propranolol / Generic mfg. - LARVOL DELTA

An open-label, multi-center Phase 2 study to assess the safety and efficacy of burixafor (GPC-100) and propranolol with G-CSF for the mobilization of hematopoietic progenitor cells in patients with multiple myeloma (ASH 2025) - P2 | "Mediantimes to neutrophil and platelet engraftment were 11 days (range 11-17 days) and 15 days (range 11-27days), respectively.ConclusionsBurixafor, in combination with propranolol and G-CSF, demonstrated an excellent safety profile andeffectively mobilized sufficient HPCs for AHCT, including patients previously treated with lenalidomideand daratumumab. Notably, burixafor enabled same-day administration with leukapheresis, offering akey advantage over other CXCR4 inhibitors, such as plerixafor and motixafortide through its rapidmobilization kinetics. Its favorable safety profile, characterized by minimal adverse events, supporting itspotential clinical utility."

Clinical • IO biomarker • P2 data • Cardiovascular • Constipation • Diabetes • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Hypotension • Multiple Myeloma • Musculoskeletal Diseases • Musculoskeletal Pain • CD34 • CXCR4

Sinoatrial node sympatho-vagal balance and intrinsic heart rate at rest: no difference between young healthy women and men. (PubMed, Am J Physiol Heart Circ Physiol) - "Pharmacological blockade of the ANS activity on the SAN was induced by sequential bolus injections of atropine (0.04 mg per kg b.w) and propranolol (0.2mg per kg b.w.) during continuous electrocardiographic recordings...There were no significant differences between women and men in any of these measures, and thus no fundamental difference in the ANS influence on the main impulse generator of the heart at rest. This result contrasts to the significant differences in electrophysiological measures at rest and their responses to stress tests, as well as to the differences in arrhythmia propensity between women and men on both the atrial and ventricular level of the heart."

Journal • Cardiovascular

CLOZAPINE Response in Biotype-1 (clinicaltrials.gov) - P4 | N=524 | Recruiting | Sponsor: University of Texas Southwestern Medical Center | Trial primary completion date: Dec 2025 ➔ Apr 2026

Trial primary completion date • Bipolar Disorder • CNS Disorders • Psychiatry • Schizophrenia

Perioperative propranolol and celecoxib (ProCel) in stage III melanoma (ANZCTR) - P2 | N=40 | Withdrawn | Sponsor: Sydney Local Health District | Not yet recruiting ➔ Withdrawn

IO biomarker • Trial withdrawal • Cutaneous Melanoma • Melanoma • Oncology • Solid Tumor • B2M • FCGR3A • HAVCR2 • MITF • PD-L1

Novel Barbed Microneedle Array-Mediated Dual-Drug Delivery for Thick Infantile Hemangiomas. (PubMed, Adv Healthc Mater) - "Oral propranolol is effective but limited by systemic side effects and resistance...Bleomycin (BLM) is loaded in the needle tips for deep ablation, while timolol (TM) is incorporated in the base hydrogel for superficial vasoconstriction, enabling synergistic therapy (TM-BLM@MN)...In vivo, treatment of TM-BLM@MN achieved a 1.93-fold greater reduction in tumor volume compared to controls and markedly suppressed pathological angiogenesis by histology. TM-BLM@MN as a minimally invasive platform demonstrates high efficacy for thick IH and holds strong potential for clinical translation and home-based therapy."

Journal • Oncology

Out of Hand, Out of Control-Fibrous Hamartoma of Infancy of the Hand: A Case Report. (PubMed, Case Rep Pediatr) - "Propranolol treatment failed...This case underscores the diagnostic challenge of FHI in the hand due to vascular mimicry. Furthermore, the tumor's infiltrative nature in complex anatomy forces a difficult trade-off: Radical excision offers cure but risks functional devastation, whereas functional preservation carries a high risk of recurrence."

Journal • Oncology • Pediatrics

β-Adrenergic Signaling Contributes to Circadian and Lipid Dysregulation in Meibomian Glands During Chronic Psychological Stress. (PubMed, Invest Ophthalmol Vis Sci) - "Experimental groups included control, stress alone, stress with propranolol (a nonselective β-adrenergic receptor antagonist), and stress with metyrapone (a glucocorticoid synthesis inhibitor). Chronic psychological stress disrupts MG homeostasis through sympathetic overactivation, affecting circadian regulation, immune responses, and lipid metabolism. β-Adrenergic blockade partially reverses these changes, highlighting a potential therapeutic approach for stress-related evaporative dry eye."

Journal • CNS Disorders • Dry Eye Disease • Hypertriglyceridemia • Metabolic Disorders • Ophthalmology • ADRB2

A retrospective study on the treatment of superficial infantile hemangiomas of the head and neck using topical compresses with 0.5% timolol maleate eye drops. (PubMed, Front Pediatr) - "Infantile hemangiomas, the commonest benign vascular tumors of infancy, often cluster on the head and neck where early treatment can avert permanent disfigurement, prompting us to evaluate 0.5% timolol maleate wet compresses as a non-invasive alternative to oral propranolol. Skin sequelae were observed in 12 (3.34%) cases. Topical timolol compresses offer a safe, effective first-line option for superficial head-and-neck infantile hemangiomas, especially when started early and directed at smaller lesions."

Journal • Retrospective data • Oncology

The effect of sex on the isolated and combined α- and β-adrenergic control of blood flow during handgrip in adults at high altitude: An exploratory study. (PubMed, Physiol Rep) - "Participants performed rhythmic handgrip for 3 min at 25% maximal voluntary contraction during local infusions of saline, propranolol (β-adrenergic blockade), and phentolamine with propranolol (α-β-adrenergic blockade)...These results suggest males and females do not respond differently to exercise at altitude, and light-intensity exercise hyperemia may be preserved during early acclimatization. α-adrenergic receptors appear important for exercising blood flow, but β-adrenergic receptors may not be critical in this response."

Journal

Effect of Propranolol on Hyperthermia Secondary to Paroxysmal Sympathetic Hyperactivity in Critically Ill Patients With Traumatic Brain Injury. (PubMed, Ann Pharmacother) - "Temperature was not significantly decreased after propranolol initiation in patients with TBI and hyperthermia; however, HR and mCFS were significantly lower. Larger studies are needed to characterize the effect of propranolol on temperature in patients with PSH."

Journal • CNS Disorders • Vascular Neurology

Endotoxin-induced inflammation promotes, via the adrenomedullary system, a hyperglycemic and anti-inflammatory reflex. (PubMed, Brain Behav Immun Health) - "Inhibiting prostaglandin synthesis with indomethacin and blocking β-adrenergic receptors with propranolol caused increased TNF levels and prevented LPS-induced hyperglycemia, without affecting the Corticosterone response. Prostaglandin administration induced hyperglycemia in Sham but not in AdMX animals, showing that prostaglandins require the adrenal to promote acute biological effects in vivo. These findings demonstrate a critical role for the adrenal medulla and adrenaline in the efferent arm of the anti-inflammatory reflex, inhibiting TNF secretion and promoting hyperglycemia, thus fueling the body's defenses during an acute immune challenge."

Journal • Anesthesia • Diabetes • Inflammation • AVEN

Comparative efficacy of pharmacological agents on abdominal aortic aneurysm growth rate: a systematic review and network meta-analysis. (PubMed, Front Pharmacol) - "Roxithromycin also demonstrated advantages over amlodipine and doxycycline in indirect comparisons. Propranolol, perindopril, metformin, azithromycin, and ticagrelor showed no significant benefits...Roxithromycin, statins, and metformin show promise for potentially limiting AAA expansion. However, findings are constrained by methodological limitations (study design, sample size), necessitating future validation via high-quality RCTs."

Journal • Retrospective data • Review • Cardiovascular

Comparing efficacy and safety of oral drugs in treatment of hyperthyroidism: a systematic review and network meta-analysis. (PubMed, PeerJ) - "The network meta-analysis showed that in terms of total effective rate, the top three interventions with the highest Surface Under the Cumulative Ranking Curve (SUCRA) probability ranking curve area were I-131 (Iodine-131)+LC (lithium carbonate), MMI (Methimazole)+PHT (Propranolol), and I-131; in terms of reducing Free Triiodothyronine (FT3), the top three interventions with the highest SUCRA probability ranking curve area were MMI+PDN (prednisone), I-131+LC, and I-131; in terms of reducing free tetraiodothyronine (FT4), the top three interventions with the highest SUCRA probability ranking curve area were I-131+PTU (Propylthiouracil), I-131+LC, and I-131; in terms of increasing thyroid-stimulating hormone (TSH), the top three interventions with the highest SUCRA probability ranking curve area were I-131+PTU, I-131, and MMI+PDN; in terms of reducing adverse reactions, the top three interventions with the highest SUCRA probability ranking curve area were I-131+PTU, I-131,..."

Clinical • Journal • Retrospective data • Review • Endocrine Disorders

Neuroinflammation and noradrenergic modulation with β2-adrenoceptors: Emerging therapeutic targets for Parkinson's diseases. (PubMed, Neural Regen Res) - "While β-blocker, particularly non-selective agents like propranolol, have been associated with exacerbated neuroinflammation and Parkinson's disease risk, β2-adrenoceptor agonists demonstrate neuroprotective effects by modulating microglial phenotypes, reducing α-synuclein aggregation, and enhancing neurotrophic support. Finally, we explore the canonical and non-canonical β2-adrenoceptor signaling pathways implicated in neuroprotection. Collectively, this review supports β2-adrenoceptors as promising therapeutic targets and underscores the need for further studies to elucidate their mechanistic roles in modulating neurodegenerative processes."

Journal • CNS Disorders • Inflammation • Movement Disorders • Parkinson's Disease

Multi-omics unravels multiple pharmacological actions in a murine model of infantile hemangioma receiving oxymatrine therapy. (PubMed, Discov Oncol) - "In conclusion, these findings suggested that treatment with OMT could suppress the growth of hemangiomas through metabolic disturbances and inducing ferroptosis, which may provide new insights to the management of IH."

Journal • Preclinical • Metabolic Disorders

The effects of Propranolol combined with Metoclopramide on stroke-associated pneumonia and related immune indicators: a clinical randomized controlled trial (ChiCTR) - P=N/A | N=150 | Completed | Sponsor: Quanzhou First Hospital; Quanzhou First Hospital

New trial • Cardiovascular • Infectious Disease • Pneumonia • Respiratory Diseases

Propranolol for Prevention of Stroke-associated Pneumonia in Intracerebral Hemorrhage (PROCHASE): A Multicenter, Randomized, End Point Blind Trial (ISC 2026) - "Available on Thursday, February 05, 2026 at 05:00pm CST."

Clinical • Late-breaking abstract • Cardiovascular • Cerebral Hemorrhage • Hematological Disorders • Infectious Disease • Pneumonia • Respiratory Diseases

A randomised pilot trial of perioperative propranolol combined with celecoxib versus standard of care in stage III melanoma: The ProCel study protocol. (PubMed, PLoS One) - P2 | "In cutaneous melanoma patients, the presence of lymph node or in transit metastasis can be associated with poor survival. The trial is supported by Sydney Cancer Partners with funding from Cancer Institute NSW (Grant ID 2021/CBG0002). The sponsors are Sydney Local Health District and Melanoma Institute Australia."

Clinical protocol • IO biomarker • Journal • Cutaneous Melanoma • Melanoma • Oncology • Solid Tumor

Takotsubo Cardiomyopathy due to Guillain-Barré Syndrome and Thyroid Storm: A Case Report. (PubMed, Acta Neurol Taiwan) - "Treatment comprised intravenous human immunoglobulin, methimazole, and propranolol. We present the first documented case of TCM attributed to dysautonomia resulting from GBS and thyroid storm."

Journal • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Complement-mediated Rare Disorders • Endocrine Disorders • Infectious Disease • Otorhinolaryngology • Pain

Mechanism of Antinociceptive Effect of Vanillin in Formalin Test. (PubMed, Int J Prev Med) - "Different groups of mice were pretreated with prazocin (2 mg/kg), yohimbine (5 mg/kg), propranolol (2 mg/kg), cyproheptadine (2 mg/kg), ondansetron (2 mg/kg), naloxone (5 mg/kg), sulpiride (20 mg/kg), arginine (100 mg/kg), L-NAME (20 mg/kg), methylene blue (5 mg/kg), or glibenclamide (10 mg/kg) to evaluate the role of pertinent receptors or pathways on vanillin-induced antinociception. Pretreatment with ondansetron, sulpiride, L-NAME, methylene blue, or glibenclamide prevented vanillin antinociceptive effect. Vanillin showed antinociceptive effect in formalin test, and according to the results, the NO/cGMP/KATP pathway and serotonin 5HT3 and dopamine D2 receptors have an important contribution to its antinociceptive effect, but opioid and adrenergic receptors are not involved in this effect."

Journal • DRD2

In vitro and in vivo treatment with propranolol influences the number of early preantral follicles in mice†. (PubMed, Biol Reprod) - "In summary, propranolol increases the transition of primordial follicles to more advanced stages of development. These findings highlight propranolol as a potential drug to induce, in vivo and in vitro, early preantral follicle growth, potentially improving fertility preservation techniques and studies."

Journal • Preclinical • CPEB1 • PI3K • PTEN

Propranolol Administration During Morphine Addiction Attenuates Reinstatement of Drug-Aversive Memories Caused by Exposure to Stressful Stimuli. (PubMed, Pharmaceuticals (Basel)) - "In contrast, when propranolol was administered intraperitoneally 30 min before the exposure to both social and physical stress, the time spent enhanced significantly (p < 0.01), supporting a role for propranolol in addiction-related memories. These results suggest that propranolol could attenuate the aversive memories that may contribute to relapse to opioid addiction."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Psychiatry

Emerging opportunities in ROP therapy: from inhibiting pathological vessel growth to promoting physiological vascularization. (PubMed, Front Med (Lausanne)) - "It is likely that in the coming years an approach similar to that leading to explore the potential of propranolol in ROP, might be used to extend to preterm infants the results of preclinical studies on the efficacy of β3-AR agonism. In this case, the goal would be to stimulate the physiological process of vascularization rather than to slowing down the progression of ROP."

Journal • Review • Ophthalmology • Retinal Disorders

Impact of Post-Traumatic Stress Disorder Management Through Reconsolidation Therapy on Fibromyalgia Syndrome: A Pilot Study. (PubMed, Biomedicines) - " This multicenter pilot study included adult women diagnosed with FMS and PTSD who underwent six sessions of reconsolidation therapy combining traumatic memory reactivation with propranolol administration... This pilot study suggests that reconsolidation-based therapy is feasible in women with comorbid FMS and PTSD and was associated with changes in PTSD symptoms and fibromyalgia-related functional impact. Given the exploratory design and absence of a control group, these findings should be interpreted cautiously and warrant confirmation in larger, controlled trials."

Journal • CNS Disorders • Depression • Fibromyalgia • Mood Disorders • Musculoskeletal Pain • Pain • Post-traumatic Stress Disorder • Psychiatry • Rheumatology

Associations between Income, Psychosocial Factors, and Markers of Biological Aging In Hematopoietic Cell Transplantation Recipients (TCT-ASTCT-CIBMTR 2026) - " We conducted a cross-sectional secondary analysis of baseline data from a phase 2 RCT of propranolol in patients with multiple myeloma undergoing first autologous HCT (n=25)... Socioeconomic adversity may contribute to elevated expression of biological aging pathways prior to HCT and is associated with increased depression and anxiety. Notably, the lower- middle-income group showed the highest expression relative to the lowest-income group, suggesting a disproportionate stress burden at moderate income levels. While associations did not reach statistical significance, consistent trends across markers in this small sample suggest a pathway linking social adversity to biological vulnerability before HCT."

Bone Marrow Transplantation • CNS Disorders • Depression • Hematological Malignancies • Mood Disorders • Multiple Myeloma • Transplantation • CDKN1A • CDKN2A