Curatoderm (tacalcitol) / EMD Serono, Teijin, Abiogen - LARVOL DELTA

Inherited palmar filiform hyperkeratosis: A case report (EADV 2024) - "However, there have been recent reports of success with topical tacalcitol 0.002% , 5-fluorouracil 5% , a combination of topical tacalcitol 0.002% and 5-fluorouracil 5% , ammonium lactate 12% , salicylic acid , or retinoids . To our knowledge, only a small number of cases of filiform keratoderma of the palms and soles have been reported. This may be explained by the fact that patients do not consult us for keratoderma filiformis because most cases are asymptomatic or cause only minimal discomfort."

Case report • Clinical • Asthma • Breast Cancer • Chronic Kidney Disease • Colorectal Cancer • Dermatology • Dyslipidemia • Gastrointestinal Cancer • Genetic Disorders • Genito-urinary Cancer • Hepatology • Immunology • Kidney Cancer • Metabolic Disorders • Myelofibrosis • Nephrology • Oncology • Polycystic Kidney Disease • Renal Cell Carcinoma • Renal Disease • Respiratory Diseases • Solid Tumor

New Topical Combination Formulas in Dermatology (INDERCOS 2024) - "In a clinical study including 60 patients with mild-moderate facial acne the efficacy and safety of Tazarotene 0.1% Plus Clindamycin 1% Gel Versus Adapalene 0.1% Plus Clindamycin 1% Gel was examined...In markets, Epiduo fort gel including 0.3% adapalene and 2.5% BPO is also available for mild-moderate acne vulgaris...Besides, Twyneo (a fixed dose comb...For the use of accompanying disorders with acne vulgaris such as acne and melasma the triple combination including Retinoic acid 0.025, Clindamycin 2%, Hydroquinone 4%; for acne and hirsutism double combination of Clindamycin 2% and Eflornithine 11.5%; for acne and seborrheic dermatitis Clotrimazole 1% and Erythromycin 2% are all available...Numerous products such as thermal waters and a variety of creams pharmaceutical compounding offers the advantage of combining with metronidazole or topical antiirritants (e.g., enoxolone, alpha bisabolol) and venotonic agents to prevent disease progression.For sensitive skin and..."

Acne Vulgaris • Alopecia • Dermatitis • Dermatology • Dermatopathology • Immunology • Infectious Disease • Obesity • Psoriasis • Rosacea • Seborrheic Dermatitis

Comparison of various excimer laser (EL) combination therapies for vitiligo: a systematic review and network meta-analysis. (PubMed, J Dermatolog Treat) - "Network Meta-Analysis showed that EL combined with antioxidants (SUCRA = 98.8%), EL combined with calcipotriol (SUCRA = 59.8%) and EL combined with tacalcitol (SUCRA = 59.6%) were the three optimal interventions achieving repigmentation rates ≥ 75%...Based on the results of the current study, EL combination therapies were safe with mild adverse events. EL combined with antioxidants was the preferred regimen for vitiligo, whereas EL alone was the regimen with the highest rate of treatment failure in vitiligo."

Combination therapy • Journal • Retrospective data • Review • Dermatology • Immunology • Vitiligo

Using a Topical Formulation of Vitamin D for the Treatment of Vitiligo: A Systematic Review. (PubMed, Cells) - "This paper presents a systematic review of the utilization of topical vitamin D, specifically cholecalciferol, calcipotriol, and tacalcitol, in the treatment of vitiligo...In addition, treating stable vitiligo with topical cholecalciferol and microneedling has shown success. Future studies are needed to ascertain an efficient method of administering vitamin D topically as an anti-vitiligo agent."

Journal • Review • Dermatology • Immunology • Vitiligo

Noncorticosteroid Topical Therapies for the Treatment of Plaque Psoriasis: A Narrative Review. (PubMed, J Pharm Technol) - "Data Sources: A literature search of the PubMed database was performed (January 1978 to May 2023) using the keywords plaque psoriasis, tapinarof, benvitimod, Vtama, roflumilast, Zoryve, pimecrolimus, tacrolimus, tazarotene, tacalcitol, calcitriol, Vectical, calcipotriene, Dovonex, tacalcitol, vitamin D analogs, salicylic acid, non-corticosteroid topical, Investigator's Global Assessment, and Physician's Global Assessment...The percentage of patients with plaque psoriasis who achieved Investigator's Global Assessment (IGA) success after 8 weeks of treatment with tacalcitol, calcipotriene/betamethasone dipropionate compound, tazarotene/halobetasol propionate, and roflumilast was 17.9%, 39.9%, 40.7%, and 42.4%, respectively...Each topical was efficacious in treating plaque psoriasis and had an adequate safety profile. Despite several treatment options for plaque psoriasis, medication adherence is a limiting factor."

Journal • Review • Dermatology • Immunology • Psoriasis

Vitamin D and Its Analogues: From Differences in Molecular Mechanisms to Potential Benefits of Adapted Use in the Treatment of Alzheimer's Disease. (PubMed, Nutrients) - "Here, we discuss these aspects, especially those of the commonly used vitamin D analogues alfacalcidol, paricalcitol, doxercalciferol, tacalcitol, calcipotriol, and eldecalcitol. Furthermore, the formation of intracellular neurofibrillary tangles involving hyperphosphorylated tau proteins contributes to the pathology of AD. In conclusion, this review emphasizes the importance of an adequate vitamin D supply and discusses the specifics of administering various vitamin D analogues compared with vitamin D in geriatric patients, especially those suffering from AD."

Journal • Review • Alzheimer's Disease • CNS Disorders • Geriatric Disorders

Investigation on the Synthesis of 24-(R)-hydroxycholesterol. (PubMed, Steroids) - "A facile and novel strategy has been developed for synthesis of 24-(R)-hydroxycholesterol, a key intermediate of tacalcitol, starting from 24-dehydrocholesterol in seven steps with 48.2% overall yield and high diastereomer ratio. Photocatalytic oxidation of olefins by employing inexpensive Rose Bengal as photosensitizer and air as the sole oxidant for the preparation of Δ-3β-Hydroxycholestadiene-24-one-3-acetate is the key step in this synthetic route. This developed strategy features mild conditions, satisfied total yield and excellent stereoselectivity (24-R/S = 97.7:2.3), providing a novel access to the 24-(R)-hydroxycholesterol."

Journal

Phytochemical investigation, structural elucidation, in silico study and anti-psoriatic activity of potent bioactive from Betula utilis. (PubMed, J Biomol Struct Dyn) - "Severe drug-associated toxicities like hepatotoxicity and nephrotoxicity (Methotrexate), teratogenicity (Tazarotene), hypercholesterolemia (Cyclosporine) and hypercalcemia (tacalcitol), are the forefront challenges that demand an alternative approach for the treatment of psoriasis...Apart from this BE shows a greater affinity towards the overexpressed Glut-1 receptor in comparison to standard drug Metformin (Met). Based on the in silico screening the isolated lead compound was further processed for the evaluation of anti-psoriatic activity via imiquimod (IMQ 5%) induced psoriasis-like skin inflammation model...These findings suggest that BE-isolated phytoconstituents from Betula utilis could be a potential agent and a step closer to psoriasis treatment. HIGHLIGHTPsoriasis is a multifaceted, immunologically mediated disease consequences production of high levels of proinflammatory mediators and overexpression of Glut-1 transporters that trigger keratinocyte proliferation..."

Journal • Dermatitis • Dermatology • Dyslipidemia • Endocrine Disorders • Hepatology • Immunology • Inflammation • Metabolic Disorders • Psoriasis • Psychiatry • IL17A • IL23A • IL6 • SLC2A1 • TNFA

Effects of 1α,25-dihydroxyvitamin D and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells. (PubMed, Biochem Biophys Rep) - "Experiments using soft agar colony formation assay in T98G and U251 cells revealed significant suppression by 1α,25-dihydroxyvitamin D and tacalcitol on anchorage-independent growth, a property for cancer invasion and metastasis known to correlate with tumorigenicity. These findings indicate that vitamin D and its analogs may be able to counteract the oncogenic transformation, invasion and metastatic potential of glioblastoma and prompt further study of these compounds in the development of improved therapy for brain cancer."

Journal • Brain Cancer • Glioblastoma • Oncology • Solid Tumor • STAT3

Micro-RNAs in Response to Active Forms of Vitamin D in Human Leukemia and Lymphoma Cells. (PubMed, Int J Mol Sci) - "Knowing that leukemia and lymphoma cells show different responses to active forms of vitamin D, we decided to investigate the role of selected miRNA molecules and regulated proteins, analyzing if there is a correlation between the selected miRNAs and regulated proteins in response to two active forms of vitamin D, calcitriol and tacalcitol...We selected five miRNA molecules-miR-27b, miR-32, miR-125b, miR-181a, and miR-181b-and the proteins regulated by these molecules, namely, CYP24A1, Bak1, Bim, p21, p27, p53, and NF-kB. The results showed that the level of selected miRNAs correlates with the level of proteins, especially p27, Bak1, NFκB, and CYP24A1, and miR-27b and miR-125b could be responsible for the anticancer activity of active forms of vitamin D in human leukemia and lymphoma."

Journal • Hematological Malignancies • Leukemia • Lymphoma • Oncology • BAK1 • CDKN1A • miR-125b • MIR181A1 • MIR181B1 • MIR27B • NFKB1

Vitamin D analogs combined with different types of phototherapy in the treatment of vitiligo: A systematic review of randomized trials and within-patient studies. (PubMed, Int Immunopharmacol) - "The current evidence suggests that the additional use of topical calcipotriol or tacalcitol to NB-UVB may increase the treatment effect of vitiligo, and the effect of tacalcitol is greater than that of calcipotriol. None of the vitamin D analogs were found to enhance the efficacy of PUVA or EL for vitiligo."

Journal • Review • Dermatology • Vitiligo

The Impact of Exosomes/Microvesicles Derived from Myeloid Dendritic Cells Cultured in the Presence of Calcitriol and Tacalcitol on Acute B-Cell Precursor Cell Lines with MLL Fusion Gene. (PubMed, J Clin Med) - "The differential effect of VDAs on ALL-B cells, which was associated with increased or decreased expression of CD27, CD24, CD38, and CD23 expression, was observed. Hence, further studies to explain the modulation in the composition of EVs by VDAs are required."

IO biomarker • Journal • Preclinical • Acute Lymphocytic Leukemia • Hematological Malignancies • Leukemia • Oncology • CD24 • CD27 • CD38 • FCER2

Polymorphism of VDR Gene and the Sensitivity of Human Leukemia and Lymphoma Cells to Active Forms of Vitamin D. (PubMed, Cancers (Basel)) - "Importantly, we first showed that sensitivity to calcitriol and tacalcitol in leukemias and lymphomas could be determined by the VDR polymorphism. The FokI polymorphism and the presence of the "bat" haplotype were observed only in the sensitive cells."

Journal • Hematological Malignancies • Leukemia • Lymphoma • Oncology

Therapeutic Options for the Treatment of Darier's Disease: A Comprehensive Review of the Literature. (PubMed, J Cutan Med Surg) - "We identified Grade B evidence for the following treatments of DD: oral acitretin, oral isotretinoin, systemic Vitamin A, topical tretinoin, topical isotretinoin, topical adapalene gel, topical 5-flououracil, topical calciptriol and tacalcitol (with sunscreen), grenz ray radiation, and x-ray radiation. All other evidence for treatments of DD consisted of case reports or case series, which is considered grade C evidence. Considering the quality and quantity of evidence, clinicians may consider initiating a trial of select topical or oral retinoids first in patients with localized or generalized DD, respectively."

Journal • Review • Dermatology • Genetic Disorders

Prevalence of vitamin D analogue toxicity in dogs. (PubMed, Clin Exp Dermatol) - "Calcipotriol, calcitriol and tacalcitol are topical vitamin D analogues commonly used to treat psoriasis...Vitamin D analogue toxicity in dogs is rarely reported with only 2 cases reported in veterinary literature , and more recently, 2 reports in dermatology literature . This is the first published study in reporting the exact number of cases and the clinical effects of vitamin D analogue toxicity in dogs."

Journal • Dermatology • Immunology • Psoriasis

Acanthosis nigricans monstre successfully treated with topical tacalcitol, metformin, and oral contraceptives. (PubMed, Dermatol Ther) - No abstract available

Journal • Long-acting Reversible Contraceptives

Allergic contact dermatitis caused by calcipotriol. (PubMed, Contact Dermatitis) - "When topical treatment with calcipotriol fails to improve, or even worsens, existing skin lesions, contact allergy should be suspected. A patch test concentration of 2 µg/ml in isopropyl alcohol seems to be the most suitable. According to the literature, patients sensitized to calcipotriol may tolerate topical therapy with other vitamin D3 analogues, particularly tacalcitol."

Journal • Biosimilar • Dermatitis • Eczema • Immunology • Psoriasis

Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid (Arch Dermatol Res) - PMID: 23435685 “...KCs were stimulated with IL-17 and subsequently treated with vitD. IL-1 family members were enhanced in psoriatic skin and in ex vivo skin organ cultures after pro-inflammatory stimuli (TNF-α, IL-17 and UVB).”

Preclinical • Psoriasis

Topical tacalcitol as neoadjuvant for photodynamic therapy of acral actinic keratoses: an intra-patient randomized study. (PubMed, Photodiagnosis Photodyn Ther) - "neoadjuvant use of topical tacalcitol might be useful to improve PDT efficacy, especially in hard-to-treat AKs on extremities."

Clinical • Journal • Actinic Keratosis • CNS Disorders • Dermatology • Dermatopathology • Pain

Divergent Effect of Tacalcitol (PRI-2191) on Th17 Cells in 4T1 Tumor Bearing Young and Old Ovariectomized Mice. (PubMed, Aging Dis) - "What is more, in young mice treated with PRI-2191 the secretion of IL-17A to the culture media by iTh17 cells was increased, whereas in aged OVX mice a significant decrease was noted. Increased expression of Spp1 in young mice treated with PRI-2191 may enhance the differentiation of Th17 cells."

Journal • Preclinical • IL17A • IL6 • Osteopontin

VDR Agonists Increase Sensitivity of MCF-7 and BT-474 Breast Cancer Cells to 5 FU. (PubMed, Anticancer Res) - "The VDR agonist used at the relatively low concentration of 10 nM may increase the sensitivity of breast cancer cells, at least of the luminal subtype, to the antiproliferative effect of 5-fluorouracil."

Journal

Combination of Tacalcitol Ointment and Photodynamic Therapy For The Treatment of Follicular Mucinosis of The Scalp. (PubMed, Photodiagnosis Photodyn Ther) - No abstract available

Journal

Tacalcitol increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating the thymidylate synthase. (PubMed, J Steroid Biochem Mol Biol) - "Our results also indicate that calcium-sensing receptor (CaSR) plays a role in the activity of PRI-2191 but has no influence on the 5-FU mechanism of action. In conclusion, we suggest that both VDR and CaSR might be useful as molecular markers for predicting treatment outcomes and identifying the CRC patient subgroups who might benefit from 5-FU-based chemotherapy combined with vitamin D analog."

Journal

Wide Distribution of Phage That Infect Freshwater SAR11 Bacteria. (PubMed, mSystems) - "Also, we illustrated that phage that infect Fonsibacter are widely distributed in freshwater habitats. In summary, the results contribute new insights into the ecology and evolution of Fonsibacter and phage."

Journal

Steroid hormone calcitriol and its analog tacalcitol inhibit miR-125b expression in a human breast cancer MCF-7 cell line. (PubMed, Steroids) - "In addition, treatment with calcitriol and tacalcitol resulted in an increase in the level of pro-apoptotic BAK1 protein encoded by the target gene of miR-125b. We are discussing the putative mechanism of inhibition of the miR-125b expression by vitamin D receptor (VDR) agonists and we suggest that calcitriol and tacalcitol may be used as a miR-125b inhibitor in breast cancer cells expressing VDR."

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