Saireito (TJ 114) / Tsumura - LARVOL DELTA

Secondary Adrenal Insufficiency Exacerbated by Switching Inhaled Corticosteroids: A Case of Steroid Withdrawal Syndrome. (PubMed, Intern Med) - "A 73-year-old man with severe asthma developed secondary adrenal insufficiency after long-term high-dose inhaled fluticasone therapy. Switching to inhaled ciclesonide worsened the symptoms (fatigue, muscle pain, diarrhea, and eosinophilia), and oral hydrocortisone had little effect...Tapering requires prolonged management, but treatment with Saireito, a Kampo medicine, may have facilitated adrenal recovery. This case highlights that inhaled corticosteroids can significantly affect the systemic corticosteroid physiology, suggesting the need for careful monitoring when changing the preparations."

Journal • Asthma • Endocrine Disorders • Eosinophilia • Fatigue • Immunology • Musculoskeletal Pain • Nephrology • Pain • Pulmonary Disease • Renal Disease • Respiratory Diseases

The use of Kampo medicine for post-mastectomy seroma in our department (JBCS 2026) - "The main herbal medicines used were Goreisan: 20 cases, Goreisan + Keishi-bukuryo-gan: 33 For example, Goreisan + Juzentaihoto: 15 cases, Goreisan + Hochuekkito: 8 cases, Saireito alone or in combination was used in 14 cases where infection was suspected...While it is difficult to plan randomized controlled trials for herbal medicines where prescriptions are determined based on individual conditions, accumulating cases and utilizing herbal medicines to prevent seromas or achieve earlier resolution seems useful in preventing stagnation in breast cancer treatment. [Conclusion] This study suggests that herbal medicine treatment may be useful for seromas after breast cancer surgery."

Breast Cancer • Infectious Disease • Solid Tumor

Integrative strategy for Long COVID neuropsychiatric symptoms: A case report on Kamikihito and Bupleurum-Scutellaria formulas guided by pharmacological rationale. (PubMed, Explore (NY)) - "Subsequently, considering the mechanism of neuroinflammation, Saireito and Saikokaryukotsuboreito-formulas containing Scutellaria root and Bupleurum root-may be added to suppress microglial activation...At three months, marked improvements were observed (EQ-5D-5L HR-QOL: 0.839, EQ-VAS: 70, and SF-12 MCS 46.7, RCS 41.8). This case suggests that an integrative approach simultaneously targeting neuroinflammation and neurogenesis offers a promising therapeutic option for Long COVID brain fog."

Journal • CNS Disorders • Depression • Fatigue • Infectious Disease • Inflammation • Mood Disorders • Novel Coronavirus Disease • Psychiatry

Antioxidative Japanese herbal medicine formula prevents diabetic renal complications. (PubMed, J Nat Med) - "At week 25, proteinuria was significantly ameliorated in the Tsudosan, dapagliflozin, vitamin E, and Saireito groups. The overlapping area ratios of podocin and CD2AP staining in the glomeruli were significantly greater in all the drug-treated and control groups than those in the diabetic group. In conclusion, the antioxidative Kampo formula, Tsudosan, demonstrated efficacy in preventing diabetic nephropathy in rats, showing superior performance compared with that of vitamin E. Specifically, Tsudosan may be most beneficial when administered in the early stages of diabetes."

Journal • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Renal Disease • CD2AP

Saireito (TJ-114) for Preventing High-Output Syndrome After Temporary Ileostomy in Rectal Cancer Surgery. (PubMed, Int J Colorectal Dis) - "Postoperative administration of Saireito in rectal cancer patients with temporary ileostomy was associated with a reduced incidence of high-output syndrome. Saireito may be a promising option for preventing HOS in such cases."

Journal • Colorectal Cancer • Oncology • Rectal Cancer • Solid Tumor

Distal colonic crypt hyperplasia is not adversely impacted by Emu Oil and Saireito in a murine model of colitis-associated colorectal cancer (AGW-GESA 2024) - "Increased crypt length in the distal colon of mice with CA-CRC was primarily attributed to a process of crypt cell hyperplasia, as opposed to hypertrophy, evidenced by an increase in colonocyte count with no change in colonocyte diameter. Treatment with Emu Oil, Saireto, or combined Emu Oil/Saireito in experimental CA-CRC did not significantly impact crypt depth, colonocyte count, nor colonocyte size in the proximal or distal colon, suggesting that the decrease in tumour burden described previously may have occurred through a different process. Future studies should investigate the impact of Emu Oil and Saireito on expression of tumour biomarkers such as p53, APC and K-ras, which are intrinsically associated with CRC development."

Preclinical • Colorectal Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Oncology • Solid Tumor • Ulcerative Colitis • KRAS • RAS

Efficacy and safety of Saireito (TJ-114) in patients with atrial fibrillation undergoing catheter ablation procedures: A randomized pilot study. (PubMed, PLoS One) - "Thirty-day use of Saireito following AF ablation was associated with a tendency toward reduced number of episodes of frequent atrial tachyarrhythmias during the treatment period, with more pronounced effect in the first two weeks."

Clinical • Journal • Atrial Fibrillation • Cardiovascular • Inflammation

Analysis of drug-induced interstitial lung disease caused by herbal medicine using the Japanese Adverse Drug Event Report database. (PubMed, BMC Complement Med Ther) - "DIILD demonstrated a dose-dependent to crude drugs. Clinicians should strive for the early detection of DIILD and avoid the inadvertent administration of herbal medicines."

Adverse events • Journal • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases

Efficacy and safety of the traditional herbal medication Chai-Ling-Tang (in China), Siryung-tang (in Republic of Korea) or Sairei-To (in Japan). (PubMed, J Ethnopharmacol) - "Sairei-To is commonly used to treat inflammatory diseases and appears efficient to decrease the side effects of corticosteroids. Its immune-regulatory action is well recognized and exploited to treat certain skin lesions and chemotherapy-related toxic effects. The activity of the Sairei-To product relies on the synergistic action of its individual ingredients. Further studies are warranted to quantify the synergy of action inherent to this interesting botanical medication."

Journal • Review • Dermatopathology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Nephrology • Oncology • Pneumonia • Renal Cell Carcinoma • Renal Disease • Respiratory Diseases

The Effect of Japanese Herbal Medicines (Kampo) Goreisan and Saireito on the Prevention of Recurrent Chronic Subdural Hematoma: A Prospective Randomized Study. (PubMed, Neurosurgery) - "This is the first study to show that Kampo medicine reduced the recurrence rate of CSDH in an overall population. This study demonstrated that byakujutsu Goreisan and Saireito may have favorable effects, unlike other studies, because byakujutsu has stronger anti-inflammatory activity than sojutsu."

Journal • CNS Disorders

Evaluation of changes in endolymphatic hydrops volume after medical treatments for Meniere's disease using 3D magnetic resonance imaging. (PubMed, Auris Nasus Larynx) - "These results indicate that daily administration of anti-vertiginous medications including ATP, ISO, and SAI could be an effective treatment option for patients with MD at an early stage before it becomes intractable. Treatments to reduce EH might offer better control of vertigo rather than improve hearing."

Journal • MRI • Otorhinolaryngology • Vertigo

Effect of prednisolone and saireito co-administration on T-cells of rheumatoid arthritis patients. (PubMed, Clin Exp Rheumatol) - "The use of 114 in combination with low-concentration PSL intensified its immunosuppressive effect. However, the concentration of IL-6 was elevated in the co-administration group, suggesting exacerbation of RA activity."

Journal • Immunology • Inflammatory Arthritis • Oncology • Osteoporosis • Rheumatoid Arthritis • Rheumatology • CD4 • CD8 • FOXP3 • IFNG • IL10 • IL17A • IL2RA • IL6

Saireito, a Japanese herbal medicine, alleviates leaky gut associated with antibiotic-induced dysbiosis in mice. (PubMed, PLoS One) - "We have previously reported on a murine model of intestinal epithelial barrier dysfunction associated with dysbiosis induced by the administration of ampicillin and vancomycin. These results suggest that Saireito alleviates leaky gut caused by antibiotic-induced dysbiosis. Our findings provide a potentially new therapeutic strategy for antibiotic-related gastrointestinal disorders."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • CDH1 • TJP1

Saireito (114) Increases IC50 and Changes T-Cell Phenotype When Used in Combination with Prednisolone Therapy in Human Peripheral Blood Mononuclear Cells. (PubMed, Evid Based Complement Alternat Med) - "However, increased IL-6 suggests potential exacerbation of IL-6-mediated diseases, such as rheumatoid arthritis. Therefore, it is necessary to monitor these clinical parameters when using 114 in combination with PSL."

Combination therapy • Journal • Immunology • Infectious Disease • Inflammatory Arthritis • Osteoporosis • Rheumatoid Arthritis • Rheumatology • CD4 • IFNG • IL10 • IL17A • IL21 • IL6

Saireito (TJ-114) Suppressed Donor-Specific Antibody Through Immunomodulatory Effects and Regulatory T Cell Induction in a Murine Heart Transplant Model. (PubMed, Transplant Proc) - "Nonetheless, when mice were treated with PC-61 at days 20, 23, and 26, DSA levels gradually increased to levels comparable to those of untreated mice by day 29, suggesting that Tregs are necessary to sustain the suppression of DSA once the effects of TJ-114 have subsided. Taken together, TJ-114 may be a promising therapeutic strategy to prolong allograft survival through its combined immunosuppressive effects in inducing Tregs and suppressing DSA production."

Journal • Preclinical • Cardiovascular • Immune Modulation • Inflammation • Transplantation • IL2RA

Prescription of Kampo Formulations for Pre-natal and Post-partum Women in Japan: Data From an Administrative Health Database. (PubMed, Front Nutr) - "The most prescribed medicines during the 180 days postpartum were kakkonto, shoseiryuto, and saireito...Tokishakuyakusan in particular is usually used in the treatment of various symptoms of pregnancy. Further research is needed to clarify the relationship between the use of Kampo medicines during pregnancy and adverse events in infants in Japan."

Clinical • Journal • Respiratory Diseases

SAIREITO INDUCED THE SUPPRESSION OF DONOR-SPECIFIC ANTIBODY IN A MURINE CARDIAC ALLOGRAFT TRANSPLANT MODEL (ESOT 2021) - "Saireito could suppress DSA production in the acute phase through its direct immunosuppressive effect and induction of Treg."

Preclinical • Cardiovascular • Transplantation • CD4 • FOXP3 • IL2RA

Effectiveness of Saireito, a Traditional Japanese Kampo Herbal Medication, on Pacemaker-Related Pleural Effusion: A Case Report. (PubMed, Am J Case Rep) - "Saireito was administered with good response; the pleural effusion resolved completely and there was no deterioration of renal function. CONCLUSIONS The present case highlights the clinical significance of Saireito as an effective therapeutic agent for late-onset pacemaker-related pleural effusion, without adverse effects such as renal dysfunction."

Clinical • Journal • Pleural effusion • Cardiovascular • Immunology • Inflammation • Nephrology • Renal Disease • Respiratory Diseases

Saireito Improves Lymphatic Function and Prevents UVB-Induced Acute Inflammation and Photodamage in HR-1 Hairless Mice. (PubMed, Evid Based Complement Alternat Med) - "These results suggest that SRT could attenuate UVB-induced photodamage. This protective effect of SRT involves suppression of upregulation of proinflammatory cytokines and improvement of lymphatic function in the early stage of inflammation."

Journal • Preclinical • Dermatology • Immunology • Inflammation • IL1B • IL6 • VEGFC

Liver Injury by the Traditional Chinese Medicine Hanshirento, Zenshikunshito, and Ninjin'yoeito in a Patient with Lung Cancer: Probable Causality Assessed by the Updated Roussel Uclaf Causality Assessment Method. (PubMed, Integr Cancer Ther) - "However, as with our case, TCM rarely induces liver injury, which is not well known to TCM users. Medical staffs need to be vigilant with their drug histories, including TCM, if patients have liver injuries."

Clinical • Journal • Fatigue • Hepatology • Liver Failure • Lung Cancer • Oncology • Solid Tumor

Emu Oil and Saireito in combination reduce tumour development and clinical indicators of disease in a mouse model of colitis-associated colorectal cancer. (PubMed, Biomed Pharmacother) - "Combined EO and Saireito reduced disease and tumour development in AOM/DSS mice, suggesting therapeutic potential in CA-CRC."

Journal • Preclinical • Colon Cancer • Colorectal Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Oncology • Solid Tumor • Ulcerative Colitis

The herbal medicines Inchinkoto and Saireito improved hepatic fibrosis via aquaporin 9 in the liver of a rat bile duct ligation model. (PubMed, Pediatr Surg Int) - "The postoperative administration of ICKT and SRT induced synergistic beneficial effects, resulting in the reduction of hepatic fibrosis via mechanisms involving the inhibition of NF-κB expression and the improvement of AQP9 downregulation."

Journal • Cholestasis • Fibrosis • Hepatology • Immunology • Inflammation • PCR

Healing Adjuncts in Craniofacial Surgery: A Practical Review of Dietary Vitamins and Supplements. (PubMed, J Craniofac Surg) - "There is ample evidence to support a role for the use of certain dietary supplements to optimize wound healing in craniofacial and facial aesthetic surgery. Controlled diet and use of appropriate supplements may have a synergistic beneficial effect on wound healing following craniofacial surgery. However, there is a need for additional reporting to allow for the creation of stronger guidelines and increased patient screening, reporting, and compliance."

Journal • Aesthetic Medicine

Adjuvant alternative successful treatment by oral Saireito (Japanese herbal medicine) for nodulocystic acne (EADV 2017) - No abstract available.

Clinical • Immunology

An analysis of the ingredients in decoctions and extracts of Kampo medicines: Amounts of baicalin and baicalein in Kampo medicines containing Scutellariae Radix (PubMed, Nihon Ronen Igakkai Zasshi) - "Because the Kampo decoctions containing SR that we examined contained 1.7-4.0 times as much BL as the corresponding Kampo extract products, medical doctors and pharmacists should be aware that Kampo decoctions containing SR might cause more severe side effects than corresponding Kampo extract products. Furthermore, we recommend that the amounts of BL and its aglycone, baicalein (BA), in Kampo extract products be made known to practitioners and patients."

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