rocuronium / Generic mfg. - LARVOL DELTA

In silico assessment of neuromuscular blocking agents and fluoroquinolones as ligands of the Mas-related G protein-coupled receptor X2. (PubMed, Pharmacol Rep) - "In contrast to fluoroquinolones, NMBAs displayed different affinity for MRGPRX2. Cellular responses in bench experiments closely reflected the MD predictions. Alanine scanning revealed that the MRGPRX2 binding pocket exhibits low susceptibility to single-site mutations that enhance receptor responsiveness."

Journal • Immunology

Hyperkalemic emergency department patients intubated with rocuronium or succinylcholine: Retrospective study of clinical outcomes. (PubMed, Am J Emerg Med) - "We found no statistically significant difference in clinical adverse events between succinylcholine and rocuronium in hyperkalemic ED patients. While limited by its retrospective design, this study questions the presumed clinical importance of potassium levels in paralytic selection for RSI."

Clinical data • Journal • Retrospective data • Cardiovascular

ROCVIDEO: Remifentanil Versus Rocuronium for Optimizing Video Laryngoscopy-assisted Tracheal Intubation (clinicaltrials.gov) - P4 | N=2648 | Recruiting | Sponsor: Nordsjaellands Hospital | Not yet recruiting ➔ Recruiting | Trial completion date: Sep 2026 ➔ Apr 2027 | Trial primary completion date: Jun 2026 ➔ Apr 2027

Enrollment open • Intubation • Trial completion date • Trial primary completion date • Anesthesia

Bibliometric analysis of sugammadex sodium literature based on the Web of Science database. (PubMed, Medicine (Baltimore)) - "Research on sugammadex sodium has received significant scholarly attention, with strong potential for future collaborative studies. The impact of sugammadex sodium on postoperative complications remains a promising area for in-depth analysis and a topic for future research."

Journal • Anesthesia

Median effective dose of rocuronium for the prevention of succinylcholine-induced fasciculation: an age-stratified study. (PubMed, BMC Anesthesiol) - P=N/A | "Prophylactic intravenous rocuronium effectively prevents succinylcholine-induced fasciculation, with the median effective dose remaining consistent across age groups (18-44, 45-59, and 60-80 years)."

Journal • Anesthesia • Musculoskeletal Pain • Pain

Comparison of the effects of different general anesthesia methods on the quality of early postoperative recovery in patients undergoing metabolic bariatric surgery: A randomized controlled trial. (PubMed, J Physiol Pharmacol) - "In both groups, patients received propofol, remifentanil and rocuronium for induction...In Group S, anesthesia was maintained with sevoflurane and remifentanil...No significant intergroup difference in QoR-40 scores was observed at 48 h postoperatively, and NRS scores were comparable between groups at both time points. The study results indicate that propofol intravenous anesthesia is associated with better recovery quality at 24 h after metabolic bariatric surgery, while the recovery difference between the two methods diminishes by 48 h."

Clinical • Journal • Anesthesia • Genetic Disorders • Obesity • Pain

Anesthetic Management Using Remimazolam for Dental Treatment in a Pediatric Patient With Dravet Syndrome. (PubMed, Anesth Prog) - "After a slow mask induction with sevoflurane, RMZ, remifentanil, and rocuronium were administered to facilitate oral intubation, after which general anesthesia was maintained with air, oxygen, and continuous infusions of RMZ and remifentanil. Intraoperative temperature and other vital signs were stable, and no fever or convulsions were observed during the perioperative period. RMZ is an ultrashort-acting benzodiazepine that may be useful for the anesthetic management of pediatric patients with DS because of its potential to prevent seizures."

Journal • Anesthesia • CNS Disorders • Epilepsy • Pediatrics

Stability of emergency medications during extreme cold: a controlled environmental study. (PubMed, Scand J Trauma Resusc Emerg Med) - "Emergency medications can remain chemically stable under extreme cold conditions when stored in sealed, insulated packaging. While our study simulated prehospital conditions without direct environmental exposure, these findings support the feasibility of extended storage and transport of emergency medications in challenging field settings. Further research should assess the impact of direct environmental exposure and evaluate additional stability parameters to optimize storage protocols in real-world scenarios."

Journal

Sex-based differences in anesthesia approaches and outcomes: a narrative review. (PubMed, Anaesth Crit Care Pain Med) - "Women exhibit reduced sensitivity to propofol, experience more rapid emergence from general anesthesia, but demonstrate increased sensitivity to opioids and neuromuscular blockers like rocuronium...This narrative review aims to summarize current evidence on sex-related differences in anesthesia and highlights key gaps in the literature according to recent considerations. While emerging data suggest meaningful sex-based variations, further research is needed to elucidate underlying mechanisms and promote a more personalized approach to perioperative management."

Journal • Review • Anesthesia • Pain

Changes in intraoperative rocuronium dosing following the introduction of sugammadex and association with postoperative respiratory complications: A retrospective cohort study. (PubMed, Anesthesiology) - "Sugammadex introduction was followed by a 45.1% increase in rocuronium doses. While sugammadex attenuated the risk of postoperative respiratory complications, it was only completely abolished with quantitative neuromuscular monitoring."

Journal • Retrospective data • Anesthesia

A practice survey of airway management in Australian and New Zealand intensive care units: A 6-year follow-up study. (PubMed, Anaesth Intensive Care) - "The use of ketamine for induction doubled (33.2% versus 15.3%; aOR = 2.96; 95%CI: 1.65 to 5.31), and rocuronium (89.6%) was the most used neuromuscular-blocking agent. A majority (81%) supports mandatory airway management continuing professional development (CPD) for fellows of the College of Intensive Care Medicine of ANZ (CICM). Despite improvements in airway management among ANZ ICU clinicians, notable gaps persist between current practices and recent trial evidence and guideline recommendations, supporting the need for airway management CPD for CICM fellows."

Journal • Anesthesia • Critical care

Rocuronium for Treatment of Sugammadex Anaphylaxis: A Case Report. (PubMed, Case Rep Anesthesiol) - "We present a case suggesting the converse might also be efficacious. In a critically ill patient with refractory anaphylaxis apparently triggered by sugammadex, administration of rocuronium rapidly restored hemodynamic stability."

Journal

Comparison of the Effects of Hyoscine-N-Butylbromide and Ondansetron on Postoperative Nausea-Vomiting after Laparoscopic Cholecystectomy: A Prospective Randomized Study. (PubMed, Niger J Clin Pract) - "The effects of hyoscine-n-butylbromide and ondansetron on PONV and pain are similar in laparoscopic cholecystectomy. In laparoscopic cholecystectomies, hyoscine-n-butylbromide is a good alternative for PONV prophylaxis in eligible patients."

Clinical • Journal • Pain

Safety and Efficacy of HRS-9190 Compared to Rocuronium for Tracheal Intubation in Adults (clinicaltrials.gov) - P2 | N=66 | Recruiting | Sponsor: Jiangsu HengRui Medicine Co., Ltd.

Intubation • New P2 trial • Anesthesia

Optimization and Validation of a Green Shelf Life HPLC Technique for Testing Sugammadex Sodium in Raw Material and Parenteral Medications. (PubMed, Biomed Chromatogr) - "An intravenous drug called sugammadex is used to counteract the adverse reactions of the relaxation medications rocuronium and vecuronium, which are given during operations to provide full anesthesia. It includes the eluting phase that comprises of 7 mL/L aqueous solution of triethylamine adjusted at pH 3.0 with phosphoric acid: ethanol (750:250) (V:V). The positive environmental impacts of the LC technique are demonstrated by the combined AES grade of 87, CACI rating of 78, AGSA rating of 75, MoGAPI rating of 80, BAGI rating of 82.5, and final whiteness rating of 96.7."

Journal • Anesthesia • Cerebral Hemorrhage

Neostigmine Versus Sugammadex for Reversal of Neuromuscular Blockade in Elderly Patients: A Blinded Randomised Study. (PubMed, Acta Anaesthesiol Scand) - P4 | "Time to TOF ≥ 0.9 was shorter after reversal with sugammadex 2 mg kg-1 compared to neostigmine/glycopyrrolate 50/10 μg kg-1 in elderly patients administered rocuronium during total intravenous anaesthesia. For neostigmine a large variation in time to recovery was detected. No significant difference in clinical signs of residual NMB was found."

Clinical • Journal • Anesthesia

Perioperative Management of Patients Undergoing Kidney Transplantation in the United States-A National Survey. (PubMed, Clin Transplant) - "This survey demonstrated significant heterogeneity in the perioperative management of kidney transplant recipients in the U.S. There is an urgent need for further research on how perioperative management strategies affect postoperative outcomes after kidney transplantation to better guide evidence-based practice."

Journal • Anesthesia • Transplantation

Developing a Physiology-Pharmacodynamic Model of Rocuronium Dose and Cardiac Output to Investigate the Onset Time of Neuromuscular Relaxation (clinicaltrials.gov) - P4 | N=32 | Not yet recruiting | Sponsor: Clare Hayes-Bradley | Initiation date: Sep 2025 ➔ Dec 2025

Trial initiation date • Anesthesia

Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease (clinicaltrials.gov) - P4 | N=490 | Recruiting | Sponsor: The University of Texas Medical Branch, Galveston | Trial primary completion date: Sep 2025 ➔ Dec 2026

Trial primary completion date • Anesthesia • Chronic Kidney Disease • Nephrology • Renal Disease

Reversal effect of sugammadex sodium on rocuronium-induced neuromuscular blockade in patients undergoing painless tracheoscopy. (PubMed, Am J Transl Res) - "In painless tracheoscopy, sugammadex sodium provides rapid and complete reversal of rocuronium, lowers postoperative complications, and improves perioperative efficiency."

Journal • Anesthesia • Cardiovascular • Pain

Effects of Different Doses of Dexmedetomidine on Perioperative Stress Response and Postoperative Recovery in Elderly Patients. (PubMed, J Perianesth Nurs) - "Dexmedetomidine administration during the perioperative period contributes to maintaining intraoperative hemodynamic stability, reducing surgical stress responses, and enhancing postoperative recovery in elderly patients. Additionally, higher doses of dexmedetomidine were associated with improved postoperative pain relief and cognitive function compared to lower doses and the control group."

Journal • Anesthesia • Pain • CRP

Rocuronium-Induced Rhabdomyolysis: A Case Report and Literature Review. (PubMed, Cureus) - "We recommend limiting the maintenance dose of rocuronium and closely monitoring patients for signs of muscle injury or elevated CK levels during and after treatment. This case highlights the importance of careful assessment and monitoring when using rocuronium, particularly in vulnerable populations, to mitigate the risk of rhabdomyolysis and other adverse effects."

Journal • Anesthesia • Movement Disorders • Pain

Risk of postoperative urinary retention after sugammadex use in laparoscopic hernia repair: A matched cohort study of 23,444 cases. (PubMed, PLoS One) - "Sugammadex use is associated with a 77% reduction in POUR and 24% fewer ED visits than neostigmine following hernia repair, suggesting that it may be the preferred reversal agent, particularly for older adults who gain the most benefit."

Journal • Retrospective data • Benign Prostatic Hyperplasia • Gastroenterology • Infectious Disease • Pneumonia • Respiratory Diseases

Intubating conditions based on the time from rocuronium administration versus the train-of-four count: A randomized, prospective, clinical trial. (PubMed, J Clin Anesth) - "Intubating conditions were better when the timing of intubation was guided by quantitative neuromuscular monitoring to ensure a TOF count ≤1 versus waiting a fixed time interval of 2 min following administration of rocuronium."

Journal • Anesthesia

Peri-operative hypersensitivity reactions to neuromuscular blocking drugs in New Zealand 2013-2019: a retrospective observational study. (PubMed, Anaesthesia) - "We found a significant difference between the rates of peri-operative hypersensitivity reactions with rocuronium and suxamethonium vs. atracurium. The increased risk of a peri-operative hypersensitivity reaction is a factor that should be weighed against the benefits of using suxamethonium or rocuronium. Females may be higher risk than males of reacting to neuromuscular blocking drugs."

Journal • Observational data • Retrospective data • Allergy • Anesthesia • Immunology