CMD03
/ Chulalongkorn University
- LARVOL DELTA
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October 03, 2025
Targeting diffuse intrinsic pontine glioma with IL-7Rα–enhanced B7-H3 (CMD03) chimeric antigen receptor T cell: preliminary results from phase 1 clinical trial
(SITC 2025)
- P1 | "Two patients developed grade 3 tumor inflammation-associated neurotoxicity (TIAN), which resolved within 24 to 72 hours following treatment with dexamethasone and anakinra. As expected with locoregional delivery, CAR T cells were not detected in peripheral blood.Conclusions Preliminary findings suggest that repeated locoregional delivery of CMD03 CAR T cells is feasible and well tolerated at the initial dose level. Continued clinical investigation is warranted to further explore the therapeutic potential of IL-7Rα-enhanced B7-H3-targeting CAR T cells in improving outcomes for children with DIPG."
CAR T-Cell Therapy • Clinical • P1 data • Brain Cancer • Diffuse Intrinsic Pontine Glioma • Glioma • Oncology • Solid Tumor • CD276 • IL7 • IL7R
April 01, 2025
Safety and Efficacy of CMD03 CAR T Cell in Children With Relapse or Refractory Solid Tumors
(clinicaltrials.gov)
- P1 | N=9 | Recruiting | Sponsor: Chulalongkorn University | Not yet recruiting ➔ Recruiting | Initiation date: Dec 2024 ➔ Apr 2025
Enrollment open • Trial initiation date • Oncology • Pediatrics • Solid Tumor • IL7R
September 25, 2024
CMD03: A Phase 1 Study of CDM03 CAR T Cell in Children With Relpase or Refractory Solid Tumors
(clinicaltrials.gov)
- P1 | N=9 | Not yet recruiting | Sponsor: Chulalongkorn University
CAR T-Cell Therapy • New P1 trial • Oncology • Pediatrics • Solid Tumor • CD276 • IFNG • IL10 • IL2 • IL6 • IL7R • TNFA
April 19, 2024
CMD03DIPG: Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG
(clinicaltrials.gov)
- P1 | N=9 | Recruiting | Sponsor: Chulalongkorn University | Not yet recruiting ➔ Recruiting
CAR T-Cell Therapy • Enrollment open • Brain Cancer • CNS Tumor • Diffuse Intrinsic Pontine Glioma • Glioma • Oncology • Solid Tumor • CD276 • IL7R
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