trimipramine / Generic mfg. - LARVOL DELTA

Phenix: Efficacy of the Combination of Trimipramine and Atezolizumab With Bevacizumab in Patients With Recurrent Glioblastoma: a Phase 2 Trial (clinicaltrials.gov) - P2 | N=59 | Recruiting | Sponsor: Centre Hospitalier Universitaire Vaudois

New P2 trial • Brain Cancer • Glioblastoma • Oncology • Solid Tumor

Druggable Genome Mendelian Randomization and GWAS-sceQTLs MR Analysis Reveal Genetic Associations Between Open-Angle Glaucoma and Immune Cells, and Identify Potential Drugs. (PubMed, Transl Vis Sci Technol) - "(3) Drug screening: Molecular docking confirmed strong binding of trimipramine, desipramine, and cyclosporin to GFPT1 (Vina score < -5), with PheWAS indicating no significant off-target effects. Three existing drugs identify potential for therapeutic repurposing. This study identifies GFPT1-driven immunometabolic dysfunction as a novel target in POAG and nominates three US Food and Drug Administration (FDA)-approved drugs for immediate clinical translation, accelerating the path to trials."

Journal • Glaucoma • Metabolic Disorders • Ophthalmology • CD4 • KLRB1 • YWHAG

Therapeutic Considerations of Sleep Disturbances in Depression (WFSBP 2025) - "Concerning, pharmacological approaches, there has been a focus on low-dose sedative antidepressants like trazodone, doxepine, mirtazapine or trimipramine. It is strongly recommended to treat insomnia in MDD, specifically, in order to relieve symptoms of depression and to foster remission. CBT-I or medication with low dose sedative antidepressants are effective and well tolerated, while chronic treatment with GABA-receptor-agonists is not recommended because of development of tolerance and withdrawal insomnia."

CNS Disorders • Depression • Insomnia • Major Depressive Disorder • Mood Disorders • Psychiatry • Sleep Disorder

Repurposing FDA approved drugs for psoriasis indications through integrated molecular docking, one-SVM algorithm, and molecular dynamics simulation approaches. (PubMed, Sci Rep) - "Further, one-SVM algorithm prediction was done to validate the docking outcome and molecular dynamics simulation of top drug-target molecule was performed to propose potential anti-psoriasis drugs. The study identified Pioglitazone, Trimipramine and Dimetindene as top three contender amongst many other drugs as a new indication against psoriasis."

FDA event • Journal • Cardiovascular • CNS Disorders • Dermatology • Immunology • Infectious Disease • Mood Disorders • Psoriasis • Psychiatry • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Repurposing Tricyclic Antidepressants for Glioblastoma Treatment (EACR 2025) - "Our lab has previously proposed a successful novel combinatorial regimen, including the tricyclic antidepressant (TCA) imipramine, the vascular endothelial growth factor (VEGF) inhibitor bevacizumab, and the immune checkpoint inhibitor anti-PD-L1, which demonstrated significant therapeutic benefit in GBM mouse models (Chryplewicz et al.; Cancer Cell, 2022)...Motivated by these results and encouraged by the clinical support, we aim to further improve this therapeutic regimen by disrupting various capabilities of tumors required for their growth and therapeutic resistance.Material and To optimize this regimen for clinical translation, we screened multiple TCAs - trimipramine, clomipramine, and amitriptyline - alongside imipramine in mouse and human GBM cell lines to evaluate their impact on cell viability... This study aims to delve deeper into TCA mechanisms of action, assess potential synergies with VEGF pathway inhibitors and immune checkpoint blockade, and ultimately..."

IO biomarker • Brain Cancer • Glioblastoma • Oncology • Solid Tumor

Pharmacotherapy of psychiatric inpatients with mental and behavioral disorders caused by sedatives or hypnotics (F13): Results from an observational pharmacovigilance program between 2000 and 2017. (PubMed, Addict Sci Clin Pract) - "We found high rates of non-SHA drugs among patients treated for SHA-SUD. The prevalent use of psychotropic drugs with strong sedating properties indicates a symptom-oriented treatment approach, which is often "off-label" but may be clinically necessary. Main limitation is the cross-sectional design of the AMSP databank. Therefore, we cannot provide any follow up data on the patient collective especially regarding outcome."

Adverse events • Journal • Addiction (Opioid and Alcohol) • Behavior Disorders • CNS Disorders • Mental Retardation • Mood Disorders • Psychiatry

Intrauterine Exposure to Psychotropic Medications as a Risk Factor for Neonatal Opioid Withdrawal Syndrome (PAS 2025) - "Those with exposure to psychotropic medication were more likely to also have exposure to other substances (i.e., alcohol, nicotine, marijuana, and methamphetamine) (84% vs. 69%; p< 0.05; Table 1). Of the 1,305 infants included in the ESC-NOW study, 297 (22.8%) had antenatal co-exposure to psychotropic medications. The mean length of stay was 1.6 days longer for infants with psychotropic exposure compared to those without exposure (12.1 vs. 10.5 days, respectively; p < 0.001) (Table 2)."

Clinical • Addiction (Opioid and Alcohol) • Substance Abuse

Comprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis. (PubMed, Orthop Surg) - "Two diagnostic and therapeutic biomarkers associated with aging-circadian rhythm in KOA were identified. Functional analysis, molecular mechanism exploration, and experimental validation further elucidated their roles in KOA, offering novel perspectives for the prevention and treatment of the disease."

Biomarker • Journal • Immunology • Infectious Disease • Osteoarthritis • Pain • Rheumatology • DDIT4 • IL1B • PFKFB4

The cardiovascular safety of tricyclic antidepressants in overdose and in clinical use. (PubMed, Ther Adv Psychopharmacol) - "Amitriptyline, clomipramine, dothiepin/dosulepin, doxepin, trimipramine and imipramine showed broadly similar toxicity and were usually reported to be less toxic than desipramine...With respect to the risk of cardiovascular events at clinically relevant exposure, amitriptyline, nortriptyline and lofepramine were associated with a greater risk of in-use cardiotoxicity. All measures of overdose toxicity were subject to external influences and confounding. The continued use of TCAs in depression and other conditions should be minimized when considering their undoubted toxicity in overdose and possible toxicity in normal clinical use."

Journal • Review • Cardiovascular • CNS Disorders • Depression • Psychiatry

Novel, fast, and reliable electrochemical dsDNA biosensor based on O-terminated pristine nanocrystalline boron-doped diamond electrode for DNA interaction studies. (PubMed, Bioelectrochemistry) - "The bioanalytical applicability of the fabricated dsDNA/O-B-NCDE biosensor was verified by examining the nature of the interaction between dsDNA and five selected DNA intercalators - namely thioridazine hydrochloride (TR), trimipramine maleate (TRIM), levomepromazine maleate (LEV), imipramine hydrochloride (IMI), and prochlorperazine maleate (PER) - where intercalation was proven for all of the five tested compounds. Moreover, the proposed novel bioanalytical test offers the possibility to selectively distinguish between the phenothiazine representatives (TR, LEV, and PER) and representatives of tricyclic antidepressants group (TRIM and IMI)."

Journal

Sustainable beeswax modified cellulose paper for the determination of tricyclic antidepressants in biofluids. (PubMed, Talanta) - "The beeswax modification of paper renders it hydrophobic, enabling the extraction of the target analytes, i.e., imipramine, desipramine, amitriptyline and trimipramine, via hydrophobic interactions. The method provided limits of detection in the range 2.0 and 3.2 μg L-1, and the precision, expressed as relative standard deviation, was better than 5.4 % and 8.5 % for intra and inter-day analyses, respectively. The accuracy, in terms of relative recovery, ranged from 90 % to 121 % using saliva as model biofluid."

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Development of Visible Spectrophotometric Methods for the Determination of Tricyclic Antidepressants Based on Formation of Molecular Complexes with p-Benzoquinones. (PubMed, Int J Mol Sci) - "The present work describes two visible (VIS) spectrophotometric techniques that utilize the formation of charge transfer complexes between four antidepressant compounds, namely, amitriptyline hydrochloride (AMI), imipramine hydrochloride (IMI), clomipramine hydrochloride (CLO), and trimipramine maleate (TRI) acting as electron donors and two p-benzoquinones, namely, p-chloranilic acid (pCA) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), serving as electron acceptors. The developed spectrophotometric techniques were validated intra-laboratory and successfully applied for quantitative assessment of the four antidepressant active ingredients in several commercial pharmaceutical formulations. The methods are relatively simple, fast, and use readily available laboratory instrumentation, making them easily applicable by most quality control laboratories worldwide."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Drug-induced phospholipidosis is not correlated with the inhibition of SARS-CoV-2 - inhibition of SARS-CoV-2 is cell line-specific. (PubMed, Front Cell Infect Microbiol) - "reported that 34 compounds, including Chloroquine and Fluoxetine, inhibit SARS-CoV-2 replication by inducing phospholipidosis, although Chloroquine failed to suppress viral replication in Calu-3 cells and patients...Trimipramine and Chloroquine induced phospholipidosis but failed to inhibit SARS-CoV-2 replication in Calu-3 cells, which contradicts the reported findings and the proposed mechanism...However, we show that compounds, such as Amiodarone, Tamoxifen and Tilorone, with antiviral activity on Calu-3 cells, also inhibited viral replication in human PCLS...Data from Vero E6 can lead to non-transferable results, underlining the importance of an appropriate cell system for analysing antiviral compounds against SARS-CoV-2. We observed a correlation between the active compounds in Calu-3 cells and PCLS."

Journal • Preclinical • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Development of electrospun nanofibers based on Poly (vinyl alcohol) for thin film solid-phase microextraction of antidepressant drugs in biological samples. (PubMed, J Chromatogr A) - "Here, a new nano sorbent was reported for the simultaneous extraction and determination of three types of antidepressant drugs (Clomipramine (CLO), Clozapine (CLZ), and Trimipramine (TRP) by the thin-film solid-phase micro-extraction (TFME-μSPE) method followed by the Gas Chromatography-flame ionization detector (GC-FID) analysis. The relative standard deviations (RSDs) were achieved in the range of 4.9-6.8% (intra-day, n = 4) and 5.4-7.9% (inter-day, n = 3) in the period of 3 days. Finally, the capability of the method was evaluated to simultaneously measure trace amounts of antidepressants aqueous sample with desirable extraction efficiency (78 to 95%)."

Journal

Super-High-Resolution Densitometry by Optical Trapping of a Single-Molecularly Imprinted Polymer Particle for Subsingle Molecule Detection. (PubMed, Anal Chem) - "Trapping a single MIP inside a solution and analyzing its Brownian motion allow for real-time determination of its target molecule [trimipramine (TMP) in our case] content...According to our data within a detection volume inside the bulk solution, 0.02-0.25 target molecules could be detectable with a detection limit of 0.005 molecules. Thus, we detected 1/1000th of the subsingle molecule in detection volume by high-resolution densitometry."

Journal

Tricyclic Antidepressants in Nociceptive and Neuropathic Pain: A Review of Their Analgesic Properties in Combination With Opioids. (PubMed, J Pharm Technol) - "Data Sources: A comprehensive literature review was conducted with the assistance of a medical reference librarian on PubMed, MEDLINE, Scopus, and Web of Science using the following search terminology: "Amitriptyline" OR "Doxepin" OR "Desipramine" OR "Imipramine" OR "Nortriptyline" OR "Clomipramine" OR "Trimipramine" AND "Analgesia." Reports of adult patients who received any TCA as an adjunctive analgesic to opioids were included... The efficacy of TCAs for neuropathic pain was not corroborated by this review, and the anticholinergic adverse effects associated with this drug class were found to be significant. Further research is needed to quantify the efficacy of TCAs in the management of nociceptive pain."

Combination therapy • Journal • Review • Addiction (Opioid and Alcohol) • Neuralgia • Pain

Potential of sodium dodecyl sulfate micellar solutions as eluents in magnetic dispersive micro-solid phase extraction with polydopamine-coated magnetite nanoparticles. Application to antidepressant drugs. (PubMed, J Chromatogr A) - "In this paper, the potential of micellar solutions of the anionic surfactant sodium dodecyl sulfate (SDS) as eluents in dispersive micro-solid phase extraction (D-μSPE) using polydopamine-coated magnetite nanoparticles (FeO@PDA NPs) for the extraction and preconcentration of seven basic drugs (bupropion, citalopram, fluoxetine, mianserin, nomifensine, trimipramine, and viloxazine) is explored for the first time (to the best to our knowledge) and compared with conventional hydro-organic eluents. The results shown in this paper demonstrate the suitability of FeO@PDA NPs as a sorbent for the extraction of antidepressants as well as the advantages of using SDS micellar solutions over classic hydro-organic eluents containing methanol, acetonitrile or tetrahydrofuran. Finally, the stability and reusability of the FeO@PDA NPs is proven."

Journal

Pathogenomic in silico approach identifies NSP-A and Fe-IIISBP as possible drug targets in Neisseria Meningitidis MC58 and development of pharmacophores as novel therapeutic candidates. (PubMed, Mol Divers) - "Two pharmacophore models comprising of 2-(biaryl) carbapenems, efavirenz, praziquantel and pyrimethamine for NSP-A and 2-(biaryl) carbapenems, trimipramine and pyrimethamine for Fe-IIISBP, showed successful docking, followed drug-likeness criteria and generated pharmacophore model with a score of 8.08 and 8.818, respectively, which had further been docked to the target stably. Thus, our study identifies NSP-A and Fe-IIISBP as novel targets in Neisseria meningitidis for which 2-(biaryl) carbapenems, efavirenz, praziquantel, trimipramine and pyrimethamine may be employed for effective treatment of meningitis."

Journal • CNS Disorders • Infectious Disease • Meningococcal Infections

Metabolomic profiling in ankylosing spondylitis using time-of-flight mass spectrometry. (PubMed, Clin Nutr ESPEN) - "Pathway analysis revealed that dysregulation in FA metabolism is associated with AS, and therefore, modulation of diet according to PA and PC may be potential therapeutic targets."

Biomarker • Journal • Ankylosing Spondylitis • Immunology • Inflammation • Inflammatory Arthritis • Rheumatology • Seronegative Spondyloarthropathies

Neuronal Monoaminergic Antidepressant Response Signatures in the L1000 Database (ACNP 2021) - "To date, we have analyzed the following antidepressants within a given class: TCAs (9) – amitriptyline, amoxapine, clomipramine, desipramine, dibenzepin, doxepin (3 datasets), maprotiline, nortriptyline, and trimipramine; SSRIs (5) – escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline; serotonin norepinephrine reuptake inhibitors (SNRIs) (2) – duloxetine and venlafaxine; and monoamine oxidase inhibitors (MAOIs) (2) – bifemelane and isocarboxazid...Potential next steps include the identification of gene expression signatures of other antidepressant “perturbagens” in the L100, including those with different mechanisms, e.g. bupropion, a norepinephrine-dopamine reuptake inhibitor and nicotine receptor antagonist. Most of the gene expression profiles were non-overlapping across monoaminergic antidepressant classes. However, in the NPC line, HLA-DMA [major histocompatibility complex class II alpha chain, catalyzing the release of class II-associated invariant..."

IO biomarker • Alzheimer's Disease • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry • CD40 • EPHA3 • GJA1 • HLA-DRB1 • SSBP2 • TSPAN8

Neuronal Monoaminergic Antidepressant Response Signatures in the L1000 Database (ACNP 2021) - "To date, we have analyzed the following antidepressants within a given class: TCAs (9) – amitriptyline, amoxapine, clomipramine, desipramine, dibenzepin, doxepin (3 datasets), maprotiline, nortriptyline, and trimipramine; SSRIs (5) – escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline; serotonin norepinephrine reuptake inhibitors (SNRIs) (2) – duloxetine and venlafaxine; and monoamine oxidase inhibitors (MAOIs) (2) – bifemelane and isocarboxazid...Potential next steps include the identification of gene expression signatures of other antidepressant “perturbagens” in the L100, including those with different mechanisms, e.g. bupropion, a norepinephrine-dopamine reuptake inhibitor and nicotine receptor antagonist. Most of the gene expression profiles were non-overlapping across monoaminergic antidepressant classes. However, in the NPC line, HLA-DMA [major histocompatibility complex class II alpha chain, catalyzing the release of class II-associated invariant..."

IO biomarker • Alzheimer's Disease • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry • CD40 • EPHA3 • GJA1 • HLA-DRB1 • SSBP2 • TSPAN8

Drug triggered pruritus, rash, papules, and blisters - is AGEP a clash of an altered sphingolipid-metabolism and lysosomotropism of drugs accumulating in the skin? (PubMed, Lipids Health Dis) - "Amiodarone, chlorpromazine, amitriptyline, and trimipramine are classified lysosomotropic as well as photosensitizing, however, they fail to trigger rash and pruritic papules in all individuals. The suggested model of a compartmentalized ceramide metabolism provides a more sophisticated explanation of cutaneous drug adverse effects and the individual sensitivity to UV radiation. Parameters such as pKa and ClogP of the triggering drug, cutaneous fatty acid profile, and ceramide profile enables new concepts in risk assessment and scoring of AGEP as well as prophylaxis outcome."

Journal • Acne Vulgaris • Dermatology • Immunology • Metabolic Disorders • Pruritus

Determination of psychoactive drugs in serum using conductive vial electromembrane extraction combined with UHPLC-MS/MS. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "EME was combined with UHPLC-MS/MS, and a method to determine selected psychoactive drugs (alimemazine, amitriptyline, atomoxetine, clomipramine, doxepin, duloxetine, fluvoxamine, levomepromazine, nortriptyline and trimipramine) and metabolites (desmethyl clomipramine and desmethyl doxepin) in serum was developed, optimized, and validated...These results thus serve as motivation for further advancing the EME technology. Until now, EME has been carried out with laboratory-build equipment, and the introduction of commercially available standardized equipment is expected to have a positive impact on future research activity."

Journal • CNS Disorders

Tricyclic antidepressants versus 'active placebo', placebo or no intervention for adults with major depressive disorder: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis. (PubMed, Syst Rev) - "Tricyclic antidepressants are recommended by clinical guidelines and frequently used worldwide in the treatment of major depressive disorder. There is a need for a thorough systematic review to provide the necessary background for weighing the benefits against the harms. This review will ultimately inform best practice in the treatment of major depressive disorder."

Journal • Retrospective data • Review • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry

Beneficial and harmful effects of antidepressants versus placebo, 'active placebo', or no intervention for adults with major depressive disorder: a protocol for a systematic review of published and unpublished data with meta-analyses and trial sequential analyses. (PubMed, Syst Rev) - "As antidepressants are commonly used to treat major depressive disorder in adults, a systematic review evaluating their beneficial and harmful effects is urgently needed. This review will inform best practice in treatment and clinical research of this highly prevalent and burdensome disorder."

Clinical • Journal • Review • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry • Suicidal Ideation