carbamazepine / Generic mfg. - LARVOL DELTA

Assessment of Drug-Induced Calcium Oscillations in hiPSC-Derived Neuron-Astrocyte Cocultures Using FDSS (Neuroscience 2026) - "To evaluate the functional maturation of the neuronal networks, the following panel of pharmacological agents that induce known neuronal responses were applied to the culture at three increasing doses: the neurotransmitters glutamate and GABA, the AMPA/kainate receptor antagonist CNQX, and the ion channel modulators carbamazepine and 4-aminopyridine (4-AP).Vehicle controls (0.1% DMSO or water) produced minimal changes in either oscillation amplitude or peak frequency. These findings demonstrate that hiPSC-derived neuron-astrocyte co-cultures develop robust spontaneous network activity and exhibit reproducible, mechanism-consistent drug-induced responses that can be quantified using complementary measures of calcium oscillation amplitude and event frequency. This quantitative assay provides a scalable approach for investigating neuronal network physiology, evaluating the effects of pharmacological agents on neural excitability, and characterizing disease-associated..."

CNS Disorders

Pharmacodynamic and pharmacokinetic interactions between carbamazepine and psilocybin (Neuroscience 2026) - "Carbamazepine did not increase psilocin half-life (29.8 ± 0.03 vs. 28.2 ± 1.43 min), reduced AUCinf from 1866 ± 566 to 1001 ± 142 min×ng/mL while increasing apparent clearance (74.7 ± 37.4 vs. 120 ± 38.3 mL/min). These findings reveal that the enhanced psilocybin-appropriate responding by carbamazepine is not attributable to increased plasma psilocin exposure."

PK/PD data • Bipolar Disorder • CNS Disorders • Epilepsy • Mental Retardation • Mood Disorders

Pharmacological characterization of rat models of chemotherapy-induced peripheral neuropathy (Neuroscience 2026) - "In the paclitaxel and oxaliplatin models, cold and mechanical allodynia were robustly inhibited following administration of morphine, gabapentin, or pregabalin, whereas administration duloxetine, carbamazepine, or nalfurafine primarily inhibited cold allodynia, with different effects observed in the paclitaxel and oxaliplatin models. Administration of ketoprofen, diclofenac, celecoxib or diazepam had minimal or no effect on cold or mechanical allodynia in these models...SNRIs, sodium channel blockers, and kappa opioid receptor agonists are less effective and primarily inhibit cold allodynia, whereas NSAIDs and benzodiazepines are largely ineffective in these models. These studies highlight efforts within the NIH HEAL Initiative’s PSPP program to characterize preclinical models of chemotherapy-induced peripheral neuropathy used to evaluate novel assets towards the development of novel non-opioid, non-addictive analgesics."

Preclinical • Addiction (Opioid and Alcohol) • CNS Disorders • Peripheral Neuropathic Pain

Employing Multi-Electrode Array (MEA) to Investigate Effects of Anti-Epileptic Drugs on Neuronal Network Activity (Neuroscience 2026) - "Five FDA-approved anti-seizure medications (i.e. stiripentol, phenytoin, rufinamide, carbamazepine, and valproic acid) were tested in this assay. Under these conditions, valproic acid (n=8, p= 0.0619), did not provide a significant reduction in neuronal activity. Using well-established, approved anti-seizure medications, we validated an MEA assay measuring hyperexcitability of primary neurons and believe that it can be a valuable tool in identifying new anti-epileptic drug candidates."

CNS Disorders • Epilepsy

Targeting cortical hyperexcitability with phenytoin improves autism spectrum disorder-like phenotypes (Neuroscience 2026) - "These findings suggest that phenytoin, but not carbamazepine, lamotrigine or perampanel, ameliorates abnormalities in the open field test in VPA-exposed mice. Moreover, the therapeutic effects observed with phenytoin may reflect mechanisms beyond a general reduction in cortical excitability."

CNS Disorders • Epilepsy

Genetic Polymorphisms CYP3A4*22, CYP3A5*3, and CYP2D6 Predicted Phenotypes Are Not Associated with Antipsychotic Treatment Outcomes in Neurotypical Prepubertal Boys with Conduct Disorders. (PubMed, Pharmaceuticals (Basel)) - " Patients taking carbamazepine (n = 11) were excluded from the analysis of associations between treatment outcomes and the CYP3A4*22 and CYP3A5*3 polymorphisms. The analysis of associations between treatment outcomes and CYP2D6 metabolism type was conducted in two stages: the overall sample and a subsample of patients who were prescribed risperidone (n = 80)... Our study identified only a few significant associations between the CYP3A4*22 polymorphism, CYP2D6 slow metabolism, and patients' reports of early adverse reactions in a 14-day observation period. Further research is needed to identify pharmacogenetic predictors of the efficacy and safety of antipsychotics in neurotypical children with conduct disorders."

Journal • Behavior Disorders • CNS Disorders • Pain • CYP3A4 • CYP3A5

Fixed-dose combination of poorly water-soluble drugs, indomethacin and carbamazepine, formulated as a multi-composed amorphous solid dispersion: a potential therapy for HC-tic (part 1). (PubMed, Int J Pharm) - "Furthermore, the MC-ASDs exhibited good physical stability. Overall, multi-composed ASDs represent a promising approach for the development of fixed-dose combinations of poorly water-soluble drugs."

Journal • Gastrointestinal Disorder • Musculoskeletal Pain • Neuralgia • Pain

Efficacy of chitosan-encapsulated carbamazepine on seizures induced by pentylenetetrazole kindling. (PubMed, Neurosci Lett) - "Characterization of the optimized nanoparticles revealed a mean particle size of 65 nm, a polydispersity index (PDI) of 0.21, a zeta potential of -34.5 mV, and an entrapment efficiency of 55.35 %, indicating favorable stability and delivery properties. Overall, this study demonstrates that chitosan‑based nanoencapsulation of carbamazepine enhances its antiepileptic efficacy in a PTZ‑kindling model, suggesting its promise as a potential therapeutic strategy for epilepsy."

Journal • CNS Disorders • Epilepsy

Acquired paroxysmal dysarthria-ataxia syndrome: A systematic review of clinical and MRI findings. (PubMed, Neurol Sci) - "Treatment mainly consisted of antiepileptic drugs (AEDs), most commonly carbamazepine, used in 14 patients (45%). These findings show that PDAS is not exclusively associated with MS and that, when treated, its prognosis is generally very good."

Journal • Review • Ataxia • CNS Disorders • Movement Disorders • Multiple Sclerosis • CNTN

Environmental Contaminants in Surface Snow Samples Made from Reclaimed Water at a Ski Resort: A Mass Spectrometry Analysis. (PubMed, ACS Environ Au) - "Nineteen pharmaceuticals were found to be increased in high artificial snowmaking samples as compared to natural snow, including carbamazepine, fexofenadine, flecainide, and lamotrigine, which were present at low ng/L concentrations in one set of high artificial snowmaking samples. A suite of inorganic contaminants was also assessed and quantified using inductively coupled plasma mass spectrometry to reveal that nine metalssodium, phosphorus, potassium, chromium, manganese, iron, zinc, arsenic, and bariumwere increased in abundance in high artificial snowmaking samples compared to levels in normal snow. Taken together, this study suggests that snow made from reclaimed water may contain anthropogenic organic and inorganic analytes, warranting further study on their environmental and human health effects."

Journal

Teratogenic risk of carbamazepine, levetiracetam, and lamotrigine treatment in pregnant women with epilepsy. (PubMed, Rev Assoc Med Bras (1992)) - "Levetiracetam and lamotrigine demonstrate favorable safety profiles, whereas carbamazepine carries a moderate teratogenic risk. Polytherapy risk is combination-dependent, and preconception seizure control is a key predictor of seizure outcomes during pregnancy."

Journal • Observational data • Retrospective data • CNS Disorders • Epilepsy

A DrugâDrug Interaction Gone Pancreatic: Clindamycin and Antiseizure Medication Toxicity (ACG 2026) - "Recent history was notable for treatment of a dental abscess with amoxicillin/clavulanate, transitioned to clindamycin on the day symptoms began. Home medications included lamotrigine, carbamazepine, and hydrochlorothiazide (HCTZ). Given the potential interaction between clindamycin and carbamazepine resulting in elevated carbamazepine exposure and drug-induced pancreatitis, clindamycin and HCTZ were discontinued, and ampicillin/sulbactam was initiated...This case highlights the importance of recognizing drug-drug interactions as an overlooked cause of pancreatitis and carefully evaluating new medications in patients receiving chronic pharmacotherapy to prevent avoidable adverse events. Figure: Figure 1: CT abdomen/pelvis with IV contrast findings of acute pancreatitis with ill-defined hypoenhancing pancreatic parenchyma to level of the body."

CNS Disorders • Dental Disorders • Depression • Epilepsy • Gastroenterology • Gastroesophageal Reflux Disease • Immunology • Neuralgia • Pancreatitis

When Constipation Becomes a Renal Emergency: Stercoral Proctocolitis With Fecaloma-Induced Bilateral Hydroureteronephrosis and Obstructive Acute Kidney Injury (ACG 2026) - "Her medications included hydroxyzine, carbamazepine, mirtazapine, primidone, pregabalin, deutetrabenazine, and venlafaxine, contributing to a high anticholinergic burden. Massive fecal impaction causing stercoral proctocolitis and obstructive uropathy. Figure Footnote: The distended colon compresses the distal ureters resulting in bilateral hydroureteronephrosis (arrows)."

Acute Kidney Injury • Bipolar Disorder • Cardiovascular • CNS Disorders • Constipation • Endocrine Disorders • Epilepsy • Gastroenterology • Gastrointestinal Disorder • Hypotension • Infectious Disease • Inflammatory Bowel Disease • Movement Disorders • Nephrology • Parkinson's Disease • Renal Disease

Understanding the influence of stabiliser selection and concentration on the physical stability of dual-drug co-suspensions. (PubMed, Int J Pharm) - "In total, nine stabilisers were screened in combination with itraconazole and carbamazepine as individual suspensions and in co-suspensions, followed by evaluation of selected stabilisers using the cinnarizine-itraconazole system and concentration optimisation for the carbamazepine-itraconazole system. Increasing stabiliser concentration either enhanced or reduced milling efficiency depending on the formulation, and the concentration providing the greatest particle size reduction did not consistently provide the optimal physical stability. These findings demonstrate that although particle size characteristics of co-suspensions may follow the trends observed for one corresponding single-drug suspension, their physical stability cannot be predicted solely from the individual suspensions."

Journal • Infectious Disease

A Study in Healthy Men to Test Whether Carbamazepine Influences the Amount of Verducatib in the Blood (clinicaltrials.gov) - P1 | N=20 | Recruiting | Sponsor: Boehringer Ingelheim | Not yet recruiting ➔ Recruiting

Enrollment open

Carbamazepine preserves systemic ionic homeostasis and hippocampal Atp1a1 expression following pentylenetetrazol-induced seizures in rats. (PubMed, Neurochem Res) - "Pretreatment with CBZ effectively prevented systemic ion shifts, preserving hippocampal Atp1a1 mRNA expression at control levels, and preserved neurovascular integrity. Our results suggest that the neuroprotective mechanism of CBZ extends beyond Na+ channel blockade, acting as a multifaceted stabilizer of ionic homeostasis and of Na+/K+-ATPase expression in the hippocampal formation."

Journal • Preclinical • CNS Disorders • Endocrine Disorders • Epilepsy • ATP1A1

Beyond histocompatibility: human leukocyte antigen as a cross-disciplinary platform for immune recognition and clinical decision-making. (PubMed, Front Immunol) - "Pharmacogenomic testing has clearer clinical value for selected drugs, including abacavir, carbamazepine and allopurinol. Clinical implementation requires reliable assays, validated clinical associations, evidence of patient benefit, multi-ancestry validation, consistent reporting and equitable access. We distinguish established clinical practice from developing risk-stratification methods and early mechanistic findings."

Journal • Review • Acute Lung Injury • Bone Marrow Transplantation • Diabetes • Graft versus Host Disease • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Metabolic Disorders • Oncology • Respiratory Diseases • Solid Organ Transplantation • Systemic Lupus Erythematosus • Transplantation • Type 1 Diabetes Mellitus • HLA-E

Discovery of potent and selective MAO-B inhibitors from a morpholine-substituted chalcone library for neurodegenerative disorders. (PubMed, Mol Divers) - "In vitro Parallel Artificial Membrane Permeability Assay (PAMPA) and microsomal stability studies revealed that TC9 exhibited high blood-brain barrier (BBB) permeability comparable to carbamazepine, while TC12 showed moderate permeability but was consistent with its predicted CNS penetration. Both TC analogues demonstrated favourable metabolic stability profiles in rat and human liver microsomes, supporting their potential for further pharmacological evaluation. Overall, TC12 represents a promising candidate for selective MAO-B inhibition."

Journal • CNS Disorders • Movement Disorders • Pain • Parkinson's Disease

Bilateral lingual epilepsy following traumatic brain injury. (PubMed, Pract Neurol) - "These events were refractory to carbamazepine, lacosamide and valproate. Electroencephalography showed irregular and sharpened left-sided slow waves but no epileptiform activity, even during episodes of lingual twitching. Bilateral lingual seizures in this patient implied that the left operculum cortex innervated both hypoglossal nuclei."

Journal • CNS Disorders • Epilepsy • Oncology • Vascular Neurology

Diagnostic value of serum NSE, and S-100β and inflammatory markers levels in epilepsy. (PubMed, J Med Biochem) - "This was a retrospective cohort of 120 patients with SE who received Sodium valproate compared with a group who received carbamazepine for different therapeutic drugs. Sodium valproate can drastically relieve the epileptic symptoms of patients with SE, and there was no great difference in ARs. Hence, it is safe and worthy of popularization and application."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Oncology • CXCL8 • IL2

Physiologically Based Pharmacokinetic Modeling to Assess Transporter-Mediated Drug-Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray. (PubMed, Clin Pharmacol Ther) - "In clinical drug-drug interaction (DDI) studies, oral zavegepant exposure increased in the presence of multiple-dose (MD) rifampin or itraconazole; however, no interaction was observed between intranasal (IN) zavegepant and itraconazole...Predicted IN zavegepant exposure change with SD cyclosporine A was 1.58-fold (AUCR) when assuming 90:10 proportion for OATP1B3:NTCP contribution to hepatic uptake. CYP3A inducers, carbamazepine and efavirenz, were predicted to have minimal effect on IN zavegepant PK. Overall, PBPK modeling and observed PK data support that CYP3A/P-gp inhibitors and inducers do not produce clinically relevant modulation in IN zavegepant plasma exposure; however, OATP1B3/NTCP inhibitors can significantly increase IN zavegepant exposure, and coadministration should be avoided."

Journal • PK/PD data • CNS Disorders • Migraine • Pain • CYP3A4

DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS) SYNDROME ASSOCIATED WITH CARBAMAZEPINE USE IN AN 11-YEAR-OLD BOY: A CASE REPORT (EADV 2026) - No abstract available

Case report • Clinical • Eosinophilia

Stevens-Johnson Syndrome Triggered by Carbamazepine Misuse for Migraine: A Severe Adolescent Case Report (EADV 2026) - No abstract available

Case report • Clinical • CNS Disorders • Migraine • Steven-Johnson Syndrome

Carbamazepine-Induced Erosive Oral Lichen Planus (EADV 2026) - No abstract available

Dermatology • Dermatopathology • Lichen Planus

Carbamazepine-Induced Toxic Epidermal Necrolysis in a Young Female with Epilepsy Successfully Managed with Intravenous Immunoglobulin-Based Combination Therapy (EADV 2026) - No abstract available

Combination therapy • CNS Disorders • Epilepsy • Steven-Johnson Syndrome