isotretinoin / Generic mfg. - LARVOL DELTA

Analysis of the FDA Maude Database for RF Microneedling Complications Isotretinoin and Fully Ablative Resurfacing for Rhinophyma: A Retrospective Study -Is it Safe? (AAD 2026) - No abstract available

Retrospective data • Dermatology

Integrating Dermatology Education into PharmD/APP Residencies: A Scalable Model for Patient Outcomes and Dermatologist Workload Optimization (AAD 2026) - " In collaboration with Western University and the University of Southern California, all incoming residents completed a 4-week dermatology module covering acne, psoriasis, atopic dermatitis, topical agents, biologics, isotretinoin safety, and compounded therapies... Embedding dermatology education into PharmD residencies enables APPs to function as effective dermatologist extenders. This model improves acne outcomes, reduces iPLEDGE errors, enhances patient satisfaction, and frees substantial dermatologist time and RVU capacity. As demand for interdisciplinary care grows, integrating structured dermatology training into pharmacy residencies offers a scalable framework for optimizing patient access, safety, and physician workload in dermatology practices."

Clinical • Acne Vulgaris • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Psoriasis

Knowledge, Attitudes, and Practices Regarding Acne Self-Medication Among Medical Students and Interns at a Large Thai Public University Hospital (AAD 2026) - "Isotretinoin was used by 15.27%... Self-medication for acne is prevalent among Thai medical students and interns. Improving knowledge and attitudes toward acne management among future physicians is crucial, as it may directly influence how they counsel and treat patients, ensuring safer, evidence-based care and preventing complications related to inappropriate medication use."

Clinical • Acne Vulgaris

Depression and Anxiety Risk in Acne Patients with PCOS Treated With Oral Contraceptives and/or Spironolactone: A 5-Year Retrospective Cohort Study using the TrinetX database (AAD 2026) - "All cohorts excluded prior isotretinoin use. These findings suggest that psychiatric outcomes in PCOS patients are potentially amplified by commonly prescribed treatments. Future prospective studies are needed to determine whether these risks reflect the underlying PCOS severity, medication effects, or both."

Retrospective data • Acne Vulgaris • CNS Disorders • Depression • Endocrine Disorders • Mood Disorders • Polycystic Ovary Syndrome • Psychiatry

Isotretinoin Prescribing Post-Dobbs Decision: A Pilot Study (AAD 2026) - "Our findings suggest that abortion restrictions in Florida may have reduced isotretinoin prescribing relative to New York. Broader multi-state studies are needed to evaluate the impact of reproductive policy changes on dermatologic prescribing and patient access to teratogenic medications."

Clinical • Acne Vulgaris • Women's Health

Efficacy and Safety of Oral Isotretinoin for the Treatment of Cutaneous Photoaging: A Systematic Review and Meta-Analysis (AAD 2026) - "Conclusion Oral isotretinoin demonstrated consistent clinical and histological improvements in photoaging with acceptable tolerability, suggesting its potential as an alternative or adjunct to topical retinoids. Larger, high-quality trials are warranted to confirm these findings."

Retrospective data • Review • Acne Vulgaris

Acne Treated with Tumor Necrosis Factor Inhibitors: A Retrospective Case Series (AAD 2026) - "33/34 received adalimumab and 4/34 received infliximab, with 3 patients treated with both sequentially...Concurrent therapies included isotretinoin (26%), antibiotics (32%), spironolactone (3%), prednisone (15%)... Acne patients treated with TNFi were primarily young, male, and racially/ethnically diverse. Addition of TNFi therapy was effective in most patients, supporting its role in severe or refractory acne, including adolescent populations. This series is the largest to date and contributes to limited evidence for biologics in severe acne."

Retrospective data • Acne Vulgaris • Hidradenitis Suppurativa • Immunology • Oncology

Differential Impact of Retinoid Agents on Risk of Melanoma and Non-Melanoma Skin Cancers: A Real-World Cohort Analysis (AAD 2026) - "Analyses were performed for overall retinoid exposure and for isotretinoin, tretinoin, vitamin A, and adapalene. Retinoid exposure is associated with lower melanoma and NMSC risk overall, but effects vary by agent. These findings underscore the need for agent-specific evaluation when considering retinoids in skin cancer prevention strategies."

Clinical • Real-world • Real-world evidence • Addiction (Opioid and Alcohol) • Basal Cell Carcinoma • Genetic Disorders • Human Immunodeficiency Virus • Infectious Disease • Non-melanoma Skin Cancer • Obesity • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma

Treatment of Granulation Tissue in the Setting of Acne Fulminans with Timolol (AAD 2026) - "Our patient continued isotretinoin with two courses of oral prednisone, oral cephalexin, and intralesional corticosteroids. This case highlights successful control of AF while continuing isotretinoin therapy and introduces topical timolol as a potentially useful adjunct for associated vascular lesions that may be treatment resistant. Further studies are needed to clarify the role of topical beta-blockers in severe inflammatory acne and its complications."

Acne Vulgaris • Hematological Disorders • Hidradenitis Suppurativa • Immunology • Inflammation

Oral doxycycline dosing and treatment pathways in acne: A multi-center cohort study, 2010-2022 (AAD 2026) - "Changes in systemic acne treatment were defined as initiation of isotretinoin, spironolactone, another oral antibiotic, or switch to topical-only regimens within 1 year. Limitations include potential misclassification of doxycycline dosing. Dermatologists should incorporate sub-antimicrobial doxycycline into acne treatment protocols and develop strategies to overcome implementation barriers."

Clinical • Acne Vulgaris

Association Between Biologic Therapy and Acne Treatment Escalation Among Patients with Inflammatory Acne: A TriNetX Database Study (AAD 2026) - "Risk ratios (RRs) of systemic acne therapy (doxycycline, minocycline, sarecycline, spironolactone, or isotretinoin) were calculated. This may be attributable to further Th1/Th17 skewing as a result of biologic therapy, thereby exacerbating immune dysregulation and rendering patients refractory to topical treatments. Further studies are warranted to clarify the clinical significance and mechanistic basis of these findings."

Clinical • Acne Vulgaris • Atopic Dermatitis • Dermatitis • Immunology • Psoriasis

Post-Isotretinoin Acne Management: A Survey of Dermatology Practitioners (AAD 2026) - "Topical retinoids and benzoyl peroxide were utilized in mild and moderate relapse, with the addition of spironolactone for females (53.1%) and doxycycline/minocycline for males (61%) in moderate cases. The variability in recommendations highlights the need for evidence-based post-isotretinoin guidelines and increased awareness of relapse risk to optimize care and reduce repeat isotretinoin therapy."

Acne Vulgaris • Dermatology

Bridging the Gap Between Dermatologic and Psychiatric Care in Acne Excoriee: Insights from a Multicenter Analysis (AAD 2026) - "Patients with AE were more likely to receive treatments such as doxycycline (AE 9.5% vs Acne 5.9%; AE: 9.0% vs ED: 6.2%; AE: 9.1% vs Acne + ED: 7.0%) and isotretinoin (AE 2.5% vs Acne 2.1%; AE: 2.6% vs ED: 0.2%; AE: 3.1% vs Acne + ED: 1.4%) than patients with ED, while receiving significantly fewer psychiatric therapies including SSRIs, antipsychotics, and CBT. Reframing AE as an early manifestation of ED with a focus on compulsive behaviors may offer a more accurate reflection of the nature of the condition and support early therapeutic intervention. This study highlights the role dermatologists play in early identification of psychiatric and psychocutaneous disease, the importance of enhanced education around targeted therapeutic interventions, and timely referrals for improved patient outcomes."

Clinical • Acne Vulgaris • CNS Disorders • Mood Disorders • Obsessive-Compulsive Disorder • Psychiatry

Benefits of a Ceramide-Containing Regimen On Isotretinoin-Induced Dryness And Barrier Disruption (AAD 2026) - "Using confocal microscopy, subjects who applied a ceramide-containing regimen had a significant increase in interkeratinocyte brightness after W12, indicating a more nourished, moisturized, and functional keratinocytes (mean change, 20.5%; P=.038). A ceramide-containing regimen was superior in providing less dryness, tightness, and scaling while improving skin hydration and strengthening the skin barrier in patients receiving isotretinoin compared with control regimen."

Acne Vulgaris

Clearance with Isotretinoin and Antiretroviral Therapy of Multiple Periungual SCC HPV Related and HIV immunosuppression (AAD 2026) - "After starting bictegravir/emtricitabine/tenofovir alafenamide, CD4 rose to 179 cells/µL by October 2024. Optimized ART improved HPV control while adjunctive isotretinoin produced effective periungual field reduction enabling nail-sparing, targeted surgery; collectively, a stepwise strategy, early biopsy, ART optimization, systemic retinoids, and selective surgery, preserves nail function and improves outcomes, consistent with prior evidence of isotretinoin efficacy for recalcitrant HPV-related periungual warts in immunosuppressed patients (Yang et al., 2019; Dave et al., 2019; Sivasankari et al., 2022; Acta Derm Venereol, 2005). Figure 1. Baseline (pre-ART/isotretinoin): multifocal periungual HSIL/SCCis with extensive verrucae."

Bowens Disease • Human Immunodeficiency Virus • Infectious Disease • Inflammation • CD4

Reliability of LLM-Cited Sources for Isotretinoin Information Sought by Patients (AAD 2026) - "For isotretinoin inquiries, Gemini most often cited lower-quality/commercial sources, with relatively few peer-reviewed/guideline links. This pattern, particularly for dosing and supportive care, poses patient-safety risks and emphasizes the importance of LLMs drawing from guideline-based sources."

Clinical

Isotretinoin and iPLEDGE Evolution: A Gender-Inclusive Analysis Over Time (AAD 2026) - "iPLEDGE reforms may have contributed to the relative improvement in disparities for TF and TM patients. Despite policy reforms, gender-based disparities persist; therefore, more work is needed to develop strategies to improve care access for all."

Acne Vulgaris

Variable Associations Of Follicular Disorders And Keloid Formation In Neurofibromatosis Type 1, Tuberous Sclerosis, And Sturge–Weber Syndrome (AAD 2026) - "Patients with NF1 (n=31,426), TSC (n=9,886), or SWS (n=18,714) were identified and propensity-matched 1:1 with healthy controls based on age, sex, race, comorbidities including diabetes mellitus, atopic dermatitis, and trauma from burns, as well as medications including glucocorticoids, immunosuppressants, and isotretinoin... Our results suggest that NF1, TSC, and SWS may confer varying protective advantages against common follicular and scarring conditions. Further mechanistic studies may facilitate future development of treatments for these disorders."

Acne Vulgaris • Atopic Dermatitis • Dermatitis • Diabetes • Fibrosis • Genetic Disorders • Hidradenitis Suppurativa • Immunology • Metabolic Disorders • Mood Disorders • Neurofibromatosis • Solid Tumor • Thermal Injury • NF1

The Rise of Dangerous At-Home “Treatments” for Psoriasis and Hidradenitis Suppurativa (AAD 2026) - "Unregulated systemic therapies involved procurement of methotrexate, isotretinoin, or biologics from black-market sources without supervision. Psoriasis and HS patients are increasingly adopting unsafe, misinformation-driven at-home treatments, worsening morbidity, and delaying engagement with evidence-based care. Recognizing how misinformation spreads across digital platforms provides a foundation for interventions, education, and equitable dermatologic access."

Dermatology • Hidradenitis Suppurativa • Immunology • Inflammation • Psoriasis

Comparison of Systemic and Topical Retinoids and the Association of Inflammatory Bowel Disease in Ichthyosis Patients: A Population-Based Cohort Study (AAD 2026) - "Patients with acquired ichthyosis, congenital ichthyosis , or ichthyosis vulgaris treated with systemic retinoids such as alitretinoin, isotretinoin, etretinate, and acitretin (n=449) were identified using validated ICD-10 codes. A comparator cohort treated with topical retinoids such as adapalene, tazarotene, bexarotene, alitretinoin, and tretinoin (n=449) was established... These findings indicate that the protective association is specific to systemic retinoid therapy and highlights the importance of treatment selection in patients with ichthyosis who have comorbid or potential IBD. Future studies should further explore the role of systemic retinoids as potential disease-modifying agents for IBD and other inflammatory conditions in ichthyosis patients."

Clinical • Atopic Dermatitis • Crohn's disease • Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • Vitiligo

Beyond the Surface: The Evolving Understanding of Hormones and Acne (AAD 2026) - "Twenty years later, patients receiving spironolactone, a mineralocorticoid receptor antagonist, developed side effects including gynecomastia and decreased libido...The treatment landscape has remained largely unchanged for the past 40 years, centered on the use of systemic antibiotics, hormonal therapies, and isotretinoin...Metformin and GLP1s have shown promise for patients with PCOS. These developments target the intricate hormonal balance, a modern manifestation of the ancient humoral theory."

Acne Vulgaris • Polycystic Ovary Syndrome • AR

Evaluating the Association Between Tetracycline-Class Antibiotics, Isotretinoin, and Idiopathic Intracranial Hypertension: A Pharmacovigilance Study Using FAERS Data (2015–2024) (AAD 2026) - "While restricted by voluntary reporting, underreporting, , and lack of case-level validation, this large-scale pharmacovigilance study highlights a reproducible safety signal. Clinicians should consider counseling patients on potential risks, avoid co-prescription when possible, and remain attentive to early signs of IIH."

Adverse events • Acne Vulgaris • Cardiovascular • CNS Disorders • Hypertension • Rare Diseases • Rosacea

Advocacy for Antimicrobial Stewardship in Michigan Medicaid: A Dermatology-Pharmacy Collaboration (AAD 2026) - "The outcome was revision of Michigan Medicaid prior authorization criteria for isotretinoin coverage to “failed/intolerant to at least a 3-month consistent trial of 1 oral antibiotic used for treatment of acne” in May 2025. The success of this project highlights the opportunity for providers to address conflicts between insurance coverage and professional treatment guidelines, as well as to bring these concerns to the attention of insurance carriers, including state Medicaid."

Medicaid • Reimbursement • US reimbursement • Acne Vulgaris • Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Vaginitis

Impact of Oral Isotretinoin Therapy on Systemic Inflammatory Markers in Acne: A Systematic Review and Meta-Analysis (AAD 2026) - "Oral isotretinoin showed measurable effects on systemic inflammatory markers in acne patients, notably decreasing NLR, LMR, and SII, while increasing MHR. Other markers revealed inconsistent changes. These findings suggest a potential immunomodulatory effect of isotretinoin."

Retrospective data • Review • Acne Vulgaris • Immunology • Inflammation • Systemic Inflammatory Response Syndrome

Gender identity and cumulative dose of isotretinoin in transgender and cisgender patients with acne (AAD 2026) - "Limitations include potential weight misclassification and limited generalizability to uninsured patients. Future research should examine isotretinoin adherence, interruption, and outcomes among transgender and cisgender patients."

Clinical • Acne Vulgaris