amoxycillin/clavulanate / Generic mfg. - LARVOL DELTA

Perioperative Antimicrobial Prophylaxis for Invasive Dental Procedures: A Systematic Review and Random-Effects Meta-Analysis of Randomized and Placebo-Controlled Studies. (PubMed, Cureus) - "Individual trials showed marked reductions in post-extraction bacteremia surrogates with chlorhexidine mouthwash prophylaxis and with intravenous amoxicillin-clavulanate in extraction settings, whereas in uncomplicated extractions among well-controlled type 2 diabetes, antibiotics did not reduce postoperative complications and were associated with greater analgesic consumption...In parallel, microbiological evidence indicates that single-dose prophylaxis can promote short-term ecological disturbance and selection of resistant oral flora. Future trials should standardize endpoints (distinguishing clinical infection/implant failure from surrogate bacteremia measures), stratify by baseline risk, and prioritize antimicrobial stewardship to identify the limited patient subsets most likely to benefit."

Journal • Retrospective data • Review • Diabetes • Infectious Disease • Metabolic Disorders • Pain • Type 2 Diabetes Mellitus

Infectious mononucleosis with ampicillin rash and a positive rapid streptococcal antigen test: a case report. (PubMed, Fukushima J Med Sci) - "We report a 22-year-old woman with fever, sore throat, lymphadenopathy, and a generalized erythematous rash after a 7-day course of amoxicillin-clavulanate. Serology confirmed acute Epstein-Barr virus infection, and throat culture revealed only alpha-hemolytic streptococci. This case underscores the diagnostic overlap between IM and streptococcal pharyngitis, the need for caution in interpreting rapid antigen tests, and the importance of avoiding unnecessary antibiotics in suspected viral illness."

Journal • Epstein-Barr Virus Infections • Infectious Disease • Otorhinolaryngology

A Mysterious Case of Autoimmune Hepatitis Triggered by Herpes Zoster Virus Versus Drug-Induced Liver Injury. (PubMed, Cureus) - "While evaluating a patient with suspected autoimmune hepatitis, common causes such as viral hepatitis, Epstein-Barr virus, and medications like amoxicillin-clavulanic acid, statins, nitrofurantoin and methyldopa must be ruled out. She was observed with findings typical of cholestatic liver disease, and an extensive workup, including imaging and liver biopsy, was done to determine the cause of liver injury. Her clinical presentation, laboratory and Imaging findings favored Herpes Zoster virus as the likely culprit for autoimmune hepatitis."

Journal • Autoimmune Hepatitis • Cholestasis • CNS Disorders • Diabetes • Endocrine Disorders • Epstein-Barr Virus Infections • Gastroenterology • Gastrointestinal Disorder • Hepatitis C • Hepatology • Herpes Zoster • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Inflammatory Bowel Disease • Keratitis • Liver Failure • Metabolic Disorders • Neuralgia • Ocular Inflammation • Ophthalmology • Pain • Rheumatoid Arthritis • Rheumatology • Scleritis • Type 1 Diabetes Mellitus • Ulcerative Colitis • Uveitis • Varicella Zoster

Molecular pharmacodynamics of amoxicillin-clavulanic acid for urinary tract infections caused by Escherichia coli (ESCMID Global 2026) - No abstract available

PK/PD data • Infectious Disease • Nephrology

Development of a rapid actinomycetoma rapid in vitro susceptibility assay for determining the susceptibility towards amikacin, trimethoprim/sulfametoxazole and amoxicillin/clavulanic acid (AMAnTA) in actinomycetoma causative agents (ESCMID Global 2026) - No abstract available

Preclinical

Cessation of amoxicillin/clavulanate selective reporting and association with antibiotic prescribing and C. difficile infection in Ontario, 2017-2024: a natural experiment (ESCMID Global 2026) - No abstract available

Infectious Disease

Combined application of bacteriophages and amoxicillin/clavulanate in a dynamic bladder infection model to target uropathogenic Escherichia coli (ESCMID Global 2026) - No abstract available

Infectious Disease

Antimicrobial levels in hepatobiliary infections (ALIBI study): a prospective PK/PD study of amoxicillin/clavulanic acid and piperacillin/tazobactam in biliary fluid (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data • Hepatology • Infectious Disease

Deciphering the impact of age on amoxicillin/clavulanate disposition in older adults: a population pharmacokinetic analysis (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data

Impact of phenoxymethylpenicillin, amoxicillin and amoxicillin/clavulanic acidon the gut microbiome, resistome and mobilome: a randomised clinical trial with healthy adults (ESCMID Global 2026) - No abstract available

Clinical

A rare case of Streptomyces fradiae hand actinomycetoma. (PubMed, IDCases) - "A skin biopsy of the lesion confirmed the diagnosis of actinomycetoma, and the patient was treated with ceftriaxone IV for 14 days followed by oral amoxicillin clavulanic acid for a total of 3 months. The patient had significant clinical recovery with no recurrence of the infection. Streptomyces fradiae is a rare causative agent of actinomycetoma, and this case highlights the importance of early diagnosis and prolonged antibiotic therapy in the management of this infection."

Journal • Infectious Disease

Prevalence and serotype distribution of nasopharyngeal carriage of Streptococcus pneumoniae in Vietnam: a systematic review and meta-analysis. (PubMed, Lancet Reg Health West Pac) - "High non-susceptibility rates were observed for penicillin (64%), macrolides (70%-91%), sulfamethoxazole-trimethoprim (70%), tetracycline (84%), and several other antibiotics. Moderate to low non-susceptibility rates were observed for amoxicillin (22%), amoxicillin-clavulanate (6%), moxifloxacin (1%), vancomycin (1%), and rifampicin (0%)...Inclusion of PCV into the country's National Immunisation Program at the earliest opportunity will have a large impact on childhood disease. Gavi, the Vaccine Alliance, and Australia's Department of Foreign Affairs and Trade (DFAT) provided funding support for this project."

Journal • Retrospective data • Infectious Disease • Pneumococcal Infections • Pneumonia

Effect of Vonoprazan-Amoxicillin Combined with Compound Lactobacillus acidophilus on Symptoms and Gut Microbiome in Patients with Functional Constipation (ChiCTR) - P=N/A | N=136 | Not yet recruiting | Sponsor: The First Affiliated Hospital with Nanjing Medical University; The First Affiliated Hospital with Nanjing Medical University

New trial • Constipation • Gastroenterology • Gastrointestinal Disorder

Resistance of uropathogens to gepotidacin: a systematic review of in vitro antimicrobial susceptibility studies. (PubMed, Int J Antimicrob Agents) - "Gepotidacin has very good antimicrobial activity against a variety of pathogens that cause uUTIs. Importantly, it retains activity against uropathogen isolates that exhibit resistance to other antibiotics commonly used for UTIs making it a useful addition to a physician's therapeutic arsenal."

Journal • Preclinical • Review • Infectious Disease • Nephrology • Pneumonia

Antibacterial resistance in urinary samples from long term care-facility and community-dwelling older people in Gauteng, South Africa. (PubMed, J Glob Antimicrob Resist) - "LTCF residence was independently associated with higher AMR in several common urinary pathogens. These findings suggest that empirical UTI regimens commonly used in community-dwelling older adults may be inadequate for LTCF residents. Setting-specific antibiograms, improved diagnostic stewardship, and strengthened AMS interventions are needed to support appropriate prescribing. Further studies incorporating patient-level clinical factors are warranted to refine empirical treatment recommendations for older adults across care settings."

Journal • Infectious Disease • Nephrology

High prevalence of class 1 integron, biofilm formation, and antimicrobial resistance profiles of Escherichia coli isolated from cattle, water, and soil in Bangladesh. (PubMed, BMC Microbiol) - "This study reveals a high prevalence of class 1 integron and the mcr-1 gene in MDR E. coli from food animals in Bangladesh, highlighting their role in resistance dissemination and the public health risk of colistin resistance. The strong association of integron with MDR and mcr-1 underscores the need for prudent antibiotic use, routine surveillance, and stronger antimicrobial stewardship in livestock to limit the spread of resistance to humans."

Journal

Prepatellar Septic Bursitis from Haemophilus influenzae After Penetrating Trauma from Broken Glass: A Case Report. (PubMed, JBJS Case Connect) - "This case highlights the critical role of curiosity and details in exploring a patient's history as well as culture-guided therapy in persistent or atypical infection presentations."

Journal • Infectious Disease • Influenza • Musculoskeletal Pain • Pain • Respiratory Diseases

Impact of the COVID-19 Pandemic on the Outcomes of a Multifaceted Program on Antibiotic Prescribing in Primary Care Among Children Under Three Years of Age. (PubMed, Antibiotics (Basel)) - "Penicillins account for 75% of prescriptions, mainly amoxicillin and amoxicillin-clavulanic acid...Ongoing educational and stewardship interventions within the Purapi framework were instrumental in maintaining rational prescribing and may have contributed to maintaining reduced antibiotic consumption among children under three years of age during and after the pandemic. Strengthening and harmonising these initiatives is essential to ensure consistent paediatric antibiotic stewardship in primary care."

Journal • Infectious Disease • Novel Coronavirus Disease • Pediatrics

Antibacterial activity of Moringa leaf extracts against Gram-negative bacteria from Wadi Ad-Dawasir, Saudi Arabia. (PubMed, Front Microbiol) - "Amoxicillin-clavulanic acid and tetracycline were used as reference antibiotics. The presence of sterols in the phytochemical profile likely enhances their bactericidal action by targeting bacterial membranes. These results suggest that Moringa could serve as a viable phytotherapeutic option for addressing the growing challenge of Gram-negative bacterial resistance."

Journal • Infectious Disease

Occurrence and Antimicrobial Susceptibility of Major Bacterial Pathogens Associated with Subclinical Mastitis in Dairy Cows in Western Romania. (PubMed, Microorganisms) - "Among S. aureus, the highest resistance rates were to fosfomycin (58.3%), penicillin (44.4%), clindamycin (44.4%), and tetracycline (41.7%), with 47.2% MDR isolates...coli showed resistance to amoxicillin/clavulanic acid (88.9%), ampicillin (55.6%), and cefotaxime (55.6%), with 66.6% MDR...aureus remains the leading cause of subclinical mastitis in Western Romania. The high MDR rates highlight the need for targeted antimicrobial stewardship, culture-based therapy, and continuous AMR monitoring under the "One Health" framework."

Journal • Infectious Disease • Pneumonia

Antibiotic Resistance Patterns of Bacteria Isolated from Canine Skin and Ear Infections in Serbia. (PubMed, Antibiotics (Basel)) - "Staphylococci showed high resistance to macrolides, clindamycin, tetracycline, and first-line β-lactams (amoxicillin-clavulanate, cephalexin), with the highest susceptibilities to amikacin, florfenicol, and rifampicin. One isolate of each species was resistant to all tested drugs. These findings confirm high levels of antimicrobial resistance in major canine skin and ear pathogens and emphasize the need for susceptibility-based therapy, rational antimicrobial use, and ongoing surveillance in small-animal practice."

Journal • Dermatology • Infectious Disease • Otorhinolaryngology

Antibiotic Resistance Profiles of Commensal and Pathogenic Bacteria Isolated from Wild Boar Carcasses in Campania Region, Southern Italy. (PubMed, Antibiotics (Basel)) - "Among potential pathogens, Escherichia coli exhibited an extended-spectrum β-lactamase (ESBL)-like phenotype, with resistance to amoxicillin/clavulanate (67%), aztreonam (54%), and ceftazidime (47%) but preserved carbapenem susceptibility...showed pronounced resistance to linezolid (57%) and erythromycin (52%), whereas Pseudomonas isolates demonstrated elevated resistance to aztreonam and ceftazidime (57% each). Opportunistic pathogens such as Alcaligenes faecalis and Pantoea agglomerans showed peak resistance to ciprofloxacin and amoxicillin/clavulanate...Although the preservation of carbapenem susceptibility underscores their potential as last-line antibiotics, the high resistance to commonly used antibiotics raises concerns for zoonotic transmission. Surveillance of wildlife reservoirs therefore remains critical for integrated AMR control."

Journal

Antimicrobial use in breeding kennels and antimicrobial resistance profile of Escherichia coli and Staphylococcus pseudintermedius isolated from healthy breeding bitches in Northern Italy. (PubMed, Front Vet Sci) - "coli exhibited the highest resistance to ampicillin (around 50%), moderate resistance to amoxicillin-clavulanic acid (~24%) and cefalexin (~47%), while resistance to the remaining agents was low (generally ≤10-15%); the prevalence of Extended Spectrum Beta-Lactamase (ESBL)-producing E. coli was 7.76%. The generally high levels of acquired resistance suggest extensive antimicrobial use, especially beta-lactams. Breeder responses were partly inconsistent, indicating that complementary strategies should be adopted to monitor antimicrobial use in dog breeding facilities."

Journal

Genetic Analysis of Virulence and β-Lactamase Determinants Related to β-Lactamase Inhibitors in Pseudomonas aeruginosa Strains from Nosocomial Infections. (PubMed, Antibiotics (Basel)) - "The MIC determination of ticarcillin/clavulanic acid and piperacillin/tazobactam was performed using the MIC test strip for antimicrobial susceptibility testing...In total, 100% (124/124) and 99.1% (123/124) of the strains isolated from patients with healthcare-associated and community-acquired infections were resistant to the β-lactamase inhibitor antibiotics, amoxicillin/clavulanic acid and ampicillin/sulbactam, respectively, while 54% (67/124) of the strains were resistant to piperacillin/tazobactam... We demonstrated different association profiles of virulence genotype related to the β-lactamase genotype, the β-lactamase inhibitor resistome, phylogroups, and clinical origin of the strains. Therefore, medical treatment regimens against infections caused by P. aeruginosa should be improved."

Journal • Infectious Disease

Identification, Serotyping and Antimicrobial Resistance in Ornithobacterium rhinotracheale Isolates from Turkeys in Poland Between 2016 and 2022. (PubMed, Animals (Basel)) - "The results of this study indicated that amoxicillin/clavulanic acid, doxycycline, florfenicol, and lincomycin/spectinomycin were the most effective agents against the isolates from turkeys. The findings showed that serotype I was the most prevalent among the tested turkey strains in Poland and was the serotype to which 29% of the O. rhinotracheale isolates affiliated."

Journal • Respiratory Diseases