Tetralysal (lymecycline) / Galderma - LARVOL DELTA

Pemphigoid lichen planus effectively treated with lymecycline (JDP 2024) - No abstract available

Dermatology • Dermatopathology • Immunology • Lichen Planus

First Trimester Tetracycline Exposure and Risk of Major Congenital Malformations. (PubMed, JAMA Netw Open) - "The RRs for specific tetracycline substances were 1.07 (95% CI, 0.93-1.23) for doxycycline, 0.83 (95% CI, 0.60-1.15) for lymecycline, and 0.78 (95% CI, 0.32-1.92) for tetracycline-oxytetracycline. In this cohort study, first trimester tetracycline exposure was not associated with increased risks of any MCMs. Additional studies are needed to rule out potential risks owing to power limitations for several MCM subgroups and individual malformations."

Journal

In silico drug repurposing using molecular docking and dynamics to target the protein interaction between the SARS-CoV-2 S-glycoprotein and the ACE2 receptor. (PubMed, F1000Res) - " Our study is unique in its comprehensive approach to identify agents that can bind to the S-glycoprotein-ACE2 interface using multiple computational platforms. Among the hit compounds shortlisted in this study, both lymecycline and hexoprenaline may be considered as candidates for preliminarily clinical studies to assess their therapeutic potential in the management of COVID-19 infections."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

efficacy and tolerability of the combination adapalene and benzoyl peroxide 0.1%/2.5%, gel in the management of acne vulgaris (EADV 2024) - "These patients were treated with a combination of oral Tetralysal 300 mg and topical adapalene 0.1%/benzoyl peroxide 2.5% (Gr A) .The second group consisted of 62 patients with mild to moderate acne... Combination therapy is commonly used to treat acne because of its proven efficacy in treating this complex, chronic condition. The fixed-dose combination of adapalene 0.1% and benzoyl peroxide (BPO) 2.5% offers a therapeutic approach combining two agents that act in different ways to target the multiple pathophysiological factors responsible for acne . Our results suggest that this combination is globally effective and well tolerated, both as monotherapy and in combination with oral therapy."

Clinical • Acne Vulgaris • Dermatology • Infectious Disease • Inflammation

Mycophenolate mofetil in the management of lichen planus pigmentosus in a woman with frontal fibrosing alopecia (BAD 2024) - "Initial management was lymecycline 408 mg once daily, tacrolimus 0.1% ointment twice daily plus mometasone furoate 0.1% two times weekly to the neck, and pimecrolimus cream twice a day to the face, as well as a sun protection factor 50 sunscreen...Lymecycline was stopped and hydroxychloroquine 200 mg once daily was started...Low-dose isotretinoin has been reported as being of benefit in LP pigmentosus but was ineffective in this case. Mycophenolate mofetil is also reported to be of benefit in the management of LP pigmentosus, and led to a significant improvement in both pigmentation and itch in this case. This case highlights the therapeutic benefit of mycophenolate mofetil in in LP pigmentosus associated with FFA."

Clinical • Alopecia • Dermatology • Dermatopathology • Fibrosis • Immunology • Lichen Planus • Pruritus

In over our heads? (BAD 2024) - "He was on lymecycline at the time of presentation, prescribed by his general practitioner, and no other medications...He was treated with rifampicin and clindamycin, in multiple short courses and once consecutively for 6 months, which yielded some improvement...He was treated with flucloxacillin (500 mg, four times daily for 2 weeks), followed by doxycycline (100 mg daily for 6 weeks), followed by azithromycin (500 mg, three times weekly for 4 weeks). He has achieved considerable improvement and is being considered for oral dapsone...This case depicts the severe end of the disease spectrum, and the issues that can arise in that context. Challenges faced by his team were not only medical, but also psychological by way of gaining the patient's trust and managing vulnerabilities."

Acne Vulgaris • Alopecia • Dermatology • Immunology • Infectious Disease • Inflammation • Pruritus

Computational drug repurposing screen targeting PLA2R antibody binding. (UKKW 2024) - "The sixteen compounds include Lymecycline, Trazodone, Mirabegron, Sulfasalazine, Methotrexate, Rosuvastatin and Montelukast. However, they all share the chemical properties of large molecular weight and have the potential to form multiple hydrogen bonds. If validated experimentally, these compounds could provide new treatment options for PLA2R antibody positive membranous nephropathy."

Glomerulonephritis • Renal Disease

The effect of lymecycline on paediatric cystic fibrosis related diabetes in the modulator era (ECFS 2024) - "This case shows that lymecycline treatment used for acne, can trigger glucose intolerance, but after discontinuation this restores to baseline levels. If lymcycline is commenced, we propose closer monitoring of blood glucose, and alternative treatment if problems of CFRD arise."

Acne Vulgaris • Cystic Fibrosis • Diabetes • Genetic Disorders • Immunology • Metabolic Disorders • Pediatrics • Pulmonary Disease • Respiratory Diseases

Computational drug repurposing screen targeting PLA2R antibody binding. (ERA-EDTA 2024) - "The sixteen compounds include Lymecycline, Trazodone, Mirabegron, Sulfasalazine, Methotrexate, Rosuvastatin and Montelukast. Structural bioinformatics methods provide a relatively fast and economical option for identifying protein-drug interactions that could result in new treatment strategies. The compounds identified for investigation are used for an array of different health conditions. However, they all share the chemical properties of large molecular weight and have the potential to form multiple hydrogen bonds."

Glomerulonephritis • Nephrology • Renal Disease

Stevens-Johnson syndrome induced by lymecycline in a 17 years old adolescent: A case report and review of the literature (PubMed, Therapie) - No abstract available

Journal • Review • Steven-Johnson Syndrome

Pediatric Hidradenitis Suppurativa in a Patient with Down Syndrome A Case Report and Review of Literature (INDERCOS 2024) - "She was diagnosed with nodular acne and was treated with oral lymecycline, metronidazole and topical mupirocin, clindamycin and chlorhexidine, she did not benefit from them...Adalimumab treatment was started but she discontinued follow-up visits...The US and Canadian HS Foundations have recommended annual HS screening in patients with DS. Given these findings, dermatologists should be aware of association between HS and DS."

Case report • Clinical • Review • Acne Vulgaris • Celiac Disease • Dermatology • Developmental Disorders • Endocrine Disorders • Genetic Disorders • Hidradenitis Suppurativa • Immunology • Pain • Pediatrics • APP

Is there a Rationale for the Use of Lymecycline for Frontal Fibrosing Alopecia? (PubMed, Dermatol Pract Concept) - No abstract available

Journal • Alopecia • Fibrosis • Immunology

Hurley Stage 3 Hidradenitis Suppurativa in pregnancy: An area of unmet need(#251) (EHSF 2024) - "Treatments prior to pregnancy included tetralysal, metformin rifampicin, clindamycin, adalimumab, ustekinumab, ixekizumab and infliximab, none of which had adequately controlled disease. At the time of conception, HS was stable on certolizumab...Many treatment options utilised in the general population are contraindicated in pregnancy, including oral contraceptives, spironolactone and tetracycline antibiotics...The authors suggest a 12-week course of dapsone, may be attempted with caution as late-line therapy for HS...HS is associated with higher risk pregnancies. Further research in this area of unmet need is warranted."

Anesthesia • Cardiovascular • Dermatology • Gastroenterology • Gynecology • Hidradenitis Suppurativa • Hypertension • Immunology • Infectious Disease • Inflammation • Obstetrics • Rheumatology • Septic Shock

Patterns of surgical procedures and medical treatments among patients with hidradenitis suppurativa before and after referral to specialized dermatological hospital care(#141) (EHSF 2024) - "Drug prescription groups included HS specific oral antibiotics (-cyclines: tetracycline, doxycycline, lymecycline; and rifampicin/clindamycin, respectively), HS specific topical drugs (azelaic acid, topical clindamycin, adapalene, benzoylperoxide, and metronidazole), non-HS specific oral antibiotics (penicillins, macrolides etc.), systemic retinoids (isotretinoin and acitretin), and HS related biologics (adalimumab, infliximab, etanercept, ustekinumab, and secukinumab). This large nationwide study showed that in the period before, compared to the period after, referral to specialized dermatological hospital care, surgical procedures and drug prescriptions changed from a less HS specific to a more HS specific pattern."

Clinical • Dermatology • Hidradenitis Suppurativa • Immunology

Hidradenitis suppurativa in children and young adults: a retrospective cross-sectional observational study in the United Kingdom. (PubMed, Int J Dermatol) - "This group had a female predominance with an apparent strong genetic predisposition which is seen in other HS CYA cross-sectional research. Treatment was varied in this cohort, however long courses of antibiotics, including combined therapy with rifampicin and clindamycin, were the mainstay of treatment, similar to management in the adult population. This study therefore adds to the limited information on the demographics and management of the HS CYA population."

Journal • Observational data • Retrospective data • Dermatology • Hidradenitis Suppurativa • Immunology

Unilateral breast enlargement – coincidence or unknown side effect of systemic isotretinoin treatment (EADV 2023) - "Due to the deterioration of her acne systemic lymecycline 300 mg a day with topical trifarotene once a day were introduced with gradual skin improvement within the next six months. To the best of our knowledge, we present the first case report of unilateral mammary gland enlargement during isotretinoin therapy for acne. It seemed to be dose dependent and subsided after lowering the dose of the medication or stopping the treatment. The cause of this phenomenon remains unknown, however dysfunction of retinaldehyde dehydrogenases should be considered as a possible explanation."

Adverse events • Acne Vulgaris • Cardiovascular • CNS Disorders • Depression • Dermatology • Dry Eye Disease • Ophthalmology • Psychiatry

Identification of unknown impurities J, RRT 2.2, 2.4, 2.6 and 3.4 in tetralysal® capsules. (PubMed, Eur J Pharm Sci) - "Based on both monographs Galderma has focused on characterizing most of specified and unspecified impurities to better understand the stability and degradation processes of the formulation. In this manuscript, through both formal synthesis, preparative LCMS and formal degradation studies, we are the first group to confirm the structural identities of 5 unidentified impurities (Impurity J (RRT 1.6), RRT 2.2, 2.4, 2.6 and 3.4), conditions which exacerbate the formation of all 5 impurities and response factors for RRT 2.2, 2.6 and 3.4."

Journal • Acne Vulgaris

Comparison between lymecycline with multidrug therapy and standard multidrug regimen (WHO-MDT) in the treatment of multibacillary leprosy patients: A retrospective cohort study (WCD 2023) - "Lymecycline 600 mg daily for 3 months can be used as an adjunct medication in cases of leprosy resistance and treatment failure among multibacillary patients. Lymecycline significantly reduces bacillary index, recurrence of skin lesions and nerve function impairment through its possible immunomodulatory, antiapoptotic, and neuroprotective effects"

Retrospective data • Dermatology • Immune Modulation • Infectious Disease

Dermatitis and the Dangers of Fashion (WCD 2023) - "She was treated for erythrasma, folliculitis and fungal infections: clobetasone butyrate, fusidic acid & betamethasone valerate, topical erythromycin, emollients, topical terbinafine, oral lymecycline and oral erythromycin...Topical lignocaine was used to alleviate ongoing dysesthesia...The presentation is highly variable, and one must exercise a high index of suspicion. In the context of today’s highly variable fashion trends these cases will likely become more prevalent"

Atopic Dermatitis • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Infectious Disease • Novel Coronavirus Disease • Pruritus

Spironolactone in Adolescent acne vulgaris: a case report (WCD 2023) - "She was initially treated with topical adapalene and benzoyl peroxide, followed by lymecycline for six months without significant improvement. The patient had refused isotretinoin as a treatment option...It is not prescribed to adolescents due to potential side effects; however, current data indicate that most side effects are mild, and that potential associations with hyperkalemia and increased risk of cancer are not sufficiently supported. Hence, spironolactone may be a safe and effective therapy for adolescent acne"

Clinical • Acne Vulgaris • Dermatology • Obesity • Oncology

Severe papulopustular rosacea with demodicosis in a 47-year-old Filipino female: A case report (WCD 2023) - "The patient was initially treated with oral lymecycline 300mg twice a day for 2 weeks without improvement. Due to the persistence of centrofacial erythema, papules and pustules, the patient was given prednisone 10mg once a day for 1 month and low dose isotretinoin 10mg once a day for 8 months which resulted in significant decrease in erythema and number of existing lesions...Gentle skin care measures, sunscreen, metronidazole 0.75% cream once a day, and desonide 0.05% cream twice a day for 1 week in cases of acute flares were maintained during the treatment course. KEY MESSAGE: An armamentarium of topical and oral antibiotics, corticosteroids, isotretinoin and non-ablative long-pulsed Nd:YAG 1064 nm laser showed significant improvement in the inflammatory papules, pustules, and centrofacial erythema of rosacea and proves to be beneficial in the maintenance of its long-term remission"

Clinical • Dermatology • Inflammation • Rosacea

Comparison between lymecycline with multidrug therapy and standard multidrug regimen (WHO-MDT) in the treatment of multibacillary leprosy patients: a retrospective cohort study. (PubMed, Int J Dermatol) - "Lymecycline 600 mg daily for 3 months can be used as an adjunct in cases of leprosy resistance and treatment failure among multibacillary patients. Lymecycline significantly reduced bacillary index, recurrence of skin lesions, and nerve function impairment through its possible immunomodulatory, antiapoptotic, and neuroprotective effects."

Journal • Retrospective data • Immune Modulation • Infectious Disease

Evaluation of a Tertiary Virtual Acne Service (EADV-Sp 2023) - "The aim of this service evaluation was to capture snapshot demographics of the patients engaging in our acne service, evaluate if our service meets patients’ needs, and assess adherence to national guidance on isotretinoin prescribing...Prior oral antibiotics had been taken in 90.4% patients, most frequently prescribed was lymecycline (73.3%)...Remote telephone or video consultations can benefit both patents and service efficacy. Table 1"

Acne Vulgaris • Infectious Disease • Novel Coronavirus Disease

Review of a children and young adults hidradenitis suppurativa service, a retrospective observational study (EADV-Sp 2023) - "At time of referral 13 (45%) patients had already trialled long courses (>3months) of antibiotics, 6 (21%) had trialled rifampicin and clindamycin, 4 (14%) had Isotretinoin and 2 (7%) had adalimumab...Of the antibiotics, lymecycline was most commonly prescribed (n=23, 56%), erythromycin (n=9, 22%), doxycycline (n=5, 12%) and clarithromycin (n=2, 5%)...We evaluated demographic data, medical and surgical interventions in a CYA HS population to add to this limited field of research. Further prospective studies would be beneficial to further assess treatment outcomes in the CYA HS group."

Observational data • Retrospective data • Review • Acne Vulgaris • Dermatology • Gastroenterology • Gastrointestinal Disorder • Hidradenitis Suppurativa • Immunology • Inflammation • Inflammatory Bowel Disease

A single-centre experience in the management of Langerhans' cell histiocytosis using trametinib (BSH 2023) - "The RAS-MAPK pathway is activated in LCH and up to 60% can have a BRAF V600 mutation and can respond well to Vemurafenib (a BRAF V600 inhibitor)...She was commenced on subcutaneous Cytarabine (100 g/m 2 ) but this was complicated by neutropenic sepsis and did not improve her skin lesions. She was switched to oral Methotrexate at 20 mg weekly but this was stopped due to acute transaminitis and failure to respond...She had a re-challenge at the same dose Trametinib and prophylactic dose Lymecycline with good effect...Side effects include dermatitis acneiform which was straightforward to manage. Patients would require LV function monitoring by echocardiography or MUGA scan while on treatment."

Clinical • Acne Vulgaris • Dermatitis • Dermatology • Hematological Disorders • Immunology • Infectious Disease • Langerhans Cell Histiocytosis • Metabolic Disorders • Oncology • Pain • Septic Shock • Solid Tumor