sublingual immunotherapy / UNC School of Medicine - LARVOL DELTA

Novel Weekly Combined Symptom Medication Score to Assess Seasonal Allergic Rhinitis Burden and Efficacy of Immunotherapy (AAAAI 2026) - P2 | "Methods Participants in the GRADUATE Trial (NCT04502966, EudraCT: 2018-003456-20), a randomized placebo-controlled trial of grass-SLIT combined with dupilumab, completed annual seasonal wCSMS and validated symptom and quality of life questionnaires, both before and during treatment, as well as out-of-season nasal allergen challenges (NAC). The wCSMS MWPC was 2.11, and the wCSMS MCID between treatment groups was 0.836. Conclusions The wCSMS tracks with pollen counts, correlates with validated symptom instruments, and may be a robust outcome measure for future clinical trials in allergic rhinitis."

Clinical • Allergic Rhinitis • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Hoxb8 Mast Cell Activation Test (Hoxb8 MAT) as Predictive Biomarker during Peanut Sublingual Immunotherapy (SLIT) (AAAAI 2026) - "Interestingly, Hoxb8 MAT changes seen at 12 months of SLIT is also suggestive of early desensitization. These data indicate that the Hoxb8 MAT may have potential as a predictive biomarker during peanut SLIT therapy."

Biomarker • IO biomarker • Food Hypersensitivity

Preliminary Safety and Tolerability Results from ALLIANCE, a Phase I/II Trial of a Peanut Sublingual Immunotherapy Tablet (AAAAI 2026) - P1/2 | "There were no treatment-related AEs leading to discontinuation, no systemic allergic reactions, no epinephrine administrations, no severe swelling of mouth/throat (i.e., requiring epinephrine), and no cases of eosinophilic esophagitis developed. In Part 2, 27/32 participants tolerated the highest UDR dose; 4 participants discontinued due to treatment-related AEs. The most common treatment-emergent AEs were mild-moderate oral pruritus, Conclusions Preliminary results indicate the peanut SLIT-tablet is well-tolerated in children, adolescents, and adults."

Clinical • P1/2 data • Dermatology • Eosinophilic Esophagitis • Food Hypersensitivity • Gastrointestinal Disorder • Immunology • Pruritus

Differences in IgE and IgG4 Binding Patterns Before and After Sublingual Immunotherapy (AAAAI 2026) - "Several peptides, including Jug r 2 (#102) (walnut), Ara h 5 (#2), Ara h 3 (#16) (peanut), and Ana o 1 (#104) (cashew), consistently ranked among those that shifted during treatment. A SHAP dot plot was generated with the top-performing Conclusions Peptide binding patterns can capture immune changes with treatment, allowing us to identify specific peptides that may aid in evaluating the outcomes of food allergy treatments."

Asthma • Atopic Dermatitis • Dermatology • Food Hypersensitivity • Immunology • Inflammation • Respiratory Diseases

Durable Clinical Efficacy of Grass Pollen Sublingual Tablet Immunotherapy in Combination with Dupilumab in Adults with Seasonal Allergic Rhinitis (AAAAI 2026) - "All secondary endpoints at year 3 including NAC peak nasal inspiratory flow 0-1hour (p=0.004), titrated grass skin prick test, early and late-phase skin responses, and seasonal and global evaluation scores (all p<0.001) supported the primary results. In exploratory analyses, SLIT/dupilumab-placebo showed a reduction in TNSS AUC 0-1hour compared to double-placebo at year 3 (19.4% Conclusions Two years of combination therapy with grass pollen SLIT and dupilumab significantly enhances long-term tolerance with clinical benefit evident for at least one year after treatment discontinuation."

Clinical • Combination therapy • Allergic Rhinitis • Immunology • Inflammation

Safety of Dose Escalation with Low Concentration Peanut Sublingual Immunotherapy (AAAAI 2026) - "Upper Conclusions Symptoms with peanut SLIT beyond local oral symptoms and symptoms requiring rescue treatment were uncommon during dose escalation. Dose escalation with peanut SLIT without multiple dilutions may be safe and may improve feasibility for patients and providers."

Clinical • Dermatology • Food Hypersensitivity • Immunology • Pruritus • Urticaria

Food Sublingual Immunotherapy in Early Life (AAAAI 2026) - "Organized by the FAED Interest Section."

Allergy • Food Hypersensitivity • Immunology

Sublingual Immunotherapy for Food Allergy: Updates in Safety, Efficacy, and Future Considerations. (PubMed, Curr Allergy Asthma Rep) - "Small studies have also demonstrated potential efficacy with SLIT for other foods such as milk, hazelnut, and peach. Evidence to date supports SLIT as effective and safe and a potential future treatment option for children with food allergy."

Journal • Review • Allergy • Food Hypersensitivity • Immunology

Peanut Sublingual Immunotherapy: a Promising Alternative to Oral Immunotherapy for Risk of Eosinophilic Esophagitis. (PubMed, Ann Allergy Asthma Immunol) - No abstract available

Journal • Eosinophilic Esophagitis • Gastrointestinal Disorder • Immunology

Vitamin B12 Attenuates CKD Progression Exacerbated by ELMO1 Overexpression in Ischemia-Reperfusion Injury (KIDNEY WEEK 2025) - "Electron microscopy showed podocyte foot process effacement, loss of filtration slits, endothelial fenestration loss, and mitochondrial swelling...Conclusion ELMO1 overexpression exacerbates oxidative stress and worsens IR-induced CKD. Vitamin B12 treatment alleviates these effects, supporting its potential as a safe, accessible therapy to reduce oxidative damage and slow CKD progression after AKI."

Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Fibrosis • Immunology • Inflammation • Metabolic Disorders • Nephrology • Renal Disease • Reperfusion Injury • CST3 • ELMO1 • GPX1

Peanut Component-Specific IgE and IgG4 Are Modulated by Sublingual Immunotherapy and Are Associated With Remission in 1-4-Year-Old Children. (PubMed, Allergy) - "Component-resolved analysis offers key insights into the immunological mechanisms in young children undergoing peanut SLIT, revealing lower baseline levels of Ah2-sIgG4 as a potential biomarker of remission."

IO biomarker • Journal • Allergy • Food Hypersensitivity • Immunology

CASCADES: UNC Cashew Sublingual Immunotherapy (clinicaltrials.gov) - P2 | N=45 | Not yet recruiting | Sponsor: University of North Carolina, Chapel Hill | Initiation date: Oct 2025 ➔ Jan 2026

Trial initiation date • Allergy • Immunology

Semi-analytical solutions of passive scalar transport in generalized Newtonian fluid flow. (PubMed, Phys Fluids (1994)) - "Transport during flow of generalized Newtonian fluids (GNFs) appears often in systems that can be treated in a simplified form as either cylindrical tubes or slit openings between parallel plates...The semi-analytical solutions derived herein were compared to microscale simulations and showed agreement with the numerical error of those simulations. Because of the general nature of the transport solutions derived herein, these solutions can be applied to other non-Newtonian fluids, such as viscoelastic or viscoplastic fluids, as a straightforward extension of this work."

Journal

CASCADES: UNC Cashew Sublingual Immunotherapy (clinicaltrials.gov) - P2 | N=45 | Not yet recruiting | Sponsor: University of North Carolina, Chapel Hill

New P2 trial • Allergy • Immunology

A review of sublingual immunotherapy for treatment of peanut allergy. (PubMed, J Food Allergy) - "Severe symptoms that require treatment with epinephrine have generally not been reported. Key questions remain with regard to the minimum duration of sublingual administration, optimal maintenance dose, and best measures of treatment efficacy. Peanut SLIT has been extensively studied, which demonstrated desensitization at levels that approach OIT while also having a simple administration and reassuring safety that may make it a good option for peanut allergy alongside OIT and anti-IgE therapy."

Journal • Allergy • Dermatology • Food Hypersensitivity • Immunology • Pruritus

Anti-IgE therapy versus allergen-specific immunotherapy for food allergy: weighing the pros and cons. (PubMed, Front Immunol) - "Several AITs have been studied for food allergy, including oral (OIT), sublingual (SLIT), and epicutaneous immunotherapy (EPIT) with varying degrees of safety and efficacy. On the other hand, AITs have been shown to effectively induce desensitization in most individuals and can lead to long-term tolerance or remission in a subset of patients. In this review, we will discuss the pros and cons of omalizumab and AITs and the potential benefit of combining both approaches in young children to achieve immediate increases in reaction threshold while also inducing tolerogenic immunologic responses."

Journal • Review • Allergy • Asthma • Food Hypersensitivity • Immunology • Pulmonary Disease • Respiratory Diseases

Fungal Planet description sheets: 1781-1866. (PubMed, Persoonia) - "Australia, Cortinarius albofolliculus on mossy soil, Cortinarius descensoriformis among leaf litter, Cortinarius kaki among leaf litter, Cortinarius lissosporus in leaf litter, Cortinarius malogranatus in leaf litter, Cortinarius meletlac on soil in mixed forest, Cortinarius sebosioides in long decayed wood litter, Helicogermslita australiensis as an endophyte from healthy leaves of Archontophoenix cunninghamiana, Puccinia clemensiorum on culms of Eleocharis ochrostachys, Puccinia geethae on leaves of Cyperus brevifolius, Puccinia marjaniae on leaves of Nymphoides indica, Puccinia scleriae-rugosae on leaves of Scleria rugosa...Persoonia 54: 327-587. doi: 10.3114/persoonia.2025.54.10."

Journal

The role of anterior segment optical coherence tomography angiography in predicting outcomes of acute ocular burns. (PubMed, Burns) - "AS-OCTA shows potential as a prognostic tool in ocular chemical injuries. Considering the early changes in angiographic parameters, we can predict specific post-chemical-burn complications."

Biomarker • Journal • Cardiovascular • Keratitis • Ocular Inflammation • Ophthalmology • Thermal Injury

A cross-sectional investigation of the ophthalmological impact of loiasis in Cameroon, Central Africa. (PubMed, PLoS Negl Trop Dis) - "This study has, for the first time, provided evidence of independent association between history of eye worm passage and unilateral ametropia, and between high Loa MFL and severe chorioretinal lesions. This suggests that loiasis should be classified as a neglected tropical disease."

Journal • Genetic Disorders • Infectious Disease • Ocular Inflammation • Ophthalmology • Retinal Disorders • Uveitis

Peanut SLIT-tablet is well-tolerated and safe: early results from ALLIANCE, a phase I/II trial (EAACI 2025) - P1/2 | "Epinephrine was administered once due to GI symptoms of moderate intensity. The majority of TEAEs in part 2 were transient, local allergic reactions that did not require treatment: 28 (88%) of participants experienced oral pruritus, 27 (84%) experienced throat irritation, and 16 (50%) experienced stomach pain during up-dosing. Conclusion Preliminary findings from the ALLIANCE trial suggest that peanut SLIT-tablets could be a safe and well-tolerated treatment option for individuals with peanut allergy."

Late-breaking abstract • P1/2 data • Allergic Rhinitis • Allergy • Food Hypersensitivity • Immunology • Inflammation

Direct-to-consumer customized nasal sprays for allergy relief: A market overview (COSM 2025) - "Both share three active ingredients: triamcinolone, ipratropium, and oxymetazoline, but differ in the antihistamine included—Allermi uses azelastine, while Nectar uses olopatadine. Allermi and Nectar are currently the only DTC sellers of customized allergy-relief IN sprays. Both emphasize convenience, transparent pricing, and customized spray formulations, with ongoing provider support. Nectar further positions the customized IN spray as a bridge to SLIT."

Allergy • Immunology

Concordance between at-home finger-prick and blood allergen-specific IgE allergy testing (COSM 2025) - "Background: Direct-to-consumer (DTC) companies now offer sublingual immunotherapy (SLIT) through entirely virtual platforms, featuring at-home allergy testing with finger-prick blood samples, virtual consultations, and delivery of allergen drops to patients... At-home allergy testing via finger-prick blood shows reasonable but not perfect concordance with serum testing. However, variability between DTC companies suggests differences in panels or methods, raising concerns about clinical reliability. While DTC testing offers convenience, discrepancies highlight the potential need for confirmatory testing in traditional healthcare settings."

Discordant • Allergy • Immunology

Baseline basophil activation and early suppression is associated with clinical outcome after peanut sublingual immunotherapy. (PubMed, J Allergy Clin Immunol) - "Following peanut SLIT, participants who achieved remission had significantly suppressed basophils by 12 months, compared to unsuccessful participants that were not desensitized, suggesting that early suppression of basophils may be indicative of peanut SLIT efficacy."

Clinical data • IO biomarker • Journal • Allergy • Food Hypersensitivity • Immunology • CD63

GRADUATE: Grass Pollen Immunotherapy Plus Dupilumab for Tolerance Induction (clinicaltrials.gov) - P2 | N=108 | Completed | Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) | Active, not recruiting ➔ Completed

Trial completion • Allergic Rhinitis • Allergy • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Improving Artificial Intelligence-based Microbial Keratitis Screening Tools Constrained by Limited Data Using Synthetic Generation of Slit-Lamp Photos. (PubMed, Ophthalmol Sci) - "Artificial intelligence-based MK classification may be improved by supplementation of limited real training data with synthetic data generated by GANs. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article."

Journal • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology