VEGF/rGel / Targa Therap - LARVOL DELTA

Light-enhanced VEGF/rGel induce immunogenic cell death and increase the antitumor activity of αCTLA4 treatment. (PubMed, Front Immunol) - "VEGF/rGel-PCI describes a novel concept for ICI enhancement which induces a rapid CD8+ dependent tumor eradication in both CT26 and MC38 tumors. The concept is based on the combination of intracellular ROS generation and vascular targeting using a plant derived toxin and will be developed towards clinical utilization."

Immunogenic cell death • Journal • Colon Cancer • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor • CD8 • HMGB1 • HSP90AA1

Light-enhanced VEGF/rGel: A tumor targeted modality with vascular and immune-mediated efficacy. (PubMed, J Control Release) - "A 50% complete remission (CR) of CT26.CL25 colon carcinoma allografts was found in immunocompetent mice while no CR was detected in CT26.CL25 bearing athymic mice. In conclusion, the present report indicate VEGF/rGel -PCI as a treatment modality with multimodal tumor targeted efficacy that should be further developed towards clinical utilization."

Clinical • Journal