carbamazepine / Generic mfg. - LARVOL DELTA

Navigating classical Hodgkin lymphoma in a patient with DIAPH1 deletion syndrome: Diagnostic and therapeutic challenges in a rare immuno-genetic context (ASH 2025) - P | "He was commenced on full dose OEPA (vincristine, etoposide, prednisolone, doxorubicin) after histopathologic confirmation of cHL, and following 2 cycles his early response assessment PET showed complete metabolic response. Due to concerns about hepatic enzyme induction and mitochondrial toxicity, anti-seizure therapy was changed to levetiracetam and clobazam, as carbamazepine is a potent CYP3A4 inducer that may decrease exposure to drugs like methylprednisolone (Bartoszek et al., 1987)...This is the first report showing feasibility of full dose induction therapy for cHL with intensive supportive care in DIAPH1 deficiency. Nonetheless, ongoing careful individualised dosing, vigilant toxicity monitoring, and multidisciplinary input remain essential."

Clinical • B Cell Lymphoma • Classical Hodgkin Lymphoma • CNS Disorders • Dental Disorders • Developmental Disorders • Diffuse Large B Cell Lymphoma • Epilepsy • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Hodgkin Lymphoma • Lymphoma • Mental Retardation • Mucositis • Neutropenia • Non-Hodgkin’s Lymphoma • Ophthalmology • Stomatitis • CYP3A4

P043 A scoping review of patient metrics, aetiology, management and complications in Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). (PubMed, Br J Dermatol) - "The most common causative individual drugs were lamotrigine (n = 76), carbamazepine (n = 71), phenytoin (n = 45), co-trimoxazole (n = 36) and pembrolizumab (n = 28). Regarding treatments, steroids are the mainstay, alongside intravenous immunoglobulin and ciclosporin. The range of complications emphasizes the need for a multidisciplinary management approach both in the short- and longer-term care of patients."

Journal • Conjunctivitis • Dermatology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Herpes Simplex • Human Immunodeficiency Virus • Infectious Disease • Keratitis • Liver Failure • Novel Coronavirus Disease • Ocular Infections • Ocular Inflammation • Oncology • Ophthalmology • Steven-Johnson Syndrome

Pharmacologic pitfalls in heart failure: A guide to drugs that may cause or exacerbate heart failure. A European Journal of Heart Failure expert consensus document. (PubMed, Eur J Heart Fail) - "The review examines the pathophysiological mechanisms, clinical evidence, and guideline-based recommendations for several drug classes, including antidiabetic agents (e.g. thiazolidinediones, dipeptidyl peptidase-4 inhibitors), antiarrhythmics (particularly Class I and III), calcium channel blockers, non-steroidal anti-inflammatory drugs, antifungals (e.g. itraconazole, amphotericin B), macrolide antibiotics, antihypertensives (e.g. α1-blockers, centrally acting sympatholytics), neurological and psychiatric medications (e.g. carbamazepine, pregabalin, lithium), and selected anaesthetic and anticancer agents such as anthracyclines and vascular endothelial growth factor inhibitors. The goal is to empower clinicians, pharmacists and nurses to optimize HF treatment while reducing the risk of drug-induced deterioration. Awareness of these pharmacologic pitfalls is critical to improving clinical outcomes and minimizing preventable adverse events and HF hospitalizations."

Journal • Anesthesia • Cardiovascular • Congestive Heart Failure • Heart Failure • Oncology • Psychiatry

Prediction of anti-epileptic drug response of patients based on peripheral blood RNA profiles and machine learning. (PubMed, Int J Clin Pharmacol Ther) - "The model of a quadratic support vector machine with a pretreatment of principal component analysis is a potential tool for predicting the response of patients with epilepsy to drug treatment."

Journal • CNS Disorders • Epilepsy

Referred facial pain associated with lung cancer: Case reports and phenotype-based management. (PubMed, Cranio) - "Both responded to phenotype-guided management, including tricyclic antidepressants, gabapentinoids, and carbamazepine. These cases highlight the diagnostic challenges of facial pain attributed to lung cancer (FPLC), its frequent misdiagnosis, the need for dedicated diagnostic criteria and phenotype-based management."

Journal • Lung Cancer • Neuralgia • Oncology • Pain • Solid Tumor

Phosphodiesterase-4 Inhibition: An Experimental Approach to Overcome Drug Resistance in a Rotenone-Corneal 6 Hz Kindling Mouse Model of Drug-Resistant Epilepsy. (PubMed, Mol Neurobiol) - "Standard anti-seizure medications (ASMs) such as pregabalin, levetiracetam, carbamazepine, phenytoin, and lamotrigine were used for resistance validation. Roflumilast as PDE4 inhibitor significantly manage DRE as evidenced by reducing seizure severity, improving cognitive functions and restoring neurochemical alterations. Its ability to modulate oxidative stress and provide neuroprotection in RCK mice underscores its promise as a novel adjunct treatment for DRE."

Journal • Preclinical • CNS Disorders • Epilepsy • Inflammation • CAT

Predicting adsorption capacities of pharmaceutical pollutants using chemoinformatics and machine learning techniques. (PubMed, Environ Geochem Health) - "In this work, we developed machine learning models to predict adsorption capacities for Aspirin, Caffeine, Carbamazepine, Ketoprofen, Sulfamethoxazole, Nimesulide, and Paracetamol using chemoinformatics descriptors derived from SMILES strings and experimental inputs, including equilibrium concentration (Ce), initial concentration (C0), temperature, and contact time. SHAP analysis highlighted the influence of charge-partitioned surface areas and nitro functionalities on adsorption outcomes. The best-performing model was deployed in a Streamlit application, enabling predictions of Qe from SMILES and experimental conditions with built-in applicability-domain checks."

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Prenatal Exposure to Antiseizure Medications and the Risk of Congenital Anomalies: A Nationwide Population-Based Study in South Korea. (PubMed, Neurology) - "This study revealed that prenatal exposure to valproate increased the risk of congenital anomalies. Although other ASMs, even in polytherapy, did not significantly increase the overall risk of congenital anomalies, carbamazepine, levetiracetam, oxcarbazepine, and topiramate were associated with specific types of congenital anomalies. Given the limited number of cases, these findings warrant further investigation in other populations."

Journal • Retrospective data • CNS Disorders • Epilepsy • Ventriculomegaly

Predicting xenobiotic metabolism: a computational approach mining LC-MS/MS data with SIRIUS and BioTransformer. (PubMed, Arch Toxicol) - "We challenged our workflow to the analysis of human metabolites from 6 well-known drugs, administered to primary human hepatocytes and human liver microsomes: amitriptyline (10 µM), carbamazepine (12.5 µM), cyclophosphamide (20 µM), fipronil (20 µM), phenytoin (50 µM), and verapamil (6 µM). This strategy proved efficient in accelerating the study of drug metabolism, potentially avoiding tedious manual metabolite identification. In sum, we demonstrate that this computational workflow holds potential in automating metabolite identification, expanding metabolite coverage, and elucidating metabolites of newly developed drugs."

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A mouse model of classical trigeminal neuralgia via intradural compression of the trigeminal nerve. (PubMed, bioRxiv) - "Pharmacological responsiveness was tested using carbamazepine administration...These findings show that our approach replicates the anatomy and clinical presentation of classical TN in humans. This model may represent a new and robust platform for future mechanistic studies of TN and subsequent preclinical evaluation of therapies in mice."

Journal • Preclinical • Inflammation • Neuralgia • Pain • PTPRC

Removal of contaminants from wastewater using the bivalve Corbicula fluminea - Comparative assessment of biofiltration and biosorption. (PubMed, J Environ Manage) - "Clams were more effective than shells in removing fluoxetine, paracetamol, carbamazepine, metformin and diclofenac whereas the opposite was observed for caffeine and naproxen. Indeed, the remarkable toxicity reduction to the microalgae exposed to the biofiltered fluoxetine sample matches the pronounced removal %, confirming the beneficial effect of C. fluminea on the quality of water contaminated with this compound. Although biofiltration outperformed biosorption in general, the requirements for clams' maintenance and the risk of spreading this invasive species might constitute a drawback for the use of this species for bioremediation of contaminated wastewaters, highlighting the importance of analyzing the pros and cons of these approaches for each specific application."

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Enhanced activation of peroxymonosulfate using Y3+ substituted magnetic nanostructured ZnFe2O4 for carbamazepine degradation. (PubMed, Environ Res) - "The enhancement of catalytic activity of ZnY0.25Fe1.75O4 was closely associated with Ov which facilitated the adsorption of PMS, promoted the production of O2•- and 1O2 and accelerated the electron transfer in the system. Finally, the reusability and universality of ZnY0.25Fe1.75O4 were investigated to assess the practical application potential."

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Treatment-induced neuropathy of diabetes overlapping with chronic inflammatory demyelinating polyradiculoneuropathy after rapid glycemic correction: a case report. (PubMed, Front Endocrinol (Lausanne)) - "The patient received insulin pump therapy for glycemic control, along with oral analgesics, including gabapentin and carbamazepine. Additionally, we review the literature on the pathophysiological mechanisms of TIND and discuss its potential relationship with CIDP, aiming to provide clinical insights that may assist in early recognition and diagnosis. To date, cases of coexisting TIND and CIDP in a single patient have rarely been reported in the literature."

Journal • Diabetes • Diabetic Neuropathy • Inflammation • Metabolic Disorders • Pain • Peripheral Neuropathic Pain • Type 1 Diabetes Mellitus

Ultra-early Gamma Knife stereotactic radiosurgery for trigeminal neuralgia (URGEnt-TN): study protocol for a single-center, two-arm, parallel group design, pragmatic, noninferiority, phase II, randomized controlled trial with intention-to-treat analysis for pre-refractory GK-SRS in classical or idiopathic TN. (PubMed, Trials) - P2 | "This trial aims to test ultra-early GK-SRS as a first-line option in TN, based on a sound rationale for offering GK-SRS prior to failure of medical therapy. If validated, ultra-early GK-SRS will represent a paradigm shift in TN management leading to improved long-term pain control free from adverse medication-related side effects."

Head-to-Head • Journal • P2 data • Neuralgia • Pain

Interaction between Carbamazepine and Concomitant Levetiracetam Therapy in Patients with Epilepsy. (PubMed, Can J Hosp Pharm) - No abstract available

Journal • CNS Disorders • Epilepsy

Peripheral IV Catheter-Associated Upper Extremity Deep Vein Thrombosis in a Patient with Psychiatric Illness: A Case Report and Literature Review. (PubMed, Int Med Case Rep J) - "We report a 44-year-old man with bipolar affective disorder on haloperidol, promethazine, and carbamazepine...The patient was initially started on low molecular weight heparin, later transitioned to apixaban...Antipsychotics, such as haloperidol and chlorpromazine, may further elevate thrombosis risk. Clinicians must maintain vigilance for UEDVT in patients with unilateral arm swelling post-cannulation, recognizing that prompt ultrasound evaluation and guideline-based anticoagulation are essential to prevent complications."

Journal • Bipolar Disorder • Cardiovascular • CNS Disorders • Hematological Disorders • Mental Retardation • Pain • Psychiatry • Thrombosis • Venous Thromboembolism • Venous Ulcer

Trigeminal neuralgia in multiple sclerosis: Epidemiology and long-term outcomes in a tertiary neurology centre in the UK (EHF-EHC 2025) - "50% currently treated with carbamazepine...61.8% (21 patients) had a good outcome complete relief or manageable.Age of MS or TN diagnosis and duration of treatment with MS DMTs didn"t have a significant effect on TN prognosis More than half of our cohort achieved good TN pain control and required significant treatment escalation (TES3) . Further research into novel treatments and long-term outcomes is needed to determine the best regimes to manage TN in MS patients."

Clinical • CNS Disorders • Multiple Sclerosis • Neuralgia • Pain

SUNCT-like headache secondary to herpes zoster in the ipsilateral ophthalmic nerve distribution: A case report (EHF-EHC 2025) - "A 52-year-old Sri Lankan male developed painful vesicular eruptions over the right ophthalmic dermatome and was treated with oral acyclovir (800 mg, five times daily)...Treatment included oral prednisolone (15 mg/day, tapered by 5 mg/week), carbamazepine (100 mg t.d.s., increased to 200 mg t.d.s. from week two), pregabalin (75 mg nocte), and tramadol (50 mg nocte)...This case underscores a SUNCT-like syndrome following ophthalmic zoster, which appears more pharmacoresponsive than primary SUNCT. Immunosuppressive states like diabetes, should be considered underlying zoster reactivation."

Case report • Clinical • Diabetes • Herpes Zoster • Metabolic Disorders • Ophthalmology • Pain • Varicella Zoster

Trigeminal neuralgia secondary to giant saccular aneurysm/endovascular procedure – Is lidocaine block an old treatment with a new indication? (EHF-EHC 2025) - "Carbamazepine is the standard first-line treatment, although alternatives such as oxcarbazepine, lamotrigine, or pregabalin may be considered in cases of intolerance or poor response...Due to poor control of pain (15 episodes/month) and intolerance to carbamazepine (ataxia, vertigo), eslicarbazepine was introduced. Trials with oxcarbazepine, lamotrigine, pregabalin, and levetiracetam were ineffective and poorly tolerated...Given the refractoriness of symptoms, the patient was submitted to peripheral nerve block with 2% lidocaine at the auriculotemporal and supraorbital branches, resulting in marked improvement and a >50% reduction in frequency and severity of attacks. Peripheral nerve block with lidocaine is a safe, accessible, and effective option for symptom relief and should be considered in cases of secondary trigeminal neuralgia refractory to pharmacological treatment."

Ataxia • Brain Cancer • Cardiovascular • Movement Disorders • Musculoskeletal Pain • Neuralgia • Otorhinolaryngology • Pain • Solid Tumor • Vertigo

Evaluating the efficacy of combined treatment in patients with Persistent Idiopathic Facial Pain (PIFP) (EHF-EHC 2025) - "All patients received combinations of medications targeting neuropathic pain and musculoskeletal tension, antidepressants (e.g., duloxetine, venlafaxine), anticonvulsants (e.g., carbamazepine, gabapentin) and COX-2 inhibitors. Treatment response often required dose titration. Combined pharmacological approaches targetting both neuropathic and affective components may provide meaningful symptom control in PIFP."

Clinical • CNS Disorders • Dental Disorders • Epilepsy • Migraine • Musculoskeletal Diseases • Musculoskeletal Pain • Neuralgia • Novel Coronavirus Disease • Pain

Trigeminal neuralgia secondary to posterior fossa arteriovenous malformation and hydrocephalus: A diagnostic and therapeutic challenge (EHF-EHC 2025) - "Carbamazepine 200 mg every 8 hours led to full pain resolution within 48 hours...This case illustrates a rare presentation of trigeminal neuralgia secondary to a large posterior fossa AVM, associated with decompensated chronic hydrocephalus. Although there was a favorable response to initial medical and surgical management, the case underscores the need for careful consideration of alternative therapeutic strategies should symptoms recur in a patient with an inoperable AVM."

Cardiovascular • CNS Disorders • Neuralgia • Ophthalmology • Pain • Ventriculomegaly

Non-paralytic botulinum toxin A in trigeminal neuralgia (EHF-EHC 2025) - "This study evaluated el-Bitox/A analgesic efficacy and safety versus native BoNT/A and carbamazepine (CBZ), to the gold-standard treatment, in a TN rat model...However, BoNT/A had significant side effects that can be avoided by using the non-paralytic el-Bitox/A. These findings highlight el-Bitox/A as a promising, effective treatment option for neuropathic pain."

CNS Disorders • Immunology • Neuralgia • Pain

Epidemiology and journeys of trigeminal neuralgia patients in UK (EHF-EHC 2025) - "The most frequently used medication was carbamazepine...There is evidence for increasing neurosurgical management given the potential long term effects of drugs and establishing national multidisciplinary centres to ensure TN patients gain faster access to services. Registries should be set up."

Clinical • Neuralgia • Novel Coronavirus Disease • Pain • Rare Diseases

Resting motor threshold in navigated transcranial magnetic stimulation: relationship between inter-individual variance and distinct clinical and anatomical factors. (PubMed, Acta Neurochir (Wien)) - "This study modeled the influence of clinical and anatomical factors on corticospinal excitability. This highlights the need for consideration of these variables when interpreting intervention-related changes in RMT or for risk stratification. Notably, the detailed analysis of common neurosurgical medications on RMT is unprecedented, emphasizing the importance of considering these factors."

Journal • Oncology

Quantifying the risk of drug-associated skin hyperpigmentation relative to the general population: A national cohort study using TriNetX. (PubMed, JAAD Int) - No abstract available

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