rocuronium / Generic mfg. - LARVOL DELTA

Ephedrine for Reducing Onset Time of Rocuronium in Elderly Patients: A Randomised Study. (PubMed, Acta Anaesthesiol Scand) - P4 | "No reduction was found in onset time of rocuronium 0.6 mg kg-1 in elderly patients after administration of ephedrine 0.15 mg kg-1 compared to placebo during induction of anaesthesia. The ephedrine group had more stable blood pressure, but a larger occurrence of tachycardia compared to placebo."

Clinical • Journal • Anesthesia • Cardiovascular • Otorhinolaryngology

Effect of Muscle Relaxants on Postoperative Sore Throat in Video Laryngeal Mask Airway(LMA) Use (clinicaltrials.gov) - P=N/A | N=90 | Recruiting | Sponsor: Samsun University

New trial • Otorhinolaryngology

Remimazolam-Based Anesthesia Without Neuromuscular Blockade for Laparoscopic Surgery in a Patient With Immune-Mediated Necrotizing Myopathy: A Case Report. (PubMed, Case Rep Anesthesiol) - "A 44-year-old woman with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody-positive immune-mediated necrotizing myopathy and marked preexisting muscle weakness underwent laparoscopic myomectomy under total intravenous anesthesia with remimazolam and remifentanil without neuromuscular blocking agents. In this patient with immune-mediated necrotizing myopathy and marked preexisting muscle weakness, laparoscopic surgery was completed without neuromuscular blocking agents under remimazolam-based total intravenous anesthesia, with low-dose rocuronium available as rescue treatment. Tracheal intubation was smooth, surgical conditions were acceptable, and postoperative respiratory recovery was uncomplicated."

Journal • Anesthesia • Myositis

Effects of cisatracurium and rocuronium on intraoperative neuromonitoring and putuative mechanical trauma in 500 robotic baba thyroidectomies. (PubMed, Surg Endosc) - "In robotic BABA thyroidectomy with IONM, a single low dose of cisatracurium 0.05 mg/kg provides excellent intubation conditions, stable EMG signals, and low RLN morbidity, without evidence of increased mechanical trauma despite the lack of force feedback. Higher cisatracurium dose and rocuronium 0.3 mg/kg yielded similar EMG and clinical outcomes in this series, but should be interpreted as exploratory due to small sample size. These findings support low-dose cisatracurium as a practical, guideline-consistent NMBA strategy for robotic thyroid surgery with IONM."

Journal • Anesthesia • Pain

REMI-MEP: REMIfentanil (2 vs. 4 mcg/kg) Facilitated Intubation Without Neuromuscular Blockade Versus Succinylcholine and Rocuronium With Sugammadex for Endotracheal Intubation in Spine Surgery Requiring Motor Evoked Potential Monitoring (clinicaltrials.gov) - P4 | N=316 | Not yet recruiting | Sponsor: Mayo Clinic

Intubation • New P4 trial • Orthopedics

Safety and Efficacy of HRS-9190 Compared to Rocuronium for Tracheal Intubation and Bolus Maintenance in Adults (clinicaltrials.gov) - P3 | N=320 | Recruiting | Sponsor: Jiangsu HengRui Medicine Co., Ltd. | Not yet recruiting ➔ Recruiting

Enrollment open • Intubation • Anesthesia

Postoperative Residual Neuromuscular Block and Passive Smoke Exposure in Pediatric Dental Patients (clinicaltrials.gov) - P=N/A | N=55 | Not yet recruiting | Sponsor: Istanbul University - Cerrahpasa

New trial • Pediatrics

Effect of Neuromuscular Blockade on Video Laryngeal Mask Airway Ventilation (clinicaltrials.gov) - P4 | N=96 | Not yet recruiting | Sponsor: Korea University Guro Hospital

New P4 trial • Anesthesia

Clinical application of sugammadex in renal impairment: pharmacokinetics and pharmacodynamics. (PubMed, Front Pharmacol) - "Sugammadex, a modified γ-cyclodextrin, rapidly and predictably reverses aminosteroid neuromuscular blockade by directly encapsulating rocuronium and vecuronium, thereby avoiding the cholinergic adverse effects associated with acetylcholinesterase inhibitors. Overall, sugammadex may serve as an effective and generally well-tolerated reversal agent in carefully selected patients with severe renal impairment. Additional prospective studies are required to establish its long-term safety and guide clinical recommendations."

Journal • PK/PD data • Review • Chronic Kidney Disease • Nephrology • Renal Disease

Prospective, randomized comparison of electromyographic neuromuscular responses from the adductor pollicis and abductor digiti minimi muscles during rocuronium-induced neuromuscular block. (PubMed, Anesthesiology) - "The present study underscores the equivalency between ADM and AP muscles for routine neuromuscular monitoring during surgery. When monitoring the non-dominant arm, the ADM and AP muscles have similar recoveries. In the dominant arm, the ADM muscle recovery is significantly faster than that of the AP muscle."

Journal • Anesthesia

Comparative Efficacy of Oliceridine and Sufentanil in Laparoscopic Postoperative Analgesia: Impact on Pain Relief and Hyperalgesia (ChiCTR) - P=N/A | N=144 | Not yet recruiting | Sponsor: Jilin Provincial People's Hospital; Jilin Provincial People's Hospital

New trial • Pain

Clinical application effect of lateral position insertion of visual occlusion bronchial intubation in unilateral thoracoscopic surgery: A single-center, prospective, randomized controlled trial (ChiCTR) - P=N/A | N=146 | Not yet recruiting | Sponsor: The First Hospital Of Jiaxing; The First Hospital Of Jiaxing

Intubation • New trial • Lung Cancer • Oncology • Solid Tumor

COMPARISON OF CLINICAL OUTCOMES IN SUCCINYLCHOLINE VS ROCURONIUM ADMINISTRATION IN PATIENTS UNDERGOING EMERGENCY AIRWAY MANAGEMENT: A SYSTEMATIC REVIEW AND META-ANALYSIS (CHEST 2026) - No abstract available

Clinical data • Retrospective data • Review

Impact of Sugammadex on Clinical and Patient-Centered Outcomes: Beyond Neuromuscular Recovery. (PubMed, J Clin Med) - "Sugammadex provides rapid and predictable reversal of rocuronium- and vecuronium-induced blockade and reduces residual neuromuscular blockade more effectively than conventional anticholinesterase-based reversal. Sugammadex may be associated with favorable selected postoperative outcomes, but it should not be regarded as an independent determinant of recovery. Its clinical effects must be interpreted as part of optimized neuromuscular management incorporating quantitative monitoring, blockade-depth-appropriate dosing, confirmation of recovery, and comprehensive perioperative care."

Journal • Review • Anesthesia • Cardiovascular • CNS Disorders • Immunology • Pain • Renal Disease

Ephedrine for Reducing Onset Time of Rocurinium in Elderly Patients (clinicaltrials.gov) - P4 | N=80 | Completed | Sponsor: Matias Vested | Recruiting ➔ Completed

Trial completion

TetraGraph to Evaluate Onset and Recovery Times of Rocuronium (clinicaltrials.gov) - P=N/A | N=130 | Enrolling by invitation | Sponsor: Nationwide Children's Hospital | Not yet recruiting ➔ Enrolling by invitation

Enrollment open

Efficacy and Safety of HRS-9190 in General Anesthesia (clinicaltrials.gov) - P3 | N=320 | Enrolling by invitation | Sponsor: The Third Xiangya Hospital of Central South University | Not yet recruiting ➔ Enrolling by invitation

Enrollment open • Intubation • Anesthesia

Effect of Dexmedetomidine on Postoperative Analgesia After Video-assisted Thoracoscopic Lobectomy Surgery. (PubMed, Int J Med Sci) - "Intraoperative rocuronium requirements, cumulative patient-controlled epidural analgesia (PCEA) consumption from the intraoperative period to 48 hours postoperatively, and the number of rescue analgesic boluses administered in the post-anesthesia care unit were significantly lower in Group D than in Group S (p = 0.002, 0.001, and 0.013, respectively). Perioperative dexmedetomidine infusion reduced postoperative epidural analgesic requirements and improved early postoperative pain control and patient satisfaction in patients undergoing VATS lobectomy with combined epidural and general anesthesia. Despite an increased incidence of transient bradycardia and hypotension, dexmedetomidine was well tolerated and may be considered an effective opioid-sparing adjunct in this surgical population."

Clinical • Journal • Video • Anesthesia • Cardiovascular • CNS Disorders • Depression • Hypotension • Pain • Psychiatry

Serial Fetal Heart Rate Monitoring During Electroconvulsive Therapy in Late Pregnancy: A Case Report of Transition From Succinylcholine to Rocuronium Reversed With Neostigmine. (PubMed, Neuropsychopharmacol Rep) - "Postpartum ECT was resumed for five additional sessions using rocuronium reversed with sugammadex, and the patient achieved clinical remission. This case suggests the feasibility of rocuronium with neostigmine reversal as an alternative to succinylcholine for ECT during late pregnancy when succinylcholine is unavailable, provided that multidisciplinary management and fetal monitoring are available."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry • Respiratory Diseases • Suicidal Ideation

Urinary Difficulty After General Anesthesia for Otolaryngology Head and Neck Surgery. (PubMed, Ear Nose Throat J) - "No patients with rocuronium plus sugammadex had POUD.ConclusionsPOUD is common following otolaryngology head and neck surgery, particularly in older male patients and with prolonged operation time. It is essential to develop targeted interventional strategies to prevent and manage POUD in these high-risk groups."

Journal • Anesthesia • Otorhinolaryngology

Awake emergency laparotomy under combined spinal epidural anaesthesia in a high-risk patient with severe pulmonary disease and neuromuscular blocking agent anaphylaxis. (PubMed, BMJ Case Rep) - "NMBAs are responsible for approximately 60-70% of anaesthesia-induced hypersensitivity reactions, with rocuronium and succinylcholine being the most frequently implicated agents...Surgery was completed successfully without conversion to general anaesthesia, and the patient had an uncomplicated perioperative course with no respiratory compromise. This case highlights the feasibility of neuraxial anaesthesia as the sole anaesthetic technique in carefully selected high-risk patients undergoing emergency abdominal surgery and underscores the importance of multidisciplinary planning and shared decision-making."

Journal • Allergy • Anesthesia • Chronic Obstructive Pulmonary Disease • Geriatric Disorders • Immunology • Pulmonary Disease • Respiratory Diseases

Laryngeal mask airway use during liver transplantation: perioperative outcomes in a propensity score-matched cohort. (PubMed, Ann Med) - "The LMA group showed a higher rate of immediate airway device removal, lower rocuronium use during anesthetic maintenance, less postoperative noninvasive ventilation, less postoperative sore throat, and a shorter postoperative hospital stay...No increase in major airway-related adverse events was observed in the LMA group. In carefully selected liver transplant recipients, use of LMA within a recovery-oriented perioperative context appeared feasible and was associated with several favorable early postoperative outcomes."

Journal • Retrospective data • Anesthesia • Critical care • Otorhinolaryngology • Transplantation

Total Rocuronium Requirement During Intermittent Bolus Versus Continuous Infusion for Deep Neuromuscular Block in Elective Abdominal Cancer Surgery: A Randomized Equivalence Trial. (PubMed, J Clin Med) - " This prospective, single-center, randomized equivalence trial enrolled 72 adults undergoing elective abdominal cancer surgery under sevoflurane-remifentanil anesthesia...Deep NMB duration (127 ± 43 vs. 132 ± 65 min; p = 0.687) and recovery after sugammadex did not differ significantly...Recovery outcomes did not differ significantly; however, the infusion protocol required rescue boluses in some patients. PTC-guided individualization is therefore needed."

Journal • Anesthesia • Oncology

Reduced-exposure neuromuscular blockade strategies for total laparoscopic hysterectomy within an ERAS pathway: a randomized controlled trial. (PubMed, BMC Anesthesiol) - P=N/A | "In this study, reduced NMBA exposure was not associated with differences in clinically acceptable intubating conditions, surgical workspace quality, or early recovery outcomes among selected patients undergoing elective total laparoscopic hysterectomy within an ERAS pathway. These findings suggest that reducing NMBA exposure may be feasible under carefully standardized anesthetic conditions. Further prospective studies incorporating quantitative neuromuscular monitoring are warranted to validate these findings."

Clinical • Journal • Anesthesia • Gynecology • Pain • IL6 • TNFA

ANESTHESIA INDUCTION and MAINTENANCE with SEVOFLURANE and REMIFENTANIL in a patient with a SEVERE ALLERGY history (ASA 2026) - "This medically challenging case will illustrate a non-traditional anesthetic induction and maintenance technique on a patient with a recent history of carboplatin-induced SJS/TEN and recent hypersensitivity reactions to prior anesthetic agents, possibly related to fentanyl, propofol, or rocuronium. Thanks to this plan, no postoperative hypersensitivity reactions were observed, which helped informed future anesthetic management for this patient. Ultimately, this case will provide learners with a new induction and maintenance technique that will help minimize exposure to anesthetic agents that may lead to hypersensitivity or anaphylactic reactions to high-risk populations in an ambulatory surgery setting"

Clinical • Allergy • Immunology • Steven-Johnson Syndrome