TRIMELVax / University of Chile - LARVOL DELTA

Early neutrophil infiltration promotes TRIMELVax-induced antitumor immunity by linking local inflammation to tumor control. (PubMed, Oncoimmunology) - "Together, these findings identify neutrophils as key early regulators of the innate inflammatory environment induced by TRIMELVax and suggest that neutrophils with APC-like features may impact DC trafficking and downstream antitumor immunity. Neutrophils, particularly those with APC-like phenotypes, emerge as promising cellular adjuvant targets for enhancing cancer vaccination strategies, offering a new avenue for rational vaccine design and combination with checkpoint blockade therapies."

Journal • Melanoma • Oncology • Solid Tumor • CCL2 • CCL3 • CDK1 • CXCL3 • CXCL5 • CXCL9 • IL12A • IL1B • IL6 • ITGAM • ITGAX • PTPRC