral haemorrhagic septicaemia virus (VHSV) NV protein: Variants that improve function. (PubMed, Fish Shellfish Immunol) - "...Here, eight different NV 07.71 fragments and eleven NV 07.71 mutants derived from the region between the two first α-helices have been studied in order to establish the mx and il8 transcript levels in ZF4 cells and the subcellular location...Taken together, the data presented in this work indicated that NV function relies on the first part of the molecule and is dependent on tertiary structure rather than on the linear one. This study could lead to a better knowledge of VHSV escape from fish antiviral mechanisms as well as to future studies on immune targets."

Journal • Biosimilar

"Our great speakers: @paulwilshaw of @blue_prism, Haydyn Phillips @AstraZeneca , @christhelwell of @EY_Seren, @ninabelk & @siobhanc of @modhuman, Rory Woods of @BiglightBuzz , Danielle Macdonald of @ReceiptBank @cgavrykov of @intersport, @tanvi07 of @KLM & @nicolesaidy @bookingcom" (@TechCircus_)

"@LilianV85273235 you may find this interesting!" (@amolmpatel)

"@MountSinaiNYC https://t.co/nv07mPoHU6" (@ebscbwi)