isotretinoin / Generic mfg. - LARVOL DELTA

A Study of the Effect of Hu3F8/GM-CSF Immunotherapy Plus Isotretinoin in Patients in First Remission of High-Risk Neuroblastoma (clinicaltrials.gov) - P2 | N=59 | Active, not recruiting | Sponsor: Memorial Sloan Kettering Cancer Center | Trial completion date: Jun 2025 ➔ Jun 2026 | Trial primary completion date: Jun 2025 ➔ Jun 2026

Trial completion date • Trial primary completion date • Neuroblastoma • Oncology • Solid Tumor • MYCN

An investigation of drug-induced mental disorders in the children and adolescents population utilizing the FDA adverse event reporting system. (PubMed, Sci Rep) - "Our analysis revealed potential associations between various drugs and mental disorders, with isotretinoin, montelukast, risperidone, methylphenidate, atomoxetine and antidepressants showing higher ROR values, indicating a possible risk of mental disorders. Additionally, we found that some drugs did not explicitly list the risk of mental disorders in their instructions for use."

Adverse events • Journal • Acne Vulgaris • ADHD (Impulsive Aggression) • Allergy • Asthma • Attention Deficit Hyperactivity Disorder • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Immunology • Mental Retardation • Narcolepsy • Psychiatry • Pulmonary Disease • Respiratory Diseases • Sleep Disorder

Management Strategies for Generalised Granuloma Annulare: A Systematic Review of Current and Emerging Therapies. (PubMed, Australas J Dermatol) - "Based on this systematic review, we propose a stepwise approach: first-line treatment includes hydroxychloroquine and phototherapy (PUVA > UVA1 > nb-UVB)...Sulfones are second-line, with oral retinoids (e.g., isotretinoin) as alternatives if contraindicated. For refractory cases, off-label anti-TNF-α agents or JAK inhibitors are recommended, with methotrexate or cyclosporine as valid alternatives...While steroids and phototherapy remain standard, emerging options like JAK inhibitors and biologics show promise for refractory cases. Tailored, multimodal strategies may improve outcomes, though further trials are needed to standardise guidelines."

Journal • Review • Dermatology • Inflammation • Rare Diseases

Alpha-1 adrenergic antagonists to sensitize neuroblastoma over isotretinoin theraphy (EACR 2025) - "Introduction: High-risk neuroblastoma (NB) is an aggressive pediatric malignancy with poor prognosis, as the 5-year disease-free survival rate remains below 50% despite intensive therapy. Our findings suggest that α1-AR antagonism sensitizes NB cells to 13cRA by facilitating the pro-differentiative and pro-apoptotic effects, potentially disrupting an autocrine catecholamine-driven pro-survival circuit. Given the druggable nature of ARs, α1-AR inhibition emerges as new a promising pharmacological therapeutic strategy for neuroblastoma treatment."

Neuroblastoma • Oncology • Pediatrics • Solid Tumor • ADRA1B • ADRB2 • CASP3 • CASP7 • MYCN

Established and Emerging Laser Treatments for Acne Vulgaris in Diverse Skin Types. (PubMed, J Clin Aesthet Dermatol) - "Lasers have demonstrated efficacy as primary or adjunctive treatment modalities for acne vulgaris in certain clinical scenarios. Larger randomized, controlled, double-blinded studies with sufficiently long follow-up periods and standardized objective measurements are needed to substantiate the efficacy of lasers in treating acne vulgaris."

Journal • Review • Acne Vulgaris • Dermatology

Minocycline Nanocrystals: A New Approach for Treating Acne with Reduced Systemic Side Effects. (PubMed, Pharmaceutics) - "Oral or topical isotretinoin, contraceptives, and antibiotics are used to treat acne. Minocycline is one of the widely used tetracyclines for this purpose; it inhibits the synthesis of proteins in bacterial ribosomes...The nanocrystal solution deposited 554.56 ± 24.13 μg of minocycline into rat skin, whereas free minocycline solution deposited 373.99 ± 23.32 μg. Minocycline nanocrystals represent a promising strategy for targeted skin delivery in the treatment of acne vulgaris, potentially reducing systemic side effects and antibiotic resistance and improving patient outcomes."

Adverse events • Journal • Acne Vulgaris • Dermatology • Infectious Disease • Inflammation

Competencies and clinical guidelines for managing acne with isotretinoin in general practice: A scoping review. (PubMed, Br J Gen Pract) - "This scoping review has identified the key clinical competencies that underpin safe management of people with acne using isotretinoin: dermatology, pregnancy prevention, mental health assessment and blood testing. Resourcing and supporting GPs to incrementally adopt this role may promote safe, timely and equitable patient access to isotretinoin, while enhancing antimicrobial stewardship."

Clinical guideline • Journal • Acne Vulgaris • Dermatology

Sexual Dysfunction in Dermatology: A Silent Epidemic. (PubMed, J Am Acad Dermatol) - No abstract available

Journal • Dermatology • Erectile Dysfunction • Sexual Disorders

Acne Vulgaris in Children and Adolescents: What's the Cause and How to Combat It. (PubMed, J Pediatr Pharmacol Ther) - No abstract available

Journal • Acne Vulgaris • Dermatology

Misdiagnosis in Hidradenitis Suppurativa: A Systematic Review (CDA 2025) - "Initial treatments included antibiotics (72.3%), incision and drainage (45.5%), isotretinoin (18.2%), and steroids (18.2%)...Thorough investigations, including skin biopsy, are crucial when alternative diagnoses are suspected. The role of infectious etiologies, especially tuberculosis, should be emphasized in clinical practice to avoid misdiagnosis."

Review • Acne Vulgaris • Crohn's disease • Dermatology • Dermatopathology • Gastroenterology • Hidradenitis Suppurativa • Immunology • Infectious Disease • Inflammatory Bowel Disease • Langerhans Cell Histiocytosis • Oncology • Pain • Respiratory Diseases • Squamous Cell Carcinoma • Tuberculosis

Efficacy Of Oral Isotretinoin Combined With Topical Clascoterone Compared To Isotretinoin Monotherapy For Severe Acne Vulgaris: A Multi-Center Study (CDA 2025) - "Our study suggests that the addition of clascoterone 1% cream may enhance the efficacy of oral isotretinoin therapy without exacerbating adverse effects, offering a promising approach for managing severe/nodular acne. Further studies are needed to confirm these results and evaluate long-term effects."

Clinical • Monotherapy • Acne Vulgaris • CNS Disorders • Dermatology

Lupus miliaris disseminatus faciei: A rare facial granulomatous disorder (CDA 2025) - "Variable improvement has been reported with systemic steroids, isotretinoin, dapsone, tetracycline or nitroimidazole-based antibiotics, antimalarials, antituberculosis therapy, tranilast, apremilast, tacrolimus, cyclosporine, and JAK inhibitors...Although doxycycline treatment failed, the patient improved with a tapering prednisone course and isotretinoin 60 mg daily...While it often resolves spontaneously, early intervention is crucial to minimize cosmetic and psychological impacts. The variable efficacy of treatments highlights the need for tailored therapeutic approaches."

Aesthetic Medicine • Dermatitis • Dermatology • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Lupus • Respiratory Diseases • Rosacea • Sarcoidosis • Tuberculosis

Aquagenic Syringeal Acrokeratoderma: Case Report and a Review of the Literature (CDA 2025) - "The condition can also occur in non-CF contexts, including secondary to medication triggers such as NSAIDs (e.g. aspirin), spironolactone, and isotretinoin. First-line treatments include topical aluminum chloride. This case illustrates the importance of recognizing and treating ASA to limit morbidity."

Case report • Clinical • Review • Alpha-1 Antitrypsin Deficiency • Cystic Fibrosis • Dermatology • Genetic Disorders • Hepatology • Immunology • Oncology • Pain • Pulmonary Disease • Respiratory Diseases • Skin Cancer • CFTR

Importance of Carnitine in Dermatology (CDA 2025) - "Topically, carnitine has shown efficacy in reducing sebum, decreasing hyperpigmentation post- laser treatment, improving skin tolerability with adapalene in acne, reducing acne severity, and enhancing quality of life...Orally, carnitine has proven effective in reducing inflammation, alleviating isotretinoin-related liver and muscle effects, easing muscle spasms in vismodegib patients, countering wasting in pemphigus vulgaris during glucocorticoid therapy, and improving adipocytokines, mental health and inflammatory markers in PCOS. It has also shown benefits in preventing cardiomyopathy progression in severe recessive dystrophic epidermolysis bullosa, reducing advanced glycation end products, and improving walking distance and ulcer healing in peripheral vascular disease. Conclusion Carnitine and its derivatives have therapeutic potential in dermatology, offering benefits both topically and orally, warranting further exploration of their clinical applications."

Acne Vulgaris • Atopic Dermatitis • Cardiomyopathy • Cardiovascular • Complement-mediated Rare Disorders • Dermatitis • Dermatology • Fibrosis • Hereditary Angioedema • Immunology • Infectious Disease • Melanoma • Metabolic Disorders • Pemphigus Vulgaris • Peripheral Arterial Disease • Polycystic Ovary Syndrome • Primary Immunodeficiency • Pruritus • Psoriasis • Sarcoidosis • Scleroderma • Solid Tumor • Systemic Sclerosis

Bioinformatics analysis based on microarray data reveals molecular crosstalk and immune relationship between sarcopenia and atherosclerosis. (PubMed, Exp Gerontol) - "Through bioinformatic analysis, we identified potential biomarkers and therapeutic targets for atherosclerosis and sarcopenia, providing a theoretical basis for future studies."

Journal • Atherosclerosis • Cardiovascular • Sarcopenia • C1QA • CSF1R • ITGAM

A prospective, randomised comparative study to evaluate safety, tolerability, and efficacy of topical minocycline gel 4% plus oral isotretinoin against oral isotretinoin only in Indian patients with moderate-to-severe acne vulgaris. (PubMed, Postepy Dermatol Alergol) - "The concurrent use of tetracyclines and isotretinoin in acne treatment can cause pseudotumor cerebri (PTC). The combination of topical gel 4% and oral isotretinoin 20 mg capsule significantly reduced inflammatory lesions, improved IGA scores, and had a higher success rate at week 12 than isotretinoin alone, with similar tolerability. Therefore, this combination can be considered a preferable treatment option for moderate-to-severe acne."

Journal • Acne Vulgaris • CNS Disorders • Dermatology • Oncology

Whole exome sequencing as a diagnostic tool for immunologic disorders. Potential clinical implications of a pathogenetic variant in CD64 gene (EULAR 2025) - "Therapy with colchicine and IL-1 inhibitor proved ineffective. TNF inhibitor therapy resolved febrile episodes but no other symptoms, while isotretinoin and repeated courses of antibiotic therapies improved skin lesions...It remains unclear whether the DKC1 variant is associated with the reduction in INF-γ level of the patient’s serum. However, this specific cytokine profile, combined with the FCGR1A pathogenetic variant, may contribute to the dysfunction of CD64-related immunological pathways, leading to dysregulated skin inflammation."

Clinical • Whole exome sequencing • Dermatitis • Immunology • Infectious Disease • Inflammation • DKC1 • FCGR1A • IFNG

Interplay Between the Epigenome, the Microenvironment, and the Immune System in Neuroblastoma. (PubMed, Cancers (Basel)) - "The current standard treatment for high-risk NB involves surgery, chemotherapy, radiotherapy, autologous stem cell transplantation, immunotherapy with anti-ganglioside GD2, and differentiation therapy with isotretinoin...Moreover, immunotherapy to enhance anticancer immune responses and by using cell-engineering techniques with chimeric antigen receptor (CAR) T and NK cells are being explored to target NB cells. Here, we review promising novel treatment strategies for NB, which target genetics, epigenetics, the tumor microenvironment, and the immune landscape, highlighting preclinical studies and ongoing clinical trials."

IO biomarker • Journal • Review • Neuroblastoma • Oncology • Solid Tumor • Transplantation

Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET (clinicaltrials.gov) - P3 | N=379 | Active, not recruiting | Sponsor: Children's Oncology Group | Trial completion date: Apr 2025 ➔ Jun 2028

Trial completion date • Brain Cancer • Medulloblastoma • Oncology • Solid Tumor

How to use Isotretinoin (EADV 2025) - No abstract available

Acne Vulgaris

Unilateral breast Darier disease: A case report and literature review. (PubMed, Med Int (Lond)) - "Emollient lotion, topical fusidic acid cream 2%, and oral isotretinoin 20 mg once daily were prescribed...Paget's disease was hidden in the background of Darier's disease of the breast in one of the cases in the literature. Darier disease may present as a localized unilateral breast lesion, characterized by multiple small, firm brown to black lesions on the nipple, leading to nipple destruction."

Journal • Oncology • Rare Diseases

Treatment of Plane Warts With Topical and Oral Retinoids (clinicaltrials.gov) - P4 | N=39 | Completed | Sponsor: Tishreen University

New P4 trial • Dermatology

Dissecting Cellulitis of the Scalp: Treatment responses in a retrospective cohort study. (PubMed, J Am Acad Dermatol) - No abstract available

Journal • Retrospective data • Dermatology

Cutis verticis gyrata in a Patient with Familial presenile sebaceous hyperplasia Presenting as "Leonine facies": A Rare Case. (PubMed, Clin Cosmet Investig Dermatol) - "Isotretinoin, with its sebocyte-suppressing effect, may reduce gland size but has a high recurrence rate upon discontinuation. Early recognition and a multidisciplinary approach are crucial to prevent further progression, particularly in older patients."

Journal • Dermatology

Sequential combination treatment with doxycycline and isotretinoin in association with topical calcineurin inhibitors and metronidazole cream for the treatment of rosacea fulminans. (PubMed, Ital J Dermatol Venerol) - No abstract available

Journal • Dermatology • Rosacea