amoxycillin/clavulanate / Generic mfg. - LARVOL DELTA

Comparative Evaluation of Amoxicillin-Clavulanate and Ertapenem in an Exploratory Rat Model of ESBL E. coli Peritonitis. (PubMed, Biomedicines) - " AMC and ERP produced broadly comparable effects on microbiological, biochemical, and inflammatory parameters in ESBL E. coli peritonitis. These findings suggest that AMC may merit further investigation as a potential narrower-spectrum option, though definitive comparisons require larger, adequately powered studies."

Journal • Preclinical • Infectious Disease • Inflammation • Pneumonia • IL1B • IL6 • TNFA

Antimicrobial Resistance and ESBL-Associated Predictors Among Uropathogens: A 2019-2024 Isolate-Level Study. (PubMed, Antibiotics (Basel)) - "Resistance rates were highest for ciprofloxacin (35.4%) and trimethoprim/sulfamethoxazole (31.7%), while fosfomycin and nitrofurantoin retained high activity against E. coli. In multivariable analyses, ESBL production was the strongest independent predictor of resistance to several antimicrobials, including ciprofloxacin (aOR 9.83), amoxicillin/clavulanic acid (aOR 3.22), trimethoprim/sulfamethoxazole (aOR 2.89), and cefotaxime (aOR 1337)... Antimicrobial resistance among uropathogens was heterogeneous and predominantly driven by pathogen identity and ESBL production. ESBL status emerged as the most consistent and powerful predictor of resistance across multiple antimicrobials, underscoring its clinical relevance for empiric treatment decisions and antimicrobial stewardship in urinary tract infections."

Journal • Infectious Disease • Nephrology • Pneumonia

Ntimicrobial-resistant Listeria species isolated from beef and beef products sold in Mpumalanga province, South Africa. (PubMed, J Food Prot) - "All 33 isolates of L. monocytogenes were susceptible to five antimicrobial agents (penicillin, ampicillin, amoxicillin-clavulanic acid, gentamicin, and trimethoprim-sulfamethoxazole, which are commonly used in the treatment of listeriosis. Resistance prevalence ranged from 3.0% to 100% for L. monocytogenes and from 1.7% to 100% for Listeria spp., with nalidixic acid showing universal resistance...This is because AMR-L. monocytogenes can transfer resistance genes/plasmids to pathogenic L. monocytogenes, thereby posing both food safety and therapeutic implications."

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Evidentiary Standards for Newly Approved Antibiotics for Uncomplicated Urinary Tract Infections. (PubMed, Antibiotics (Basel)) - "Interventions: Sulopenem/probenecid was compared to ciprofloxacin and to amoxicillin/clavulanate and gepotidacin was compared to nitrofurantoin. Pivotal clinical trials for sulopenem/probenecid and gepotidacin for uUTI had significant design limitations and relied on surrogate endpoints of limited clinical interpretability, undermining reliability and clinical relevance. Future antibiotic development for uUTI should prioritize representative populations, standard-of-care comparators, clinically meaningful outcomes and robust, well-controlled trial designs to ensure meaningful clinical evidence of safety and efficacy."

Clinical • Journal • Infectious Disease • Nephrology

CSI: Tales from the Liver Pathology Unit - The Case of the Tumor that Wasn't (USCAP 2026) - "She has been on a statin for hyperlipidemia and was prescribed amoxicillin/clavulanic acid for diverticulitis the prior year... The clinical presentation of hepatic AVM can be broad, and the diagnosis should therefore be considered in patients presenting with high-output heart failure, portal hypertension, biliary disease, hepatic necrosis, and even mass-lesions. The histologic findings of hepatic AVM can also be varied, and diagnosis can be difficult to establish on biopsy. Hepatic AVM can be associated with AVMs at other sites and may be part of a genetic syndrome."

Clinical • Cardiovascular • CNS Disorders • Congestive Heart Failure • Dyslipidemia • Fibrosis • Gastrointestinal Disorder • Heart Failure • Hematological Disorders • Hepatology • Hypertension • Immunology • Oncology • Portal Hypertension • Pulmonary Arterial Hypertension • Respiratory Diseases • Thrombocytopenia • ACVRL1 • ALK1 • ENG • SMAD4

Assessment of Antibiotic Prescribing Patterns Among Dentists and their Impact on Antimicrobial Resistance in Oral Infections. (PubMed, J Pharm Bioallied Sci) - "Antibiotics were prescribed in 82.0% of dental consultations, with amoxicillin-clavulanic acid (46.7%) being the most commonly prescribed drug, followed by metronidazole (28.0%)...Suboptimal antibiotic prescribing practices are prevalent among dentists and are significantly associated with increased antimicrobial resistance in oral infections. Implementation of antibiotic stewardship programs and continued professional education are essential to promote rational antibiotic use in dental practice."

Journal • Infectious Disease

Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial (RATIONAL-PT) (clinicaltrials.gov) - P2/3 | N=900 | Recruiting | Sponsor: Monash University | Not yet recruiting ➔ Recruiting

Enrollment open • Trial initiation date • Chronic Lymphocytic Leukemia • Hematological Malignancies • Infectious Disease • Leukemia • Lymphoma • Multiple Myeloma • Non-Hodgkin’s Lymphoma • Oncology

Tularemia from a cat bite: Case report and review of the literature. (PubMed, IDCases) - "Prior to admission, she had been treated with ceftriaxone and clindamycin without improvement. She failed to improve on vancomycin and piperacillin-tazobactam...Her antibiotics were switched to ciprofloxacin (for F. tularensis) and oral amoxicillin-clavulanate (for coverage of other feline oral flora) with improvement...She was then treated with six weeks of doxycycline with complete resolution...This case illustrates the importance of considering F. tularensis in cat-related infections not improving with standard antibiotic therapy. The case also underscores the importance of recognizing relapse of F. tularensis infection as a common complication, as well as the importance of engaging with public health authorities to be aware of changes in epidemiology that may affect patient care."

Journal • Infectious Disease

Piperacillin-tazobactam resistance in Klebsiella pneumoniae is often associated with IS26-mediated blaSHV-1 amplification in a widespread Klebsiella-adapted plasmid. (PubMed, Antimicrob Agents Chemother) - "To elucidate these mechanisms, we analyzed K. pneumoniae clinical isolates resistant to TZP but susceptible to cefotaxime and cefepime. Among 53 isolates, 14 were further studied by MIC testing for TZP, amoxicillin-clavulanic acid (AMC), and ceftazidime (CAZ)...Analysis of a K. pneumoniae genome data set confirmed the frequent co-occurrence of this plasmid and the PTnSHV-L marker in strains with multiple blaSHV copies. These findings suggest the emergence of an epidemic plasmid adapted to K. pneumoniae and driving TZP resistance through blaSHV-1 amplification, underscoring the need for genomic surveillance to detect amplification-based resistance overlooked by standard phenotypic or PCR assays."

Journal • Infectious Disease • Pneumonia

APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis) (clinicaltrials.gov) - P2 | N=100 | Not yet recruiting | Sponsor: Vanderbilt University Medical Center

New P2 trial • Gastrointestinal Disorder

Pediatric cervicofacial actinomycosis presenting with mandibular osteomyelitis: a diagnostic and therapeutic challenge and literature review. (PubMed, Turk J Pediatr) - "The patient initially received empirical intravenous vancomycin, cefotaxime, and metronidazole. Due to persistent fever and elevated inflammatory markers, the regimen was switched to teicoplanin plus piperacillin/tazobactam. Therapy was subsequently escalated to meropenem due to recurrent fever and based on magnetic resonance imaging findings suggestive of osteomyelitis, then vancomycin was replaced with teicoplanin because of vancomycin-associated nephrotoxicity. Following clinical improvement, the patient was discharged on oral amoxicillin/clavulanate to complete a total of six weeks of therapy...Early recognition and combined medical-surgical management are crucial to avoid complications. This case highlights the importance of considering infectious causes in mandibular masses and underscores the diagnostic challenges associated with them."

Journal • Review • Infectious Disease • Inflammation • Musculoskeletal Pain • Oncology • Pain • Pediatrics

Unlocking the potential of Pseudomonas aeruginosa QS intermediates as antimicrobial synergists against three multidrug-resistant enteric bacteria. (PubMed, Front Microbiol) - "Pyocyanin showed the highest synergistic effect, with a 300% increase in the inhibition zone when combined with sulfamethoxazole/trimethoprim (23.75/1.25 µg/mL) against S. Typhimurium-W20. Rhamnolipids exhibited a 106% increase in synergy with ceftriaxone (30 μg/mL) against E. coli-SS1, whereas HHQ (10 μg/mL) showed a 257% increase with ampicillin (10 μg/mL) against E. coli-SS1. PQS displayed the highest synergistic effect of 109% with amoxicillin clavulanic acid (30 μg/mL) against E. coli-SS1. Moreover, growth curve analysis revealed a dose-dependent reduction in bacterial growth with sub-inhibitory concentrations of antimicrobials, particularly for the combinations exhibiting the highest synergy across the QS effectors. These findings demonstrate the potential of the QS effectors in reducing the required dosage of antibiotics against resistant Enterobacteriaceae strains and highlight the need to develop a comprehensive understanding of the underlying mechanisms..."

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Understanding selective aminopenicillin allergy: findings from a long-term case series. (PubMed, Int Arch Allergy Immunol) - "All patients underwent a standardized work-up including skin prick and intradermal tests, patch tests and/or delayed intradermal testing when indicated, specific IgE measurement in immediate reactions, and drug challenge tests (DCT) with amoxicillin or amoxicillin-clavulanic acid. Notably, all patients tolerated phenoxymethylpenicillin (penicillin V) during DCT, confirming selective sensitization to the aminopenicillin side chain and supporting the safe use of other β-lactams in this population. These findings highlight the clinical relevance of selective aminopenicillin allergy and underscore the importance of comprehensive diagnostic algorithms to optimize antibiotic stewardship and expand therapeutic options for labeled β-lactam-allergic patients."

Journal • Allergy • Cardiovascular • Dermatology • Immunology • Urticaria

Minimum inhibitory concentration targets among critically ill patients receiving amoxicillin/clavulanate and piperacillin/tazobactam by continuous infusion compared to intermittent bolus (ESCMID Global 2026) - No abstract available

Clinical • Late-breaking abstract

Amoxicillin-clavulanate vs amoxicillin for acute sinusitis in adults (ESCMID Global 2026) - No abstract available

Clinical • Late-breaking abstract • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Molecular pharmacodynamics of amoxicillin-clavulanic acid for urinary tract infections caused by Escherichia coli (ESCMID Global 2026) - No abstract available

PK/PD data • Infectious Disease • Nephrology

Development of a rapid actinomycetoma rapid in vitro susceptibility assay for determining the susceptibility towards amikacin, trimethoprim/sulfametoxazole and amoxicillin/clavulanic acid (AMAnTA) in actinomycetoma causative agents (ESCMID Global 2026) - No abstract available

Preclinical

Cessation of amoxicillin/clavulanate selective reporting and association with antibiotic prescribing and C. difficile infection in Ontario, 2017-2024: a natural experiment (ESCMID Global 2026) - No abstract available

Infectious Disease

Antimicrobial levels in hepatobiliary infections (ALIBI study): a prospective PK/PD study of amoxicillin/clavulanic acid and piperacillin/tazobactam in biliary fluid (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data • Hepatology • Infectious Disease

Deciphering the impact of age on amoxicillin/clavulanate disposition in older adults: a population pharmacokinetic analysis (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data

Combined application of bacteriophages and amoxicillin/clavulanate in a dynamic bladder infection model to target uropathogenic Escherichia coli (ESCMID Global 2026) - No abstract available

Infectious Disease

Impact of phenoxymethylpenicillin, amoxicillin and amoxicillin/clavulanic acidon the gut microbiome, resistome and mobilome: a randomised clinical trial with healthy adults (ESCMID Global 2026) - No abstract available

Clinical

Case report of Enterococcus thailandicus bacteremia, with genomic characterization of its clinical isolate. (PubMed, ASM Case Rep) - "She was treated for the perianal abscess and pyelonephritis with intravenous penicillins combined with beta-lactamase inhibitors for 2 weeks, followed by oral amoxicillin-clavulanic acid for 4 weeks...Phylogenetic analysis suggested that infection with E. thailandicus in this patient may have originated in Japan. The prognosis after treatment with penicillins was favorable."

Journal • Crohn's disease • Gastroenterology • Immunology • Infectious Disease • Inflammatory Bowel Disease • Nephrology

AC-CIF: Efficacy of an Empirical Treatment With Amoxicillin-clavulanate (AC) Compared to the Combination Amoxicillin-clavulanate and Ciprofloxacin (AC+C) in the Outpatient Care of Chemotherapy-induced Fever in Adult Haematology Patients. (clinicaltrials.gov) - P3 | N=1526 | Not yet recruiting | Sponsor: Versailles Hospital

New P3 trial • Hematological Disorders • Myelodysplastic Syndrome • Neutropenia

Sustaining stewardship: longitudinal evaluation of an integrated antimicrobial programme in the ICU. (PubMed, J Antimicrob Chemother) - "This study demonstrates the long-term effectiveness and sustainability of an ICU-AMS programme, achieving high recommendation acceptance and sustained reductions in broad-spectrum antimicrobial use. Continued efforts should focus on optimizing stewardship practices, addressing barriers to acceptance, and evaluating compensatory prescribing patterns."

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