isotretinoin / Generic mfg. - LARVOL DELTA

P046 Investigating sexual side-effects in female patients on isotretinoin via routine screening questionnaires. (PubMed, Br J Dermatol) - "Clin Exp Dermatol 2024; 49: 1396-404). This study highlights the need for monitoring platforms to prompt dermatologists to explore genital symptoms and for clear guidance for managing sexual side-effects should these occur.TableOutcomes for positive responders (n = 27)OutcomeNumber of patients (%)Resolution of sexual side-effects7 (26)Sexual side-effects not acknowledged by clinicians9 (33)Sexual side-effects acknowledged by clinicians2 (7)Sexual side-effects acknowledged & managed7 (26)Stopped isotretinoin due to multiple side-effects2 (7)."

Adverse events • Journal • Observational data • Retrospective data • Sexual Disorders

PA09 Exploring the potential impact of adhering to the Medicines and Healthcare products Regulatory Agency 'introduction of new safety measures for isotretinoin' guidelines (October 2023). (PubMed, Br J Dermatol) - "While our study highlights that our department has adhered well to the new guidance, it also shows that this has had potential costs on the provision of services and hinders our approach to deliver sustainable healthcare. With long waiting lists across dermatology departments, we question the appropriateness of these guidelines in providing a well-rounded dermatological service that serves our entire patient population.TableAdditional time for appointments Time (min)Dermatology Life Quality Index2Patient Health Questionnaire -93General Anxiety Disorder-72Male acknowledgement-of-risk form9.5Female acknowledgement-of-risk form11Second prescriber7.5Scanning and uploading eight sheets to patient record4."

Journal • Acne Vulgaris • CNS Disorders • Dermatology • General Anxiety Disorder • Mood Disorders • Pediatrics • Psychiatry

P097 Atypical pemphigoid and an acneiform eruption in a patient with inflammatory bowel disease. (PubMed, Br J Dermatol) - "The differential diagnosis included fungal and bacterial infections, and his scalp responded to terbinafine and ciprofloxacin, with partial improvement of his face and trunk...He responded rapidly to high-dose oral prednisolone, which was tapered over 3 months...His working diagnosis is two concurrent conditions: an atypical pemphigoid and a separate acneiform/pustular eruption possibly on the pyoderma gangrenosum-hidradenitis suppurativa spectrum in the context of irritable bowel disease. He is now well controlled on dapsone and doxycycline, with isotretinoin added recently, given an overarching clinical feature of an acneiform eruption at present."

Journal • Acne Vulgaris • Dermatology • Gastroenterology • Gastrointestinal Disorder • Hidradenitis Suppurativa • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Pyoderma Gangrenosum • Ulcerative Colitis

O03 Implications of the implementation of the new UK regulatory framework for the prescribing of isotretinoin: an assessment of the impact on outpatient capacity. (PubMed, Br J Dermatol) - "There is an urgent need to review the interpretation of the scientific evidence underpinning the change in the regulatory framework; it is apparent that the views of expert, experienced, dermatologists were not appropriately heeded. It is also very important to work with the CHM to mitigate the very significant impacts of the changes on (i) people with acne, including the harm of withholding treatment or deterring patients from accepting treatment (e.g. scarring, depression and other adverse psychosocial outcomes) and (ii) people with other skin conditions."

Journal • Acne Vulgaris • CNS Disorders • Depression • Dermatology • Erectile Dysfunction • Genetic Disorders • Oncology • Psychiatry • Skin Cancer

BC01 Isotretinoin plus 420-nm intense pulsed light vs. isotretinoin alone for the treatment of acne vulgaris: a randomized, controlled study of efficacy, safety and patient satisfaction. (PubMed, Br J Dermatol) - "Topical agents for both groups included adapalene 0.1% gel and fusidic acid 2% cream. Other major advantages included lightening basic skin tone and relieving erythema. It achieved clinical improvement within a limited treatment duration, and may have a particularly beneficial effect in patients who expect a rapid remission."

Clinical • Journal • Acne Vulgaris • Dermatology

PA41 Treating severe nodulocystic acne with isotretinoin in children with cystic fibrosis. (PubMed, Br J Dermatol) - "Alternative acne treatments, such as antibiotics, carry the risk of antibiotic resistance, a significant challenge in this population. This case highlights the importance of individualized approaches to isotretinoin treatment and multidisciplinary collaboration."

Journal • Review • Acne Vulgaris • Cystic Fibrosis • Dermatology • Diabetes • Genetic Disorders • Hepatology • Immunology • Liver Failure • Metabolic Disorders • Pediatrics • Pulmonary Disease • Respiratory Diseases • Transplantation

DP04 A case of elastosis perforans serpiginosa in a patient with trisomy 21. (PubMed, Br J Dermatol) - "Regular medications were notable for tofacitinib to treat her psoriatic arthritis, moderately potent topical steroid preparations, and coal tar shampoo to treat her scalp psoriasis...Noted associations with EPS include connective tissue diseases such as cutis laxa, pseudoxanthoma elasticum, Ehlers-Danlos syndrome (EDS), Marfan syndrome and systemic sclerosis; trisomy 21; Rothmund-Thompson syndrome; and medications such as D-penicillamine...Reported treatments include topical corticosteroids, topical retinoids, cryotherapy, topical imiquimod, narrowband ultraviolet B radiation, oral isotretinoin and ablative carbon dioxide laser, with variable results. This case highlights that EPS should be considered in patients with trisomy 21 given the association. It also highlights that when undertaking a biopsy in suspected EPS it is important to take samples from the keratotic papules to ensure diagnostic accuracy."

Journal • Dermatology • Dermatopathology • Genetic Disorders • Hurler Syndrome • Immunology • Inflammatory Arthritis • Psoriasis • Psoriatic Arthritis • Rare Diseases • Rheumatology • Scleroderma • Seronegative Spondyloarthropathies • Systemic Sclerosis

BT13 A remote nurse prescriber service: enhancing capacity for new patients and streamlining services to ensure high-quality patient care and satisfaction. (PubMed, Br J Dermatol) - "Nurse prescribers work remotely and conduct isotretinoin services...Costs are reduced as nurses work from home and no office space is needed. All of these aspects contribute to the success of the scheme and increase revenue while ensuring patient care is at the forefront of the initiative."

Journal • Atopic Dermatitis • Dermatology • Immunology • Infectious Disease • Mood Disorders • Novel Coronavirus Disease • Psoriasis • Psychiatry

The history, development and current status of isotretinoin: a review article. (PubMed, Clin Exp Dermatol) - "The review also addresses contemporary concerns such as the drug's teratogenicity and potential link to depression, providing an overview of regulatory measures and mixed research findings on mental health and sexual dysfunction. Additionally, the current status of isotretinoin in other medical areas, including its exploration as a chemotherapy adjunct, is examined."

Journal • Acne Vulgaris • CNS Disorders • Depression • Dermatology • Oncology • Psychiatry • Sexual Disorders

Combining 675 nm Laser with Isotretinoin for Enhanced Acne Vulgaris Treatment Outcomes. (PubMed, Healthcare (Basel)) - "Pain was reported as mild in most cases, and no discontinuations occurred. These findings indicate that the 675 nm laser is a safe and effective therapeutic option for acne vulgaris, with isotretinoin addition resulting in more rapid and pronounced clinical improvement."

Journal • Acne Vulgaris • Dermatology • Pain

A Red Lobulated Facial Mass: A Clinicopathological Challenge. (PubMed, Int J Dermatol) - "The condition was refractory to initial methotrexate and isotretinoin therapy. We report a rare and clinically challenging case of RDD diagnosed with the aid of histopathology and immunohistochemistry. Additionally, we emphasize the role of a combined approach of serial surgical excisions and systemic dapsone therapy."

Journal • Dermatofibrosarcoma Protuberans • Hematological Malignancies • Immunology • Lymphoma • Non-Hodgkin’s Lymphoma • Non-melanoma Skin Cancer • Oncology • Rare Diseases • Sarcoidosis • Sarcoma • Soft Tissue Sarcoma • Solid Tumor • TNFRSF8

Metabolic stress sensing by epithelial RXRα links westernization of diet with Crohn's disease. (PubMed, Cell Metab) - "Oral exposure to isotretinoin ameliorated PUFA-induced metabolic enteritis in two mouse models, and isotretinoin therapy reduced the odds of developing CD in an analysis of electronic health care records from 170,597 patients. Collectively, we identify RXRα in Paneth cells as a metabolic stress sensor that enables enteritis, providing novel perspectives for the prevention and treatment of CD."

Journal • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • CXCL1

Topical retinoid use in women of reproductive age and risk of major congenital malformations in exposed pregnancies - a Nordic cohort study. (PubMed, Br J Dermatol) - "We observed a 3.3-fold increase in topical retinoid use over the past 18 years among women of reproductive age in the Nordic countries. We did not observe an increased risk of MCM associated with use of topical retinoids. Limiting to pregnancies resulting in a birth could underestimate both the prevalence of topical retinoid exposure and MCM risk."

Journal • Acne Vulgaris

Discrete papular lichen myxedematosus successfully treated with isotretinoin. (PubMed, JAAD Case Rep) - No abstract available

Journal

Rates of missed windows and premature treatment discontinuation for those treated with isotretinoin via telemedicine. (PubMed, J Am Acad Dermatol) - No abstract available

Journal

Unsuspected Adverse Drug Reactions to Dermatologic Medications: An Epidemiological Hypothesis-Free Screening Study of Real-World Data in Denmark. (PubMed, Drug Saf) - "Systematic hypothesis-free screening using SSA on nationwide real-world data can effectively identify potential unknown ADRs for dermatological drugs. The specific signals found in this study potentially have clinical implications and warrant further targeted investigations to support causality. This approach supports the implementation of routine real-world data screening to supplement traditional pharmacovigilance."

Adverse drug reaction • Journal • Real-world evidence • Atrial Fibrillation • Cardiovascular • Dermatology • Gastroenterology

Laser Therapy in the Isotretinoin-Induced Sacroiliitis (clinicaltrials.gov) - P=N/A | N=50 | Recruiting | Sponsor: Uşak University

New trial

Exercise Therapy for Isotretinoin Users (clinicaltrials.gov) - P=N/A | N=160 | Recruiting | Sponsor: Uşak University | Not yet recruiting ➔ Recruiting

Adverse events • Enrollment open • Musculoskeletal Diseases

Isotretinoin-induced severe dry eye disease and meibomian gland alterations in patients with acne vulgaris: A noncontact ocular surface analysis. (PubMed, Med J Malaysia) - "Isotretinoin therapy in patients with AV is remarkably associated with greater MGL, severe dry eye symptoms, and reduced tear film stability, supporting a lipiddeficient mechanism in isotretinoin-induced DED. Routine ocular surface evaluations are recommended for the early detection and management of ocular complications in patients receiving isotretinoin."

Journal • Observational data • Acne Vulgaris • Dermatology • Dry Eye Disease • Ophthalmology

Isotretinoin Does Not Increase the Risk of Inflammatory Bowel Disease: A TriNetX Retrospective Cohort Analysis. (PubMed, J Drugs Dermatol) - "Long-term isotretinoin therapy does not increase the risk of IBD in acne patients. &nbsp."

Journal • Retrospective data • Acne Vulgaris • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

A Case of Generalized Bowen's Disease Accompanied by Generalized Seborrheic Keratosis with Literature Review. (PubMed, Case Rep Dermatol) - "Treatment included cryotherapy, oral acitretin capsules, and topical isotretinoin cream. Clinicians should maintain a high index of suspicion when evaluating irritated or inflamed SK lesions, as they may mask underlying Bowen's-like changes. Early recognition and appropriate management are essential to ensure optimal patient outcomes."

Journal • Bowens Disease • Oncology

Prescription Drugs Subject to a Risk Evaluation and Mitigation Strategy: Patient Perspectives on Risk Communication and the Value of Educational Materials. (PubMed, Drug Saf) - "Gaps in patients' and caregivers' understanding of REMS programs and drug risks highlight the merits of reviewing communication materials and strategies. Clear, concise, and comprehensive educational documents could promote understanding and adherence to REMS requirements."

Journal • Infectious Disease

Roflumilast as an Emerging Treatment for Oral Lichen Planus: A Case Series (ISDS 2025) - "Management typically relies on off-label medications such as topical corticosteroids (TCS), systemic corticosteroids, calcineurin inhibitors (TCI), oral retinoids, and cyclosporine. Phosphodiesterase-4 (PDE-4) inhibitors, including apremilast and roflumilast, have recently been explored for OLP...Case Series: We present three cases of OLP in patients aged 65, 66, and 69, each with recurrent flares after multiple prior therapies, including TCS, TCI, hydroxychloroquine, and minoxidil...Adjunctive therapy included isotretinoin in two cases and topical tacrolimus swish and spit in the third case... This case series suggests that OR may be an effective treatment option for OLP. Further studies are warranted, as only one prior investigation of OR in OLP exists."

Clinical • Anorexia • Dermatitis • Dermatology • Dermatopathology • Gastrointestinal Disorder • Immunology • Inflammation • Lichen Planus • Movement Disorders • Mucositis • Pruritus • CD8

The Rise of Dangerous At-Home "Treatments" for Psoriasis and Hidradenitis Suppurativa (ISDS 2025) - "- Unregulated systemic therapies: procurement of methotrexate, isotretinoin, or biologics from black-market sources. Psoriasis and HS patients are increasingly adopting unsafe, misinformation-driven at-home treatments, ranging from caustic chemicals to black-market biologics. Published reports and media analyses demonstrate that these practices worsen morbidity and delay engagement with evidence-based care. Acknowledging how misinformation spreads and intensifies across digital platforms provides a foundation for public health interventions, patient education efforts, and policies aimed at expanding equitable access to safe dermatologic care."

Dermatology • Hidradenitis Suppurativa • Immunology • Infectious Disease • Inflammation • Psoriasis • Thermal Injury

Transcriptome-Guided Treatment in Refractory Acne Fulminans: A Case Report (ISDS 2025) - "Over a four-year period, conventional (isotretinoin, antibiotics, and dapsone) and off-label treatments (TNF-α and interleukin 17A inhibitors, and TYK2 blockade) failed to achieve sustained improvement...Based on these molecular signatures, off-label treatment with the pan-JAK inhibitor tofacitinib (10 mg/day) was initiated... This case highlights the potential of transcriptomic profiling to identify treatable pathways and guide personalized management in severe, treatment-refractory inflammatory diseases, where standard diagnostic and therapeutic approaches are insufficient."

Case report • Clinical • Acne Vulgaris • Atopic Dermatitis • Cushing’s Disease • Dermatitis • Dermatology • Endocrine Disorders • Immunology • Inflammation • Musculoskeletal Pain • Psoriasis • IL17A • JAK1 • TNFA • TYK2