sublingual immunotherapy / UNC School of Medicine - LARVOL DELTA

Peanut Sublingual Immunotherapy: a Promising Alternative to Oral Immunotherapy for Risk of Eosinophilic Esophagitis. (PubMed, Ann Allergy Asthma Immunol) - No abstract available

Journal • Eosinophilic Esophagitis • Gastrointestinal Disorder • Immunology

Vitamin B12 Attenuates CKD Progression Exacerbated by ELMO1 Overexpression in Ischemia-Reperfusion Injury (KIDNEY WEEK 2025) - "Electron microscopy showed podocyte foot process effacement, loss of filtration slits, endothelial fenestration loss, and mitochondrial swelling...Conclusion ELMO1 overexpression exacerbates oxidative stress and worsens IR-induced CKD. Vitamin B12 treatment alleviates these effects, supporting its potential as a safe, accessible therapy to reduce oxidative damage and slow CKD progression after AKI."

Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Fibrosis • Immunology • Inflammation • Metabolic Disorders • Nephrology • Renal Disease • Reperfusion Injury • CST3 • ELMO1 • GPX1

Peanut Component-Specific IgE and IgG4 Are Modulated by Sublingual Immunotherapy and Are Associated With Remission in 1-4-Year-Old Children. (PubMed, Allergy) - "Component-resolved analysis offers key insights into the immunological mechanisms in young children undergoing peanut SLIT, revealing lower baseline levels of Ah2-sIgG4 as a potential biomarker of remission."

IO biomarker • Journal • Allergy • Food Hypersensitivity • Immunology

CASCADES: UNC Cashew Sublingual Immunotherapy (clinicaltrials.gov) - P2 | N=45 | Not yet recruiting | Sponsor: University of North Carolina, Chapel Hill | Initiation date: Oct 2025 ➔ Jan 2026

Trial initiation date • Allergy • Immunology

Semi-analytical solutions of passive scalar transport in generalized Newtonian fluid flow. (PubMed, Phys Fluids (1994)) - "Transport during flow of generalized Newtonian fluids (GNFs) appears often in systems that can be treated in a simplified form as either cylindrical tubes or slit openings between parallel plates...The semi-analytical solutions derived herein were compared to microscale simulations and showed agreement with the numerical error of those simulations. Because of the general nature of the transport solutions derived herein, these solutions can be applied to other non-Newtonian fluids, such as viscoelastic or viscoplastic fluids, as a straightforward extension of this work."

Journal

CASCADES: UNC Cashew Sublingual Immunotherapy (clinicaltrials.gov) - P2 | N=45 | Not yet recruiting | Sponsor: University of North Carolina, Chapel Hill

New P2 trial • Allergy • Immunology

A review of sublingual immunotherapy for treatment of peanut allergy. (PubMed, J Food Allergy) - "Severe symptoms that require treatment with epinephrine have generally not been reported. Key questions remain with regard to the minimum duration of sublingual administration, optimal maintenance dose, and best measures of treatment efficacy. Peanut SLIT has been extensively studied, which demonstrated desensitization at levels that approach OIT while also having a simple administration and reassuring safety that may make it a good option for peanut allergy alongside OIT and anti-IgE therapy."

Journal • Allergy • Dermatology • Food Hypersensitivity • Immunology • Pruritus

Anti-IgE therapy versus allergen-specific immunotherapy for food allergy: weighing the pros and cons. (PubMed, Front Immunol) - "Several AITs have been studied for food allergy, including oral (OIT), sublingual (SLIT), and epicutaneous immunotherapy (EPIT) with varying degrees of safety and efficacy. On the other hand, AITs have been shown to effectively induce desensitization in most individuals and can lead to long-term tolerance or remission in a subset of patients. In this review, we will discuss the pros and cons of omalizumab and AITs and the potential benefit of combining both approaches in young children to achieve immediate increases in reaction threshold while also inducing tolerogenic immunologic responses."

Journal • Review • Allergy • Asthma • Food Hypersensitivity • Immunology • Pulmonary Disease • Respiratory Diseases

Fungal Planet description sheets: 1781-1866. (PubMed, Persoonia) - "Australia, Cortinarius albofolliculus on mossy soil, Cortinarius descensoriformis among leaf litter, Cortinarius kaki among leaf litter, Cortinarius lissosporus in leaf litter, Cortinarius malogranatus in leaf litter, Cortinarius meletlac on soil in mixed forest, Cortinarius sebosioides in long decayed wood litter, Helicogermslita australiensis as an endophyte from healthy leaves of Archontophoenix cunninghamiana, Puccinia clemensiorum on culms of Eleocharis ochrostachys, Puccinia geethae on leaves of Cyperus brevifolius, Puccinia marjaniae on leaves of Nymphoides indica, Puccinia scleriae-rugosae on leaves of Scleria rugosa...Persoonia 54: 327-587. doi: 10.3114/persoonia.2025.54.10."

Journal

The role of anterior segment optical coherence tomography angiography in predicting outcomes of acute ocular burns. (PubMed, Burns) - "AS-OCTA shows potential as a prognostic tool in ocular chemical injuries. Considering the early changes in angiographic parameters, we can predict specific post-chemical-burn complications."

Biomarker • Journal • Cardiovascular • Keratitis • Ocular Inflammation • Ophthalmology • Thermal Injury

A cross-sectional investigation of the ophthalmological impact of loiasis in Cameroon, Central Africa. (PubMed, PLoS Negl Trop Dis) - "This study has, for the first time, provided evidence of independent association between history of eye worm passage and unilateral ametropia, and between high Loa MFL and severe chorioretinal lesions. This suggests that loiasis should be classified as a neglected tropical disease."

Journal • Genetic Disorders • Infectious Disease • Ocular Inflammation • Ophthalmology • Retinal Disorders • Uveitis

Peanut SLIT-tablet is well-tolerated and safe: early results from ALLIANCE, a phase I/II trial (EAACI 2025) - P1/2 | "Epinephrine was administered once due to GI symptoms of moderate intensity. The majority of TEAEs in part 2 were transient, local allergic reactions that did not require treatment: 28 (88%) of participants experienced oral pruritus, 27 (84%) experienced throat irritation, and 16 (50%) experienced stomach pain during up-dosing. Conclusion Preliminary findings from the ALLIANCE trial suggest that peanut SLIT-tablets could be a safe and well-tolerated treatment option for individuals with peanut allergy."

Late-breaking abstract • P1/2 data • Allergic Rhinitis • Allergy • Food Hypersensitivity • Immunology • Inflammation

Direct-to-consumer customized nasal sprays for allergy relief: A market overview (COSM 2025) - "Both share three active ingredients: triamcinolone, ipratropium, and oxymetazoline, but differ in the antihistamine included—Allermi uses azelastine, while Nectar uses olopatadine. Allermi and Nectar are currently the only DTC sellers of customized allergy-relief IN sprays. Both emphasize convenience, transparent pricing, and customized spray formulations, with ongoing provider support. Nectar further positions the customized IN spray as a bridge to SLIT."

Allergy • Immunology

Concordance between at-home finger-prick and blood allergen-specific IgE allergy testing (COSM 2025) - "Background: Direct-to-consumer (DTC) companies now offer sublingual immunotherapy (SLIT) through entirely virtual platforms, featuring at-home allergy testing with finger-prick blood samples, virtual consultations, and delivery of allergen drops to patients... At-home allergy testing via finger-prick blood shows reasonable but not perfect concordance with serum testing. However, variability between DTC companies suggests differences in panels or methods, raising concerns about clinical reliability. While DTC testing offers convenience, discrepancies highlight the potential need for confirmatory testing in traditional healthcare settings."

Discordant • Allergy • Immunology

Baseline basophil activation and early suppression is associated with clinical outcome after peanut sublingual immunotherapy. (PubMed, J Allergy Clin Immunol) - "Following peanut SLIT, participants who achieved remission had significantly suppressed basophils by 12 months, compared to unsuccessful participants that were not desensitized, suggesting that early suppression of basophils may be indicative of peanut SLIT efficacy."

Clinical data • IO biomarker • Journal • Allergy • Food Hypersensitivity • Immunology • CD63

GRADUATE: Grass Pollen Immunotherapy Plus Dupilumab for Tolerance Induction (clinicaltrials.gov) - P2 | N=108 | Completed | Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) | Active, not recruiting ➔ Completed

Trial completion • Allergic Rhinitis • Allergy • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Improving Artificial Intelligence-based Microbial Keratitis Screening Tools Constrained by Limited Data Using Synthetic Generation of Slit-Lamp Photos. (PubMed, Ophthalmol Sci) - "Artificial intelligence-based MK classification may be improved by supplementation of limited real training data with synthetic data generated by GANs. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article."

Journal • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Characterizing gastrointestinal symptoms and the risk of eosinophilic esophagitis during peanut sublingual immunotherapy in toddlers (AAAAI-WAO 2025) - "The risks of GI symptoms and EoE appear low with SLIT. However, further research on screening for EoE prior to, and during, immunotherapy is needed."

Eosinophilic Esophagitis • Food Hypersensitivity • Gastrointestinal Disorder • Immunology • Pain • Pediatrics

Impact of Adherence Rates on Pediatric Peanut Sublingual Immunotherapy (SLIT) Outcomes (AAAAI-WAO 2025) - "Conclusions Children had generally high adherence with peanut SLIT, and our data suggests similar potential for desensitization and remission across a range of adherence rates. Larger studies are needed to validate these results."

Adherence • Clinical • Food Hypersensitivity • Immunology • Pediatrics

The Role of SLIT and EPIT in Food Allergy (AAAAI-WAO 2025) - "Organized by the FAED Interest Section in conjunction with WAO."

Allergy • Food Hypersensitivity • Immunology

Early Suppression Of Basophils In Peanut Sublingual Immunotherapy Is Associated With Clinical Remission of Peanut Allergy (AAAAI-WAO 2025) - No abstract available

Clinical • Allergy • Food Hypersensitivity • Immunology

Peanut component-specific IgE and IgG4 are modulated by sublingual immunotherapy and are associated with remission in young children (AAAAI-WAO 2025) - No abstract available

Clinical

Histochemical indications for a chemically complex signal produced by the cervical gill slit gland of the pygmy sperm whale (Kogia breviceps). (PubMed, Anat Rec (Hoboken)) - "Thus, uric acid may contribute to the chemical message produced by K. breviceps in its marine environment. We hypothesize that the chemical signals produced by the gill slit gland may be shared at close-range by conspecifics, and that the mode of sensory reception is likely gustation."

Journal

PAPA: Preventing Childhood Asthma Using Prophylactic House Dust Mite Allergen Immunotherapy (clinicaltrials.gov) - P2 | N=0 | Withdrawn | Sponsor: Boston Children's Hospital | N=270 ➔ 0 | Not yet recruiting ➔ Withdrawn

Enrollment change • Trial withdrawal • Allergy • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

Food allergy: History, definitions and treatment approaches. (PubMed, J Food Allergy) - "In contrast to oral immunotherapy, epicutaneous and sublingual immunotherapies have demonstrated modest efficacy in clinical trials, with a favorable adverse effect profile, which suggests that these therapies may be possible contenders to oral immunotherapy in certain clinical situations. Familiarity with the various treatment approaches is vital for guiding patients and families as more therapeutic modalities become available for use outside of the research setting."

Journal • Allergy • Food Hypersensitivity • Immunology