CT2074 / Cognition Therap - LARVOL DELTA

Sigma-2 Receptor Modulation Promotes Retinal Pigmented Epithelial Cell Survival Following Chronic 7-Ketocholesterol Exposure (ARVO 2025) - "Treatment with S2R modulator CT2074 significantly increased the number of adherent viable cells in 7KC-treated cultures compared to cells treated with 7KC alone (100μM 7KC: 44% ± 14.8 SEM viable cells + CT2074 vs 25% ±16.5 SEM +Vehicle; n=3 experiments, p<0.05 two-way ANOVA)...Ongoing studies using the chronic 7KC in vitro model are underway to test the protective capacity of additional S2R modulators, including the investigational therapeutic CT1812 that is being tested in a Phase 2 clinical trial for geographic atrophy secondary to dry AMD. Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Age-related Macular Degeneration • Dry Age-related Macular Degeneration • Macular Degeneration • Ophthalmology • Retinal Disorders

Delineating Mechanisms of Sigma-2 Receptor Modulators in Regulating Retinal Pigmented Epithelial Lipid Uptake (ARVO 2025) - "To assess effects of S2R modulation, cells were treated with vehicle or S2R modulators (CT1812, CT2074, CT2168) for 16 hrs prior to and during LDL-DyL. Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Age-related Macular Degeneration • Dry Age-related Macular Degeneration • Macular Degeneration • Ophthalmology • Retinal Disorders • LDLR • VCL

Neuroprotective Effect of Sigma-2 Modulator CT2074 in a Mouse Model of Ocular Hypertension. (PubMed, Exp Eye Res) - "This study underscores the potential of CT2074 administered orally to protect RGCs exposed to elevated IOP, as evidenced by substantial preservation of RGCs and their axons compared to Vehicle-treated mice. These findings signify a promising avenue for the development of sigma-2 receptor-targeted therapeutics in glaucoma and related neurodegenerative diseases, addressing a critical unmet need in the field of ocular neuroprotection."

Journal • Preclinical • Cardiovascular • Cholera • CNS Disorders • Glaucoma • Ophthalmology

Differentiated retinal pigment epithelial cells as a model for uncovering sigma-2 receptor functions and novel therapeutics for dry AMD (ARVO 2024) - "Ability of S2R modulators including CT2074 and a tool compound, Z4857158944, to regulate LDL uptake was also assessed (1, 3, 10μM for 16 hr)... Differentiated ARPE-19s may be a useful model for exploring relationships between LDL trafficking, S2R-LDLR interactions, and RPE cell function. Elucidating these mechanisms may be beneficial for devising new therapeutic approaches and investigating S2R modulation as a means of restoring RPE function in dAMD."

Dry Age-related Macular Degeneration • Ophthalmology • MERTK