propranolol / Generic mfg. - LARVOL DELTA

From focal lesion to fat sparing: Unmasking Zieve's syndrome with clinical vigilance (ASH 2025) - "We present the case of a 29-year-old man with a history of essential tremor managed on propranolol, who was transferred for further evaluation of worsening jaundice following a brief, self-resolving viral-like illness...In conclusion, Zieve's syndrome is characterized by a triad of hemolytic anemia, cholestatic jaundice, and transient hyperlipidemia. Prompt recognition of this underdiagnosed condition is crucial, as it can prevent unnecessary invasive interventions and shift the clinical focus toward supportive care and alcohol cessation, which remains the cornerstone of treatment."

Clinical • Dyslipidemia • Essential Tremor • Gallbladder Cancer • Hematological Disorders • Hepatology • Liver Failure • Movement Disorders • Thrombocytopenia • HP

R-propranolol Promotes lipid synthesis via a novel, non-adrenergic pathway to treat sickle cell cardiomyopathy (ASH 2025) - "R-propranolol is a novel therapeutic for sickle cardiomyopathy in mice. Mechanistically, r-propranolol induces SREBP1 activation, resulting in reduced IL-18 activation and cardiac inflammation."

Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Inflammation • CD1D • IL18 • SCD

An open-label, multi-center Phase 2 study to assess the safety and efficacy of burixafor (GPC-100) and propranolol with G-CSF for the mobilization of hematopoietic progenitor cells in patients with multiple myeloma (ASH 2025) - P2 | "Mediantimes to neutrophil and platelet engraftment were 11 days (range 11-17 days) and 15 days (range 11-27days), respectively.ConclusionsBurixafor, in combination with propranolol and G-CSF, demonstrated an excellent safety profile andeffectively mobilized sufficient HPCs for AHCT, including patients previously treated with lenalidomideand daratumumab. Notably, burixafor enabled same-day administration with leukapheresis, offering akey advantage over other CXCR4 inhibitors, such as plerixafor and motixafortide through its rapidmobilization kinetics. Its favorable safety profile, characterized by minimal adverse events, supporting itspotential clinical utility."

Clinical • IO biomarker • P2 data • Cardiovascular • Constipation • Diabetes • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Hypotension • Multiple Myeloma • Musculoskeletal Diseases • Musculoskeletal Pain • CD34 • CXCR4

Dose-Dependent Cardioprotection of Pterocarpus indicus Extract in Rats With Myocardial Ischemia: Targeting Oxidative Stress, Inflammation, and Apoptosis. (PubMed, Dose Response) - "Rats were pretreated for 14 days and divided into control, ISO, propranolol, and P.indicus (LD, MD, HD) groups...P. indicus extract confers dose-dependent cardioprotection against ISO-induced myocardial injury through dual modulation of the Nrf2/HO-1 and Bax/Bcl-2/Caspase-3 pathways, with the medium dose (54 mg/kg) identified as optimally effective and well-tolerated."

IO biomarker • Journal • Preclinical • Cardiovascular • Fibrosis • Immunology • Inflammation • Myocardial Ischemia • BCL2 • CASP3 • IL1B • IL6 • TNFA

A Study of Propranolol to Treat Kaposi Sarcoma (clinicaltrials.gov) - P2 | N=25 | Not yet recruiting | Sponsor: AIDS Malignancy Consortium | Trial completion date: Aug 2029 ➔ Jun 2027 | Trial primary completion date: Aug 2028 ➔ Jun 2027

Trial completion date • Trial primary completion date • Kaposi Sarcoma • Oncology • Sarcoma • Solid Tumor

ECG artefact or life-threatening arrhythmia? A neonatal presentation of Long QT syndrome type 3 with a de novo SCN5A mutation. (PubMed, Cardiol Young) - "Genetic testing identified a de novo SCN5A c.796C > G (p.L266V) mutation associated with Long QT syndrome type 3. At 1 year of age, the patient remains stable and asymptomatic while receiving combined therapy with propranolol and mexiletine."

Journal • Cardiovascular

Serotonin Syndrome With Quetiapine, Rizatriptan, Gabapentin, and Propranolol. (PubMed, Prim Care Companion CNS Disord) - No abstract available

Journal

A Systematic Review of the Efficacy and Safety of Sirolimus (Rapamycin) in the Management of Infantile Hemangioma. (PubMed, J Res Pharm Pract) - "The use of rapamycin (sirolimus) in the treatment of infantile hemangioma (IH) is a persistent challenge in dermatology. Combination therapy, especially in patients resistant to treatment for IH, is a preferred choice for IH treatment and reduces the side effects of propranolol. It is also preferred for the treatment of lesions in the mucosal areas and near important organs."

Journal • Review • Dermatology • Hypoglycemia

Propranolol for Misophonia (clinicaltrials.gov) - P1 | N=20 | Recruiting | Sponsor: Bloom Mental Health, LLC

New P1 trial

Dosing trajectories of antihypertensive agents among preterm neonates: A retrospective, cross-sectional analysis. (PubMed, PLoS One) - "Propranolol is often initiated at a target dose and maintained with less titration, while both captopril and esmolol are titrated more often. Younger gestational age patients typically required higher doses of propranolol."

Journal • Retrospective data • Cardiovascular • Hypertension

Intrinsic Versus Extrinsic Sinus and Atrioventricular Nodes Dysfunction in Athletes: Insights From Transesophageal Electrophysiological Testing With Autonomic Blockade. (PubMed, Rev Cardiovasc Med) - "In the case group, 24 athletes exhibited abnormal parameters at baseline and underwent a repeat EPS following complete autonomic blockade with intravenous propranolol and atropine, aimed at suppressing extrinsic autonomic influences...The EPS with a pharmacological autonomic blockade represents a useful approach for distinguishing extrinsic, functional bradycardia from intrinsic nodal disease in athletes. While AV node dysfunction appears exclusively vagally mediated and reversible, a subset of sinus node dysfunction cases may reflect early, possibly epigenetically driven, intrinsic alterations."

Journal • Cardiovascular • Ventricular Tachycardia

Determinants of Exercise Intolerance in Postural Orthostatic Tachycardia Syndrome: A Systematic Review. (PubMed, Exerc Sport Mov) - "Exercise training, as well as propranolol, improved peak VO2...Increased HR accompanies reduced SV, but cardiac output is generally maintained or increased, making it unlikely to cause symptoms. Reducing HR may improve exercise capacity in POTS by delaying peak HR and reducing symptoms."

Journal • Cardiovascular

Interplay and selectivity of selected pharmaceuticals and organic contaminants adsorption onto magnetic biochar: Mechanistic insights. (PubMed, J Environ Manage) - "Ketoprofen (KP), antipyrine (AP), and propranolol hydrochloride (PH) were selected as representative anionic, neutral, and cationic contaminants, respectively, to investigate the competitive adsorption behavior of MBC...The competitive effects of background ions and organic substances emphasize the multifunctional adsorption capacity of MBC. Importantly, MBC maintained high reusability over multiple adsorption-desorption cycles, highlighting its practical application potential for contaminant removal."

Journal

The Role of Quinine to Prevent Ventricular Fibrillation and ICD Shocks in Early Repolarization Syndrome. (PubMed, JACC Case Rep) - "This case highlights the possible role of quinine in suppression of short-coupled premature ventricular complexes and ventricular fibrillation in patients with ERS."

Journal • Cardiovascular • Genetic Disorders

Evaluating agreement between physician and ChatGPT in migraine prophylaxis selection: A pilot comparative study (EHF-EHC 2025) - "To evaluate the level of agreement between human clinicians and an artificial intelligence (AI) model (ChatGPT) in recommending first-line prophylactic therapies for patients with migraine, and to assess the potential clinical value of AI-generated support.In this observational pilot study, we analyzed 21 consecutive patients with a confirmed diagnosis of episodic migraine evaluated at a pain clinic.For each patient, the treating clinician selected a first-line preventive treatment among four options: amitriptyline, propranolol, topiramate or flunarizine. This pilot study demonstrates that ChatGPT can produce clinically coherent prophylactic treatment proposals in the management of migraine, with a statistically significant moderate agreement with experienced pain physicians. Further validation on larger cohorts is warranted to explore its potential as a clinical decision support tool."

CNS Disorders • Migraine • Pain

Post-migraine hemorrhagic manifestations: Evidence from two clinical cases (EHF-EHC 2025) - "The first is a 42-year-old woman with chronic migraine since age 36, on propranolol 40mg/day...After starting a continuous progesterone-only pill in May, both headaches and bruising completely resolved. The second is a 40-year-old woman with episodic migraine since age 30, on topiramate 100mg/day...The link between attacks and bleeding, along with improvement following hormonal or neural interventions, suggests a possible interplay between neurovascular dysregulation, hormonal modulation and peripheral tissue response. Greater clinical awareness of these manifestations may enhance diagnostic and therapeutic approaches in migraine care."

Clinical • CNS Disorders • Hematological Disorders • Inflammation • Migraine • Pain

Preventive migraine care before headache clinical referral: Are we doing it right? (EHF-EHC 2025) - "Commonly prescribed agents in primary care shifted from propranolol and amitriptyline in 2017 to topiramate and amitriptyline in 2023. Our findings suggest a clear evolution toward more appropriate and guideline-informed referral practices. Primary care providers are increasingly initiating preventive therapy before seeking specialist input."

Clinical • CNS Disorders • Migraine • Pain

CSF hypotension headache and Postural Orthostatic Tachycardia Syndrome (POTS) (EHF-EHC 2025) - "The patient began propranolol that resolved his complaints This case shows the clinical overlap between CSF hypotension manifestations and POTS...The persistence of symptoms with orthostatism should motivate the exclusion of complications and additional investigation of other etiologies that are associated with orthostatic headaches. The association between these two conditions requires further investigation as a causality is yet to be established with certainty"

Anesthesia • Cardiovascular • Hematological Disorders • Hypotension • Pain • Thrombosis

When migraine meets maternity: A case highlighting the risks of non-selective β-blockers in pregnancy (EHF-EHC 2025) - "A healthy 30-year-old woman with migraine without aura since age 20, previously on propranolol 40 mg/day for prophylaxis and sertraline 50 mg/day, had propranolol continued during the preconception period - following a risk-benefit discussion - due to frequent migraine attacks. This case highlights the need for individualized treatment planning. In cases using non-selective agents like propranolol, fetal risks - particularly IUGR - must be considered and monitored carefully."

Clinical • CNS Disorders • Migraine • Pain

Specialist transition headache clinic from an UK perspective: From children to young adults (EHF-EHC 2025) - "The most common preventive treatments tried were pizotifen, propranolol and amitriptyline. A structured transition headache clinic can successfully bridge the gap and provide continuity of care during a pivotal time in the young adult"s lives, both academically and developmentally. As more patients access novel treatments in adulthood, continued follow-up will be crucial to assess long-term outcomes."

Clinical • CNS Disorders • Migraine • Pain

Cluster-like migraine? A case of seasonal headache with autonomic features responding to propranolol (EHF-EHC 2025) - "Careful clinical characterization and monitoring treatment response are key. In selected cases, beta-blockers may be effective even when autonomic signs are present, if the overall course is more consistent with migraine."

Clinical • CNS Disorders • Migraine • Pain

Primary cough headache – Botulinum toxin protocol treatment with a new indication? (EHF-EHC 2025) - "Indomethacin is the first-line treatment, but alternatives like acetazolamide or cerebrospinal fluid drainage have shown benefit in refractory or contraindicated cases...Initial treatment with flunarizine was ineffective...Trials with amitriptyline and propranolol were unsuccessful. A PREEMPT protocol with botulinum toxin was initiated, resulting in a reduction in headache frequency to 15 days/month after the first cycle, and fewer than 5/month after the second, with sustained improvement. Botulinum toxin is a safe and effective therapeutic option for PCH, especially in patients unresponsive to or intolerant of standard pharmacological treatments."

Clinical • Cardiovascular • CNS Disorders • Cough • Gastroenterology • Hypertension • Migraine • Otorhinolaryngology • Pain • Rare Diseases • Renal Disease • Respiratory Diseases • Sleep Disorder • Vertigo

Side-shifting pattern of hemicrania continua: A rare variant (EHF-EHC 2025) - "Multiple migraine pharmaceutical regimens (propranolol, amitriptyline, triptans) yielded minimal benefit. Continuous headache with autonomic features should prompt consideration of HC even when laterality is not strictly side-locked. An indomethacin trial with withdrawal–rechallenge can confirm diagnosis and rapidly resolve symptoms, preventing years of ineffective migraine-directed therapy."

CNS Disorders • Migraine

Breaking the chronic migraine cycle: Semaglutide modulates pain, well-being, and cannabinoid signaling in a preclinical study (EHF-EHC 2025) - "GLP-1 receptor agonists, particularly liraglutide, have shown potential in reducing pain hypersensitivity in preclinical and clinical settings...Male and female mice developed a CM-like state through repeated intraperitoneal ( i.p. ) nitroglycerin injections. Semaglutide (subcutaneous) or propranolol ( i.p. , reference drug) was administered daily over nine days...Semaglutide modulated ECS in a sex-specific manner, indicating distinct neurobiological responses in males and females. These results support semaglutide as a promising candidate for CM therapy ."

Preclinical • CNS Disorders • Immunology • Migraine • Pain • CNR1 • MGLL

Middle meningeal artery lidocaine infusion for refractory migraine: First case report in Portugal (EHF-EHC 2025) - "Various pharmacologic classes were tried without benefit: antihypertensives and calcium channel blockers (propranolol, candesartan, flunarizine), antiepileptics (valproic acid, topiramate, oxcarbazepine), antidepressants (amitriptyline, nortriptyline, venlafaxine, fluvoxamine, sertraline, clomipramine), other preventives (prednisolone, oxitriptan, melatonin), cycles of botulinum toxin (PREEMPT protocol), monoclonal antibodies (galcanezumab, fremanezumab, erenumab), and atogepant. At the time of the procedure, the patient was on eptinezumab 100 mg and botulinum toxin every three months but continued to have daily headaches, with severe intensity and reliance on eletriptan for acute relief...It constitutes an invasive therapeutic approach that should be considered only as a rescue option for carefully selected patients with severely refractory migraine. Further studies and long-term follow-up are needed to assess efficacy and safety."

Case report • Clinical • Anorexia • CNS Disorders • Migraine • Pain