isotretinoin / Generic mfg. - LARVOL DELTA

Drug-induced intestinal obstruction: insights from the FDA Adverse Event Reporting System. (PubMed, Ther Adv Drug Saf) - "Humira (10,356 cases) was the most frequently reported drug, followed by Remicade (2223 cases), Avastin (1580 cases), Vedolizumab (1385 cases), Clozaril (1229 cases), and Accutane (1088 cases). Disproportionality analysis revealed that the top five drugs with the highest ROR and PRR were Accutane, Teduglutide, Lonsurf, Avastin, and Lynparza...The high volume of reports associated with certain drugs may reflect usage patterns, underlying disease conditions, or reporting behaviors. Caution should be exercised in clinical translation."

Adverse events • Journal • Gastrointestinal Disorder

When Medications Harm Muscles: A Case of a Teenager With Acute Rhabdomyolysis. (PubMed, Cureus) - "This case emphasizes the need for early recognition of isotretinoin-associated rhabdomyolysis, particularly in physically active patients. Prompt imaging, cessation of the offending agent, and timely intervention can prevent renal injury and improve outcomes."

Journal • Immunology • Myositis • Pain • Renal Disease • MB

Dissecting Cellulitis of the Scalp: A Case Report. (PubMed, Cureus) - "This narrative introduces a representative case of dissecting cellulitis in an adult Black male, summarizes the epidemiology, etiology, pathology, and evaluation of the condition, reviews evidence-based best practices for management and interdisciplinary consultation, and highlights racial disparities associated with the disorder. By shedding light on dissecting cellulitis, this case report aims to facilitate early diagnosis, optimal management, and favorable outcomes for this progressive and debilitating condition."

Journal • Alopecia • Dermatology • Immunology • Pain

U051 Acne and Hidradenitis Suppurativa: Clinical and Pathogenetic Correlations (AAD 2026) - "Isotretinoin is effective on AV in the first case and not in the second situation...3. Identify the most appropriate treatment in the two situations."

Clinical • Acne Vulgaris • Dermatology • Hidradenitis Suppurativa • Immunology

Isotretinoin for Acne (AAD 2026) - No abstract available

Acne Vulgaris

Update on Isotretinoin (AAD 2026) - No abstract available

Acne Vulgaris • Dermatology • Dermatopathology • Rosacea

S007 Acne and Rosacea (AAD 2026) - "2. Examine information for best practices in the use of isotretinoin, hormonal therapy and antibiotics."

Acne Vulgaris • Dermatology • Rosacea

Challenges of Acne Management in Aviation Careers. (PubMed, J Am Acad Dermatol) - No abstract available

Journal • Acne Vulgaris • Pediatrics • Retinal Disorders

Drug strategies for the treatment and prevention of proliferative vitreoretinopathy: an overview of innovative treatment concepts. (PubMed, Int Ophthalmol) - "Pharmacological modulation of PVR is conceptually well supported by preclinical data, but clinical translation remains limited. Well-designed randomized trials in clearly defined high-risk populations are needed to validate efficacy, determine optimal treatment windows, and develop standardized protocols for both prophylaxis and therapy."

Journal • Review • Hematological Disorders • Inflammation • Mood Disorders • Retinal Disorders • TGFB1

Refractory and Relapsed Neuroblastoma: Exploring New Treatment Methods to Improve Outcomes. (PubMed, Indian J Surg Oncol) - "Recent developments in cell biology and molecular genetics of NBL tissue have led to the discovery of several potential molecular targets that may improve the treatment results. This review discusses the various clinical aspects of HR and R&R NBL, newer treatment interventions, targeted and immunotherapies, and applicability."

Journal • Review • Neuroblastoma • Oncology • Pediatrics • Solid Tumor • Transplantation

Atypical papular mucinosis with thyroid cancer: comparison of isotretinoin and erbium:YAG laser treatment. (PubMed, Skin Health Dis) - "However, significant improvement was observed following ablative erbium:YAG laser therapy, resulting in a marked reduction of lesions with no recurrence. This case highlights the classification of PM and demonstrates the potential effectiveness of laser therapy as a treatment option for this challenging condition."

Journal • Dermatology • Endocrine Disorders • Fatigue • Oncology • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Papillary Carcinoma

Dual-filter IPL vs. LED phototherapy combined with systemic therapy for moderate-to-severe acne in Asian patients. (PubMed, Front Med (Lausanne)) - P=N/A | "IPL is comparable to LED in clinical efficacy for the treatment of moderate-to-severe acne in Asian patients when combined with doxycycline or isotretinoin, with both modalities demonstrating rapid symptomatic improvement early in the treatment course. Identifier, ChiCTR2500107064."

Journal • Acne Vulgaris • Dermatology • Pain

Upadacitinib for treatment of solid facial edema. (PubMed, JAAD Case Rep) - No abstract available

Journal

The Price of Survival: Global Inequities in Anti-GD2 Immunotherapy for Neuroblastoma. (PubMed, Pediatr Blood Cancer) - "Global access to anti-GD2 therapy is highly unequal. Strategic measures, including negotiations for reduced drug costs, research-based access, and WHO Essential Medicines List inclusion, could help address these disparities."

Journal • Neuroblastoma • Oncology • Solid Tumor

Comparison of Efficacy and Safety of Combined Red and Blue Light with Intense Pulsed Light (400-600 nm/800-1200 nm) Plus Isotretinoin or Doxycycline in the Treatment of Moderate-to-Severe Acne (ChiCTR) - P=N/A | N=40 | Completed | Sponsor: The Fourth Affiliated Hospital of Soochow University (Suzhou Dushuhu Hospital); The Fourth Affiliated Hospital of Soochow University (Suzhou Dushuhu H | Not yet recruiting ➔ Completed

Trial completion • Acne Vulgaris • Dermatology

The efficacy of red and blue light-emitting diode phototherapy combined with oral minocycline for acne conglobata: a retrospective cohort study. (PubMed, Front Med (Lausanne)) - "The control group (n = 13) was treated with a heterogeneous conventional regimen, including oral isotretinoin and/or extended minocycline (8 weeks) plus topical agents. Combining red-blue LED phototherapy with a 4-week course of minocycline is a rapid, highly effective, and safe therapeutic strategy for AC, outperforming conventional polypharmacy while halving the duration of systemic antibiotic exposure. Despite the inherent limitations of a retrospective design, these findings support the integration of LED therapy to optimize the management of severe acne."

Journal • Retrospective data • Acne Vulgaris • Dermatology • Pruritus

Divergent System Organ Class Safety Profiles of Isotretinoin Versus Topical Retinoids: An EudraVigilance Disproportionality Analysis. (PubMed, Pharmaceuticals (Basel)) - " Aggregated ADR data for isotretinoin and four topical retinoids (tretinoin, adapalene, tazarotene, trifarotene) were retrieved from the EMA ADRreports portal (April 2025). Isotretinoin presents a distinct safety profile characterized by consistently elevated reporting of psychiatric, gastrointestinal, and musculoskeletal adverse events, independent of age and sex. These results refine the comparative safety landscape of systemic versus topical retinoids and support focused pharmacovigilance monitoring."

Journal • Acne Vulgaris • Cardiovascular • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Mental Retardation • Musculoskeletal Diseases • Oncology • Otorhinolaryngology • Psychiatry • Rheumatology

Physician Awareness of FDA's Relaxation of REMS-Required Laboratory Testing Requirements and Changes in Prescribing Practices During the COVID-19 Pandemic. (PubMed, Drug Saf) - "Although policy awareness was correlated with laboratory practice changes, fewer than half of physicians who were aware of the FDA's policy reported changing their practices."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Femoral Neck Bone Marrow Edema During Isotretinoin Therapy: A Case Report. (PubMed, Am J Phys Med Rehabil) - "Isotretinoin was discontinued, and the patient was treated conservatively with weight-bearing restriction, vitamin D and calcium supplementation, and analgesics, leading to complete clinical and radiologic resolution within three months. This case represents the first report of isolated femoral neck BME linked to isotretinoin therapy and underscores the importance of early recognition, as timely diagnosis through precise clinical assessment and targeted imaging enables unloading strategies that can prevent progression to stress fracture and ensure favorable outcomes in isotretinoin-treated patients presenting with hip pain."

Journal • Acne Vulgaris • Immunology • Infectious Disease • Inflammatory Arthritis • Musculoskeletal Diseases • Orthopedics • Pain • Rheumatology

Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin (clinicaltrials.gov) - P1 | N=99 | Completed | Sponsor: Children's Oncology Group | Active, not recruiting ➔ Completed | Trial completion date: Sep 2025 ➔ Dec 2025

Trial completion • Trial completion date • Ganglioneuroblastoma • Neuroblastoma • Oncology • Solid Tumor • Transplantation • MYCN

Acne Incidence and Severity in Transgender Individuals. (PubMed, JAMA Dermatol) - "The secondary outcome was moderate to severe acne (incident acne followed by prescription fill for isotretinoin or 30 or more days of oral antibiotics)...Clinicians should monitor and treat acne in transmasculine individuals prescribed testosterone per clinical guidelines, particularly during the first year. Clinicians should also recognize that acne may develop in transfeminine individuals after estradiol initiation."

Journal • Acne Vulgaris

Efficacy of Cosmetic Product RV3278B-OS0386 in the Maintenance Phase After Oral Isotretinoin Treatment of Adults Subjects With Facial Acne. (clinicaltrials.gov) - P=N/A | N=102 | Active, not recruiting | Sponsor: Pierre Fabre Dermo Cosmetique

New trial • Acne Vulgaris

A pilot study of chemoimmunotherapy in the postconsolidation setting for high-risk neuroblastoma (ANBL19P1): A report from the Children's Oncology Group. (PubMed, Cancer) - "The administration of chemoimmunotherapy in the postconsolidation setting after tandem ASCT is feasible and tolerable. Future studies will be needed to define the population most likely to benefit from this augmented postconsolidation therapy."

Journal • Neuroblastoma • Oncology • Solid Tumor • Transplantation

Drug-induced risk of depression: A 20-year real-world pharmacovigilance analysis based on the FAERS database. (PubMed, Medicine (Baltimore)) - "The analysis showed that drugs such as Varenicline, Isotretinoin and Adalimumab were highly associated with depressive AEs and that the risk associated with depression was not mentioned in the labeling of 12 drugs, revealing new drug signals. The in-depth analysis of DIAEs in the FAERS database revealed the epidemiological characteristics, demographic distribution, and potential risk factors of depressive AEs, which provides an important basis for drug safety monitoring, clinical decision-making, and drug labeling updates. The study also identified multiple signals of drug depression that were not labeled in drug labels, suggesting that the monitoring of high-risk drugs should be strengthened in clinical practice."

Adverse events • Journal • Real-world evidence • CNS Disorders • Depression • Mood Disorders • Psychiatry

Comparing two medications (itraconazole and isotretinoin) in treating fungal infection. (ANZCTR) - P2 | N=94 | Active, not recruiting | Sponsor: PAKISTAN NAVAL SHIP SHIFA HOSPITAL,KARACHI

New P2 trial • Dermatology • Infectious Disease