Surfacen (natural lung surfactant) / Centro Nacional de Sanidad Agropecuaria - LARVOL DELTA

Deep Sequencing of Hepatitis B Virus Reveals Clinically Relevant Low-Frequency Variants Among People Living with HIV in Botswana. (PubMed, Viruses) - "(3) A total of six escape mutations were detected in 8/104 (7.7%) sequences, with surfaceN131T being the most prevalent (5/8)...(4) Deep sequencing results identified clinically significant mutations, including those below the 20% detection limit of traditional sequencing, that would go unreported. This highlights the possible underreporting of mutational burden in people living with HBV/HIV, indicating the importance of deep sequencing to aid in HBV/HIV understanding and management."

Journal • Tumor mutational burden • Hepatitis B • Hepatocellular Cancer • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Oncology • Solid Tumor • TMB

A Parallel Meshless Voronoi Method for Generalized SurfaceNets. (PubMed, IEEE Trans Vis Comput Graph) - "Characterization of parallel performance is also quantified, including producing Voronoi and Delaunay tessellations of 128 million hulls and more than 750 million tetrahedra. A software implementation is available from the open source the Visualization Toolkit (VTK) system at vtk.org."

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Inhalable liposomal delivery of osimertinib and DNA for treating primary and metastasis lung cancer. (PubMed, Nat Commun) - "Upon inhalation, these nanoparticles efficiently penetrate pulmonary barriers and accumulate in lungs by mimicking natural lung surfactants. This strategy effectively inhibits both primary and metastatic tumors while enhancing antitumor immune responses. This work suggests that this inhalable nanomedicine offers a safe and versatile strategy for cancer therapy."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor

Water-based lignin nanoparticle/cellulose nanofibril functional films via spray deposition (ACS-Sp 2024) - "This allows for facile application together with CNFs due to their hydrophilic surfacenature and excellent film forming abilities...The self-assembly of the LNP and CNF depends on the different routes and results in different roughness, porosity, and nanostructure of these thin films. The nanostructures from different routes also result in different UV-absorption properties, which allow the optimized UV absorption while maintaining transparency of the visible light."

Targeted DPPC/DMPG Surface-Modified Voriconazole Lipid Nanoparticles Control Invasive Pulmonary Aspergillosis in Immunocompromised Population: In-vitro and In-vivo Assessment. (PubMed, Int J Pharm) - "Inspired by natural lung surfactants, dipalmitoyl phosphatidylcholine/dimyristoyl phosphatidylglycerol (DPPC/DMPG)-surface modified lipid nanoparticles (LNPs) were scrutinized for pulmonary administration...A preclinical study using a cyclophosphamide-induced neutropenic rat model demonstrated a 3-fold reduction in BALF-Galactomannan down to 0.515±0.22 µg/L confirming DPPC/DMPG-VRZ-LNPs potential in hyphal growth inhibition...Nevertheless, DPPC/DMPG-VRZ-LNPs-treated animals displayed minimal hyphae with no signs of invasiveness. The developed bioinspired nanoparticles serve as prospective bioactive nanocarrier candidates for pulmonary administration of VRZ in the management of IPA."

Journal • Preclinical • Pulmonary Disease • Respiratory Diseases

Surface Pressure-Area Mechanics of Water-Spread Poly(ethylene glycol)-Based Block Copolymer Micelle Monolayers at the Air-Water Interface: Effect of Hydrophobic Block Chemistry. (PubMed, Langmuir) - "Amphiphilic block copolymer micelles can mimic the ability of natural lung surfactant to reduce the air-water interfacial tension close to zero and prevent the Laplace pressure-induced alveolar collapse...High surface pressure and a high compressibility modulus were also found to be correlated with the formation of wrinkles in the micelle monolayer (visualized by Brewster angle microscopy (BAM)). From this study, we conclude that polymer micelles based on hydrophobic block materials having higher T and θ are more suitable for surfactant replacement therapy applications that require the therapeutic surfactant to produce a high surface pressure and modulus at the alveolar air-water interface."

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