isotretinoin / Generic mfg. - LARVOL DELTA

Effect of Different Diets on Isotretinoin Users to Serum Lipid Levels (clinicaltrials.gov) - P=N/A | N=46 | Completed | Sponsor: Igdir University | Recruiting ➔ Completed

Trial completion • Acne Vulgaris

Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma (clinicaltrials.gov) - P3 | N=1449 | Active, not recruiting | Sponsor: National Cancer Institute (NCI) | Trial completion date: Mar 2025 ➔ Mar 2026

Trial completion date • Bone Marrow Transplantation • CNS Tumor • Neuroblastoma • Oncology • Solid Tumor • Transplantation

Isotretinoin Effects on Nasal Contouring: The Role of Facial Landmark Detection Technology. (PubMed, Dermatol Surg) - No abstract available

Journal

Isotretinoin-Loaded Topical Lipid Liquid Crystal for the Treatment of Acne: In-Vitro and In-Vivo Evaluations. (PubMed, AAPS PharmSciTech) - "In-vivo, LLC-IT reduced inflammation significantly more than untreated or commercial gel-treated groups, indicating enhanced therapeutic efficacy of LLC-IT formulation. The isotretinoin-loaded lipid liquid crystal formulation shows superior stability and efficacy with reduced side effects compared to conventional treatments, offering a more effective and patient-friendly solution, as well as a promising alternative for industrial production in acne management."

Journal • Preclinical • Acne Vulgaris • Cardiovascular • CNS Disorders • Depression • Dyslipidemia • Hypertension • Hypertriglyceridemia • Inflammation • Psychiatry

Unaddressed confounders in the evaluation of isotretinoin pregnancy prevention compliance: A call for refined analyses. (PubMed, J Eur Acad Dermatol Venereol) - No abstract available

Compliance • Journal

Isotretinoin-related post-surgical interface alterations during sun light exposure: A case report. (PubMed, Eur J Ophthalmol) - "Concurrent UVB exposure during corneal healing can exacerbate these effects, causing metabolic activation, extracellular matrix production, and corneal thickening. This case report highlights the importance of deepened patient's anamnesis before refractive surgery and suggests further studies on the relative contraindication of perioperative isotretinoin."

Journal • Acne Vulgaris • Diabetes • Dry Eye Disease • Metabolic Disorders • Ophthalmology • Polycystic Ovary Syndrome

Cost-Utility analysis of Dinutuximab Beta in Treating High-Risk Neuroblastoma: A Partitioned Survival Model Using R programming Language (ISPOR 2025) - "Dinutuximab beta is not a cost effective option compared to Isotretinoin at a threshold value of 40,000 JOD per QALY from a Jordanian health care system perspective. Price negotiations including customized risk sharing agreements are required to improve the value and affordability of Dinutuximab beta."

HEOR • CNS Tumor • Neuroblastoma • Oncology • Pediatrics • Solid Tumor

Isotretinoin in Thick-Skin Rhinoplasty: A Review. (PubMed, Int Arch Otorhinolaryngol) - "After 6 months, studies with a control group did not show a significant difference in patient satisfaction rates. A strong framework and specific surgical maneuvers may be more important than isotretinoin for better outcomes in thick-skin rhinoplasty."

Journal • Review • Aesthetic Medicine

Recalcitrant isotretinoin-induced acne fulminans successfully treated with oral dapsone. (PubMed, Ital J Dermatol Venerol) - No abstract available

Journal • Acne Vulgaris

Balancing Autonomy and Parental Consent in the Use of Isotretinoin for a Minor. (PubMed, Clin Exp Dermatol) - No abstract available

Journal

Microtomographic, Histomorphological, and Histomorphometric Analysis of Bone Healing in the Midpalatal Suture After Treatment with Isotretinoin. (PubMed, Dent J (Basel)) - "No significant differences were observed between the groups regarding collagen fiber formation. It was concluded that the daily administration of Isotretinoin at the standard dose for the treatment of severe acne does not cause significant alterations in the bone repair process following the opening of the median palatine suture in rats."

Journal • Acne Vulgaris

Isotretinoin has no effect on event-free survival across high-risk medulloblastoma molecular groups when added to maintenance: A secondary analysis of the Children's Oncology Group ACNS0332 data. (PubMed, Neurooncol Adv) - "The Children's Oncology Group (COG) study ACNS0332 examined the effect of adding carboplatin and isotretinoin to high-risk medulloblastoma therapy. All 4 medulloblastoma groups were identified: Randomization to isotretinoin was not associated with any difference in EFS in patients with group 3 (n = 79, P = .87), group 4 (n = 101, P = .53), SHH (n = 37, P = .69) or WNT (n = 14, P = 1) medulloblastoma. This study confirms that isotretinoin in addition to radiation and chemotherapy did not improve EFS in pediatric high-risk medulloblastoma regardless of molecular subgroup."

Journal • Brain Cancer • CNS Tumor • Medulloblastoma • Oncology • Pediatrics • Solid Tumor

Isotretinoin use should be examined in young individuals with inflammatory spinal pain, sacroiliitis or hyperostosis. (PubMed, Arch Rheumatol) - No abstract available

Journal • Pain

Isotretinoin-Induced Hypertriglyceridemia: A Silent Trigger for Acute Pancreatitis in a Young Patient" (ENDO 2025) - "Her only medications were drospirenone-ethinyl estradiol and isotretinoin (40 mg twice daily), which she had been using for 8 months...Isotretinoin was discontinued; she was discharged with fenofibrate... Isotretinoin-induced hypertriglyceridemia leading to acute pancreatitis, though rare, should be considered when a patient on isotretinoin presents with symptoms of pancreatitis. Clinicians should be proactive in educating patients on the signs of pancreatitis and consider lipid screening, especially for those with risk factors for hypertriglyceridemia.*. .*"

Clinical • Acne Vulgaris • Cardiovascular • Dermatology • Dyslipidemia • Gastroenterology • Hepatology • Hypertriglyceridemia • Pain • Pancreatitis

A Double-Blind Randomized Study of Two Doses of Oral Isotretinoin in the Treatment of Recalcitrant Facial Flat Warts: Impact on Quality of Life, Anxiety, and Depression. (PubMed, Health Sci Rep) - "It is considered that warts were recalcitrant if the patient was treated for at least 3 years with at least two of the following options: retinoids, 5-fluorouracil, imiquimod, and cryotherapy. Prolonged treatment with isotretinoin for over 12 weeks in adults can increase the overall response rate. Trial Registration: Registry of ClinicalTrials.gov identifier: NTC04290572; https://classic.clinicaltrials.gov/."

HEOR • Journal • CNS Disorders • Depression • Dermatology • Mood Disorders • Oncology • Psychiatry

Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation (clinicaltrials.gov) - P1 | N=15 | Not yet recruiting | Sponsor: C17 Council

New P1 trial • Brain Cancer • CNS Tumor • Embryonal Tumor • Eye Cancer • Medulloblastoma • Medulloepithelioma • Neuroblastoma • Oncology • Pineoblastoma • Rhabdoid Tumor • Sarcoma • Solid Tumor

Effectiveness of Isotretinoin in Patients With a Thick Nasal Skin Envelope Undergoing Nasal Surgery: A Systematic Review (COSM 2025) - "Conclusion Based on the results of this study, effectiveness of isotretinoin in rhinoplasty though promising could not be determined. More high-quality research is required on the topic."

Clinical • Review • Surgery • Aesthetic Medicine • Otorhinolaryngology

Isotretinoin Use within Six Months of Rhinoplasty: A Systematic Review (COSM 2025) - "Conclusion The findings suggest that isotretinoin can be safely used within six months of rhinoplasty, potentially improving early aesthetic outcomes and patient satisfaction. These results challenge current guidelines and suggest the need for updated recommendations regarding isotretinoin use in the perioperative setting."

Review • Acne Vulgaris • Aesthetic Medicine

Disseminated Superficial Actinic Porokeratosis in a Mother and Daughter: A Case Report. (PubMed, Cureus) - "Diagnosed as DSAP, treatment with oral isotretinoin and topical keratolytics showed significant improvement within one and a half months. This case report highlights familial DSAP cases in a mother and daughter, which is rare, emphasizing the importance of early diagnosis and management for better outcomes and reduced malignancy risk."

Journal • Oncology

Prescribing and Dispensing of Oral Isotretinoin and Noncompliance with Recommendations in France before and during the COVID-19 Pandemic. (PubMed, Dermatol Ther (Heidelb)) - "The effect of the COVID-19 pandemic on isotretinoin use was mainly observed during the first lockdown. This study also highlights persistent noncompliance and the need to assess the new French communication actions."

Journal • Dermatology • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Factors Associated With Completion of Isotretinoin Therapy in Acne Patients Reporting Mood Disturbance. (PubMed, J Cosmet Dermatol) - No abstract available

Journal • Acne Vulgaris • CNS Disorders • Dermatology

Management of folliculitis decalvans: The EADV task force on hair diseases position statement. (PubMed, J Eur Acad Dermatol Venereol) - "Oral isotretinoin should be considered as the first-line therapy in patients with mild active disease (perifollicular erythema and hyperkeratosis, no pustules or crusts)...Photodynamic therapy, biologics (preferably adalimumab), JAK inhibitors, oral dapsone, hydroxychloroquine or cyclosporine may also be effective...Topical tacrolimus 0.1% or dapsone 5% may be considered as second-line topical therapeutic options. In patients with folliculitis decalvans, surgical excision or laser therapy can be useful. Hair transplantation can be considered in patients with inactive disease."

Journal • Aesthetic Medicine • Alopecia • Dermatology • Immunology • Inflammation • Transplantation

Isotretinoin and peanut allergy: evidence of safety is staring us in the face. (PubMed, Br J Dermatol) - No abstract available

Journal • Allergy • Food Hypersensitivity • Immunology

EJACULATED SPERM INDUCTION WITH ISOTRETINOIN IN AZOOSPERMIA AND CRYPTOZOOSPERMIA: WHO ARE THE LIKELY RESPONDERS (AUA 2025) - "RA supplementation is associated with improved ejaculated sperm production in NOA and cryptozoospermic men. Response to therapy correlates best with testis biopsy pattern. Testes with maturation arrest patterns appear to respond best to isotretinoin."

Infertility • Sexual Disorders

Isotretinoin Improves De Nevo Sperm Production in Non-Obstructive Azoospermic and Cryptozoospermatic Men (AUA 2025) - "AUA2025 is hosting two full days of programming focused on enriching the education of APPs and other allied healthcare professionals. Scheduled for Saturday, April 26, and Sunday, April 27, 2025, this program aims to benefit both novice and experienced urologic APPs by covering topics that are highly relevant to their practice."

Urology