rocuronium / Generic mfg. - LARVOL DELTA

Association of Sarcopenia With Rocuronium Use in Liver Transplant Recipients (clinicaltrials.gov) - P=N/A | N=3 | Completed | Sponsor: Inonu University | Recruiting ➔ Completed

Trial completion • Fibrosis • Gastroenterology • Hepatology • Immunology • Liver Cirrhosis • Sarcopenia • Transplantation

Rocuronium versus Succinylcholine Use in Pediatric Emergency Department Intubations and Adverse Airway Outcomes: A National Emergency Airway Registry for Pediatric Emergency Medicine (NEAR4PEM) Study (PAS 2026) - No abstract available

Adverse events • Clinical • Intubation • Pediatrics

Safety and Efficacy of HRS-9190 Compared to Rocuronium for Bolus Maintenance in Adults (clinicaltrials.gov) - P2 | N=90 | Recruiting | Sponsor: Jiangsu HengRui Medicine Co., Ltd. | Not yet recruiting ➔ Recruiting

Enrollment open • Anesthesia

SUGAPEDIA: A Dose-response Study to Determine the Right Dosage of Sugammadex as a Reversal Agent of Rocuronium in Infants Between 1 and 24 Months Old (clinicaltrials.gov) - P4 | N=99 | Not yet recruiting | Sponsor: University Hospital, Caen

New P4 trial

Hemodynamic Effects of Ketamine Versus Etomidate for RSI in Critically Ill Patients (SCCM 2026) - "Rocuronium was the primary neuromuscular blocker administered after induction (88%) and most patients were intubated in the ED (73%). There was no difference in the incidence of post-intubation hypotension between ketamine and etomidate when used for RSI in normotensive critically ill patients. This study highlights that both of these induction agents for RSI are hemodynamically neutral."

Clinical • Cardiovascular • Hypotension • Respiratory Diseases

Roc'd by Anaphylaxis, Saved by Sugammadex (SCCM 2026) - "Awake fiberoptic intubation was performed with lidocaine, fentanyl, and remimazolam. Sugammadex avoided the need for additional epinephrine, IV fluids, and complex airway procedures. Our findings add to the limited literature and suggest a novel consideration of including sugammadex with epinephrine as first line treatment for rocuronium-induced anaphylaxis."

Aesthetic Medicine • Hypotension • Immunology • Infectious Disease • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder • Squamous Cell Carcinoma

Evaluation of Clinical Outcomes With Varying Doses of Sedation in Rapid Sequence Intubation (SCCM 2026) - "The low-dose cohort was defined as patients who received lower than guideline-recommended doses of sedation based on actual body weight (i.e. etomidate < 0.3 mg/kg, ketamine < 1 mg/kg) in combination with a NMBA...Mean doses of rocuronium (0.75 mg/kg vs 1.01 mg/kg) and succinylcholine (1.19 mg/kg vs 1.83 mg/kg) were higher in the standard-dose cohort... Utilizing lower doses of sedation induction during RSI in combination with NMBA did not result in a different rate of first pass success but did result in a lower incidence of hemodynamic instability."

Clinical • Clinical data • Intubation • Cardiovascular • Hypotension

Neuromuscular block in paediatric patients undergoing airway management: a narrative review. (PubMed, Curr Opin Anaesthesiol) - "NMBAs are a key component of paediatric airway management when spontaneous ventilation is unnecessary. Routine integration of quantitative monitoring and appropriate pharmacological reversal is essential to reduce residual block and improve patient safety."

Journal • Pediatrics

Neuromuscular Blockade for Intracranial Hypertension: Quantifying Real-World Effectiveness on Intracranial Pressure. (PubMed, J Intensive Care Med) - "Adjusted GAM modeling demonstrated reductions of -1.66 mm Hg at 3 h and -2.23 mm Hg at 6 h.ConclusionsContinuous Rocuronium infusion was associated with modest (approximately 1-2 mm Hg) reductions in ICP and improved CPP. Although these physiologic changes are small and may have limited clinical significance, this study provides the largest real-world evaluation and quantification of the effect of continuous neuromuscular blockade on ICP control and directly informs a major evidence gap highlighted in contemporary guidelines."

Journal • Real-world evidence • Cardiovascular • CNS Disorders • Hypertension • Vascular Neurology

A pilot study of a novel portable mass spectrometer for rapid, simultaneous detection of multiple anesthetic drug concentrations. (PubMed, Front Vet Sci) - "Etomidate (ET, 1.5 mg/kg), rocuronium bromide (ROC, 5 mg/kg), and lidocaine (LID, 2 mg/kg) were administered, and plasma samples from rats were analyzed using the Cell portable MS and compared with results obtained by high-performance liquid chromatography with mass spectrometry (HPLC-MS)...Bland-Altman analysis showed small mean biases, with most data points falling within the 95% limits of agreement and no proportional bias observed. Overall, the Cell portable MS demonstrated good quantitative agreement with conventional HPLC-MS for rapid, simultaneous measurement of multiple anesthetic drug concentrations, supporting its potential for real-time anesthetic drug toxicity monitoring and individualized dosing, particularly in emergency settings."

Journal • Anesthesia

Postoperative residual neuromuscular blockade and hypoventilation after rocuronium and sugammadex or neostigmine for kidney transplantation: A randomized clinical trial. (PubMed, J Clin Anesth) - P4 | "Sugammadex was non-inferior to neostigmine on the incidence of RNMB and hypoventilation, even after adjusting for RNMB, opioids, and other covariates, in PACU and up to three days after kidney transplantation."

Clinical • Journal • Anesthesia • Nephrology • Pulmonary Disease • Transplantation

Pupillometry as a Novel Tool for Pain Monitoring: Evaluating the Antinociceptive Effect of Intravenous Lidocaine During Orotracheal Intubation. (PubMed, J Clin Med) - "Standardized anesthesia induction was performed using propofol, fentanyl, and rocuronium. Intravenous lidocaine attenuates the pupillary response to nociceptive stimuli during orotracheal intubation but does not influence PPI scores. Pupillometry remains a valuable adjunct for intraoperative nociceptive monitoring."

Intubation • Journal • Anesthesia • Pain

Sugammadex vs Neostigmine for Reversal of Neuromuscular Blockade and Association with Postoperative Atelectasis After Video-Assisted Thoracoscopic Surgery: A Propensity Score-Matched Cohort Study. (PubMed, Drug Des Devel Ther) - "From the TriNetX Global Collaborative Network (2016-2024), adults undergoing elective VATS who received rocuronium reversed with either sugammadex or neostigmine were identified. Sugammadex use was associated with a reduced postoperative atelectasis risk in patients undergoing VATS. Prospective randomized trials are warranted to confirm these findings and establish causality."

Clinical • Journal • Retrospective data • Video • Cardiovascular • Genetic Disorders • Infectious Disease • Obesity • Pneumonia • Respiratory Diseases • Septic Shock

Effect of Neuromuscular Block Depth on Driving Pressure in Open Abdominal Surgery (clinicaltrials.gov) - P=N/A | N=128 | Not yet recruiting | Sponsor: Ankara City Hospital Bilkent

New trial

Heart Transplantation with Donation After MAiD (ISHLT 2026) - "MAiD was performed according to local protocols, utilizing propofol, rocuronium, and potassium chloride...Rabbit anti-thymocyte globulin (rATG) was used for induction therapy...Current outcomes with DCD-HT after MAiD internationally are mixed, with a 30-day survival of 100% albeit with a severe PGD rate of 50%. Appropriate implementation of DCD-HT after MAiD is dependent on strict adherence to ethical principles that puts donor self-determination and autonomy at the centre."

Cardiomyopathy • Cardiovascular • Transplantation

A Novel and Sustainable HPLC Method for Monitoring Mutagenic Impurity in Injectable Medicines and Raw Ingredients via Microscale Preparation: Assessment via Greenness Tools. (PubMed, Biomed Chromatogr) - "The goal of the presented methodology was to evolve and verify a simple, environmentally friendly, white HPLC stability-indicating technology that can identify the mutagenic contaminant allyl bromide in both raw materials and parenteral rocuronium bromide medications...The HPLC method features simple implementation, environmental sustainability, and compliance with ICH Q2(R2), ICH M7, and US FDA validation criteria. It offers advantages like shorter retention time, reduced reagent use, microscale sample preparation, and lower costs compared to complex systems like UPLC-MS."

Journal • Cerebral Hemorrhage

The Effect of Deep Versus Moderate Muscle Relaxants in Men During and After Robotic Surgery for Prostate Cancer (clinicaltrials.gov) - P2 | N=139 | Active, not recruiting | Sponsor: Memorial Sloan Kettering Cancer Center | Trial completion date: Jan 2026 ➔ Jan 2027

Trial completion date • Genito-urinary Cancer • Oncology • Pain • Prostate Cancer • Solid Tumor

A case report: intravenous provocation testing clears rocuronium after sugammadex-rocuronium complex-induced anaphylaxis. (PubMed, BJA Open) - No abstract available

Journal

Monitoring of neuromuscular block for safe anesthesia: FAQs for proper understanding. (PubMed, J Anesth) - "Quantitative monitoring of the TOF ratio is particularly essential during emergence from anesthesia, as it also serves as an indicator for calculating the optimal dose of the rocuronium antagonist sugammadex. Evaluation of the TOF ratio in hand muscles indicates recovery of the upper airway muscles, which are highly sensitive to rocuronium. This would facilitate safe tracheal extubation and ensure adequate ventilatory recovery."

Journal • Review • Anesthesia • Infectious Disease • Pneumonia • Respiratory Diseases

Postoperative Urinary Retention After Reversal of Neuromuscular Block by Neostigmine versus Sugammadex in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Trial. (PubMed, Anesth Analg) - "In patients undergoing laparoscopic cholecystectomy, neuromuscular blockade with rocuronium followed by reversal with sugammadex provides a significant reduction in postoperative urinary retention when compared to reversal with neostigmine, without any major adverse effects."

Journal • Anesthesia

Time to Sedation and Analgesia After Rapid Sequence Intubation in the Emergency Department. (PubMed, Emerg Med Australas) - "We observed a median time of 7.5 min between paralysis and administration of post-intubation sedation or analgesia within an Australian ED. Ongoing surveillance with strategies to minimise "sedation gap" is indicated."

Intubation • Journal • Anesthesia • Mood Disorders

Uncommon intraoral source of generalized tetanus: Case report and review of intensive care strategies. (PubMed, IDCases) - "He was admitted to the intensive care unit (ICU) of a tertiary referral hospital in Indonesia for 19 days and received spasm control (diazepam, midazolam, rocuronium, magnesium sulfate), bacterial eradication (metronidazole, procaine penicillin), stepwise mechanical ventilation, and both enteral and parenteral nutritional support. Despite a prolonged and complex clinical course, the patient favorable outcome. This case highlights that intraoral wounds, though uncommon, may serve as clinically relevant source of tetanus infection due to the anaerobic and necrotic environment that facilitates Clostridium tetani spore germination."

Journal • Critical care • Endocrine Disorders • Infectious Disease • Pain • Pneumonia • Respiratory Diseases • Tetanus

Perioperative Anaphylaxis in Children at a Large, Academic Pediatric Hospital (AAAAI 2026) - "3 on skin prick testing (morphine, rocuronium, sugammadex) and 2 on ID testing (vecuronium, midazolam). The 3 patients with elevated tryptase levels all had severe anaphylaxis or arrest (grades 3 or 4 on Ring and Messmer scale) and positive skin testing to medication during subsequent evaluation. Conclusions In this cohort of pediatric patients with perioperative anaphylaxis, confirmatory allergy testing identified drug culprits in less than half of cases."

Clinical • Immunology • Pediatrics

Ideal Versus Actual Body Weight for Dosage of Sugammadex in Patients With Body Mass Index Less Than 18.5: A Randomized Controlled Trial. (PubMed, Cureus) - "There was no significant difference in sugammadex recovery time from deep neuromuscular block between dosing based on actual body weight and dosing based on ideal body weight in underweight patients."

Journal • Anesthesia

Application of Low-dose Muscle Relaxants in Bronchoscopic Interventional Procedures (clinicaltrials.gov) - P=N/A | N=153 | Completed | Sponsor: Harbin Medical University | Recruiting ➔ Completed | Trial completion date: Jan 2028 ➔ Jul 2025 | Trial primary completion date: Jun 2026 ➔ Jul 2025

Trial completion • Trial completion date • Trial primary completion date • Respiratory Diseases