amoxycillin/clavulanate / Generic mfg. - LARVOL DELTA

Otitis media caused by Vibrio cholerae in a child: a case report and literature review. (PubMed, Infez Med) - "Treatment with amoxicillin/clavulanate was complemented with ciprofloxacin and dexamethasone otic drops and led to a complete recovery without sequelae...In a context where vibriosis is increasingly common, our case exemplifies the importance of considering Vibrio spp. among the possible causative agents of otitis, especially in coastal areas or when exposure to potentially contaminated water cannot be ruled out, even in the absence of predisposing conditions."

Journal • Cholera • Mood Disorders • Otorhinolaryngology

Evaluation of resistance modulation in MDR Pseudomonas aeruginosa and Klebsiella pneumoniae using peppermint oil nanoemulsion: integrating antibacterial assays and molecular modeling. (PubMed, Front Microbiol) - "The bacterial isolates were resistant to Levofloxacin, Penicillin G, Ceftazidime, and amoxicillin-clavulanic acid (AMC). These results position PEONE as a promising, plant-based alternative for combating antibiotic-resistant urinary tract infections. Further in vivo studies are warranted to explore its clinical applicability and safety profile."

Journal • Infectious Disease • Nephrology • Pneumonia

Repurposing Povidone-Iodine for the Treatment of Chronic Suppurative Otitis Media in Nigerian Children. (PubMed, Otol Neurotol) - "This study shows that 0.5% povidone-iodine aural irrigation is at least as effective as 0.3% ciprofloxacin otic suspension in treating uncomplicated CSOM. In addition, any benefit from the use of oral antibiotics in treating uncomplicated CSOM appears to be negligible."

Clinical • Journal • Inflammation • Otorhinolaryngology • Pediatrics

Penicillin remains an effective agent against Group A Streptococcus in low- and middle-income countries: A systematic review and meta-analysis of antibiotic resistance and associated genes. (PubMed, S Afr Med J) - "This review comprehensively characterises the latest evidence on the prevalence of antibiotic resistance in Strep A in LMICs. Strep A in LMICs continues to be highly susceptible to antibiotics in vitro, primarily to penicillins. Strep A macrolide resistance patterns in LMICs are similar to those observed in high-income countries. The findings of this review may serve to inform effective treatment decisions and public health interventions."

Clinical • Journal • Retrospective data • Review

Intravenous antibiotic use in a private mining hospital in North West Province, South Africa. (PubMed, S Afr Med J) - "There is a need to monitor IV antibiotic use and encourage IV antibiotic de-escalation to limit the rampant use of broad- spectrum antibiotics and manage the most prevalent infections effectively in the shortest possible time, consequently reducing the average duration of hospitalisation. IV antibiotic treatment review is therefore pivotal to optimise antibiotic therapy, the transition of IV to oral antibiotics, and discontinuation of IV antibiotics when they are no longer necessary."

Journal • Retrospective data • Infectious Disease • Respiratory Diseases

Bacteraemia with Hepatic Abscess Due to Actinomyces Odontolyticus Associated with Gastrointestinal Foreign Body. (PubMed, Eur J Case Rep Intern Med) - "Always consider gastrointestinal foreign bodies: In elderly patients with dementia presenting with liver abscesses that do not respond to conventional treatment, foreign body perforation should be suspected and actively investigated using a contrast-enhanced computed tomography scan.Actinomyces spp. should be considered: In cases of liver abscess of unknown aetiology, Actinomyces spp. should be considered - a slow-growing anaerobic bacterium requiring matrix-assisted laser desorption/ionization matrix-assisted laser desorption/Ionization time-of-flight mass spectrometry for accurate species identification and targeted antibiotic therapy guidance.Combined treatment is the key to success: Optimal management requires a combination of three elements - surgical removal of the foreign body, thorough abscess drainage, and prolonged beta-lactam antibiotics to prevent recurrence."

Journal • Alzheimer's Disease • CNS Disorders • Dementia • Hepatology • Infectious Disease • Pain

Rapid-Onset Drug-Induced Liver Injury Following Amoxicillin-Clavulanate: A Case Report. (PubMed, Clin Case Rep) - "The usual onset of DILI varies from a few days to 8 weeks after initiation of medication. Here, we report a case of an atypically rapid onset of amoxicillin-clavulanate induced liver injury in a 32-year-old female following just two doses."

Journal • Hepatology • Liver Failure

Trends and factors associated with pneumonia mortality at Buea Regional Hospital in Cameroon from 2020 to 2023. (PubMed, PLoS One) - "Although the number of pneumonia cases fluctuated over time, they remained consistently present across all months from 2020 to 2023, highlighting the year-round nature of pneumonia transmission and its endemicity in the Buea Health District. Being hospitalized for less than 10 days and not using amoxicillin-clavulanic acid for treatment were risk factors of pneumonia mortality. These findings underscore the importance of timely diagnosis and empiric treatment with guideline recommended agents such as amoxicillin-clavulanic acid so as to reduce pneumonia mortality in the Buea regional hospital."

Journal • Retrospective data • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

PK-plèvre: Pharmacokinetics and Pleural Fluid Penetration of Amoxicillin and Clavulanic Acid in Patients With Pleural Infections (clinicaltrials.gov) - P=N/A | N=11 | Completed | Sponsor: Centre Hospitalier Universitaire, Amiens | Active, not recruiting ➔ Completed

Trial completion • Infectious Disease • Pneumonia • Respiratory Diseases

Commensal Clostridia in the preterm gut as reservoirs of antimicrobial resistance: susceptibility profiles, and resistance genes. (PubMed, FEMS Microbiol Ecol) - "While most isolates were susceptible to amoxicillin-clavulanic acid, imipenem, and metronidazole, resistance to tetracycline (12%), clindamycin (35%), and cefotaxime (35%) was observed. Distinct species-specific resistance included linezolid (Clostridium argentinense), chloramphenicol (Clostridium innocuum), and tigecycline (Paeniclostridium sordellii), and a one Robinsonella peoriensis isolate displayed vancomycin resistance. The detection of tet and erm genes corresponded with phenotypic resistance, while β-lactamase activity was uncommon. Although colonizing at low levels, these findings highlight the ecological significance of rarely studied commensal Clostridia and their contribution to the neonatal resistome, acting as underappreciated reservoirs of AMR genes during a critical window of microbiome assembly."

Journal

High-Throughput Screening Using the Self-Controlled Tree-Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury. (PubMed, Pharmacoepidemiol Drug Saf) - "High-throughput screening using tree-based scan statistics detected potentially hepatotoxic drugs for investigation in future pharmacoepidemiology studies."

Journal • CNS Disorders • Gastroenterology • Hepatology • Liver Failure • Pain

FTAA: Fast Track Therapeutic Model in Acute Complicated Appendicitis in Pediatrics (clinicaltrials.gov) - P4 | N=158 | Recruiting | Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | Trial completion date: Dec 2026 ➔ Dec 2027 | Trial primary completion date: Sep 2026 ➔ Nov 2027

Trial completion date • Trial primary completion date • Gastroenterology • Gastrointestinal Disorder • Pediatrics • CRP

Prevalence of antibiotic-resistant Escherichia coli isolates from healthy chicken droppings. (PubMed, PLoS One) - "The high prevalence of multidrug-resistant E. coli in broiler chickens underscores the urgent need for stricter antibiotic stewardship in poultry farming. The findings support Sustainable Development Goals (SDGs) 3 (Good Health and Well-being), 12 (Responsible Consumption and Production), and 15 (Life on Land) by promoting antimicrobial surveillance and sustainable livestock management."

Journal

Clinical impact of antibiotic resistance in odontogenic infections: a 12-year analysis of 740 cases. (PubMed, Clin Oral Investig) - "Continuous resistance surveillance and adaptation of empirical therapy are essential for managing severe odontogenic infections and reducing life-threatening infection-related complications, emphasizing the need for antimicrobial stewardship."

Journal • Retrospective data • Immunology • Infectious Disease

Prevalence, Antimicrobial Resistance, and Risk Factors of Enteric Bacterial Infections Among Children Under Five in Nairobi County, Kenya. (PubMed, Int J Microbiol) - "High resistance to ampicillin and amoxicillin-clavulanic acid was common, exceeding 70% in key pathogens like E. coli and E. cloacae. In contrast, meropenem, amikacin, gentamicin, and ciprofloxacin retained near-complete efficacy...Urgent integrated interventions are needed, including strengthening WASH infrastructure, promoting rational antibiotic use, and enhancing AMR surveillance. These findings provide a critical baseline for public health action and underscore the need to safeguard last-line antibiotics."

Journal • Infectious Disease

When a Budget-Friendly Drug Leads to a Premium Diagnosis: A Case Report of Severe Cholestasis Following Amoxicillin-Clavulanate Use. (PubMed, Case Reports Hepatol) - "Physicians must remain vigilant about rare adverse effects of commonly prescribed drugs and recognize their characteristic clinical patterns. Early identification and management can prevent complications, reduce unnecessary interventions, and optimize patient outcomes."

Journal • Cardiovascular • Cholestasis • Heart Failure • Hepatology • Immunology • Inflammation • Liver Failure • Otorhinolaryngology • Respiratory Diseases • Sinusitis

The Prevalence of Asymptomatic Bacteriuria Among Jordanian Pregnant Women. (PubMed, Int J Womens Health) - "Furthermore, the antibiotic sensitivities of the isolated E. coli showed high percentages (≥90%) to nitrofurantoin, aminoglycosides, and some types of cephalosporins, but low (56%) to amoxicillin-clavulanic acid. These findings emphasized the importance of routine screening for ASB during pregnancy, particularly in the third trimester and in grand multiparous women. Although no significant association was found with maternal age or common comorbidities such as diabetes and hypertension, further extensive studies are needed."

Journal • Cardiovascular • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology

Severe cutaneous adverse reaction to amoxicillin-clavulanate: Pediatric toxic epidermal necrolysis in the Gulf: A case report and literature review. (PubMed, Int J Surg Case Rep) - "Though TEN remains a medical emergency, even in severe cases, the timely and multidisciplinary approach can have a good outcome. It is a clinical reminder for clinicians to maintain a high index of suspicion of drug-induced severe cutaneous reactions, especially in children."

Journal • Acute Respiratory Distress Syndrome • Conjunctivitis • Critical care • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology • Pediatrics • Respiratory Diseases • Septic Shock • Steven-Johnson Syndrome

Five-year surveillance of antimicrobial resistance patterns among blood culture isolates at the University Teaching Hospital, Kigali, Rwanda. (PubMed, Ann Clin Microbiol Antimicrob) - "This study reveals a substantial burden of AMR in blood culture isolates, particularly affecting hospitalized and pediatric patients. The high resistance rates to commonly used antibiotics highlight an urgent need for strengthened antimicrobial stewardship programs, improved infection prevention measures, and enhanced diagnostic laboratory capacity to guide therapy."

Journal • Infectious Disease • Pediatrics • Pneumonia

Clinical management of trapeziometacarpal joint infections: a European Delphi consensus and literature review. (PubMed, J Hand Surg Eur Vol) - "This Delphi process, supported by literature review, provides the first structured guidance for the management of PJIs of the trapeziometacarpal joint of the thumb. Recommendations align with principles from large-joint infection management but are tailored to the anatomical and clinical context of the hand. These statements establish a practical framework for clinical decision-making and highlight priorities for future research."

Journal • Infectious Disease • Orthopedics

Sarcoid Pleural Effusion Presenting With Pachypleuritis: A Rare Manifestation in a Young Adult. (PubMed, Cureus) - "He was empirically treated with amoxicillin/clavulanic acid and azithromycin for community-acquired pneumonia. Despite its low incidence, SAPE should be considered in the differential diagnosis of pleural effusion, particularly in young patients without comorbidities and with a high pleural fluid lymphocyte count. Exclusion of tuberculosis is fundamental for an accurate diagnosis, and in cases of active pleural disease, systemic treatment is essential to prevent pachypleuritis."

Journal • Pleural effusion • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Sarcoidosis • Tuberculosis

Morganella morganii Urinary Tract Infection in Jordanian Children: Case series from a Tertiary Hospital. (PubMed, Infect Chemother) - "M. morganii should be considered in pediatric UTIs, especially among children with urinary tract anomalies or catheter use. Awareness of its distinct resistance profile is critical for selecting appropriate empiric therapy."

Journal • Infectious Disease • Nephrology • Pediatrics

Pseudotumoral Lesion of the Lacrimal Sac Unveiling Seronegative IgG4-Related Disease: A Diagnostic Challenge. (PubMed, Case Rep Ophthalmol) - "Initially diagnosed as chronic dacryocystitis, antibiotic therapy with amoxicillin clavulanate was continued, and an orbital MRI was conducted for further evaluation...This case underscores the diagnostic challenges of IgG4 disease, emphasizing the importance of a comprehensive approach, including histological confirmation. Distinguishing it from malignancies is crucial, and biopsy should be considered in cases of diagnostic uncertainty before invasive or systemic treatments for suspected tumors."

Journal • Anesthesia • Fibrosis • Immunology • Oncology • Pain • Squamous Cell Carcinoma

Temporal Changes in Microbial Etiology and Antibiotic Resistance Profiles of Osteoarticular Infections: An 11-Year Retrospective Analysis. (PubMed, Cureus) - "This retrospective longitudinal study identified Enterobacteriaceae as the predominant pathogens in OAIs, coupled with a significant rise in antimicrobial resistance. These findings highlight the critical need to adapt prophylactic and empirical treatment guidelines to contemporary resistance trends to ensure optimal patient outcomes."

Journal • Retrospective data • Infectious Disease • Novel Coronavirus Disease

Impact of Clinical Intervention and Improper Storage on Amoxicillin-Clavulanate Effectiveness: A Case of Foot Infection in a Hot Climate. (PubMed, Cureus) - "In hot climates, it is very important for antibiotics to stay stable and for patients to follow their treatment plan to achieve the best results. Interventions led by doctors and pharmacists are crucial for stopping unnecessary therapeutic failures and encouraging the right use of antibiotics."

Journal • Infectious Disease